姓名

魏东辉

性别

男

出生年月

1983年12月

职称

副教授

民族

汉

籍 贯

河南省长葛市

电子邮箱

donghuiwei@zzu.edu.cn

最终学位

博士研究生

学术头衔/兼职

博士生导师，郑州大学优秀青年教师发展基金获得者，郑州大学青年拔尖人才，郑州大学青年学术骨干教师。

研究方向

理论与计算化学

主要学习、科研和工作经历

2006年本科毕业于郑州大学化学系，2010年-2012年以国家公派联合培养博士研究生的身份赴美国肯塔基大学药学院学习，2012年博士毕业于郑州大学化学与分子工程学院后留校任教，2016年晋升为副教授，2018年被聘为郑州大学校直聘教授。长期围绕有机催化反应和生物酶反应的反应机理及其选择性进行理论计算研究工作。近年来，以第一或通讯作者的身份在催化反应机理的理论研究领域发表论文70余篇，包括J. Am. Chem. Soc. (1)、ACS Catal. (3)、Chem. Sci. (1)等。

代表性

教学成果与荣誉

2018-2019学年郑州大学“三育人”先进个人

代表性

科研成果

一、科研项目

1. 国家自然科学基金面上基金项目，**，不含金属和辅因子的氧化酶和加氧酶催化反应机理的理论研究，2018/01-2021/12，65万元，主持；

2.国家自然科学基金青年科学基金项目，**，蛋白酶体与不同类型抑制剂反应的理论研究，2014/01-2016/12，25万元，主持；

3.中国博士后科学基金第八批特别资助项目，2015T80776，尿酸酶催化氧化和水化尿酸反应的理论研究，2015/07-2016/12，15万元，主持；

4.中国博士后科学基金第53批面上一等资助项目，2013M530340，蛋白酶体催化水解反应的理论研究，2013/05-2016/12，8万元，主持；

5.郑州大学优秀青年教师发展基金资助项目，**01，氮杂环卡宾催化的环化、C-H活化和C-C活化反应的理论研究，2016/1-2018/12，18万元，主持。

二、论文论著

近三年以第一或通讯作者身份在SCI收录杂志上发表的有代表性文章的目录如下：

(1) Wang, Guanjie, Shi, Qianqian, Hu, Wenyao, Chen, Tao, Guo, Yingying, Hu, Zhouli, Gong, Mminghua, Guo, Jingcheng, Wei, Donghui*, Fu, Zhenqian*, Huang, Wei*, Organocatalytic Asymmetric N-Sulfonyl Amide C-N Bond Activation to Access Axially Chiral Biaryl Amino Acids. Nat. Commun., 2020, 11, 946. (中科院分区化学一区)

(2) Liu, Ning*, Xie, Yafei, Wang, Chuan, Li, Shijun, Wei, Donghui*, Dai, Bin*, Cooperative Muti-Functional Organocatalysts for Ambient Conversion of Carbon Dioxide into Cyclic Carbonates, ACS Catal., 2018, 8, 9945-9957. (中科院分区化学一区)

(3) Wei, Donghui, Huang, Xiaoqin, Qiao, Yan, Rao, Jingjing, Wang, Lu, Liao, Fei, Zhan, Chang-Guo*, Catalytic Mechanisms for Cofactor-Free Oxidase-Catalyzed Reactions: Reaction Pathways of Uricase-Catalyzed Oxidation and Hydration of Uric Acid, ACS Catal., 2017, 7, 4623-4636. (中科院分区化学一区)

(4) Li, Sha, Tang, Ziwei, Wang, Yang, Wang, Dang, Wang, Zhanlin, Yu, Chenxia, Li, Tuanjie, Wei, Donghui*, Yao, Changsheng*, NHC-Catalyzed Aldol-Like Reactions of Allenoates with Isatins: Regiospecific Syntheses of γ-Functionalized Allenoates, Org. Lett., 2019, 21, 1306-1310. (中科院分区化学一区)

(5) Sun, Kai^#, Li, Shi-Jun^#, Chen, Xiao-Lan*, Liu, Yan, Huang, Xian-Qiang, Wei, Donghui*, Qu, Ling-Bo, Zhao, Yu-Fen, Yu, Bing*, Silver-Catalyzed Decarboxylative Radical Cascade Cyclization toward Benzimidazo[2,1-a]Isoquinolin-6(5H)-Ones, Chem. Commun., 2019, 55, 2861-2864. (中科院分区化学一区)

(6) Chen, Xi-Meng, Liu, Si-Cong, Xu, Cong-Qiao, Jing, Yi, Wei, Donghui*, Li, Jun*, Chen, Xuenian*, Unravelling A General Mechanism of Converting Ionic B/N Complexes into Neutral B/N Analogues of Alkanes: H^δ+⋯H^δ– Dihydrogen Bonding Assisted Dehydrogenation, Chem. Commun., 2019, 55, 12239-12242. (中科院分区化学一区)

(7) Zhang, Qiao-Chu, Li, Xue, Wang, Xinghua, Li, Shi-Jun*, Qu, Ling-Bo, Lan, Yu, Wei, Donghui*, Insights into Highly Selective Ring Expansion of Oxaziridines under Lewis Base Catalysis: A DFT Study. Org. Chem. Front., 2019, 6, 679-687. (中科院分区化学一区)

(8) Shi, Qianqian, Wang, Wei, Wang, Yang, Lan, Yu, Yao, Changsheng*, Wei, Donghui*, Prediction on the Origin of Chemoselectivity in Lewis Base-Mediated Competition Cyclizations between Allenoates and Chalcones: A Computational Study, Org. Chem. Front., 2019, 6, 2692-2700. (中科院分区化学一区)

(9) Guo, Yingying, Wang, Zhoulu, Zhu, Ying, Zhang, Qiaochu, Wei, Donghui*, Liu, Xiang*, Fu, Zhenqian*, Access to Polyfunctionalized Carbazoles through π-Extension of 2-Methyl-3-Oxoacetate Indoles, Org. Chem. Front., 2019, 6, 3741–3745. (中科院分区化学一区)

(10) Wang, Yang, Du, Cong, Wang, Yanyan, Guo, Xiaokang, Fang, Lei, Song, Mao-Ping, Niu, Jun-Long*, Wei, Donghui*, High-Valent Cobalt Catalyzed C-H Activation/Annulation of 2-Benzamidopyridine 1-Oxide with Terminal Alkyne: A Combined Theoretical and Experimental Study, Adv. Synth. Catal., 2018, 360(14), 2668-2677. (中科院分区有机化学一区)

(11)Sun, Fang, Yin, Tingrui, Wang, Yang, Feng, Anni, Yang, Liuqing, Wu, Wenchao,Yu, Chenxia, Li, Tuanjie*, Wei, Donghui*, Yao, Changsheng*, A Combined Experimental and Computational Study of NHC-Promoted Desulfonylation of Tosylated Aldimines. Org. Chem. Front., 2020, DOI: 10.1039/C9QO01402K. (中科院分区化学一区)

(12)Tao, Sheng Bu, Qingqing, Shi, Qianqian, Wei, Donghui*, Dai, Bin*, Liu, Ning*, Synthesis of Benzodiazepines via Ring Opening/Ring Closure of Benzimidazole Salts. Chem. Eur. J., 2020, https://doi.org/10.1002/chem.**8.

(13)Bo, Chun-Bo, Bu, Qingqing, Li, Xue, Ma, Ge, Wei, Donghui*, Guo, Cheng*, Dai, Bin, Liu, Ning*, Highly Active and Robust Ruthenium Complexes Based on Hemilability of Hybrid Ligands for C-H Oxidation. J. Org. Chem.,2020, https://doi.org/10.1021/acs.joc.0c00025.

(14) Wang, Yang, Qu, Ling-Bo, Lan, Yu*, Wei, Donghui*，Origin of Regio- and Stereoselectivity in the NHC-Catalyzed Reaction of Alkyl Pyridinium with Aliphatic Enal. ChemCatChem, 2020, https://doi.org/10.1002/cctc.**5.

(15) Liu, Qiuli, Wang, Yang, Wang, Yanyan*, Li, Xue, Qu, Ling-Bo, Lan, Yu, Wei Donghui*, Computational Study on N-Heterocyclic Carbene (NHC)-Catalyzed Intramolecular Hydroacylation-Stetter Reaction Cascade. Mol. Catal., 2020, 484, 110723.

(16) Liu, Si-Cong, Li, Xue, Li, Sh-Jun*, Wei, Donghui*, Insight into Isothiourea-Catalyzed Enantioselective Addition of Saturated Esters to Iminium Ions. Chem. Asian J., 2019, 14, 4322-4327.

(17) Chen, Xi-Meng, Wang, Jin, Liu, Si-Cong, Zhang, Jie*, Wei, Donghui*, Chen, Xuenian*, Controllable Syntheses of B/N Anionic Aminoborane Chain Complexes by the Reaction of NH₃BH₃ with NaH and the Mechanistic Study, Dalton Trans., 2019, 48, 14984–14988.

(18) Liu, Qiuli, Sun, Ling, Li, Shi-Jun*, Li, Xue, Qu, Ling-Bo, Lan, Yu, Wei, Donghui*, Insights into N-Heterocyclic Carbene (NHC)-Catalyzed Asymmetric Addition of 2H-Azirine with Aldehyde. Chem. Asian J., 2019, 14, 2000-2007.

(19)Li, Xue, Li, Shi-Jun, Wang, Yanyan, Wang, Yang, Qu, Ling-Bo, Li, Zhongjun*, Wei, Donghui*, Insights into NHC-Catalyzed Oxidative α-C(sp³)-H Activation of Aliphatic Aldehydes and Cascade [2 + 3] Cycloaddition with Azomethine Imines. Catal. Sci. Technol., 2019, 9, 2514-2522.

(20) Li, Xue, Duan, Ruihong, Wang, Yanyan, Qu, Ling-Bo, Li, Zhongjun*, Wei, Donghui*, Insights into N‑Heterocyclic Carbene-Catalyzed Oxidative α‑C(sp³)-H Activation of Aliphatic Aldehydes and Cascade [2 + 2] Cycloaddition with Ketimines. J. Org. Chem., 2019, 84, 6117-6125.

(21) Wang, Yang, Qu, Ling-Bo, Lan, Yu*, Wei, Donghui*, Unravelling the Mechanism and Selectivity of the NHC-catalyzed Three-Membered Ring-Opening/Fluorination of Epoxy Enals: A DFT Study. ChemCatChem, 2019, 11, 2919-2925.

(22) Wang, Yang*, Qu, Ling-Bo, Wei, Donghui*, Prediction on the Origin of Selectivities in Base-controlled Switchable NHC-catalyzed Transformations, Chem. Asian J., 2019, 14, 293-300.

(23) Wang, Yang, Wu, Qiu-Yu, Lai, Tian-Hua, Zheng, Kai-Jun, Qu, Ling-Bo*, Wei, Donghui*, Prediction on the Origin of Selectivities of NHC Catalyzed Asymmetric Dearomatization (CADA) Reactions. Catal. Sci. Technol., 2019, 9, 465-476.

(24) Qiao, Yan, Zhao Jimin, Chang, Junbiao*, Wei, Donghui*, Insights into the Oxidative Palladium-Catalyzed Regioselective Synthesis of 3-Arylindoles from N-Ts-Anilines and Styrenes: A Computational Study, ChemCatChem, 2019, 11, 780-789.

(25) Wang, Yang, Wei, Donghui*, Zhang, Wenjing*, Recent Advances on Computational Investigations of N-Heterocyclic Carbene Catalyzed Cycloaddition/Annulation Reactions: Mechanism and Origin of Selectivities, ChemCatChem, 2018, 10, 338-360.

(26) Wang, Yang, Wang, Yanyan, Wang, Xinghua, Li, Xue, Qu, Ling-Bo*, Wei, Donghui*, Competing Mechanisms and Origins of Chemo- and Stereo-Selectivities of NHC-Catalyzed Reactions of Enals with 2-Aminoacrylates, Catal. Sci. Technol., 2018, 8, 4229-4240.

(27) Shi, Qianqian, Wang, Yang, Wang, Yanyan, Qu, Ling-Bo, Qiao, Yan*, Wei, Donghui*, Insights into N-Heterocyclic Carbene-Catalyzed [3 + 4] Annulation Reactions of 2-Bromoenals with N-Ts Hydrazones, Org. Chem. Front., 2018, 5, 2739-2748.

(28) Wang, Yang, Zhang, Shou-Ren, Wang, Yanyan, Qu, Ling-Bo*, Wei, Donghui*, Insights into the NHC-Catalyzed Cascade Michael/Aldol/Lactamization Reaction: Mechanism and Origin of Stereoselectivity, Org. Chem. Front., 2018, 5, 2065-2072.

(29) Li, Xue, Tang, Mingsheng, Wang, Yanyan, Wang, Yang, Li, Zhongjun*, Qu, Ling-Bo, Wei, Donghui*, Insights into the N-Heterocyclic Carbene (NHC)-Catalyzed Intramolecular Cyclization of Aldimines: General Mechanism and Role of Catalyst, Chem. Asian J., 2018, 13, 1710-1718.

(30) Li, Xue, Wang, Yanyan, Wang, Yang, Tang, Mingsheng, Qu, Ling-Bo, Li, Zhongjun*, and Wei, Donghui*, Insights into the N-Heterocyclic Carbene (NHC)-Catalyzed Oxidative γ-C(sp³)−H Deprotonation of Alkylenals and Cascade [4+2] Cycloaddition with Alkenylisoxazoles, J. Org. Chem., 2018, 83(15), 8543-8555.

(31) Shi, Qianqian, Zhang, Wei, Wang, Yang, Qu, Ling-Bo*, Wei, Donghui*, Insights into the Isothiourea-Catalyzed Asymmetric [4+2] Annulation of Phenylacetic Acid with Alkylidene Pyrazolone, Org. Biomol. Chem., 2018, 16, 2301-2311.

(32) Wang, Yang, Qiao, Yan, Wei, Donghui*, Tang, Mingsheng, Computational Study on NHC-Catalyzed Enantioselective and Chemoselective Fluorination of Aliphatic Aldehydes, Org. Chem. Front., 2017, 4, 1987-1998.

(33) Wang, Yang, Wei, Donghui*, Tang, Mingsheng, Computational Study on γ-C–H Functionalization of α,β-Unsaturated Ester Catalyzed by N-Heterocyclic Carbene: Mechanisms, Origin of Stereoselectivity, and Role of Catalyst, J. Org. Chem., 2017, 82, 13043-13050.