姓名

王敏灿

性别

男

出生年月

1962.10

职称

教授

民族

汉

籍 贯

河南禹州市

电子邮箱

wangmincan@zzu.edu.cn

最终学位

博士

学术头衔/兼职

研究方向

不对称有机合成/有机合成方法学

主要学习、科研和工作经历

工作经历

2005-至今 郑州大学化学与分子工程学院 教授

1998-2005 郑州大学化学系 副教授

1993-至今 郑州大学化学院工作

学习经历

1982-1986 河南师大化学系本科学习

1990-1993 北京大学化学系硕士研究生

2001-2004 郑州大学化学系博士研究生

代表性

教学成果与荣誉

代表性

科研成果

主要从事有机化学的教学与科研工作，研究领域涉及国际前沿的立体选择性有机合成（Steroselectivity in Organic Synthesis）、金属有机试剂在有机合成中的应用（OMCOS）以及新型功能高分子（Noble Properties Functional Polymers）的合成与应用研究。

已主持完成国家自然科学基金4项(**，**，**，**)、河南省杰出青年计划基金1项(**0001)、河南省高等学校创新人才工程基金(2003KYCX007)。

目前主持在研国家自然科学基金1项，2019-2022年，项目编号：**。

2004年以来在国内、外有影响的期刊上发表的代表性成果：

1. Meng-Meng Liu, Xiao-Chao Yang, Yuan-Zhao Hua, Jun-Biao Chang*, and Min-Can Wang* “Synthesis of Chiral Bispirotetrahydrofuran oxindoles by Cooperative Bimetallic Catalyzed Asymmetric Cascade Reaction” Org. Lett. 2019, 21. 2111.

2. Meng-Meng Liu, Xiao-Chao Yang, Yuan-Zhao Hua,* Jun-Biao Chang,* and Min-Can Wang* “Dinuclear Zinc Catalyzed Asymmetric Tandem Reaction of α-Hydroxy 1-Indanone: Access to Spiro[1-indanone-5,2’-γ-butyrolactones]” Org. Lett. 2019, 21. 7089.

3. Shanshan Liu, Wen-Chao Gao, Yu-Hang Miao and Min-Can Wang* “Dinuclear Zinc-AzePhenol Catalyzed Asymmetric Aza-Henry Reaction of N-Boc Imines and Nitroalkanes under Ambient Conditions” J. Org. Chem. 2019, 84, 2652.

4. Xiao-Chao Yang, Meng-Meng Liu, François Mathey, Hua Yang, Yuan-Zhao Hua,* and Min-Can Wang* “Access to Chiral 2,5-Pyrrolidinyl Dispirooxindoles via Dinuclear Zinc Catalyzed Asymmetric Cascade Reactions” J. Org. Chem. 2019, 84, 7762.

5. Shanshan Liu, Xi Wang, Hao-Ran Zhu, Zhi-Hua Xu, Min-Can Wang* “Azetidine-Derived Dinuclear Zinc-Catalyzed Asymmetric Conjugate Addition of Bioactive Heterocycles to β,γ-Unsaturated α-Ketoesters” J. Org. Chem. 2019, 84, 13881.

6. Bing-Kai Tao, Hua Yang, Yuan-Zhao Hua,* Min-Can Wang* “Dinuclear Zinc Synergistic Catalytic Asymmetric Phospha-Michael/Michael Cascade Reaction: Synthesis of 1,2,3-Trisubstituted Indanes Bearing Phosphoryl Group” Org. Biomol. Chem. 2019, 17, 4301.

7. Yu-Hang Miao, Yuan-Zhao Hua, and Min-Can Wang* “Dinuclear Zinc Cooperative Catalytic Three-Component Reactions for Highly Enantioselective Synthesis of 3,3′-Dihydrofuran Spirooxindoles” Org. Biomol. Chem. 2019, 17, 7172.

8. Yuan-Yuan Gao, Yuan-Zhao Hua,* and Min-Can Wang* “Asymmetric 1,6-Conjugate Addition of para-Quinone Methides for the Synthesis of Chiral β,β-Diaryl-α-Hydroxy Ketones” Adv. Synth. Catal. 2018, 360, 80–85.

9. Wang, Mincan* “Enantioselective analysis: the Logic of Chiral Ligand Design for Asymmetric Addition of Diethylzinc to Benzaldehyde” Chin. J. Org. Chem. 2018, 38, 162-170.

10. Hua, Yuanzhao Han, Xingwang Huang, Lihua* Wang, Mincan* “ Asymmetric Friedel–Crafts Alkylation of Pyrrole with Chalcones Catalyzed by a Dinuclear Zinc Catalyst” Chin. J. Org. Chem. 2018, 38, 237-245.

11. Yuan-Zhao Hua, Jun-Wei Chen, Hua Yang,* Min-Can Wang* “Asymmetric Friedel–Crafts Alkylation of Indoles with Trifluoromethyl Pyruvate Catalyzed by a Dinuclear Zinc Catalyst” J. Org. Chem. 2018, 83,1160-1166.

12. Zhao-Fei Zhang, Xiao-Chao Yang, Hui-Jie Lu, and Min-Can Wang* “Enantioselective Direct Synthesis of syn- and anti-α,β-Dihydroxy γ-Ketoesters by a Dinuclear Zinc-AzePhenol Complex” Eur. J. Org. Chem. 2018, 785-793.

13. Na Shao, Yong-Yang Luo, Hui-Jie Lu, Yuan-Zhao Hua* and Min-Can Wang* “Enantioselective Phospha-Michael Reaction of Diethyl Phosphite with Exocyclic α,β-Unsaturated Benzocyclic Ketones Catalyzed by a Dinuclear Zinc Catalyst” Tetrahedron, 2018, 74, 2130-2142.

14. Shanshan Liu,^a Gao-Wei Li,^b Xiao-Chao Yang,^b De-Yang Zhang^b and Min-Can Wang*^b “Dinuclear zinc complex catalyzed asymmetric methylation and alkynylation of aromatic aldehydes” Org. Biomol. Chem. 2017, 15, 7147.

15. Shanshan Liu,^a Na Shao,^b Feng-Zhen Li,^b Xiao-Chao Yang,^b and Min-Can Wang*^b “Azetidine-derived dinuclear zinc catalyzed asymmetric phospha-Michael addition of dialkyl phosphite to α,β-unsaturated carbonyl compounds” Org. Biomol. Chem. 2017, 15, 9465.

16. Guo, Yifei; Hao, Chunying; Wang, Xiangkang; Zhao, Yanna; Han, Meihua;Wang, Mincan*; Wang, Xiangtao* “Well-defined podophyllotoxin polyprodrug brushes: preparation via RAFT polymerization and evaluation as drug carriers” Polymer Chemistry, 2017.2.7, 8(5): 901~909 ; SCIE

17. Xin-Wei Wang, Yuan-Zhao Hua,* and Min-Can Wang* “Synthesis of 3‑Indolylglycine Derivatives via Dinuclear Zinc Catalytic Asymmetric Friedel−Crafts Alkylation Reaction J. Org. Chem. 2016, 81, 9227-92347.”

18. Yuan-Zhao Hua, Xiao-Chao Yang, Meng-Meng Liu, Xixi Song, Min-Can Wang* and Jun-Biao Chang* “Asymmetric copolymerization of cyclopentene oxide and CO₂ using a dinuclear zinc-AzePhenol catalyst: enlightened by DFT calculations, Macromolecules, 2015, 48, 1651-1657.”

19. Yuan-Zhao Hua, Meng-Meng Liu, Pei-Jin Huang, Xixi Song, Min-Can Wang,* and Jun-Biao Chang* “A New Strategy for Enantioselective Construction of Multisubstituted Five-membered Oxygen Heterocycles via Domino Michael/Hemiketalization Reaction, Chem. Eur. J. 2015, 21, 11994-11998.”

20. Yuan-Zhao Hua, Liu-Jie Lu, Pei-Jin Huang, Dong-Hui Wei, Ming-Sheng Tang, Min-Can Wang* and Jun-Biao Chang* “Highly Enantioselective Catalytic System for Asymmetric Copolymerization of Carbon Dioxide and Cyclohexene Oxide at One Atmosphere Pressure and Room Temperature” Chem. Eur. J. 2014, 20, 12394-12398.

21. Xixi Song, Jing-Guo Shi, Ping-Ping Sun, Min-Can Wang* and Jun-Biao Chang* “Diastereomeric Aziridine Carbinol Catalyzed Enantioselective Arylation Reaction: towards the Asymmetric Synthesis of Both Enantiomers of Chiral 3-Aryl Phthalide” J. Org. Chem. 2014, 79, 6087-6093.

22. Yuan-Zhao Hua, Xing-Wang Han, Xiao-Chao Yang, Xixi Song, Min-Can Wang* and Jun-Biao Chang* “Enantioselective Friedel-Crafts Alkylation of Pyrrole with Chalcones Catalyzed by a Dinuclear Zinc Catalyst” J. Org. Chem. 2014, 79, 11690-11699.

23. Xixi Song, Ai-Xiang Liu, Shan-Shan Liu, Wen-Chao Gao, Min-Can Wang* and Junbiao Chang* “Enantiopure azetidine-2-carboxamides as organocatalysts for direct asymmetric aldol reactions in aqueous and organic media” Tetrahedron 2014, 70, 1464-1470.

24. Xixi Song, Jing Liu, Meng-Meng Liu, Xi Wang, Zhao-Fei Zhang, Min-Can Wang* and Junbiao Chang* “Dinuclear zinc catalyzed asymmetric tandem Michael addition/acetalization reactions of cyclic diketones and β,γ–unsaturated α-ketoesters” Tetrahedron 2014, 70, 5468-5474.

25. Min-Can Wang,* Pei-Jin Huang, Xiao-Chao Yang, Xixi Song and Hui-Jie Lu “Effect of conformational equilibrium on enantioselectivity of catalysts: a quantitative relationship for the evaluation, design, and prediction of chiral ligand in addition of diethylzinc to benzaldehyde” Tetrahedron: Asymmetry 2014, 25, 781-786.

26. Min-Can Wang,* Gao-Wei Li, Wen-Bo Hu, Yuan-Zhao Hua, Xixi Song and Hui-Jie Lu* “A mathematical expression for enantioselectivity and thermodynamic factors in conformational equilibrium of catalysts in addition of diethylzinc to benzaldehyde” Tetrahedron: Asymmetry 2014, 25, 1360-1365.

27. De-Yang Zhang, Chang-Bin Yu, Min-Can Wang,* Kai Gao, Yong-Gui Zhou* “A new electronically deficient atropisomeric diphosphine ligand (S)-CF₃O-BiPhep and its application in asymmetric hydrogenation” Tetrahedron Lett. 2012, 53, 2556-2559.

28. Min-Can Wang,* Yong-Hui Wang, Gao-Wei Li, Ping-Ping Sun, Jie-Xi Tian, and Hui-Jie Lu “Applications of Conformational Design: Rational Design of Chiral Ligands Derived from a Common Chiral Source for Highly Enantioselective preparation of (R)- and (S)-Enantiomers of Secondary Alcohol” Tetrahedron: Asymmetry 2011, 22, 761-768.

29. De-Yang Zhang, Duo-Sheng Wang, Min-Can Wang,* Chang-Bin Yu, Kai Gao, Yong-Gui Zhou*“Synthesis of Electronically Deficient Atropisomeric Bisphosphine Ligands and Their Application in Asymmetric Hydrogenation of Quinolines” Synthesis 2011, 2796-2802.

30. Min-Can Wang,* Zhi-kang Liu, Song Li, Xue Ding, Yuan Li and Ming-Sheng Tang “An Experimental and Theoretical Study on Free Ligand Conformational Preferences and Enantioselectivity Relationship for the Asymmetric Addition of Diethylzinc to Benzaldehyde” Tetrahedron: Asymmetry 2010, 21, 486-493.

31. Min-Can Wang,* Qing-Jian Zhang, Gao-Wei Li and Zhi-Kang Liu “Highly enantioselective addition of dimethylzinc to arylaldehydes catalyzed by (2S)-1-ferrocenyl-methylaziridin-2- yl(diphenyl)methanol”. Tetrahedron: Asymmetry 2009, 20, 288-292.

32. Jun-Long Niu, Min-Can Wang,* Pei-Pei Kong, Qing-Tao Chen, Yu Zhu, Mao-Ping Song*“Origin of Enantioselectivity with Heterobidentate Sulfide-Tertiary Amine (sp³) Ligands in Palladium-Catalyzed Allylic Substitution”. Tetrahedron 2009, 65, 8869-8878.

33. Jun-Long Niu, Min-Can Wang,* Liu-jie Lu, Guo-Liang Ding, Hui-Jie Lu, Qing-Tao Chen, Mao-Ping Song* “Enantioselective addition of alkynylzinc to arylaldehydes catalyzed by azetidino amino alcohols with an additional chiral centre”. Tetrahedron: Asymmetry 2009, 20, 2616-2621.

34. Min-Can Wang,* Qing-Jian Zhang, Wen-Xian Zhao, Xiao-Dan Wang, Xue Ding, Tao-Tao Jing and Mao-Ping Song. “Evaluation of Enantiopure N-Ferrocenylmethyl Azetidin-2-yl(diphenyl)methanol for Catalytic Asymmetric Addition of Organozinc Reagents to Aldehydes”. J. Org. Chem. 2008, 73, 168-176.

35. Min-Can Wang,* Xiao-Dan Wang, Xue Ding and Zhi-Kang Liu. “Catalytic asymmetric aryl transfer: highly enantioselective preparation of (R)- and (S)-diarylmethanols catalyzed by the same chiral ferrocenyl aziridino alcohol”. Tetrahedron 2008, 64, 2559-2564.

36. Min-Can Wang,* Wen-Xian Zhao, Xiao-Dan Wang, and Mao-Ping Song*. “New enantiopure N-ferrocenylmethyl azetidin-2-yl(diphenyl)methanol and its application in catalytic asymmetric ethylation and arylation of arylaldehydes”. Synlett. 2006, 3443-3445.

37. Min-Can Wang,* Cui-Lian XU, Fu Cheng and Xue Ding. “Chiral ferrocenyl amidophosphine ligand for highly enantioselective addition of diethylzinc to N-diphenylphosphinoylimines”. Tetrahedron 2006, 62, 12220-12226.

38. Min-Can Wang,* Xue-Hui Hou, Chao-Xian Chi, Ming-Sheng Tang* “The effect of direct steric interaction between substrate substituents and ligand substituents on enantioselectivities in asymmetric addition of diethylzinc to aldehydes catalyzed by sterically congested ferrocenyl aziridino alcohols”. Tetrahedron: Asymmetry 2006, 17, 2126-2132.

39. Lan-Tao Liu, Min-Can Wang,* Wen-Xian Zhao, Yan-Li Zhou, Xiao-Dan Wang. “The ortho effect: copper-catalyzed highly enantioselective 1,4-conjugate addition of diethylzinc to chalcones”. Tetrahedron: Asymmetry 2006, 17, 136-141.

40. Min-Can Wang,* Xue-Hui Hou, Cui-Lian Xu, Lan-Tao Liu, Gui-Lan Li, De-Kun Wang. “Novel C₂-Symmetric 1,1’-Disubstituted Ferrocenyl Aziridino Alcohols Ligands: Remarkable Improvement of Enantioselectivity in the Catalytic Asymmetric Addition of Diethylzinc to Aldehydes” Synthesis 2005, 3620-3626.

41. XU, Cui-Lian, WANG, Min-Can*, HOU, Xue-Hui, LIU, Hong-Min and WANG, De-Kun. “Synthesis of New Chiral [2-(1-hydroxyalkyl)pyrrolidino]methylferrocenes and Application to the Catalytic Asymmetric Addition of Diethylzinc to Arylaldehydes” Chin. J. Chem. 2005, 23, 1443-1448.

42. Min-Can Wang,* Lan-Tao Liu, Yuan-Zhao Hua, Jun-song Zhang, Yan-Yan Shi and De-Kun Wang. “Novel chiral copper complexes of N, P-ferrocenyl ligands with central and planar chirality as efficient catalyst for asymmetric addition of diethylzinc to imines” Tetrahedron: Asymmetry 2005, 16, 2531-2534.

43. Min-Can Wang,* Cui-Lian Xu, Yu-Xi Zou, Hong-Min Liu* and De-Kun Wang. “New chiral ferrocenyl amidophosphine ligand for remarkable improvement of enantioselectivities in copper-catalyzed addition of diethylzinc to N-sulfonylimines” Tetrahedron Lett. 2005, 46, 5413-5416.

44. Junsong Zhang, Mincan Wang*, Jianhai Wang, Yanyan Shi, Jingchao Tao* and Dekun Wang. “Group transfer polymerization of acrylonitrile in bulk at ambient temperature” Polymer Bulletin, 2005, 54(3), 157-161.

45. WANG, Min-Can WANG, De-Kun* LOU, Jian-Ping HUA, Yuan-Zhao. “Novel chiral ferrocenyl aziridino alcohol catalysts promoting asymmetric addition of diethylzinc to aldehydes” Chin. J. Chem. 2004, 22, 512-514.

46. Min-Can Wang, * Lan-Tao Liu, Jun-Song Zhang, Yan-Yan Shi and De-Kun Wang. “Synthesis of chiral ferrocenyl aziridino alcohols and use in the catalytic asymmetric addition of diethylzinc to aldehydes” Tetrahedron: Asymmetry 2004, 15, 3853-3859.

47. Min-Can Wang, De-Kun Wang,* Yu Zhu, Lan-Tao Liu and Yi-Fei Guo. “Enantiopure N-ferrocenylmethylaziridin-2-ylmethanols from L-serine: Synthesis, crystal structure and application” Tetrahedron: Asymmetry 2004, 15, 1289-1294.

主持的部分国家级及省部级科研项目

1、国家自然科学基金，2007-2009年，项目编号：**项目名称：空间拥挤的二茂铁基氮杂小环手性配体的合成及应用研究，28 万元，项目负责人：王敏灿。

2、国家自然科学基金，2010-2012年，项目编号：** 项目名称：具有氮杂半冠醚结构的手性配体合成及其应用研究，35 万元，项目负责人：王敏灿。

3、国家自然科学基金，2013-2016年，项目编号：** 项目名称：二氧化碳与环氧化物的催化不对称交替共聚反应研究，80 万元，项目负责人：王敏灿。

4、国家自然科学基金，2019-2022年，项目编号：** 项目名称：双核锌协同催化的不对称串联反应研究，65 万元，项目负责人：王敏灿。

5、河南省杰出青年计划，2008-2010年，项目编号：**0001项目名称：具有半冠醚结构手性配体的合成及应用研究，20万元，项目负责人：王敏灿。