个人简介：马春华，男，博士，讲师，中国化学会会员。E-mail: **@htu.edu.cn
教育经历：
2004.09-2008.06山东大学药学院，药学专业，理学学士；
2008.09-2013.12山东大学药学院，药物化学专业，理学博士；
工作经历：
2013.12-2015.12，复旦大学药学院，药物化学专业，博士后；
2005.03-至今，河南师范大学化学与环境科学学院讲师。
研究领域与兴趣：
1、小分子抗肿瘤药物的设计合成
2、基于靶点的先导化合物的设计和结构优化
近年来主持的主要科研项目:
1、河南省自然科学基金：小分子神经生长因子模拟物的设计、合成及作用机制研究，项目编号：**2，2017.1-2018.12，10万元
2、河南省高等学校重点科研项目基础研究计划：小分子NGF模拟物的设计、合成及应用研究，项目编号：17A350008, 2017.1-2018.12，3万元
3、高端外国专家项目：I类新药布鲁顿酪氨酸激酶抑制剂（BTK inhibitor HB040）的研究与开发，项目编号：GDW，30万元
代表性论文：
1) Ma, C.; Jin, K.; Cao, J.; Zhang, L.; Li, X.; Xu, W.*, Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry 2013, 21 (7), 1621-1627.
2) Ma, C.; Li, X.; liang, X.; Jin, K.; Cao, J.; Xu, W.*, Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry Letters 2013, 23 (17), 4948-4952.
3) Ma, C.; Cao, J.; Liang, X.; Huang Y.; Wu, P; Li, Y.; Xu, W.; Zhang, Y.*; Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, Synthesis and activity evaluation. European Journal of Medicinal Chemistry 2016, 108, 21-27.
4) Ma, C.; Fan, G.; Wu, P.; Li, Z.; Zhou, Y.; Ding, Q.; Zhang, W.*, 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water. Organic & Biomolecular Chemistry 2017, 15 (46), 9889-9894.
5) Ma, C.; Miao, Y.; Zhao, M.; Wu, P.; Zhou, J.; Li, Z.; Xie, X.; Zhang, W.*, Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH). Tetrahedron 2018, 74 (27), 3602-3607.
获得荣誉与奖励：
河南师范大学优秀教师








Individual profile：Chunhua Ma，Male，Ph D，lecturer，Membership of China Chemical Society.E-mail: **@htu.edu.cn
Education experience：
2004.09-2008.06School of pharmaceutical sciences Shandong University, Pharmacology, Bachelor of Science;
2008.09-2013.12School of pharmaceutical sciences Shandong University,Medicinal chemistry, Doctor of Medicine.
Work experience：
2013.12-2015.12, School of Pharmacy Fudan University, Medicinal chemistry, Post doctor;
2005.03-until now, School of Chemistry and Chemical Engineering, Henan Normal University, Lecturer.
Research Interest：
1、The design and synthesis of small molecular compounds with antitumor activity
2、Target-based design and structure optimization of lead compounds
近年来主持的主要科研项目:
1、Henan Natural Science Foundation：The design, synthesis and mechanism of small molecular never growth factor mimics, Project number：**2, 2017.1-2018.12, 0.1Million
2、Basic Research Plan of Key Scientific Research Projects in Henan Higher Education Institutions：The design, synthesis and application of small molecular never growth factor mimics, Project number：17A350008, 2017.1-2018.12，0.03 Million
3、High-end Foreign Expert Project：Research and Development of Bruton Tyrosine Kinase Inhibitor (BTK inhibitor HB040), Project number：GDW，3 Million
代表性论文：
1) Ma, C.; Jin, K.; Cao, J.; Zhang, L.; Li, X.; Xu, W.*, Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry 2013, 21 (7), 1621-1627.
2) Ma, C.; Li, X.; liang, X.; Jin, K.; Cao, J.; Xu, W.*, Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry Letters 2013, 23 (17), 4948-4952.
3) Ma, C.; Cao, J.; Liang, X.; Huang Y.; Wu, P; Li, Y.; Xu, W.; Zhang, Y.*; Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, Synthesis and activity evaluation. European Journal of Medicinal Chemistry 2016, 108, 21-27.
4) Ma, C.; Fan, G.; Wu, P.; Li, Z.; Zhou, Y.; Ding, Q.; Zhang, W.*, 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water. Organic & Biomolecular Chemistry 2017, 15 (46), 9889-9894.
5) Ma, C.; Miao, Y.; Zhao, M.; Wu, P.; Zhou, J.; Li, Z.; Xie, X.; Zhang, W.*, Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH). Tetrahedron 2018, 74 (27), 3602-3607.
获得荣誉与奖励：
Excellent Teachers of Henan Normal University