任桂萍
性 别： 女 出生年月： 1974-03-01
职 称： 教授 工作单位： 生命科学学院
招生学科1： 生物化学与分子生物学 招生学科2： 无
办公电话： E-mail： renguiping@126.com

 开设研究生课程情况
课程编号 课程名称 课程级别 学时
 近五年主持科研项目概况
1. 东北农业大学治疗2型糖尿病新基因药物脂糖素开发项目（省发改委），1000万
2. 猪流行性腹泻、鸡传染性法氏囊和鸭病毒性肝炎Ⅰ型+Ⅲ型重组治疗抗体（CHO细胞源）的研制，160万
3. 动物重大疫病新型广谱中和抗体疫苗研发【国家重点研发计划，十三五项目】，410万元
4. 高效生产治疗结直肠癌的西妥昔单抗工程细胞株构建、筛选与生产工艺的建立（省攻关），50万
5. 治疗类风湿关节炎新型多靶点双特异性抗体药物的开发，50万

 近五年项目获奖概况
1.“成纤维细胞生长因子-21治疗2型糖尿病关键技术创新与应用”【2018年度高等学校科学研究优秀成果奖（科学技术），教育部】，发明奖，二等奖

 近五年代表性著作、论文
1. Yeboah Kwaku Opoku, Zhihang Liu, Justice Afrifa, Mir Hassan Khoso, Guiping Ren, Deshan Li. Therapeutic Role of Fibroblast Growth Factor 21 (FGF21) in the Amelioration of Chronic Diseases. International Journal of Peptide Research and Therapeutics
(Impact Factor: 1.132) 通讯作者
2. Xiaochen Guo, Qi Zheng, Xinghao Jiang, Chao Wu, Teng Zhang, Dan Wang, Xiangxiang Wang, Tianyan Liu, Nan Wang, Yiyao Jiang, Deshan Li, Guiping Ren. The composite biological adjuvants enhance immune response of porcine circovirus type2 vaccine. Veterinary Microbiology, 2019, 228: 69-76
( Impact Factor:2.524) 通讯作者
3. Zhihang Liu, Han Liu, Pengfei Xu, Qi Yin, Yaoqun Wang, Yeboah Kwaku Opoku, Jiarui Yang, Liying Song, Xu Sun, Teng Zhang, Dan Yu, Xiangxiang Wang, Guiping Ren, Deshan Li. Ameliorative effects of a fusion protein dual targeting interleukin 17A and tumor necrosis factor α on imiquimod-induced psoriasis in mice. Biomed Pharmacother. 2018;108:1425-1434.
(Impact Factor: 2.326) 通讯作者
4. Zhihang Liu, Liying Song, Yunxin Wang, Pengfei Xu, Xiaochen Guo, Jiarui Yang, Han Liu, Yuyang Wang, Chao Wu, Teng Zhang, Dan Yu, Yeboah Kwaku Opoku, Mir Hassan Khoso, Guiping Ren, Deshan Li. A novel fusion protein attenuates collagen–induced arthritis by targeting interleukin 17A and tumor necrosis factor α. International Journal of Pharmaceutics, 2018; 547(1-2):72-82.
(Impact Factor: 3.649) 通讯作者
5. Dan Yu, Xianlong Ye, Ruixiang Che, Qiang Wu, Jianying Qi, Liying Song, Xiaochen Guo, Shengqi Zhang, Hongsong Wu, Guiping Ren, Deshan Li. FGF21 exerts comparable pharmacological efficacy with Adalimumab in ameliorating collagen-induced rheumatoid arthritis by regulating systematic inflammatory response. Biomedicine & pharmacotherapy, 2017;89:751-760.
(Impact Factor: 2.326 ) 通讯作者
6. Yongbi Yang, Teng Zhang, Hongxue Cao, Dan Yu, Tong Zhang, Shaojuan Zhao, Xiaohui Jing, Liying Song, Yunye Liu, Ruixiang Che, Xin Liu, Deshan Li, Guiping Ren. The pharmacological efficacy of the anti-IL17 scFv and sTNFR1 bispecific fusion protein in inflammation mouse stimulated by LPS. Biomedicine & Pharmacotherapy, 2017,92: 905-912
(Impact Factor: 2.326 ) 通讯作者
7. Pengfei Xu, Yingjie Zhang, Xinghao Jiang, Junyan Li, Liying Song, Mir Hasson Khoso, Yunye Liu, Qiang Wu, Guiping Ren, Deshan Li. Canine Fibroblast Growth Factor 21 Ameliorates Hyperglycemia Associated with Inhibiting Hepatic Gluconeogenesis and Improving Pancreatic Beta-Cell Survival in Diabetic Mice and Dogs. PLoS One. 2016 May 20;11(5):e**.
(Impact Factor: 3.234) 通讯作者
8. Shenglong Zhu, Yunzhou Wu, Xianlong Ye, Lei Ma, Jianying Qi, Dan Yu, Yuquan Wei, Guangxiao Lin, Guiping Ren, Deshan Li. FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagy. Molecular and Cellular Biochemistry, 2016, 420:107–119
(Impact Factor: 2.613 ) 通讯作者
9. Ying An, Tianyan Liu, Jinjiao He, Hongsong Wu, Rui Chen, Yunye Liu, Yunzhou Wu, Yin Bai, Xiaochen Guo, Qi Zheng, Chang Liu, Jiechao Yin, Deshan Li, Guiping Ren. Recombinant Newcastle disease virus expressing P53 demonstrates promising antitumor efficiency in hepatoma model. Journal of Biomedical Science, 2016, 23(1):55
(Impact Factor: 2.935 ) 通讯作者
10. Qiang Wu, Yunxin Wang, Qiuying Wang, Dan Yu, Yuyang Wang, Liying Song,Zhihang Liu, Xianlong Ye, Pengfei Xu, Hongxue Cao, Deshan Li, Guiping Ren. The bispecific antibody aimed at the vicious circle of IL-1β and IL-17A, is beneficial for the collagen-inducedrheumatoid arthritis of mice through NF-κB signaling pathway. Immunology Letters, 2016, 179:68-79.
(Impact Factor: 2.483 ) 通讯作者
11. Xiaochen Guo, Hongxue Cao, Yunxin Wang, Yang Liu, Yanmin Chen, Nan Wang, Shan Jiang, Shengqi Zhang, Qiang Wu, Tianhe Li, Yingjie Zhang, Bing Zhou, Jiechao Yin, Deshan Li, Guiping Ren. Screening scFv antibodies against infectious bursal disease virus by co-expression of antigen and antibody in the bacteria display system. Veterinary Immunology and Immunopathology, 2016, 180: 45–52
(Impact Factor: 1.664 ) 通讯作者
12. Pengfei Xu, Yingjie Zhang, Liying Song, Mir Hassan Khoso, Junyan Li, Xinghao Jiang, Jinjiao He, Jian Li, Xiaohui Ma, Guiping Ren, Deshan Li. Efficacy of a combination of high and low dosage of PEGylated FGF-21 in treatment of diabetes in db/db mice. Biomedicine & Pharmacotherapy , 2016,84: 97-105
(Impact Factor: 2.326 ) 通讯作者
13. Tianyuan Zhang, Yunye Liu, Hui Wang, Xu Zhang, Shenglong Zhu, Pengfei Xu, Jiechao Yin, Guiping Ren, Jingli Liu, Deshan Li. Recombinant NDV expressing cytokines or fliC confers a quick immune response against NDV challenge and resistance to maternal antibody. Veterinary Microbiology, 2016, 196: 107-117
(Impact Factor: 2.564) 通讯作者
14. Xianlong Ye, Jianying Qi, Guiping Ren, Pengfei Xu, Yunzhou Wu, Shenglong Zhu, Dan Yu, Shujie Li, Qiang Wu, Rasool Lubna Muhi, Deshan Li. Long-lasting anti-diabetic efficacy of PEGylated FGF-21 and liraglutide in treatment of type 2 diabetic mice. Endocrine, 2015,49（3）：683–692
( Impact Factor: 3.527) 通讯作者
15. Yinhang Yu, Siming Li, Yaonan Liu, Guiyou Tian, Qingyan Yuan, Fuliang Bai, Wenfei Wang, Zhiyi Zhang, Guiping Ren, Yu Zhang, Deshan Li. Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway. International Immunopharmacology. 2015,25(1):74-82
( Impact Factor: 2.711) 通讯作者
16. Yinhang Yu, Fuliang Bai, Yaonan Liu, Yongbi Yang, Qingyan Yuan, Dehua Zou, Susu Qu, Guiyou Tian, Liying Song, Tong Zhang, Siming Li, YunYe Liu, Wenfei Wang, Guiping Ren, Deshan Li. Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways. Mol Cell Biochem. 2015, 403(1-2):287-299
( Impact Factor: 2.388) 通讯作者
17. Pengfei Xu, Xianlong Ye, Yingjie Zhang, Qingyan Yuan, Mingyao Liu, Qiang Wu, Guiping Ren, Deshan Li. Long-acting hypoglycemic effects of PEGylated FGF21 and insulin glargine in mice with type 1 diabetes. Journal of Diabetes and its Complications. 2015,29(1):5-12
（Impact Factor：3.005） 通讯作者
18. Yinhang Yu, Fuliang Bai, Wenfei Wang, Yaonan Liu, Qingyan Yuan, Susu Qu, Tong Zhang, Guiyou Tian, Siming Li, Deshan Li, Guiping Ren. Fibroblast growth factor 21 protects mouse brain against D-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation. Pharmacology, Biochemistry and Behavior, 2015, 133:122-131
( Impact Factor: 2.82) 通讯作者
19. Pengfei Xu, Yingjie Zhang, Wenfei Wang, Qingyan Yuan, Zhihang Liu, Lubna Muhi Rasoul, Qiang Wu, Mingyao Liu, Xianlong Ye, Deshan Li, Guiping Ren. Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice. Digestive Diseases and Sciences, 2015, 60（10）:3032-3043
( Impact Factor: 2.613) 通讯作者
20. Yin Bai, Yanmin Chen, Nan Zhang, Xiaochen Guo, Jingzhuang Zhao, Fuxiang Wang, Pengfei Xu, Qingyan Yuan, Jianying Qi, Wenfei Wang, Deshan Li and Guiping Ren. Isolation of the neutralization ScFvs against HBV infection from the immunized population. Current Pharmaceutical Biotechnology, 2015, 16(10): 902-910.
( Impact Factor: 1.95) 通讯作者
21. Guiping Ren, Guiyou Tian, Yunye Liu, Jinjiao He, Xinyu Gao, Yinhang Yu, Xin Liu, Xu Zhang, Tian Sun, Shuangqing Liu, Jiechao Yin, and Deshan Li. Recombinant Newcastle Disease Virus Encoding IL-12 and/or IL-2 as Potential Candidate for Hepatoma Carcinoma Therapy. Technology in Cancer Research & Treatment, first published on August 24, 2015，1-12
( Impact Factor: 1.730) 第一作者
22. Pengfei Xu, Yingjie Zhang, Yunye Liu, Qingyan Yuan, Liying Song, Mingyao Liu, Zhihang Liu, Yongbi Yang, Junyan Li, Deshan Li, Guiping Ren. Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways. Toxicology and Applied Pharmacology, 290 (2016) 43-53
(Impact Factor: 3.705) 通讯作者
23. Dan Yu, Xianlong Ye, Qiang Wu, Shujie Li, Yongbi Yang, Jinjiao He, Yunye Liu, Xiaoyu Zhang, Qingyan Yuan, Mingyao Liu, Deshan Li, Guiping Ren. Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway. Endocrine. 2015 Nov 25
(Impact Factor: 3.878) 通讯作者
24. Shenglong Zhu, Lei Ma, Yunzhou Wu, Xianlong Ye, Tianyuan Zhang, Qingyang Zhang, Lubna Muhi Rasoul,Yunye Liu,Mo Guo, Bing Zhou, Guiping Ren, and Deshan Li. FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway. Acta Biochim Biophys Sin. 2014; 46(12):1041-1048. （Impact Factor：2.089） 通讯作者
25. Fangming Kan, Guiping Ren, Mo Guo, Jianying Qi, Yu Zhang, Yang Han, Yakun Zhang, Deshan Li. Construction of an anti-IL-1β scfv and TNFRI fusion protein and its therapeutic effect on RA mice model. Current Pharmaceutical Biotechnology, 2013, 14（12）：1048-1061
（Impact Factor：2.69） 通讯作者
26. Ye X, Qi J, Sun G, Ren G, Zhu S, Wu Y, Yu D, Zhao J, Liu M, Li D. Enhancement of the pharmacological efficacy of FGF-21 by genetic modification and PEGylation. Curr Pharm Biotechnol. 2013;14(15):1287-1298.
（Impact Factor：2.69） 通讯作者

 近五年授权的专利等情况
1. 可溶性表达NotⅠ的工程菌及其构建方法和应用
发明人：任桂萍，李德山，张巧，叶贤龙

2. 突变的人源成纤维生长因子及在治疗内分泌疾病中的用途
发明人：李德山，任桂萍，高华山，王文飞，刘铭瑶
已转化
3. 重组小分子泛素样修饰物蛋白酶及其制备方法和应用
发 明 (设计)人：李德山，傅俊华，任桂萍，王文飞，刘铭瑶
已实施许可

4. 突变的成纤维细胞生长因子及在治疗II型糖尿病中的用途
发 明 (设计)人：王文飞;吴云舟;刘铭瑶;李德山;何昆;任桂萍
已转化

5. 突变hFGF-21蛋白成熟肽及其与聚乙二醇的交联物以及它们的应用
发 明 (设计)人：李德山 叶贤龙 任桂萍 孙国鹏 刘铭瑶
已转化

6. 一种人FGF21单克隆抗体的轻链和重链可变区
发明人：刘铭瑶;郝智超;王文飞;吴云舟;任桂萍;李德山

7. 一种FGF-21突变体蛋白的制备及其在治疗非酒精性脂肪肝中的应用
发明人：任桂萍；朱升龙；李德山；王文飞；刘铭瑶；叶贤龙

 其他获奖及荣誉称号
黑龙江省生物制药职业教育集团理事
黑龙江省生物工程学会理事