＞副教授 姓　　名： 刘洪波 部　　门： 计算表观基因组学教研室 职　　称： 副教授 学　　历： 博士 职　　务： 办公电话： 办公地址： 外语学馆412室 Email： hongbo919(at)gmail.com 主要研究方向： 计算表观遗传学和功能基因组学 个人简介 　　刘洪波，男，博士，副教授。主要研究方向是生物信息学和计算表观遗传学。目前的研究工作主要集中于癌症干细胞的表观遗传调控机制。整合高通量的基因组和表观基因组学数据，基于生物信息学的方法和策略挖掘与癌症发生发现密切相关的表观遗传调控元件，并研究各种调控元件协同调控肿瘤的生成、转移的分子机制。自2007年从事生物信息学研究至今已累计发表SCI论文22篇，总SCI影响因子118.8。通讯/(并列)第一作者论文11篇，其中有6篇SCI论文发表在影响因子为9.112的国际著名期刊《Nucleic Acids Research》上。目前已主持国家自然科学基金1项，完成省级、校级课题两项，先后参加国家级、省级课题5项。获得黑龙江省科学技术学术成果奖一等奖2项，于哈尔滨工业大学攻读博士期间获得博士国家奖学金1项。 　　受教育经历（从大学本科开始，按时间倒排序）： 2012/09 – 2015/10，哈尔滨工业大学，生命科学与技术学院，博士，导师吴琼教授 2007/09 – 2010/07，哈尔滨医科大学，生物信息科学与技术学院，硕士，导师张岩教授 2003/09 – 2007/07，曲阜师范大学，数学科学学院，学士本科生 　　研究工作经历（按时间倒排序）： 2015/09 – 至今，哈尔滨医科大学，生物信息科学与技术学院，副教授 2012/09 – 2015/08，哈尔滨医科大学，生物信息科学与技术学院，讲师 2010/07 – 2012/08，哈尔滨医科大学，生物信息科学与技术学院，助教 　　主要承担的课题项目： 1、基于高通量组学数据的干细胞多能性相关DNA甲基化调控元件识别及其功能分析，项目编号：61403112，经费来源：国家自然科学基金青年科学基金项目，起止年月：2015.01-2017.12，经费金额：25万，课题角色：负责人 2、整合高通量DNA甲基化数据识别疾病相关的生物标记，项目编号：12521270，经费来源：黑龙江省教育厅科学技术研究项目，起止年月：2012.01-2014.12，经费金额：1万，课题角色：负责人 3、基于高通量表观基因组图谱的癌症分子分型的系统分析，项目编号：31371334，经费来源：国家自然科学基金面上项目，起止年月：2014.01-2017.12，经费金额：60万，课题角色：参与 4、融合高通量信息的癌症表观遗传异常的特征提取技术，项目编号：61075023，经费来源：国家自然科学基金面上项目，起止年月：2011.01-2013.12，经费金额：38万，课题角色：参与 5、结肠癌早期肝转移的多模态分子影像特征识别及分析，项目编号：81471736，经费来源：国家自然科学基金面上项目，起止年月：2015.01-2018.12，经费金额：73万，课题角色：参与 6、基于功能组学的人类恶性肿瘤风险microRNA系统识别与优化，项目编号：31100948，经费来源：国家自然科学基金青年科学基金项目，起止年月：2012.01-2014.12，经费金额：18万，课题角色：参与 　　主要科研奖励情况： 1)张岩,苏建忠,刘洪波,吴琼,修有成,吕杰.黑龙江省教育厅，高通量表观遗传修饰数据的整合分析技术平台，黑龙江省高校科学技术自然科学一等奖，2013. 2)张岩,吕杰,刘洪波.黑龙江省科技厅，第十二届黑龙江省科学技术学术成果奖，一等奖，2011. 3)刘洪波，博士研究生国家奖学金，2014. 　　专著： 1)张岩,刘洪波. 生物信息学理论与医学实践(第十一章计算表观遗传学)，人民卫生出版社. 3万字，2013. 　　专利： 1)张岩，李霞，刘洪波. 基于熵定量筛选差异甲基化区域软件，2011.02.10，中国版权中心软件著作权，2011R11S006683. 　　主要发表的论文列表： 　　2016: 1.Liu H*, Liu X, Zhang S, Lv J, Li S, Shang S, Jia S, Wei Y, Wang F, Su J et al: Systematic identification and annotation of human methylation marks based on bisulfite sequencing methylomes reveals distinct roles of cell-type-specific hypomethylation in regulation of cell identify genes. Nucleic Acids Res 2016, 44(1):75-94. (First and Corresponding author) 2.Wei Y, Zhang S, Shang S, Zhang B, Wang X, Li S, Liu H*, Zhang Y*: SEA: a comprehensive Super-Enhancer Archive. Nucleic Acids Research 2016, 44(D1):D172-179. (Corresponding author) 　　2015: 3.Lv J, Liu H, Yu S, Liu H, Cui W, Gao Y, Zheng T, Qin G, Guo J, Zeng T et al: Identification of 4438 novel lincRNAs involved in mouse pre-implantation embryonic development. Molecular genetics and genomics : MGG 2015, 290(2):685-697. (Co-first author) 4.Wang F, Zhang S, Liu H, Wei Y, Wang Y, Han X, Su J, Zhang D, Xie B, Zhang Y*: CellMethy: Identification of a focal concordantly methylated pattern of CpGs revealed wide differences between normal and cancer tissues. Scientific reports 2015, 5:18037. 5.Yan H, Zhang D, Liu H, Wei Y, Lv J, Wang F, Zhang C, Wu Q, Su J, Zhang Y*: Chromatin modifications and genomic contexts linked to dynamic DNA methylation patterns across human cell types. Scientific reports 2015, 5:8410. 6.Zhang C, Zhao H, Li J, Liu H, Wang F, Wei Y, Su J, Zhang D, Liu T, Zhang Y*: The identification of specific methylation patterns across different cancers. PLoS One 2015, 10(3):e0120361. 7.Zhang M, Zhang S, Wen Y, Wang Y, Wei Y, Liu H, Zhang D, Su J, Wang F*, Zhang Y*: DNA Methylation Patterns Can Estimate Nonequivalent Outcomes of Breast Cancer with the Same Receptor Subtypes. PLoS One 2015, 10(11):e0142279. 　　2014: 8.Liu, H., Zhu, R., Lv, J., He, H., Yang, L., Huang, Z., Su, J., Zhang, Y., Yu, S. * and Wu, Q*. (2014) DevMouse, the mouse developmental methylome database and analysis tools. Database : the journal of biological databases and curation, 2014, bat084. (First author) 9.Lv, J., Huang, Z., Liu, H., Liu, H., Cui, W., Li, B., He, H., Guo, J., Liu, Q., Zhang, Y. * et al. (2014) Identification and characterization of long intergenic non-coding RNAs related to mouse liver development. Molecular genetics and genomics : MGG. (Co-first author) 10.Wei, Y., Su, J., Liu, H., Lv, J., Wang, F., Yan, H., Wen, Y., Liu, H., Wu, Q. * and Zhang, Y. * (2014) MetaImprint: an information repository of mammalian imprinted genes. Development, 141, 2516-2523. 11.Cai, J., Yang, L. *, He, H.J., Xu, T., Liu, H.B., Wu, Q., Ma, Y., Liu, Q.H. and Nie, M.H. (2014) Antioxidant capacity responsible for a hypocholesterolemia is independent of dietary cholesterol in adult rats fed rice protein. Gene, 533, 57-66. 　　2013: 12.Liu, H., Chen, Y., Lv, J., Zhu, R., Su, J., Liu, X., Zhang, Y. and Wu, Q. * (2013) Quantitative epigenetic co-variation in CpG islands and co-regulation of developmental genes. Scientific reports, 3, 2576. (First author) 13.Lv, J., Liu, H., Huang, Z., Su, J., He, H., Xiu, Y., Zhang, Y. * and Wu, Q. * (2013) Long non-coding RNA identification over mouse brain development by integrative modeling of chromatin and genomic features. Nucleic Acids Res, 41, 10044-10061. (Co-first author) 14.Lv, J., Cui, W., Liu, H., He, H., Xiu, Y., Guo, J., Liu, Q., Zeng, T., Chen, Y., Zhang, Y. et al. (2013) Identification and Characterization of Long Non-Coding RNAs Related to Mouse Embryonic Brain Development from Available Transcriptomic Data. PLoS ONE, 8, e71152. (Co-first author) 15.Wang, F., Zhang, S., Wen, Y., Wei, Y., Yan, H., Liu, H., Su, J., Zhang, Y. * and Che, J. * (2013) Revealing the architecture of genetic and epigenetic regulation: a maximum likelihood model. Briefings in bioinformatics. 16.Su, J., Yan, H., Wei, Y., Liu, H., Wang, F., Lv, J., Wu, Q. * and Zhang, Y. * (2013) CpG_MPs: identification of CpG methylation patterns of genomic regions from high-throughput bisulfite sequencing data. Nucleic Acids Res, 41, e4. 17.Xiao, X., Li, Z., Liu, H., Su, J., Wang, F., Wu, X., Wu, Q. * and Zhang, Y. * (2013) Genome-wide identification of Polycomb target genes in human embryonic stem cells. Gene, 518, 425-430. 18.Wu, X., Liu, H., Liu, H., Su, J., Lv, J., Cui, Y., Wang, F. and Zhang, Y. * (2013) Z curve theory-based analysis of the dynamic nature of nucleosome positioning in Saccharomyces cerevisiae. Gene, 530, 8-18. 　　2012: 19.Lv, J., Liu, H., Su, J., Wu, X., Li, B., Xiao, X., Wang, F., Wu, Q. * and Zhang, Y. * (2012) DiseaseMeth: a human disease methylation database. Nucleic Acids Res, 40, D1030-1035. (Co-first author) 20.Su, J., Shao, X., Liu, H., Liu, S., Wu, Q. and Zhang, Y. * (2012) Genome-wide dynamic changes of DNA methylation of repetitive elements in human embryonic stem cells and fetal fibroblasts. Genomics, 99, 10-17. 21.Su, J., Qi, Y., Liu, S., Wu, X., Lv, J., Liu, H., Zhang, R. and Zhang, Y. * (2012) Revealing epigenetic patterns in gene regulation through integrative analysis of epigenetic interaction network. Mol Biol Rep, 39, 1701-1712. 　　2011: 22.Zhang, Y. *, Liu, H., Lv, J., Xiao, X., Zhu, J., Liu, X., Su, J., Li, X., Wu, Q., Wang, F. et al. (2011) QDMR: a quantitative method for identification of differentially methylated regions by entropy. Nucleic Acids Res, 39, e58. (Co-first author) 23.Liu, H., Su, J., Li, J., Liu, H., Lv, J., Li, B., Qiao, H. and Zhang, Y. (2011) Prioritizing cancer-related genes with aberrant methylation based on a weighted protein-protein interaction network. BMC Syst Biol, 5, 158. 　　2010: 24.Zhang, Y. *, Lv, J., Liu, H., Zhu, J., Su, J., Wu, Q., Qi, Y., Wang, F. and Li, X. * (2010) HHMD: the human histone modification database.Nucleic Acids Res, 38, D149-154. (Co-first author) 25.Su, J., Zhang, Y. *, Lv, J., Liu, H., Tang, X., Wang, F., Qi, Y., Feng, Y. and Li, X. * (2010) CpG_MI: a novel approach for identifying functional CpG islands in mammalian genomes. Nucleic Acids Res, 38, e6. 26.Lv, J., Qiao, H., Liu, H., Wu, X., Zhu, J., Su, J., Wang, F., Cui, Y. and Zhang, Y. * (2010) Discovering cooperative relationships of chromatin modifications in human T cells based on a proposed closeness measure. PLoS ONE, 5, e14219. 27.Lv, J., Su, J., Wang, F., Qi, Y., Liu, H. and Zhang, Y. * (2010) Detecting novel hypermethylated genes in breast cancer benefiting from feature selection. Comput Biol Med, 40, 159-167.