叶非
性 别： 男 出生年月： 1964-04-01
职 称： 教授 工作单位： 研究生院
招生学科1： 应用化学 招生学科2： 农药学
办公电话： E-mail： yefei@neau.edu.cn

 开设研究生课程情况
课程编号 课程名称 课程级别 学时
化学文献 硕士课 32
应用化学研究生讨论班 硕士课 32
 近五年主持科研项目概况

1. 新型卤代磺酰氧（氮）杂桥环安全剂的设计、合成及活性研究 国家自然科学基金

2. 新型磺酰脲类除草剂的安全剂设计、制备及活性 黑龙江省自然科学基金（重点项目）

 3．新型磺酰脲类除草剂的安全剂设计与创制 哈尔滨市科技创新人才研究专项

4．新型卤代甲磺酰取代氧氮杂桥环类安全剂的设计、合成及活性研究 黑龙江省自然科学基金

5．新型卤代甲磺酰取代氮氧杂环类安全剂的设计合成与构效研究 哈尔滨市科技创新人才研究专项

6. 新型卤代甲磺酰取代氮氧杂环类安全剂的合成、活性与构效研究 黑龙江省教育厅科学技术研究项目

7. 新型卤代磺酰氮氧杂二环类安全剂的设计合成及活性研究 黑龙江省博士后科研启动基金项目

 近五年项目获奖概况

1. 安全剂保护作物免受除草剂药害研究 黑龙江省科学技术进步二等奖 2016年

2. 安全剂保护作物免受除草剂药害研究 黑龙江省农业科学技术一等奖 2016年

3. 除草剂污染土壤的生物修复及作物保护 黑龙江省科学技术进步二等奖 2015年

4. 除草剂污染土壤的生物修复及作物保护 黑龙江省高校科学技术二等奖 2015年

5. 基于磺酰脲类除草剂的安全剂活性与构效研究 黑龙江省科学技术三等 2006年

 近五年代表性著作、论文

近期发表的主要论文：

1. Nan Wu, Li-Xia Zhao, Chun-Yu Jiang, Ping Li, Yulong Liu, Ying Fu*, Fei Ye**. A naked-eye visible colorimetric and fluorescent chemosensor for rapid detection of fluoride anions: Implication for toxic fluorine-containing pesticides detection. Journal of Molecular Liquids, 2020, 302:112549

2. Ying Fu, Dong Zhang, Shuai-Qi Zhang, Yong-Xuan Liu, You-Yuan Guo, Meng-Xia Wang, Shuang Gao, Li-Xia Zhao, Fei Ye*. Discovery of N-Aroyl Diketone/Triketone Derivatives as Novel 4-Hydroxyphenylpyruvatedioxygenase Inhibiting-based Herbicide. Journal of Agricultural and Food Chemistry, 2019, 67(43):11839-11847

3. Fei Ye, Yue Zhai, Ke-Liang Guo, Yong-Xuan Liu, Na Li, Shuang Gao, Li-Xia Zhao, Ying Fu*. Safeners improve maize tolerance under herbicide toxicity stress by increasing the activity of enzyme in vivo. Journal of Agricultural and Food Chemistry, 2019,67(42):11568-11576

4. Ying Fu, Yong-Xuan Liu, Ke-Han Yi, Ming-Qiang Li, Jia-Zhong Li, Fei Ye*. Quantitative Structure Activity Relationship Studies and Molecular Dynamics Simulations of 2-(Aryloxyacetyl)cyclohexane-1,3-Diones Derivatives as 4- Hydroxyphenylpyruvate Dioxygenase Inhibitors. Frontiers in Chemistry, 2019,7:556(热点论文)

5. Ying Fu, Yong-Xuan Liu, Tao Kang, Yi-Na Sun, Jia-Zhong Li, Fei Ye*. Identification of novel inhibitors of p-hydroxyphenylpyruvate dioxygenase using receptor-based virtual screening. Journal of the Taiwan Institute of Chemical Engineers, 2019, 103:33-43

6. Fei Ye, Nan Wu, Ping Li, Yu-Long Liu, Shi-Jie Li, Ying Fu*. A lysosome-targetable fluorescent probe for imaging trivalent cations Fe3+, Al3+ and Cr3+ in living cells.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019,22(5):117242

7. Ying Fu, Shuai-Qi Zhang, Yong-Xuan Liu, Jing-Yi Wang, Shuang Gao, Li-Xia Zhao, Fei Ye*. Design, Synthesis, SAR and Molecular Docking of Novel Green Niacin-Triketone HPPD Inhibitor. Industrial Crops and Products, 2019,137:566-575(热点和高被引论文)

8. Fei Ye, Yue Zhai, Tao Kang, Shi-Long Wu, Juan-Juan Li，Shuang Gao, Li-Xia Zhao, Ying Fu* Rational Design, Synthesis and Structure-Activity Relationship of Novel Substituted Oxazole Isoxazole Carboxamides as Herbicide Safener.Pesticide Biochemistry and Physiology，2019,157:60-68(高被引论文)

9. Fei Ye, Xiao-Min Liang, Ke-Xin Xu, Xiao-Xiao Pang, Qiong Chai, Ying Fu⁎ A novel dithiourea-appended naphthalimide “on-off” fluorescent probe for detecting Hg2+ and Ag+ and its application in cell imaging. Talanta, 2019,200:494–502

10. Fei Ye, Xiao-Min Liang, Nan Wu, Ping Li, Qiong Chai, Ying Fu⁎ A novel dithiourea-appended naphthalimide “on-off” fluorescent probe for detecting Hg2+ and Ag+ and its application in cell imaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy，2019，216:359–364

11. Ying Fu, Dong Zhang, Tao Kang, You-Yuan Guo, Wen-Geng Chen, Shuang Gao, Fei Ye^⁎. Fragment splicing-based design,synthesis and safener activity of novel substituted phenyl oxazole derivatives. Bioorganic & Medicinal Chemistry Letters，2019,29(4):570-576

12. Ying Fu, Kui Wang, Peng Wang, Jing-Xin Kang, Shuang Gao, Li-Xia Zhao, Fei Ye*. Design, Synthesis and Herbicidal Activity Evaluation of Novel Aryl-Naphthyl Methanone Derivatives. Frontiers in Chemistry, 2019, 7:2(高被引论文)

13. Ying Fu, Xiao-Xiao Pang, Zhi-Qiang Wang, Qiong Chai, Fei Ye*. A highly sensitive and selective fluorescent probe for determination of Cu (II) and application in live cell imaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2019,208:198-205

14. Fei Ye, Peng Ma, Yuan-Yuan Zhang, Ping Li, Fei Yang and Ying Fu*. Herbicidal Activity and MolecularDocking Study of Novel ACCase Inhibitors. Frontiers in Plant Science, 2018, 9:1850(热点论文)

15. Fei Ye, Peng Ma, Yue Zhai, Fei Yang, Shuang Gao, Li-Xia Zhao, Ying Fu*. Design, microwave-assistant synthesis, bioactivity and SAR of novel substituted 2-phenyl-2-cyclohexanedione enol ester derivatives. Rsc Advances. 2018,8(35):19883-19893

16. Ying Fu, Yi-Na Sun, Ke-Han Yi, Ming-Qiang Li, Hai-Feng, Cao, Jia-Zhong Li, Fei Ye*. Combination of Virtual Screening Protocol by in silico towards the Discovery of Novel HPPD Inhibitors. Frontiers in Chemistry, 2018,6:14

17. Fei Ye, Chen Wang, Peng Ma, Li-Xia Zhao, Shuang Gao, and Ying Fu*. Synthesis, Crystal Structure and Biological Activity of Novel N-substituted Diazabicyclo Derivatives. Journal of Heterocyclic Chemistry,2018,55(1):335-341

18. Ying Fu, Yi-Na Sun, Hai-Feng Cao, Ke-Han Yi, Li-Xia Zhao, Jia-Zhong Li, Fei Ye*. New Research for Quinazoline-2,4-diones as HPPD Inhibitors Based on 2D-MLR and 3D-QSAR Models. Combinatorial Chemistry & High Throughput Screening，2017, 20（9）:748-759

 近五年授权的专利等情况

1. 一种N-二氯乙酰基噁唑烷类除草剂安全剂的制备方法. 国家发明专利 ZL4.3

2. 用超声波法提取苦参碱的方法. 国家发明专利 ZL1.8

3. N-二氯乙酰基-6,7-二氯-1,2,3,4-四氢喹喔啉及其制备方法.国家发明专利 ZL 2013 1 **.1

4. 一种用于禾本科作物田的除草剂及其用途. 国家发明专利 ZL 2016 1 **.3

5. 一种用于单子叶作物的除草组合物及其应用. 国家发明专利 ZL 2015 1 **.4

 其他获奖及荣誉称号

教育部霍英东青年教师三等奖

黑龙江省教学名师

黑龙江省优秀教师

教育部高等学校大学化学课程教学指导委员会委员

中国学位与研究生教育学会理事

黑龙江省化学学会副理事长

哈尔滨市院士专家服务团成员

农业部教材建设专家委员会委员