基本情况

姓 名：李鑫 性 别：女

出生年月：1989.07 籍 贯：山东省诸城市

政治面貌：中共党员 毕业院校：吉林大学

学 历：博士研究生研究方向：分子免疫学与微生态方向

工作单位：郑州大学 基础医学院 职 称：讲师

病理生理学

联系方式

联系电话：**616 邮 箱：lixin0930@zzu.edu.cn

教育背景

2015.9-2018.7 博士研究生 吉林大学基础医学院 生物化学与分子生物学（硕博连读）

2013.9-2015.7 硕士研究生 吉林大学基础医学院 生物化学与分子生物学（推免）

2008.9-2013.7 本科 吉林大学公共卫生学院 预防医学

科研项目

1.2019年度河南省重点研发与推广专项（科技攻关），靶向PD-1mRNA的反义脱氧寡 核苷酸的疫苗佐剂效应研究，2019.01-2020.12，10万元，在研，主持

2.国家自然科学基金面上项目，**，CTLA-4mRNA3’UTR靶向性寡核苷酸及其 疫苗佐剂功能，2017.01-2020.12，60万元，在研，参加

科研成果

1. Li X,Yang L, Zhao P, Yao Y, Lu F, Tu L, Liu J, Li Z, Yu Y, Wang L. Adjuvanticity ofa CTLA-4 3' UTR complementary oligonucleotide for emulsion formulatedrecombinant subunit and inactivated vaccines. Vaccine. 2017; 35: 2379-89.

2. Li X,Meng X, Wang S, Li Z, Yang L, Tu L, Diao W, Yu C, Yu Y, Yan C, Wang L.Virus-like particles of recombinant PCV2b carrying FMDV-VP1 epitopes induceboth anti-PCV and anti-FMDV antibody responses. Applied microbiology andbiotechnology. 2018; 102: 10541-50.

3. Li X,Wang J, Yao Y, Yang L, Li Z, Yu C, Zhao P, Yu Y, Wang L. Comparative efficacyand safety of immune checkpoint inhibitor-related therapies for advancedmelanoma: a Bayesian network analysis. Oncotarget. 2017; 8: 83637-49.

4. Li X,Guo S, Yang L, Hua L, Li Z, Hao X, Yu Y, Sun W, Wang L. Impact of antigens,adjuvants and strains on sexually dimorphic antibody response to vaccines inmice. Biologicals : journal of the International Association of Biological Standardization.2017; 48: 47-54.

5. Wang J, Li X, Cao G, Wu X, Wang Z, Yan T. COVID-19 in a Kidney TransplantPatient. European urology. 2020;77:769-70.（共同一作）

6. Wang J, LiX, Wu X, Wang Z, Zhang C, Cao G, Zhang X, Peng F, Yan T. Role of immunecheckpoint inhibitor-based therapies for metastatic renal cell carcinoma in thefirst-line setting: A Bayesian network analysis. EBioMedicine. 2019; 47: 78-88.（共同一作）

7. Wang J, LiX, Wu X, Wang Z, Zhang C, Cao G, Yan T. Expression Profiling of ExosomalmiRNAs Derived from the Peripheral Blood of Kidney Recipients with DGF UsingHigh-Throughput Sequencing. BioMed research international. 2019; 2019: **.（共同一作）

8. Yu C, Li X,Diao W, Liu J, Yao Y, Hua L, Yu Y, Yu Y, Wang L. A simple method of extractingCap antigen of PCV2b from emulsified vaccines for testing its stability and antigenicity.Biologicals : journal of the International Association of BiologicalStandardization. 2017; 46: 114-23.

9. Yu C, Li X,Liu J, Diao W, Zhang L, Xiao Y, Wei H, Yu Y, Yu Y, Wang L. Replacing the decoyepitope of PCV2b capsid protein with a protective epitope enhances efficacy ofPCV2b vaccine. Vaccine. 2016; 34: 6358-66.

10. Gao S, Li X, Nie S,Yang L, Tu L, Dong B, Zhao P, Wang Y, Yu Y, Wang L, Hua S. An AAAG-RichOligodeoxynucleotide Rescues Mice from Bacterial Septic Peritonitis byInterfering Interferon Regulatory Factor 5. International journal of molecularsciences. 2017; 18.

11. Guo S, Li X, Wan M,Hua L, Xiao Y, Dong B, Liu J, Diao W, Yu Y, Wang L. Impact of Fighting onAntibody Response to Hepatitis B Virus Vaccine in Mice. Viral immunology. 2015;28: 517-23.

12. Xiao Y, Lu W, Li X,Zhao P, Yao Y, Wang X, Wang Y, Lin Z, Yu Y, Hua S, Wang L. Anoligodeoxynucleotide with AAAG repeats significantly attenuates burn-inducedsystemic inflammatory responses via inhibiting interferon regulatory factor 5pathway. Molecular medicine. 2017; 23: 166-76.

13. Xiao Y, Zhao P, Du J, LiX, Lu W, Hao X, Dong B, Yu Y, Wang L. High-level expression andimmunogenicity of porcine circovirus type 2b capsid protein without nuclearlocalization signal expressed in Hansenula polymorpha. Biologicals : journal ofthe International Association of Biological Standardization. 2018; 51: 18-24.

14. Dong B, Wang L, Nie S, LiX, Xiao Y, Yang L, Meng X, Zhao P, Cui C, Tu L, Lu W, Sun W, Yu Y.Anti-glioma effect of intracranial vaccination with tumor cell lysate plusflagellin in mice. Vaccine. 2018; 36: 8148-57.

15. Li Z, Song Y, Cui C, Lan Y, Li X, Liu Y, Lu F, Zhang Y, Yu Y, Wang L. A LAG3-interferingoligonucleotide acts as an adjuvant to enhance the antibody responses inducedby recombinant protein vaccines and inactivated influenza virus vaccines.Applied microbiology and biotechnology. 2019; 103: 6543-57.

16. Yang L, Tu L, Zhao P, Wang Y, Wang S, Lu W, Wang Y, Li X, Yu Y, Hua S, Wang L. Attenuationof interferon regulatory factor 7 activity in local infectious sites of tracheaand lung for preventing the development of acute lung injury caused by influenzaA virus. Immunology. 2019; 157: 37-51.

17. Hua L, Fang M, Dong B, Guo S, Cui C, Liu J, Yao Y, Xiao Y, Li X, Ren Y, Meng X, Hao X, Zhao P,Song Y, Wang L, Yu Y. Attribution of NKG2DL to the inhibition of early stageallogeneic tumors in mice. Oncotarget. 2016; 7: 82369-83.

18. Yang Z, Wang L, Yu H, Wang R, Gou Y, Zhang M, Kang C, Liu T,Lan Y, Wang X, Liu J, Cooper MA, Li X,Yue K, Yu Y, Wang L, Kim BYS, Jiang W, Sun W. Membrane TLR9 Positive NeutrophilMediated MPLA Protects Against Fatal Bacterial Sepsis. Theranostics. 2019; 9:6269-83.