叶茂
教授、博士生导师
Tel:
E-mail:goldleaf@hnu.edu.cn



























基本信息
叶茂：博士生导师，化学生物传感与计量学国家重点实验室/湖南大学生物学院/湖南大学分子科学与生物医学实验室教授。2007年－2010年于美国纽约血液中心Lindsley F. Kimball Research Institute (LFKRI)从事博士后研究工作。担任湖南省生物化学与分子生物学学会理事、中国转化医学联盟云南省转化医学分会常务委员、全国科学技术名词审定委员会肿瘤学名词编写委员会编委。主持国家自然科学基金、湖南省重点研发计划、湖南省自然科学基金、浙江省自然科学基金、长沙市科技计划等多项。获得国家授权发明专利五项。发表SCI论文近五十篇，其中第一或通讯作者在PNAS、Trends Biochem Sci、Angew. Chem. Int. Ed、Theranostics、Chemical Science等国际学术期刊上发表SCI论文文章近三十篇。 2009年获得教育部高等学校科学研究优秀成果二等奖，2010年获得湖南省自然科学一等奖，2017年获得湖南省自然科学二等奖。


本课题组属于化学生物传感与计量学国家重点实验室/湖南大学分子科学与分子医学实验室（Molecular Science and Biomedicine Laboratory, MBL）
办公室：湖南大学生物学院逸夫楼南栋二楼212
电话：


教育背景
2005年毕业于中南大学湘雅医学院肿瘤研究所，获得医学博士学位。
研究领域
主要从事肿瘤生物学、抗肿瘤分子靶向治疗、化学生物学等方向的研究工作。研究具体内容以恶性肿瘤细胞增殖、分化、转移、凋亡等生物学行为为切入点，通过分子生物学、基因组学和蛋白质组学的方法和手段，探讨恶性肿瘤发生、发展的分子病理学机制，寻找恶性肿瘤的早期诊断、治疗或预后有指导意义的分子标志物和分子靶标，并借助生物分析和功能纳米材料的方法和手段，开展恶性肿瘤分子成像、分子诊断和分子靶向治疗。


本实验室具有一流的科研环境和科研氛围。本方向招收博士后、博士和硕士研究生，欢迎对科研有浓厚兴趣并有志于从事肿瘤学研究的学生随时与我们联系（Email：goldleaf@hnu.edu.cn; yemaocsu@hotmail.com）。


科研项目
[1]湖南省重点研发计划（2018SK2128), 项目负责人
[2]国家自然科学基金面上项目（**），项目负责人
[3]国家科技部973项目(2013CB932702) ，子项目负责人
[4]国家自然科学基金面上项目 (**)， 项目负责人
[5]国家自然科学基金面上项目（**，项目负责人
[6]湖南省自然科学基金（12JJ6077）， 项目负责人
[7]湖南大学交叉学科研究项目, 项目负责人




学术成果
一、发表文章 (2013-2019,*:通讯作者)
Hui Li, Juan Liu, Wenjie Cao, Xiaojuan Xiao, Long Liang, Feng Liu-Smith, Weiwei Wang, Hong Liu, Peng Zhou, Ruoyuan Ouyang, Zhijun Yuan, Jing Liu*, Mao Ye*, Bin Zhang*. C-myc/miR-150/EPG5 axis mediated dysfunction of autophagy promotes development of non-small cell lung cancer. Theranostics 2019; 9(18): 5134-5148 (IF:8.063)
Wu Xiaoqiu^#; Liu Honglin^#;Han Dongmei^#; Peng Bo; Zhang Hui; Zhang Lin; Li Jianglin; Liu Jing; Cui Cheng; Fang Senbiao; Li Min; Ye Mao*; Tan Weihong*, Elucidation and structural modeling of CD71 as a molecular target for cell-specific aptamer binding., Journal of the American Chemical Society, 2019 (http://doi.org/10.1021/jacs.9b03720) (IF:14.357)
Liang Long; Peng Yuanliang; Zhang Jieying; Zhang Yibin; Roy Mridul; Han Xu; Xiao Xiaojuan; Sun Shuming; Liu Hong; Nie Ling; Kuang Yijin; Zhu Zesen; Deng Jinghui; Xia Yang; Sankaran Vijay G; Hillyer Christopher D; Mohandas Narla; Ye Mao*; An Xiuli*; Liu Jing*, Deubiquitylase USP7 regulates human terminal erythroid differentiation by stabilizing GATA1., Haematologica, 2019-3-14. （IF:9.09）
Fu, Ting^#; Lyu, Yifan^#; Liu, Hui; Peng, Ruizi; Zhang, Xiaobing; Ye, Mao*; Tan, Weihong*. DNA-Based Dynamic Reaction Networks, Trends in Biochemical Sciences,43 (2018) 547-560.（IF:15.678）
Jin, Cheng^#; Zhang, Hui^#; Zou, Jianmei; Liu, Yan; Zhang, Lin; Li, Fengjie; Wang, Ruowen; Xuan, Wenjing; Ye, Mao*; Tan, Weihong*. Floxuridine Homomeric Oligonucleotides “Hitchhike” with Albumin In Situ for Cancer Chemotherapy, Angewandte Chemie International Edition, 57 (2018) 8994-8997.（IF:12.102）
Deng, Tanggang^#; Yan, Guobei^#; Song, Xin^#; Xie, Lin; Zhou, Yu; Li, Jianglin; Hu, Xiaoxiao; Li, Zhen; Hu, Jun; Zhang, Yibin; Zhang, Hui; Sun, Yang; Feng, Peifu; Wei, Dong; Hu, Bin; Liu, Jing*; Tan, Weihong*; Ye, Mao*. Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses, Proceedings of the National Academy of Sciences, 115 (2018) 4678-4683.（IF:9.504）
Wu, Xiaoqiu^#; Zhao, Zilong^#; Bai, Huarong; Fu, Ting; Yang, Chao; Hu, Xiaoxiao; Liu, Qiaoling; Champanhac, Carole; Teng, I-Ting; Ye, Mao*; Tan, Weihong* DNA aptamer selected against pancreatic ductal adenocarcinoma for in vivo imaging and clinical tissue recognition, Theranostics, 5 (2015) 985-994.（IF:8.537）
Roy, Mridul#; Liang, Long^#; Xiao, Xiaojuan^#; Peng, Yuanliang; Luo, Yuhao; Zhou, Weihua; Zhang, Ji; Qiu, Lugui; Zhang, Shuaishuai; Liu, Feng; Ye, Mao*; Zhou, Wen*; Liu, Jing*. Lycorine downregulates HMGB1 to inhibit autophagy and enhances bortezomib activity in multiple myeloma, Theranostics, 6 (2016) 2209.（IF:8.537）
Yi, Yi; Wang, Huijing; Wang, Xuewei; Liu, Qiaoling*; Ye, Mao*; Tan, Weihong, A Smart, Photocontrollable Drug Release Nanosystem for Multifunctional Synergistic Cancer Therapy, ACS applied materials & interfaces, 9 (2017) 5847-5854.（IF:8.097）
Peng, Lu; Wu, Cuichen Sam; You, Mingxu; Han, Da; Chen, Yan; Fu, Ting; Ye, Mao*; Tan, Weihong*, Engineering and applications of DNA-grafted polymer materials, Chemical science, 4 (2013) 1928-1938.（IF:9.063）
Sun, Yang^#; Cao, Lanqin^#; Sheng, Xunan; Chen, Jieying; Zhou, Yu; Yang, Chao; Deng, Tanggang; Ma, Hongchang; Feng, Peifu; Liu, Jing; Tan, Weihong*; Ye, Mao*. WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway, Cell death & disease, 8 (2017) e2743.（IF:5.638）
Zhang, Hui; Wang, Zhibo; Xie, Lin; Zhang, Yibin; Deng, Tanggang; Li, Jianglin; Liu, Jing; Xiong, Wei; Zhang, Lei; Zhang, Lin; Peng, Bo; He, Leye; Ye, Mao*, Hu, Xiaoxiao*; Tan, Weihong*. Molecular Recognition and In-Vitro-Targeted Inhibition of Renal Cell Carcinoma Using a DNA Aptamer, Molecular Therapy-Nucleic Acids, 12 (2018) 758-768.（IF:5.66）
Hu Bin; Deng Tanggang; Ma Hongchang; Liu Yan; Feng Peifu; Wei Dong; Ling Neng; Li Ling; Qiu Siyuan; Zhang Lin; Peng Bo; Liu Jing; Ye Mao*, Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells., Cells, 8(4), 2019-3-31. （IF:4.829）
Zhou, Weihua; Zhang, Yibin; Zeng, Yayue; Peng, Minyuan; Li, Hui; Sun, Shuming; Ma, Bianying; Wang, Yanpeng; Ye, Mao*; Liu, Jing*. Screening and characterization of a Annenix A2 binding aptamer that inhibits the proliferation of myeloma cells, Biochimie, (2018).（IF:3.188）
Roy, Mridul; Liang, Long; Xiao, Xiaojuan; Feng, Peifu; Ye, Mao*; Liu, Jing*. Lycorine: A prospective natural lead for anticancer drug discovery, Biomedicine & Pharmacotherapy, 107 (2018) 615-624.（IF:3.457）
Chen, Jieying^#; Sheng, Xunan^#; Ma, Hongchang^#; Tang, Zhengshan; Yang, Chao; Cao, Lanqin; Sun, Yang; Deng, Tanggang; Feng, Peifu; Hu, Bin; Wei, Dong; Liu, Jing; Xiong, Wei*; Ye, Mao*. WDR79 mediates the proliferation of non‐small cell lung cancer cells by regulating the stability of UHRF1, Journal of cellular and molecular medicine, 22 (2018) 2856-2864.（IF:4.302）
Wang, Zi; Zhang, Jingxin; Zeng, Yayue; Sun, Shuming; Zhang, Ji; Zhang, Bin; Zhu, Min; Ouyang, Ruoyun; Ma, Bianyin; Ye, Mao*; An, Xiuli*; Liu, Jing*. Knockout of 4.1 B triggers malignant transformation in SV40T‐immortalized mouse embryo fibroblast cells, Molecular carcinogenesis, 56 (2017) 538-549.（IF:3.851）
Peng, Yongbo^#; Zhao, Zilong^#; Liu, Teng^#; Xie, Guojian; Jin, Cheng; Deng, Tang gang; Sun, Yang; Li, Xiong; Hu, Xiaoxiao; Zhang, Xiaobing; Ye, Mao; Tan, Weihong*. A Multi‐Mitochondrial Anticancer Agent that Selectively Kills Cancer Cells and Overcomes Drug Resistance, ChemMedChem, 12 (2017) 250-256.（IF:3.009）
Peng, Minyuan; Li, Yanming; Zhang, Jian; Wu, Yong; Yang, Xiaoyang; Lei, Ye; Ye, Mao; Liu, Jing; Han, Xu; Kuang, Yijin; Zhao, Xielan; Chen, Fangping*. Vector-independent transmembrane transport of oligodeoxyribonucleotides involves p38 mitogen activated protein kinase phosphorylation, Scientific reports, 7 (2017) 13571.（IF:4.122）
Jin, Cheng^#; Fu, Ting^#; Wang, Ruowen*; Liu, Hui; Zou, Jianmei; Zhao, Zilong; Ye, Mao; Zhang, Xiaobing; Tan, Weihong*. Fluorinated molecular beacons as functional DNA nanomolecules for cellular imaging, Chemical science, 8 (2017) 7082-7086.（IF:9.063）
Hu, Jingping; Ye, Mao; Zhou, Zhiguang*, Aptamers: novel diagnostic and therapeutic tools for diabetes mellitus and metabolic diseases, Journal of Molecular Medicine, 95 (2017) 249-256.（IF:4.938）
Han, Xu; Zhang, Jieying; Peng, Yuanliang; Peng, Minyuan; Chen, Xiao; Chen, Huiyong; Song, Jianhui; Hu, Xiao; Ye, Mao; Li, Jianglin; Sankaran,Vijay G; Hillyer, Christopher D; Mohandas, Narla; An, Xiuli; Liu, Jing.Unexpected role for p19INK4d in posttranscriptional regulation of GATA1 and modulation of human terminal erythropoiesis, Blood, 129 (2017) 226-237.（IF:15.132）
Wang, Zi^#; Ma, Bianyin^#; Li, Hui^#; Xiao, Xiaojuan^#; Zhou, Weihua; Liu, Feng; Zhang, Bin; Zhu, Min; Yang, Qin; Zeng, Yayue; Sun, Yang; Sun, Shuming; Wang, Yanpeng; Zhang, Yibin; Weng, Haibo; Chen, Lixiang; Ye, Mao*; An, Xiuli*; Liu, Jing*. Protein 4.1 N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC, Oncotarget, 7 (2016) 509.
Wang, Ruowen*^,#; Lu, Danqing^#; Bai, Huarong^#; Jin, Cheng; Yan, Guobei; Ye, Mao; Qiu, Liping; Chang, Rongshan; Cui, Cheng; Liang, Hao; Tan, Weihong*. Using modified aptamers for site specific protein–aptamer conjugations, Chemical science, 7 (2016) 2157-2161.（IF:9.063）
Sun, Yang^#; Yang, Chao^#; Chen, Jieying; Song, Xin; Li, Zhen; Duan, Minlan; Li, Jianglin; Hu, Xiaoxiao; Wu, Kuangpei; Yan, Guobei; Yang, Cai; Liu, Jing; Tan, Weihong*; Ye, Mao*. Overexpression of WDR 79 in non‐small cell lung cancer is linked to tumour progression, Journal of cellular and molecular medicine, 20 (2016) 698-709.（IF:4.302）
Duan, Minlan^#; Long, Yuqian^#; Yang, Cai; Wu, Xiaoqiu; Sun, Yang; Li, Jianglin; Hu, Xiaoxiao; Lin, Wei; Han, Dongmei; Zhao, Yifan; Liu, Jing; Ye, Mao *, Tan, Weihong *. Selection and characterization of DNA aptamer for metastatic prostate cancer recognition and tissue imaging, Oncotarget, (2016).
Long, Yuqian^#; Qin, Zhiqiang^#; Duan, Minlan^#; Li, Shizhu; Wu, Xiaoqiu; Lin, Wei; Li, Jianglin; Zhao, Zilong; Liu, Jing; Xiong, Dehui; Huang, Yi; Hu, Xiaoxiao; Yang, Chao; Ye, Mao*; Tan, Weihong*. Screening and identification of DNA aptamers toward Schistosoma japonicum eggs via SELEX, Scientific reports, 6 (2016) 24986.（IF:4.122）
Li, Hui; Ouyang, Ruoyun; Wang, Zi; Zhou, Weihua; Chen, Huiyong; Jiang, Yawen; Zhang, Yibin; Liao, Mengting; Wang, Weiwei; Ye, Mao; Ding, Zhigang; Feng, Xueping*; Liu, Jing*; Zhang, Bin*. MiR-150 promotes cellular metastasis in non-small cell lung cancer by targeting FOXO4, Scientific reports, 6 (2016) 39001.（IF:4.122）
Zhu, Huijie; Li, Jin; Zhang, Xiao‐Bing*; Ye, Mao; Tan, Weihong*, Nucleic acid aptamer‐mediated drug delivery for targeted cancer therapy, ChemMedChem, 10 (2015) 39-45.（IF:3.009）
Ye, Mao*^,#; Tang, Yani^#; Tang, Shijun^#; Liu, Jing; Wu, Kuangpei; Yao, Shan; Sun, Yang; Zhou, Lei; Deng, Tanggang; Chen, Ying; Huang, Chenghan; Tan, Weihong*.STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation, Oncotarget, 6 (2015) 34718.
Tang, Yani^#; Yan, Guobei^#; Song, Xin; Wu, Kuangpei; Li, Zhen; Yang, Chao; Deng, Tanggang; Sun, Yang; Hu, Xiaoxiao; Yang, Cai; Bai, Huarong; Li, Hui; Tan, Weihong; Ye, Mao*; Liu, Jing*. STIP overexpression confers oncogenic potential to human non‐small cell lung cancer cells by regulating cell cycle and apoptosis, Journal of cellular and molecular medicine, 19 (2015) 2806-2817.（IF:4.302）
Luo, Yuhao^#; Roy, Mridul^#; Xiao, Xiaojuan^#; Sun, Shuming; Liang, Long; Chen, Huiyong; Fu, Yin; Sun, Yang; Zhu, Min; Ye, Mao; Liu, Jing*. Lycorine induces programmed necrosis in the multiple myeloma cell line ARH-77, Tumor Biology, 36 (2015) 2937-2945.
Hu, Jun^#; Zhao, Zilong^#; Liu, Qiaoling; Ye, Mao; Hu, Bingqiang; Wang, Jing; Tan, Weihong*. Study of the Function of G‐Rich Aptamers Selected for Lung Adenocarcinoma, Chemistry–An Asian Journal, 10 (2015) 1519-1525.（IF:3.692）
Wang, Zi^#; Zhang, Ji^#; Ye, Mao^#; Zhu, Min; Zhang, Bin; Roy, Mridul; Liu, Jing*; An, Xiuli*. Tumor suppressor role of protein 4.1 B/DAL-1, Cellular and molecular life sciences, 71 (2014) 4815-4830.（IF:6.721）
Wang, RuoWen; Zhu, Guizhi; Mei, Lei; Xie, Yan; Ma, Haibin; Ye, Mao; Qing, Feng-Ling; Tan, Weihong*, Automated modular synthesis of aptamer–drug conjugates for targeted drug delivery, Journal of the American Chemical Society, 136 (2014) 2731-2734.（IF:14.357）
Dai, Hongjuan^#; Ye, Mao^#; Peng, Mingyuan; Zhou, Weihua; Bai, Huarong; Xiao, Xiaojuan; Ma, Bianying; Zhou, Jiajie; Tang, Shijun; Yao, Shan; Cao, Ye; Qin, Zhiqiang; Liu, Jing*; Tan, Weihong*. Aptamer TY04 inhibits the growth of multiple myeloma cells via cell cycle arrest, Tumor Biology, 35 (2014) 7561-7568
Wang, Hui; Donovan, Michael J; Meng, Ling; Zhao, Zilong; Kim, Youngmi; Ye, Mao; Tan, Weihong*, DNAzyme‐Based Probes for Telomerase Detection in Early‐Stage Cancer Diagnosis, Chemistry–A European Journal, 19 (2013) 4633-4639.（IF:5.16）
Roy, Mridul; Luo, Yu-Hao; Ye, Mao*; Liu, Jing*, Nonsmall cell lung cancer therapy: insight into multitargeted small-molecule growth factor receptor inhibitors, BioMed research international, 2013 (2013).（IF:2.583）



二、专利
[1]叶茂,谭蔚泓,张慧,熊炜. 一种检测人葡萄膜黑色素瘤细胞的核酸适体[P]. 湖南：CNA,2018-05-15.（公开）
[2]谭蔚泓,孙洋,莫柳婷,赵子龙,叶茂. 一种靶向PD1#PDL1的双特异性核酸适体及其衍生物[P]. 湖南：CNA,2018-03-13.（公开）
[3]谭蔚泓,孙洋,叶茂,方晓红,莫柳婷,赵子龙. 检测人PDL1蛋白的核酸适体及其在制备检测制剂中的应用[P]. 湖南：CNA,2018-03-13.（公开）
[4]叶茂,谭蔚泓,胡小晓,张慧. 一种检测人肾透明细胞癌细胞的核酸适体及其在制备检测制剂中的应用[P]. 湖南：CNA,2017-05-31.（授权）
[5]叶茂,谭蔚泓,龙禹乾,段敏兰. 一种检测人膀胱移行细胞癌细胞的核酸适配体及其在制备检测制剂中的应用[P]. 湖南：CNA,2016-06-01.（授权）
[6]谭蔚泓,秦志强,叶茂,龙禹乾. 一种检测日本血吸虫卵的核酸适配体及其在制备检测制剂中的应用[P]. 湖南：CNA,2015-10-07.（授权）
[7]谭蔚泓,赵子龙,武晓秋,叶茂,白华荣. 一种检测胰腺导管癌的核酸适配体、试剂盒及方法[P]. 湖南：CNA,2015-05-06.（授权）
[8]刘静,谭蔚泓,叶茂,宋健辉,戴红娟. 一种核酸适配体制备治疗多发性骨髓瘤的药物或制品的用途[P]. 湖南：CNA,2013-12-11.（授权）
[9]谭蔚泓,叶茂,刘静,宋健辉,戴红娟. 一种核酸适配体及其制备治疗白血病的药物或制品的用途[P]. 湖南：CNA,2013-11-27. (授权)



奖励与荣誉
湖南大学2019年度优秀教师
湖南省2017年自然科学二等奖

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教育部2009年度高等学校科学研究优秀成果（自然科学奖）二等奖
题目：EB病毒潜伏膜蛋白1致瘤分子机制的研究
温州市2009年第十三届自然科学优秀论文一等奖
题目：HGF通过PI3K/AKT信号转导通路介导葡萄膜黑色素瘤转移