姓名： 仉晓文
职称： 副教授（硕导）
办公电话： **

电子邮箱： zxwhtu@163.com








个人简介：
仉晓文副教授2011年毕业于山东大学，获动物学博士学位。其后任职于河南师范大学，讲授生物化学与分子生物学。自攻读博士学位至今，一直从事甲壳动物先天免疫研究，尤其对模式识别受体C-型凝集素的研究有着丰富的理论知识与实验经历。获得国家自然科学基金、河南省科技厅及教育厅项目的资助，在Molecular immunology、Developmental and Comparative Immunology、Fish and shellfish immunology、Scientific Reports等国际免疫相关期刊发表SCI论文数十篇。

研究领域：
甲壳动物先天免疫。对我国重要的甲壳动物养殖品种中国明对虾、克氏原螯虾和中华绒螯蟹的重要先天免疫组分进行研究，包括模式识别受体，抗菌肽及免疫信号通路。
主要学术及社会兼职：
生物化学与分子生物学学会会员
水产学会会员
主持或参加科研项目情况：
1．中华绒螯蟹C-型凝集素参与白斑综合征病毒感染的机制研究，编号**6，河南省自然科学基金项目。2017.01-2018.12，负责人。
2. 螯虾含免疫球蛋白结构域C-型凝集素的免疫功能研究,编号**， ?国家自然科学基金青年基金项目，2014.01-2016.12,负责人。
3. 螯虾中含免疫球蛋白结构域的C-型凝集素抗病作用研究，编号**0，河南省基础与前沿技术研究计划项目，2013.01-2015.12，负责人。
4. 中华绒螯蟹模式识别受体参与病原防御的分子机制研究，编号12A180018，河南省教育厅科学技术研究重点项目，2012.01-2014.12，负责人。
5. 对虾抗病毒相关基因的功能与抗病毒机理分析，编号**，国家自然科学基金重点项目，2012.01-2016.12，参与。
6. 生物乙醇生产菌株改良研究，编号，河南省科技厅，2008.01-2010.12，参与。

学术成果：
代表性论文：
(1)Zhang HW, Man X, Wang Y, Song QS, Stanley D, Hui KM, Zhang XW*. Characterization of a double WAP domain-containing protein from the red swamp crayfish Procambarus clarkia. Fish & Shellfish Immunology. 71,329-337(2017) IF3.15
(2)Zhang HW, Huang Y, Man X, Wang Y, Hui KM, Yin SW, Zhang XW*. HcToll3 was involved in anti-Vibrio defense in freshwater pearl mussel, Hyriopsis cumingii. Fish & Shellfish Immunology.63, 189-95 (2017) IF3.15
(3)Zhang XW*, Wang Y, Wang XW, Wang L, Mu Y, Wang JX. A C-type lectin with an immunoglobulin-like domain promotes phagocytosis of hemocytes in crayfish Procambarus clarkii. Sci Rep. 6, 29924. (2016) IF 4.26
(4)Zhang XW, Wang XW, Huang Y, Hui KM, Shi YR, Wang W, Ren Q. Cloning and characterization of two different ficolins from the giant freshwater prawn Macrobrachium rosenbergii. Dev Comp Immunol 44(2), 359-69 (2014). IF 3.238
(5)Zhang XW, Ren Q, Zhang HW, Wang KK, Wang JX. A C-type lectin could selectively facilitate bacteria clearance in red swamp crayfish, Procambarus clarkii. Fish Shellfish Immunol 35(5), 1387-94 (2013). IF 2.94
(6)Zhang XW, Liu YY, Mu Y, Ren Q, Zhao XF, Wang JX. Over expression of a C-type lectin enhances bacterial resistance in red swamp crayfish Procambarus clarkii. Fish Shellfish Immunol 34(5), 1112-8 (2013). IF 2.94
(7)Li XC, Zhang XW, Zhou JF, Ma HY, Liu ZD, Zhu L, Yao XJ, Li LG, Fang WH. Identification, characterization, and functional analysis of tube and pelle homologs in the mud crab Scylla paramamosain. PLoS One 8(10) ，(2013).（并列第一作者）IF 3.73
(8)Zhang XW, Wang XW, Sun C, Zhao XF, Wang JX. C-type lectin (Pc-Lec1) from freshwater crayfish Procambarus clarkii and its function in hemocyte encapsulation. Arch Insect Bio chem. Physiol 76 (3), 168-84 (2011). IF 1.515
(9)Zhang XW, Xu WT, Wang XW, Mu Y, Zhao XF, Yu XQ, Wang JX. A novel C-type lectin with two CRD domains from Chinese shrimp Fenneropenaeus chinensis functions as a pattern recognition protein. Mol Immunol 46 (8-9), 1626-37 (2009). IF 3.202
(10) Ren Q, Zhang XW, Sun YD, Sun SS, Zhou J, Wang ZH, Zhao XF, Wang JX. Two cysteine proteinases respond to bacterial and WSSV challenge in Chinese white shrimp Fenneropenaeus chinensis. Fish Shellfish Immunol 29 (4), 551-6 (2010).
(11) Wang XW, Zhang XW, Xu WT, Zhao XF, Wang JX. A novel C-type lectin (FcLec4) facilitates the clearance of Vibrio anguillarum in vivo in Chinese white shrimp. Dev Comp Immunol 33 (9), 1039-47 (2009).
(12) Lan JF, Zhou J, Zhang XW, Wang ZH, Zhao XF, Ren Q, Wang JX. Characterization of an immune deficiency homolog (IMD) in shrimp (Fenneropenaeus chinensis) and crayfish (Procambarus clarkii).Dev Comp Immunol 41(4), 608-17(2013).
(13) Mu Y, Lan JF, Zhang XW, Wang XW, Zhao XF, Wang JX. A vector that expresses VP28 of WSSV can protect red swamp crayfish from white spot disease. Dev Comp Immunol 36(2),442-9 (2012)
(14) Xu WT, Wang XW, Zhang XW, Zhao XF, Yu XQ, Wang JX. A new C-type lectin (FcLec5) from the Chinese white shrimp Fenneropenaeus chinensis. Amino Acids 39 (5), 1227-39 (2010).
(15) Wang XW, Xu WT, Zhang XW, Zhao XF, Yu XQ, Wang JX. A C-type lectin is involved in the innate immune response of Chinese white shrimp. Fish Shellfish Immunol 2 (4), 556-62 (2009).