谢启光
职称：教授
联系电话：86-** (C)
传真：86-
E-mail：qiguang.xie@henu.edu.cn
研究方向：生物钟调控重要农艺性状机制研究



谢启光，男，博士，教授，博士生导师。

1996年于河北师范大学生物教育专业获理学学士学位，1999年于河北师范大学分子遗传学专业获理学硕士学位，2002年于武汉大学发育生物学专业获理学博士学位。2002.10-2004.7在美国加州大学河边分校Isgouhi Kaloshian实验室做博士后（Postdoc.）研究，研究领域为番茄抗线虫和蚜虫分子机制。2004.8-2006.07在美国范德堡大学（Vanderbilt University）Carl H. Johnson实验室，2006.08-2015.8在美国达特茅斯学院（Dartmouth College）Rob McClung实验室做副研究员（Research Associate），研究领域均为植物/作物生物钟 (Circadian Clock)。2015.11-2018.10为河北师范大学“精英人才计划”海外引进教授，博士生导师，入选河北省“****”。2018年11月至今，河南大学生命科学学院、省部共建植物逆境生物学重点实验室教授。现任中国细胞生物学学会生物节律分会学术委员会委员。


主要研究方向：生物钟调控重要农艺性状机制研究
1. 大豆生物钟调控网络及其参与重要农艺性状调控机制研究
2. 生物钟蛋白复合体动态调控机制及生物钟关键组分转录及转录后水平调控。


主持的重要研究项目：
1. 主持国家自然科学基金面上项目：植物生物钟时空特异性及其参与农艺性状调控的机理研究（），2017.01-2020.12；
2. 主持河北省****：河北省****资助项目（E），2017.01-2020.12；
3. 主持河北省应用基础研究计划重点基础研究项目：生物钟整合逆境胁迫信号途径的分子机制研究（**D），2017.01-2020.12。


入选人才项目：
1. 河北省“****”资助项目，项目号E。


代表性研究论文和著作：
1. Wang, P., Cui, X., Zhao, C., Shi, L., Zhang, G., Sun, F., Cao, X., Yuan, L., Xie, Q., and Xu, X. (2017). COR27 and COR28 encode nighttime repressors integrating Arabidopsis circadian clock and cold response. J Integr Plant Biol 59, 78-85.
2. Zhang, Y., Robertson, J.B., Xie, Q., and Johnson, C.H. (2016). Monitoring Intracellular pH Change with a Genetically Encoded and Ratiometric Luminescence Sensor in Yeast and Mammalian Cells. Methods Mol Biol 1461, 117-130.
3. Xie, Q., Lou, P., Hermand, V., Aman, R., Park, H.J., Yun, D.J., Kim, W.Y., Salmela, M.J., Ewers, B.E., Weinig, C., Khan, S.L., Schaible, D.L., and McClung, C.R. (2015). Allelic polymorphism of GIGANTEA is responsible for naturally occurring variation in circadian period in Brassica rapa. Proc Natl Acad Sci U S A 112, 3829-3834.
4. Xing, H., Wang, P., Cui, X., Wang, L., Zhang, C., Liu, X., Yuan, L., Li, Y., Xie, Q., and Xu, X. (2015). LNK1 and LNK2 recruitment to the evening element require morning expressed circadian related MYB-like transcription factors. Plant Signal Behav 10, e**.
5. Xie, Q., Wang, P., Liu, X., Yuan, L., Wang, L., Zhang, C., Li, Y., Xing, H., Zhi, L., Yue, Z., Zhao, C., McClung, C.R., and Xu, X. (2014). LNK1 and LNK2 Are Transcriptional Coactivators in the Arabidopsis Circadian Oscillator. Plant Cell 26, 2843-2857.
6. Rosas, U., Mei, Y., Xie, Q., Banta, J.A., Zhou, R.W., Seufferheld, G., Gerard, S., Chou, L., Bhambhra, N., Parks, J.D., Flowers, J.M., McClung, C.R., Hanzawa, Y., and Purugganan, M.D. (2014). Variation in Arabidopsis flowering time associated with cis-regulatory variation in CONSTANS. Nature communications 5, 3651.
7. McClung, C.R., and Xie, Q. (2014). Measurement of luciferase rhythms. Methods Mol Biol 1158, 1-11.
8. Ng, D.W., Miller, M., Yu, H.H., Huang, T.Y., Kim, E.D., Lu, J., Xie, Q., McClung, C.R., and Chen, Z.J. (2014). A Role for CHH Methylation in the Parent-of-Origin Effect on Altered Circadian Rhythms and Biomass Heterosis in Arabidopsis Intraspecific Hybrids. Plant Cell 26, 2430-2440.
9. Zhang, C., Xie, Q., Anderson, R.G., Ng, G., Seitz, N.C., Peterson, T., McClung, C.R., McDowell, J.M., Kong, D., Kwak, J.M., and Lu, H. (2013). Crosstalk between the Circadian Clock and Innate Immunity in Arabidopsis. PLoS Pathog 9, e**.
10. Wang, X.*, Wu, F.*, Xie, Q.*, Wang, H., Wang, Y., Yue, Y., Gahura, O., Ma, S., Liu, L., Cao, Y., Jiao, Y., Puta, F., McClung, C.R., Xu, X., and Ma, L. (2012). SKIP Is a Component of the Spliceosome Linking Alternative Splicing and the Circadian Clock in Arabidopsis. Plant Cell 24, 3278-3295. (*co-first author)
11. Zhang, Y.*, Xie, Q.*, Robertson, J.B., and Johnson, C.H. (2012). pHlash: a new genetically encoded and ratiometric luminescence sensor of intracellular pH. PloS one 7, e43072. (*co-first author)
12. Lou, P.*, Xie, Q.*, Xu, X., Edwards, C.E., Brock, M.T., Weinig, C., and McClung, C.R. (2011). Genetic architecture of the circadian clock and flowering time in Brassica rapa. Theor Appl Genet 123, 397-409. (*co-first author)
13. Edwards, C.E., Ewers, B.E., Williams, D.G., Xie, Q., Lou, P., Xu, X., McClung, C.R., and Weinig, C. (2011). The genetic architecture of ecophysiological and circadian traits in Brassica rapa. Genetics 189, 375-390.
14. Xie, Q., Soutto, M., Xu, X., Zhang, Y., and Johnson, C.H. (2011). Bioluminescence resonance energy transfer (BRET) imaging in plant seedlings and mammalian cells. Methods Mol Biol 680, 3-28.
15. Xu, X., Xie, Q., and McClung, C.R. (2010). Robust circadian rhythms of gene expression in Brassica rapa tissue culture. Plant Physiol 153, 841-850.
16. Xu, X., Graeff, R., Xie, Q., Gamble, K.L., Mori, T., and Johnson, C.H. (2009). Comment on "The Arabidopsis circadian clock incorporates a cADPR-based feedback loop". Science 326, 230.
17. Salome, P.A., Xie, Q., and McClung, C.R. (2008). Circadian timekeeping during early Arabidopsis development. Plant Physiol 147, 1110-1125.
18. Hotta, C.T., Xu, X., Xie, Q., Dodd, A.N., Webb, A.A., and Johnson, C.H. (2008). Are there multiple circadian clocks in plants? Plant Signaling & Behavior 5, 344-342.
19. Bhattarai, K.K., Xie, Q., Mantelin, S., Bishnoi, U., Girke, T., Navarre, D.A., and Kaloshian, I. (2008). Tomato susceptibility to root-knot nematodes requires an intact jasmonic acid signaling pathway. Mol Plant Microbe Interact 21, 1205-1214.
20. Xu, X., Soutto, M., Xie, Q., Servick, S., Subramanian, C., von Arnim, A.G., and Johnson, C.H. (2007). Imaging protein interactions with bioluminescence resonance energy transfer (BRET) in plant and mammalian cells and tissues. Proc Natl Acad Sci U S A 104, 10264-10269.
21. Xu, X., Hotta, C.T., Dodd, A.N., Love, J., Sharrock, R., Lee, Y.W., Xie, Q., Johnson, C.H., and Webb, A.A. (2007). Distinct light and clock modulation of cytosolic free Ca2+ oscillations and rhythmic CHLOROPHYLL A/B BINDING PROTEIN2 promoter activity in Arabidopsis. Plant Cell 19, 3474-3490.
22. Bhattarai, K.K., Xie, Q., Pourshalimi, D., Younglove, T., and Kaloshian, I. (2007). Coil-dependent signaling pathway is not required for Mi-1-mediated potato aphid resistance. Mol Plant Microbe Interact 20, 276-282.
23. Li, Q., Xie, Q., Smith-Becker, J., Navarre, D.A., and Kaloshian, I. (2006). Mi-1-Mediated aphid resistance involves salicylic acid and mitogen-activated protein kinase signaling cascades. Mol Plant Microbe Interact 19, 655-664.
24. Wang, Y., Liang, S., Xie, Q., and Lu, Y.T. (2004). Characterization of a calmodulin-regulated Ca2+-dependent-protein-kinase-related protein kinase, AtCRK1, from Arabidopsis. Biochem J 383, 73-81.
25. Martinez de Ilarduya, O., Xie, Q., and Kaloshian, I. (2003). Aphid-induced defense responses in Mi-1-mediated compatible and incompatible tomato interactions. Mol Plant Microbe Interact 16, 699-708.
26. Xie, Q., Wang, Y., Liang, S., Lu, Y. (2002). Characterization of a calmodulinbinding protein kinase from Arabidopsis thaliana. Chinese Science Bulletin 47, 1650-1655.
27. Liu, B., Xie, Q., and Lu, Y. (2001). Identifying the orientation of DNA fragment in recombinant plasmid by capillaryelectrophoresis with a non-gel sieving solution. Anal Sci 17, 1253-1256.

任职专业学会情况：
中国细胞生物学会生物节律分会理事(Chinese Society for Biological Rhythms)
中国蛋白质组学会植物蛋白质组学工作组理事


专业学会会员：
1. Society for Research on Biological Rhythms, USA (2006-)
2. American Society of Plant Biologists, USA (2006-)


讲授课程：
1. 研究生课程：主讲《分子细胞生物学大实验》，参讲《细胞信号转导》，参讲
2. 本科生课程：主讲《细胞生物学（双语）》（本科生专业必修课）、主讲《时间生物学》（专业任意选修课）。




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