毕晶晶：博士，副教授
Email: bijingjing2008@126.com
欢迎访问我们课题组的网站: http://zgsktz.860373.cn/





教育与研究经历：
2015.7-至今河南师范大学，化学化工学院，教师
2009.9-2015.6中国科学院生态环境研究中心， 获博士学位
2009.9-2012.6河南师范大学化学与环境科学学院，获硕士学位
2005.9-2009.6 河南师范大学化学与环境科学学院，获学士学位
主讲课程：

本科生课程：《药物合成反应基础》，《药物分析》，《化学导论》
研究生课程：《高等药物合成》
研究领域与兴趣：
绿色有机合成化学，糖化学生物学（主要通过有机化学、生物化学等方法从事糖苷的设计、合成及生物活性的研究工作及糖链合成方法学研究）。
近年来主持的主要科研项目:
1.国家自然科学青年基金，编号：**，高效诱导Th2型免疫应答的α-半乳糖脂三氮唑类模拟物的设计合成与活性研究。主持，26万，2018.01-2020.12；
2. 河南省高等学校重点科研项目计划，编号：17A350006；TPE-糖共聚物荧光探针的构建及其应用研究。主持，3万，2017.01.01-2018.12.31；
3. 中科院生态环境研究中心环境化学与生态毒理学国家重点实验室开放基金，编号：KF2016-01,一类新颖双三唑类不对称汞离子荧光探针的设计与开发，主持，5万，2017.01-2018.12
4.河南师范大学青年科学基金,编号：02,新型免疫调节剂α-GalCer三氮唑类模拟物的设计、合成及活性研究，主持，3万，2017.01-2019.01
5.国家自然科学青年基金，编号：**，饱和环状叔胺的C-N键氧化断裂与重组及其在官能团化环胺衍生物合成中的应用。参与，25万，2018.01-2020.12
6. 国家自然科学面上基金，编号：**，N-芳基酰胺类惰性C(aryl)-N键直接活化/官能团化研究，参与，64万，2018.01-2021.12

代表性论文：
22. Ma Weiwei; Bi Jingjing*; Wu Hao; Zhang Guisheng*. An Intrinsic Aggregation-Induced-Emissive and Tumor-Targeting Amphiphilic Micromolecule Self-Assembles

into Vesicles for Visualized and Targeted Drug Delivery.ACS Med. Chem. Lett.2020, accepted（SCI二区，IF = 3.7）
21. Ma Weiwei; Bi Jingjing*; Zhao Chuanfang; Zhang Zhiguo; Liu Tongxin; Zhang Guisheng*; Synthesis and biological activities of amino acids functionalized α-GalCer
analogues, Bioorganic & Medicinal Chemistry, Doi: 10.1016/j.bmc.2019.115141(通讯作者，SCI三区，IF = 2.8).
20. Ma Weiwei; Bi Jingjing*; Zhao Chuanfang; Gao Yangguang; Zhang Guisheng*; Design, synthesis and biological evaluation of acridone glycosides as selective BChE
inhibitors, Carbohydrate Research, doi.org/10.1016/j.carres.2020.107977（SCI四区，IF = 2.0）.
19. Yanwei Chi, Zhiying Wang, Jie Wang, Wenpei Dong, Pengyang Xin, Jingjing Bi, Tao Jiang*, Chang-Po Chen*, Dimeric camptothecin-loaded mPEG-PCL nanoparticles
with high drug loading and reduction-responsive drug release.Coloid and Polyer Science, 2020, 298, 51–58.
18. 毕晶晶，梁榕，时蕾，张贵生*，陈长坡*，新型萘-乙烯基醚类Hg2+荧光探针的合成及细胞成像研究，分析试验室，2018，37（12）:1375-1379
17. Mao Guo-Jiang*; Liang Zhen-Zhen; Bi Jingjing; Zhang Hua*; Meng Hong-Min; Su Li; Gong Yi-Jun; Feng Suling; Zhang Guisheng*.A near-infrared fluorescent probe
based on photostable Si-rhodamine for imaging hypochlorous acid during lysosome-involved inflammatory response. Analytica Chimica Acta, 2019, 1048, 143-153.
DOI:10.1016/j.aca.2018.10.01416.
16.Bi Jingjing; Li Linlin; Ma Nana; Xia Dingding; Zhang Hua; Zhang Zhiguo; Liu Tongxin; Zhang Guisheng*. Novel Anthraquinone-based Fluorescent Probes for Detection
of Silver Ion , Density Functional Theory and Living Cells Imaging,Chinese Journal of Analytical Chemistry, 2019, 47(2): 198-206.
15. Gao Yangguang*; Cao Zhou; Zhang Qiang; Guo Rui; Ding Fei; You, Qingliang; Bi Jingjing; Zhang Yongmin*. Total Synthesis of the Proposed Structure of Penasulfate
A: L-Arabinose as a Source of Chirality. J Nat. Prod., 2019, 82, (7), 1908-1916. DOI:10.1021/acs.jnatprod.9b00245
14. Wan Yameng; Zhang Zhiguo; Ma Nana; Bi Jingjing; Zhang Guisheng. Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay
Reactions for p-Oxygen and o-Nitrogen Incorporation. J Org. Chem., 2019, 84(2), 780-791. DOI:10.1021/acs.joc.8b02636.
13. Hu Beibei; Liu Tong-Xin; Zhang Pengling; Liu Qingfeng; Bi Jingjing; Shi Lei; Zhang Zhiguo; Zhang Guisheng. N-Heterocyclic Carbene-Catalyzed alpha,beta-Unsaturated
Aldehydes Umpolung in Fullerene Chemistry: Construction of [60]Fullerene-Fused Cyclopentan-1-ones and Cyclohex-2-en-1-ones.Org. Lett., 2018, 20(16), 4801-4805.
DOI:10.1021/acs.orglett.8b01956
12. Shi Lei; Xu Jingjing;Bi Jingjing; Zhang Zhiguo; Liu Tongxin; Yang Xiaolan; Zhang Guisheng. Synthesis and Biological Activity of Benzo[h]quinolinium Hydrazine
Compounds. Chinese Journal of Organic Chemistry, 2018, 38(11), 3016-3025. DOI:10.6023/cjoc.
11. Zhang Zhiguo; Zheng Dan; Wan Yameng; Zhang Guisheng; Bi Jingjing; Liu Qingfeng; Liu Tongxin; Shi Lei. Selective Cleavage of Inert Aryl C-N Bonds in N-Aryl
Amides. J Org. Chem., 2018, 83(3), 1369-1376. DOI: 10.1021/acs.joc.7b02880
10. Tong-Xin Liu,* Shaoshuai Hua, Nana Ma, Pengling Zhang, Jingjing Bi, Zhiguo Zhang, Guisheng Zhang*.Reactivity and Synthetic Applications of α-Functionalized
Oxime Acetates: Divergent Access to Fulleropyrrolidines and Mono- and Disubstituted 1-Fulleropyrrolines via Copper-Catalyzed Redox-Neutral N-Heteroannulation with
[60]Fullerene. Adv. Synth. Catal., 2018, 360(1), 142-152.
9.时蕾,鹿泽华,龚毅君,毕晶晶,麻娜娜,徐晶晶,张贵生*.新罗丹明酰胺基硫脲荧光探针在水溶液中对Hg 2+的识别.分析实验室，2017，36(12), 1365-1370.
8. Zhang Zhiguo*; Zheng Dan; Ma Nana; Bi Jingjing.Bronsted Acid-Promoted the Synthesis of Furo[2,3-b]quinolines.Chin. J. Org. Chem.2017,37(7), 1824-1829.
7. Zhiguo Zhang*, Xiaolong Gao, Haifeng Yu,Jingjing Bi, Guisheng Zhang*. Tandem Oxidative α-Hydroxylation/β-Acetalization Reaction of β-Ketoamides and Its
Applications. ACS Omega, 2017,2(11), 7746–7754.
6. Yueyang Liu, Zhiguo Zhang*, Yameng Wan, Guisheng Zhang*, Zhonglian Li, Jingjing Bi, Nana Ma, Tongxin Liu, Qingfeng Liu.Oxidation of beta-Ketoamides:
The Synthesis of VicinalTricarbonyl Amides.J. Org. Chem.,2017,82(7), 3901–3907.
5. Jingjing Bi, Jing Wang, Kai Zhou, Yuancheng Wang, Min Fang*, Yuguo Du*. Synthesis and biological activities of 5-Thio-α-GalCers.ACS Med. Chem. Lett.
2015, 6, 476–480（SCI二区，IF = 3.7）.
4. Jingjing Bi, Chaoli Zhang, Qiuli Shan, Yuguo Du*. Synthesis of C3- symmetric S-linked trimannose: binding ability to concanavalin A.Carbohydr. Res.,
2015, 412, 56-65（SCI四区，IF = 2.0）.
3. Jun Liu*, Xing Zhang, Yi Liu, Jingjing Bi, Yuguo Du *. Total Synthesis of (-)-isoaltholactone.Sci. China, Ser. B, 2013, 56, 928–932.
2. Zhiguo Zhang*, Jingjing Bi, Qingfeng Liu, Guisheng Zhang*. The synthesis of α,α-di?uoroacetamides via electrophilic?uorination in the mixed-solvent of water
and PEG-400.J. Fluorine Chem., 2013, 151, 45–49（SCI四区，IF = 2.0）.
1. Jingjing Bi,Zhiguo Zhang*, Qingfeng Liu, Guisheng Zhang*.Catalyst-free and High Selective Electrophilic Mono-fluorination of Acetoacetamides: Facile and
Efficient Preparation of2-Fluoro Acetoacetamides in PEG-400.Green Chem., 2012, 14, 1159-1162. (SCI一区，IF = 9.4).
专利：
1. 具有抗癌活性的蝴蝶霉素类似物及合成方法。2013.2，中国，ZL 2.
2. 具有血凝活性的硫代甘露三糖及其簇合物的合成。2014.9，中国，6.1
3. 具有抗肿瘤活性的KRN7000类似物及合成方法。2014.9，中国，0.6
4. 具有免疫活性的α-GalCer磷酸酯类化合物及其合成方法。2017.08，中国，1.2
5.一类具有环状结构的蒽醌糖缀合物及其制备方法和在环境检测中的应用，2017.03，中国，1.1
6. 不对称双-1,2,3-三氮唑类化合物及其制备方法和应用，2017.08，中国，9.4