删除或更新信息,请邮件至freekaoyan#163.com(#换成@)

湖南农业大学动物医学院导师教师师资介绍简介-刘兆颖副教授简介

本站小编 Free考研考试/2021-08-22

姓 名
刘兆颖
性 别



籍 贯
湖南涟源
年 龄
39

学 历
博士研究生
职 称
副教授

Email
liu_zhaoying@sina.com
电 话
**







招生类型
招生学科
研究方向

博士研究生
兽医学
兽医药理学与毒理学

硕士研究生
兽医学
中兽药学







1998/9 - 2002/6,湖南农业大学,动物医学,学士
2003/9 - 2009/6,华中农业大学,兽医药理学与毒理学,硕博连读,博士
2014/3 - 2015/3,俄亥俄州立大学,药理学,访问****
2018/9- 2019/9, 浙江大学,访问****










(1) 国家重点研发计划子课题,2017YFD**,中兽药药效提升与关键技术创研与产业化应用,2017/7-2020/12, 在研,主持
(2) 国家重点研发计划子课题,2018YFE**,植物源饲用抗生素替代产品研究与创制,2019/9-2022/7,在研,主持
(3) 国家自然科学基金面上项目,**,基于多组分代谢与残留的钩吻作用物质基础研究,2020/1-2023/12,在研,主持
(4) 湖南省教育厅重点项目,18A088,钩吻生物碱的比较代谢与处置研究,2019/1-2021/12,在研,主持
(5) 湖南省****项目,2017JJ1017基于代谢的中兽药作用物质基础 与药理作用机制研究,2017/9-2019/9,在研,结题










发表的第一作者与通讯作者SCI论文
2020
1) Yisong Liu?, Qi Tang?, Pi Cheng?, Mingfei Zhu,Hui Zhang, Jiazhe Liu, Mengting Zuo, Chongyin Huang, Changqiao Wu, Zhi-Liang Sun,* Zhao-Ying Liu*. Whole-genome sequencing and analysis of the Chinese herbal plant Gelsemium elegans.Acta Pharm SinB. 2020 Feb;10(2):374-382. doi:
10.1016/j.apsb.2019.08.004. 期刊号:2211-3835 IF:5.808,
2) Zuo MT, Wang ZY, Yang K, Li YJ, Huang CY, Liu YC, Yu H, Zhao XJ, Liu ZY*.
Characterization of absorbed and produced constituents in goat plasma urine and faeces from the herbal medicine Gelsemium elegans by using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Ethnopharmacol. 2020 Apr 24;252: 112617. doi: 10.1016/j.jep.2020.112617. Epub 2020 Jan 24
3) Wu Y, Zhao NJ, Cao Y, Sun Z, Wang Q, Liu ZY*, Sun ZL. Sanguinarine metabolism and pharmacokinetics study in vitro and in vivo.
J Vet Pharmacol Ther. 2020 Jan 14. 43:208-214 doi: 10.1111/jvp.12835
4) Lin L, Li XY, Liu SS, Qing ZX, Liu XB, Zeng JG, Liu ZY*.Systematic identification of compounds in Macleaya microcarpa by HPLC-Q/TOF-MS/MS combined with mass spectral fragmentation behavior of Macleaya alkaloids.
Rapid Commun Mass Spectrom. 2019 Dec 30. 34:e8715. doi: 10.1002/rcm.8715
5) Cao JJ, Yang K, Huang CY, Li YJ, Yu H, Wu Y, Sun ZL, Liu ZY*.
Pharmacokinetic Study of Multiple Components of Gelsemium elegans in Goats by Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry.J Anal Toxicol. 2020 Jan 25. pii: bkz100. doi: 10.1093/jat/bkz100
2019
6) Sha-Sha Liu, Kun Yang, Xiaofeng Zheng, Zhi-Liang Sun, Xia Bai, Zhao-Ying Liu*. A novel two-dimensional liquid chromatography system for the simultaneous determination of three monoterpene indole alkaloids in biological matrices. Anal Bioanal Chem. 2019b Jul;411(17):3857-3870. Doi: 10.1007/s00216-019-01859-2期刊号:1618-2642 IF:3.286,
7) Zi-Yuan Wang, Meng-Ting Zou, Zhao-Ying Liu* The Metabolism and Disposition of Koumine, Gelsemine and Humantenmine from Gelsemium. Curr Drug Metab. 2019 Jun 14. doi: 10.2174/**66**4. 期刊号:1389-2002 IF:2.277
8) Li Lin, Yan-Chen Liu, Zhao-Ying Liu*. The Difference in Cytotoxic Activity between Two Optical Isomers of Gelsemine fromGelsemium elegansBenth. on PC12 Cells. Molecules. 2019 May 25;24(10). pii: E2004. doi: 10.3390/molecules**,期刊号:1420-3049 IF:3.06
9) Hu NX, Chen M, Liu YS, Shi Q, Yang B, Zhang HC, Cheng P, Tang Q, Liu ZY*, Zeng JG*. Pharmacokinetics of sanguinarine, chelerythrine, and their metabolites in broiler chickens following oral and intravenous administration. J Vet Pharmacol Ther. 2019 Mar;42(2):197-206. 期刊号:0140-7783
10) Yang K, Long XM, Cao JJ, Li YJ, Wu Y, Bai X, Sun ZL*, Liu ZY*. An analytical strategy to explore the multicomponent pharmacokinetics of herbal medicine independently of standards: Application in Gelsemium elegans extracts. JournalofPharmaceuticalandBiomedicalAnalysis. 2019 Aug 23;176:112833. 期刊号:0731-7085 IF:2.983
11) HuangCY,YangK,CaoJJ,LiYJ,WangZY,YuH,SunZL,ZhengX,Liu ZY*. GeneexpressionprofileanalysisofileumtranscriptomesinpigsfedGelsemiumelegansplants. SciRep.2019Oct31;9(1):15756.doi:10.1038/s41598-019-52374-4. 期刊号:
12) ZhangHH,HuangYJ,LiuYC,JiangXY,ZhangSX,Liu ZY*. CharacterizationofgelsevirinemetabolitesinratliverS9byaccuratemassmeasurementsusinghigh-performanceliquidchromatography/quadrupole-time-of-flightmassspectrometry.RapidCommunMassSpectrom.2019Jul30;33(14):1179-1184.doi:10.1002/rcm.8457.
2018
13) Zuo MT, Liu SS, Lin L, Wang ZY, Bai X, Sun ZL, Liu ZY*, Characterization of N-methylcanadine and N-methylstylopine metabolites in rat liver S9 by high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2018 Dec 15;32(23):2047-2054. doi: 10.1002/rcm.8286.
14) Yang K, Long XM, Liu YC, Chen FH, Liu XF, Sun ZL, Liu ZY*, Development and in-house validation of a sensitive LC-MS/MS method for simultaneous quantification of gelsemine, koumine and humantenmine in porcine plasma, J Chromatogr B Analyt Technol Biomed Life Sci,2018,1076:54-60 doi: 10.1016/j.jchromb
15) Kun Yang, Ya-Jun Huang, Sa Xiao, Yan-Chen Liu, Zhi-Liang Sun, Yi-Song Liu , Qi Tang, Zhao-Ying Liu*. Identification of gelsemine metabolites in rat liver S9 by high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2018-01-15, 32(1): 19-22 doi: 10.1002/rcm.8012
16) Li Lin, Yan-Chen Liu, Jia-Lu Huang, Xiu-Bin Liu, Zhi-Xing Qing, Jian-Guo Zeng*, Zhao-Ying Liu*. Medicinal plants of the genus Macleaya (Macleaya cordata, Macleaya microcarpa): A review of their phytochemistry, pharmacology, and toxicology. Phytotherapy research : 2018, 32(1): 19-48 ISSN: 0951-418X Doi: 10.1002/ptr.5952 IF:3.766
17) Ya-Jun Huang, Pi Cheng, Zhou-Yi Zhang, Shi-Jie Tian, Zhi-Liang Sun , Jian-Guo Zeng, Zhao-Ying Liu*. Biotransformation and tissue distribution of protopine and allocryptopine and effects of Plume Poppy Total Alkaloid on liver drug-metabolizing enzymes. Scientific reports, 2018, 8(1): 537 ISSN: 2045-2322 DOI: 10.1038/s41598-017-18816-7 IF:4.011
18) Li Lin, Xiu-Bin Liu, Qiao-Yun Zhou, Sha-Sha Liu, Meng-Ting Zuo, Jian-Guo Zeng, Zhao-Ying Liu*. Characterization of in vitro metabolites of three tetrahydroprotoberberine alkaloids in rat liver S9 by high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 2018, 32(17): 1540-1548 DOI: 10.1002/rcm.8199
19) Jia-Di Dai, Yu-juan Li, Zhuo-Yi Zhang, Yong-Wu, Yi-Song Liu, Zhi-Liang Sun and Zhao-Ying Liu*.Comparison of the Cytotoxicity and Mitochondrial Effects of Gelsemium elegans Extracts on Human Hepatocellular Carcinoma Cells. Pharmacologla,2018.74.84 DOI: 10.5567/ Pharmacologla.
第一作者与通讯作者发表的中文
20) 肖 洒,黄亚军,刘艳纯,孙志良,刘兆颖*,钩吻素子在猪的的体外代谢,中国兽医学报,2018.8,第38卷第8期,1568-1684
21) 陈梅,张换成,柳亦松,刘兆颖*,曾建国*,二氢血根碱和二氢白屈菜红碱在鸡肌肉中的定量检测方法,中国兽医学报,2018.9,第38卷第9期,1766-1770
22) 张换成,陈梅,柳亦松,唐昭山,曾建国,刘兆颖 *,在模拟人工胃肠道环境中博落回主要生物碱类成分的稳定性特征分析,中国现代中药2017,19(10):1387-1390
23) 俞春红; 潘任桃; 孙志良; 刘兆颖 *. 氟喹诺酮类药物致神经系统和软骨毒性的机制研究进展,中国抗生素杂志,2013,38(11):810-814.
24) 李玉娟,代佳娣,张大生,孙志良,刘兆颖*,氧化应激介导达氟沙星诱导LLC-PK1细胞周期阻滞,中国抗生素杂志,2016,41(5),388-395
25)








1、专利:刘兆颖,刘艳纯,孙志良,一种快速检测与鉴定钩吻中化学成分的分析方法。2017.07.04专利号:ZL20**。
2、2008年2月,获第二届亚太药代国际会议 “青年****研究奖”, Characterization of olaquindox metabolites in rat liver microsomes by high-performance liquid chromatography combined with ion trap/time-of- flight mass spectrometry (Abstract). Drug Metabolism Reviews, 2008, 40(supplement 2): 131。
3、喹噁啉类在大鼠、猪和鸡的比较代谢研究,获全国百篇优秀博士论文提名奖, 2011.11
4、畜禽细菌性疫病防治兽药制剂新技术研究与应用, 湖南省人民政府, 湖南省科技进步三等奖,2012.10









1. 中国畜牧兽医学会兽医药理毒理学分会理事
2. 全国兽用化学药品产业技术创新战略联盟成员
3. 中国毒理学学会兽医毒理专业委员理事
4. 湖南省神经科学学会神经药理与毒理专业委员会委员
5. 湖南省畜牧兽医学会兽药专业委员会秘书长
6. 国家自然科学基金项目评议人





相关话题/动物医学院 湖南农业大学