王彦明
联系方式
地址：河南大学生命科学院，河南省开封市
Email：yuw12@psu.edu

研究方向
染色质的表观遗传学调控与转化


教师简介
王彦明，博士，教授，博士生导师，河南大学“杰出人才特区支持计划”第二层次****。在国际知名的各类专业期刊杂志发表研究论文近 60 篇，其中包括世界范围影响广泛的Cell（影响因子:31.957)、Science（影响因子:31.027)、Nature（影响因子:38.597)等顶级期刊杂志，他引次数已超过15 000次(截至2018.05)。关于组蛋白磷酸化、甲基化调控染色质功能和结构的三项研究成果被编入世界生命科学研究人员广为使用的经典教材《基因》最新版(Gene，XII)。在生物化学，分子细胞生物学，表观遗传学，先天免疫学及恶性肿瘤的病理及治疗方面有近二十年的教学与科研工作。具备较强的突破重大技术、学术问题的持续创新能力和成果转化能力。在转化医学方面取得了显著成果，利用表观遗传学原理进行创新性药物研发，其所研究的肽酰基精氨酸脱亚胺酶4 抑制剂已获得了两项美国专利授权，一项中国专利授权，将进一步进入临床前实验研究，以实现其创新成果的社会价值和经济效益。其研究的靶向抗肿瘤药物成果具有自主知识产权，处于国际领先水平。



教育背景

1990-1994 学士，生物化学，山东大学
1994-1997 硕士毕业文凭，发育生物学，中国科学院上海细胞生物学研究所
1998-2001 博士，分子细胞发育生物学，美国衣阿华州立大学


工作经历
1997 – 2001: 博士研究生研究助理，美国爱荷华州立大学
2001 – 2005: 博士后研究助理，美国洛克斐勒大学
2005 – 2011: 助理教授， 美国宾州州立大学
2011 – 现在: 副教授（终身职称）, 美国宾州州立大学.
2016 – 现在: Helios Biotechnology & Pharmaceuticals, LLC，创始人
2018 – 现在: 河南大学****



获奖情况
2014 ECoS’ Lab Bench to Commercial Innovation Grant
2014 PBCC’s breast and cervical cancer research grant award
2012 PSU Inventor Incentive Award
2009 PSU Clinical and Translational Science Institute Pilot Grant Award
2006 Johnson & Johnson and PSU Innovative Technology Research Seed Grant Award



杂志编委及审稿人

Cell & Developmental Biology (2012-present)；Biochemica et Biophysica Acta (BBA) ? Mechanisms in Gene Regulation (2012-present)；Cancer Cell； Nature Medicine；Journal of Experimental Medicine；Journal of Cell Biology； Science Translational Medicine；Molecular Cellular Biology； Journal of Biological Chemistry；Frontiers Bioscience； PLoS One；Journal of Molecular Medicine



发表论文：
1. Raup-Konsavage WM, Wang Y, Wang WW, Feliers D, Ruan H, Reeves WB. (2017) Neutrophil peptidylarginine deiminase 4 has a pivotal role in ischemia/reperfussion-induced acute kidney injury. Kidney Int. pii: S0085-2538(17)30611-7. doi: 10.1016/j.kint.2017.08.014. [Epub ahead of print]
2. Pan B, Alam HB, Chong W, Mobley J, Liu B, Deng Q, Liang Y, Wang Y, Chen E, Wang T, Tewari M, Li Y. CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock. (2017) Sci Rep. 2017 Aug 21;7(1):8972. doi: 10.1038/s41598-017-09337-4.
3. Saha P, Yeoh BS, Olvera RA, Xiao X, Singh V, Awasthi D, Subramanian BC, Chen Q, Dikshit M, Wang Y, Parent CA, Vijay-Kumar M. (2017) Bacterial siderophores hijack neutrophil functions. J Immunol. 198(11):4293-4303.
4. Klionsky DJ et al. …Wang Y… (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1):1-222. (Cited 4006 times, not included in the total count)
5. Vollger L, Akong-Moore K, Cox L, Goldmann O, Wang Y, Schafer S, Naim H, Nizet V, von Kockritz-Blickwede M (2016) Iron chelating agents desferrioxamine and L-mimosine stimulate neutrophil extracellular traps (NETs) 36(3). pii: e00333. DOI: 10.1042/BSR**.
6. Demers M, Wong SL, Martinod K, Gallant M, Cabral JE, Wang Y, Wagner DD (2016) Priming of neutrophils toward netosis promotes tumor growth. OncoImmunology. 5(5):e**.DOI:10.1080/**X.2015.** (Cited 7 times)
7. Tohme S, Yazdani HO, Al-Khafaji AB, Chidi AP, Lougharn P, Mowen K, Wang Y, Simmons RL, Huang H, Tsung A. (2016) Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress. Cancer Res. 76(6):1367-80 (Cited 60 times)
8. Zhang L, Yin JC, Yeh H, Ma NX, Lee G, Chen XA, Wang Y, Lin L, Jin P, Wu GY, Chen G. Small molecules efficiently reprogram human astroglial cells into functional neurons. (2015) Cell Stem Cell. 17:735-747. PMID: **
9. He W, Zhou P, Chang Z, Liu B, Liu X, Wang Y, Li Y, Alam HB. Inhibition of peptidylarginine deiminase attenuates inflammation and improves survival in a rat model of hemorrhagic shock. (2015) Journal of Surgical Research. 200:610-618. PMID: **
10. Wong SL, Martinod K, Demers M, Gallant M, Wang Y, Kahn CR, and Wagner DD (2015) Diabetes primes neutrophils to undergo NETosis which severely impairs wound healing. Nature Medicine 21:815-819. PMCID: PMC** (Cited 160 times)
11. Wang S, Chen XA, Hu J, Jiang JK, Li Y, Chan-Salis KY, Gu Y, Chen G, Thomas C, Pugh BF, and Wang Y (2015) ATF4 gene network mediate cellular response to the anticancer PAD4 inhibitor YW3-56. Molecular Cancer Therapeutics 14:877-888. PMID: ** (Cited 9 times)
12. Huang H, Thome S, Al-Khafaji AB, Tai S, Loughran P, Chen L, Kim J, Billiar T, Wang Y, Tsung A (2015) DAMPs-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury. Hepatology. 62:600-614. PMID: ** (Cited 77 times)
13. Chen XA, Sun J, Wang Y. (2015) Techniques Analyzing Chromatin Modifications at Specific Loci. Epigenetic Technological Applications. 79-103.
14. Martinod K, Fuchs TA, Wong SL, Demers M, Gallant M, Wang Y, Wagner DD (2015) PAD4-deficiency does not worsen polymicrobial sepsis mortality and ameliorates endotoxemia. Blood 125:1948-56. PMID: ** (Cited 56 times)
15. Sabulski MJ, Wang Y, Pires MM (2015) PAD2 activity monitored via a fluorescent substrate analog. Chemical Biology & Drug Design. 86:599-605. PMID: **
16. Chang GS, Chen XA, Park B, Rhee HS, Li P, Han KH, Mishra T, Chan-Salis KY, Li Y, Hardison RC, Wang Y, Pugh BF (2014) A comprehensive and high resolution genome-wide response of p53 to stress. Cell Report 24:514-27.
17. Li Y, Liu Z, Liu B, Zhao T, Chong W, Wang Y, and Alam HB (2014) Citrullinated histone H3 – a novel target for treatment of sepsis. Surgery. 156:229-34. (Cited 14 times)
18. Jerjomiceva N, Seri H, Vollger L, Wang Y, Zeitouni N, Naim HY, von Kockritz-Bickwede M (2014) Enrofloxacin enhances the formation of neutrophil extracellular traps in bovine granulocytes. J. Innate Immunity. 6:706-12.
19. Shelef MA, Sokolove J, Lahey LJ, Wagner CA, Sackmann EK, Warner TF, Wang Y, Beebe DJ, Robinson WH, Huttenlocher A (2014) Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha induced inflammatory arthritis. Arthritis & Rheumatism. 66:1482-91. (Cited 19 times)
20. Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD (2014) VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice. Blood 23:141-8. (Cited 81 times)
21. Wang S and Wang Y (2013) Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis. Biochim. Biophys. Acta. 1829:1126-35. (Cited 94 times)
22. Hu J and Wang Y (2013) p53 and the PWWP domain containing effector proteins in chromatin damage repair. Cell & Developmental Biology 2:112.
23. Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD (2013) Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis. Proc. Natl. Acad. Sci. 110:8674-9. (Cited 168 times)
24. Zhu H, Wang Y, Wang Y, Zhao S, Zhao M*, Gui L, Xu W, Chen XA, Wang Y*, Peng S* (2013) Folded conformation, cyclic pentamer, nano-structure and PAD4 binding mode of YW3-56. Journal of Physical Chemistry C. 117:10070-10078. (*authors of correspondence)
25. Leshner M, Wang S, Lewis C, Zheng H, Chen XA, Santy L, Wang Y. (2012) PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap like structures. Frontiers in Immunology. 3:307. (Cited 137 times)
26. Xu L, Hu J, Zhao Y, Hu J, Xiao J, Wang Y, Ma D, Chen Y. (2012) PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway. Apoptosis. 17:1235-1245.
27. Hu J*, Yao H*, Gan F, Torkaski A, Wang Y. (2012) Coordination of OKL38 and p53 in apoptosis induction by regulating mitochondria morphology and function. PLoS One. 7(8):e43362. (*authors of equal contribution).
28. Wang Y¹, Li P¹, Wang S¹, Hu J, Chen XA, Wu J, Fisher M, Oshaben K, Zhao N, Gu Y, Chen G*,Wang Y*. (2012) Anticancer PAD inhibitors regulate autophagy and the mammalian target ofrapamycin complex 1 activity. Journal of Biological Chemistry. 287:25941-25953. (¹authors of equal contribution, *authors of correspondence). (Cited 81 times)
29. Shi K, Edwards PS, Hu J, Xu Q, Wang Y, Psaltis D, and Liu Z. (2012) Holographic coherent antistokes raman scattering bio-imaging. Biomedical Optics Express. 3:1744-1749.
30. Li, P., Hu, J., and Wang, Y. (2012) Methods for analyzing histone citrullination in chromatin structure and gene regulation. Methods in Molecular Biology. 809:473-488.
31. Wu L, Zee BM, Wang Y, Garcia BA, and Dou Y (2011) The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 ubiquitylation and is important for H3 K4/K79 methylation and transcription activation. Molecular Cell. 43:132-144. (Cited 102 times)
32. Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, and Min J (2011) Structural and histone binding ability characterizations of human PWWP domains. PloS ONE. 6(6): e18919. (Cited 94 times)
33. Liu Y, Chan YM, Wu J, Chen C, Benesi A, Hu J, Wang Y, and Chen G (2011) Chemical Synthesis of a bisphosphorylated mannose-6-phosphate N-glycan and its facile monoconjugation with human carbonic anhydrase II for in vivo fluorescence imaging. ChemBioChem. 12:685-690.
34. Joo, H.Y., Jones, A., Yang, C., Zhai, L., Smith IV, A.D., Zhang, Z., Chandrasekharan, M.B., Sun, Z.W., Renfrow, M., Wang, Y., Chang, C., and Wang, H. (2011) Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. Journal of Biological Chemistry. 286:7190-7201. (Cited 65 times)
35. Li P, Li M, Lindberg M, Xiong N, Wang Y. (2010) PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. Journal of Experimental Medicine. 207:1853-1862. (Cited 513 times)
36. Li P, Wang D, Yao H, Doret P, Hao G, Shen Q, Qiu H, Zhang X, Wang Y, Chen G, Wang Y. (2010) Coordination of PAD4 and HDAC2 in the regulation of p53 target gene expression. Oncogene. 29:3153-62. (Cited 83 times)
37. Jin, Y., Xia, M., Saylor, C.M., Narayan, K., Kang, J., Wiest, D.L., Wang, Y., and Xiong, N. (2010) Intrinsic programming of thymic T cells for specific peripheral tissue localization. Journal of Immunology. 185:7156-7160.
38. Chow, O.A., von Kockritz-Blickwede, M., Bright, A.T., Hensler, M.E., Zinkernagel, A.S., Cogen, A.L., Gallo, R.L., Monestier, M., Wang, Y., Glass, C.K., and Nizet, V. (2010) Statins enhance formation of phagocyte extracellular traps. Cell Host & Microbe. 8:445-54. (Cited 214 times)
39. Wang Y*, Li M, Stadler S, Correll S, Li P, Wang D, Hayama R, Leonelli L, Han H, Grigoryev S, Allis CD, Coonrod SA* (2009) Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. Journal of Cell Biology. 184:205-13. (*Correspondence authors) (Cited 597 times)
40. Hao G, Wang D, Gu J, Shen Q, Gross SS, Wang Y. (2009) Neutral loss of isocyanic acid in peptide CID spectra: a novel diagnostic marker for mass spectrometry identification of protein citrullination. Journal of American Society for Mass Spectrometry. 20:723-7. (Cited 23 times)
41. Yao H, Li P, Venters BJ, Zheng S, Thompson PR, Pugh BF, Wang Y. (2008) Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. Journal of Biological Chemistry. 283:20060-8. (Cited 137 times)
42. Li P, Yao H, Zhang Z, Li M, Luo Y, Thompson PR, Gilmour DS, Wang Y. (2008) Regulation of p53 target gene expression by peptidylarginine deiminase 4. Molecular Cellular Biology 28:4745-58. (Cited 177 times)
43. Wang, Y (2006) Methylation and demethylation of histone Lys and Arg residues in chromatin structure and function. In the ENZYMES protein methyltransferases XXIV, 123-153. Elsevier, New York.
44. Bao X, Zhang W, Krencik R, Deng H, Wang Y, Girton J, Johansen J, Johansen KM. (2005) The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells. Journal of Cell Science 118:5079-87.
45. Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou, Y, Roeder RG, Clarke S, Stallcup MR, Allis CD*, Coonrod SA*. (2004) Human PAD4 regulates histone arginine methylation levels via demethylimination. Science. 306:279-83. (*Correspondence authors) (Featured in Nature News and Views (2004), Nature, 431:637-9) (Cited 849 times)
46. Sarmento OF, Digilio LC, Wang Y, Perlin J, Herr JC, Allis CD, Coonrod SA. (2004) Dynamic alterations of specific histone modifications during early murine development. Journal of Cell Science. 117:4449-59. (Cited 193 times)
47. Barber CM, Turner FB, Wang Y, Hagstrom K, Taverna SD, Mollah S, Ueberheide B, Meyer BJ, Hunt DF, Cheung P, Allis CD. (2004) The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved. Chromosoma. 112:360-71. (Cited 101 times)
48. Wang Y, Wysocka J, Perlin JR, Leonelli L, Allis CD, Coonrod SA. (2004) Linking histone modifications to epigenetics: the rigidity and plasticity of the marks. Cold Spring Harbor Symposium Quantitative Biology 69:161-170. (Cited 48 times)
49. Wang Y, Fischle W, Cheung W, Jacobs S, Khorasanizadeh S, Allis CD. (2004) Beyond the double helix: writing and reading the histone code. In: Reversible protein acetylation. Novartis Foundation Symposium. 259:3-20. (Cited 183 times)
50. Fischle W, Wang Y, Allis CD (2003) Binary switches and modification cassettes in histone biology and beyond. Nature. 425:475-9. (Cited 666 times)
51. Fischle W*, Wang Y*, Jacobs SA*, Kim Y, Allis CD, Khorasanizadeh S. (2003) Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by polycomb and HP1 chromodomains. Genes & Development. 17:1870-81. (*Authors of equal contribution) (Cited 945 times)
52. Fischle W*, Wang Y*, Allis CD. (2003) Histone and Chromatin Cross-talk. Current Opinion in Cell Biology. 15:172-83. (*Authors of equal contribution) (Cited 1296 times)
53. Zhang, W, Wang Y, Long J, Girton J, Johansen J, Johansen KM. (2003) A developmentally regulated splice-variant from the complex lola locus encoding multiple different zinc-finger domain proteins interacts with the chromosomal kinase JIL-1. Journal of Biological Chemistry. 278:11696-704. (Cited 21 times)
54. Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D. (2002) PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Molecular Cell. 9:1201-13. (Cited 487 times)
55. Wang Y, Zhang W, Jin Y, Johansen J, Johansen KM. (2001) The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell. 105:433-43. (Cited 213 times)
56. Jin, Y*, Wang, Y*, Johansen, J, and Johansen, KM. (2000) JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the MSL dosage compensation complex. Journal of Cell Biology .149: 1005-10. (*Authors of equal contribution) (Cited 158 times)
57. Walker DL, Wang D, Jin Y, Rath U, Wang Y, Johansen J, Johansen KM. (2000) Skeletor, a novel chromosomal protein that redistributes during mitosis provides evidence for the formation of a spindle matrix. Journal of Cell Biology. 151:1401-12. (Cited 108 times)
58. Jin Y, Wang Y, Walker DL, Dong H, Conley C, Johansen J, and Johansen KM. (1999) JIL-1: A novel chromosomal tandem kinase implicated in transcriptional regulation in Drosophila. Molecular Cell. 4:129-35. (Cited 179 times)
59. Johansen KM, Johansen J, Jin Y, Walker DL, Wang D, Wang Y. (1999) Chromatin structure and nuclear remodeling. Critical Review in Eukaryotic Gene Expression. 9:267-77.


专利
1. Wang Y, Chen X, Wang Y, Peng S, Zhao M. App No. ** Methods and Compositions Relating to Treatment of Cancer (Filed on August 31, 2016)
2. Chen G, Wang Y, Li P, Hu J, Wang S, Wang Y. CN Pat. App CN A (Priority date November 1, 2010, issued date June 29, 2016)Therapeutic compositions and methods (of PAD4 inhibitors in cancer and autoimmune diseases).
3. Chen G, Wang Y, Li P, Hu J, Wang S, Wang Y. US Pat. App US**. (Priority date November 1, 2010, issued date March 3, 2015)
4. Chen G, Wang Y, Li P, Hu J, Wang S, Wang Y. US Pat. App US**. (Priority date November 1, 2010, issued date April 29, 2014)Therapeutic compositions and methods (of PAD4 inhibitors in cancer and autoimmune diseases).Therapeutic compositions and methods (of PAD4 inhibitors in cancer and autoimmune diseases).
5. Allis CD, Fischle W, Wang Y, Hunt DF. US Pat. App 1,0548,747. (Filed March 9, 2004) Posttranslational modifications of proteins as regulatory switches.
6. Allis CD, Herr JC, Coonrod SA, Wang Y. US Pat. App 1,0542,178. (Filed January 9, 2004) Epad, an
oocyte specific protein.





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