＞副教授 姓　　名： 顾云燕 部　　门： 系统生物学教研室 职　　称： 副教授 学　　历： 博士研究生 职　　务： 教研室秘书 办公电话： 0451-86699584 办公地址： 分子生物学馆122室 Email： guyunyan(at)ems.hrbmu.edu.cn 主要研究方向： 肿瘤系统生物学 个人简介 　　顾云燕，博士、副教授，2011年毕业于哈尔滨医科大学获生物物理学博士学位，同年至哈尔滨医科大学计算系统生物学教研室工作，主要从事肿瘤系统生物学的研究和计算系统生物导论及软件课程的教学工作。2012年晋升为副教授，先后协助博士生导师培养硕士研究生7人，指导本科生毕业设计10人。近年来，顾云燕副教授于Humuan Mutations, Molecular Cancer Therapeutics等国际著名期刊发表论文18篇，承担家自然科学基金青年项目、中国博士后基金、黑龙江省博士后基金、黑龙江省教育厅科学技术研究项目等科研课题。 　　主要承担的课题项目： 1) 基于蛋白质互作网络识别癌相关共扰动模块并解析其功能协同机制 (81201822)（2013年1月-2015年12月） 项目来源：国家自然科学基金项目 说明：课题负责人。经费：23万。 完成情况：在研，按计划进行。 2) 基于单样本miRNA表达模式识别乳腺癌生存标志物(12541330)（2014年1月-2016年12月） 项目来源：黑龙江省教育厅科学技术研究项目 说明：课题负责人。经费：2.5万。 完成情况：在研，按计划进行。 3) 胶质母细胞瘤相关功能模块共扰动机制研究(2012M510988)（2012年-2014年） 项目来源：中国博士后科学基金 说明：课题负责人。经费：5万。 完成情况：在研，按计划进行。 4) 基于癌基因组高通量数据识别癌症治疗靶点(LBH-Z11083)（2012年-2014年） 项目来源：黑龙江省政府博士后资助基金 说明：课题负责人。经费：2万。 完成情况：在研，按计划进行。 　　主要发表的论文列表： 1. Gu Yunyan, Yang Da, Zou Jinfeng, Ma Wencai, Wu Ruihong, Zhao Wenyuan, Zhang Yuannv, Xiao Hui, Gong Xue, Zhang Min, Zhu Jing, and Zheng Guo (2010) Systematic interpretation of comutated genes in large-scale cancer mutation profiles. Mol Cancer Ther 9, 2186-2195 (SCI IF=5.225) 2. Gu Yunyan, Zhao Wenyuan, Xia Jiguang, Zhang Yuannv, Wu Ruihong, Wang Chenguang, and Zheng Guo (2011) Analysis of pathway mutation profiles highlights collaboration between cancer-associated superpathways. Hum Mutat 32, 1028-1035 (SCI IF=5.686) 3. Gu Yunyan, Wang Hongwei, Qin Yao, Zhang Yujing, Zhao Wenyuan, Qi Lishuang, Zhang Yuannv, Wang Chenguang, and Zheng Guo (2013) Network analysis of genomic alteration profiles reveals co-altered functional modules and driver genes for glioblastoma. Mol Biosyst 9, 467-477 (通讯作者，SCI IF=3.35) 4. Liang Haihai, Gu Yunyan, Li Tianyu, Zhang Ying, Huangfu Longtao, Hu Meiyu, Zhao Dandan, Chen Yang, Liu Shanshan, Dong Yuechao Li Xuelian, Lu Yanjie, Yang Baofeng, Shan Hongli (2014) Integrated analyses identify the involvement of microRNA-26a in epithelial-mesenchymal transition during idiopathic pulmonary fibrosis. Cell Death & Disease. doi: 10.1038/cddis.2014.207. (并列一作，SCI IF=6.044) 5. Zhou Xianxiao, Li Bailiang, Yuannv. Zhang, Gu Yunyan, Chen Beibei, Shi Tongwei, Ao Lu, Pengfei Li, Shan. Li, Liu Chunyang, and Zheng Guo (2013) A relative ordering-based predictor for tamoxifen-treated estrogen receptor-positive breast cancer patients: multi-laboratory cohort validation. Breast Cancer Res Treat 142, 505-514 (SCI IF=4.469) 6. Wang Jing, Zhou Xianxiao, Zhu Jing, Gu Yunyan, Zhao Wenyuan, Zou Jinfeng, and Zheng Guo (2012) GO-function: deriving biologically relevant functions from statistically significant functions. Brief Bioinform 13, 216-227(SCI IF=5.298) 7. Qi Lishuang, Li Bailiang, Dong Yu , Xu Hui , Chen Libin, Wang Hongwei , LiPengfei , Zhao Wenyuan, Gu Yunyan, Wang Chenguang , Guo Zheng (2014) Deconvolution of the gene expression profiles of valuable banked blood specimens for studying the prognostic values of altered peripheral immune cell proportions in cancer patients. PLoS One. doi: 10.1371/journal.pone.0100934 (SCI IF=3.73) 8. Zhao Wenyuan, Qi Lishuang, Qin Yao, Wang Hongwei, Chen Beibei, Wang Ruiping, Gu Yunyan, Liu Chunyang, Wang Chenguang, and Zheng Guo (2013) Functional comparison between genes dysregulated in ulcerative colitis and colorectal carcinoma. PLoS One 8, e71989 (SCI IF=3.73) 9. Liang Haihai, Li Xuelian, Wang Lu, Yu Shaonan, Xu Zhidan, Gu Yunyan, Pan Zhenwei, Li Tianyu, Hu Meiyu, Cui Hairong, Liu Xue, Zhang Ying, Xu Chaoqian, Guo Rui, Yang Baofeng, and Hongli Shan (2013) MicroRNAs contribute to promyelocyte apoptosis in As2O3-treated APL cells. Cellular Physiology and Biochemistry 32, 1818-1825 (SCI IF=3.415) 10. 王栋, 黄燕, 程立新, 李朋飞, 顾云燕, 吴瑞红, 王明月, 李宾, 王晨光, and 郭政 (2012) 微阵列数据揭示基因在癌样本中广泛表达. 生物信息学 10, 5 (核心) 11. Wang Dong, Cheng Lixin, Zhang Yuannv, Wu Ruihong, Wang Mingyue, Gu Yunyan, Zhao Wenyuan, Li Pengfei, Li Bin, Wang Hongwei, Huang Yan, Wang Chenguang, and Guo Zheng (2012) Extensive up-regulation of gene expression in cancer: the normalised use of microarray data. Mol Biosyst 8, 818-827(SCI IF=3.35) 12. 王靖, 周贤孝, 朱晶, 赵文媛, 顾云燕, and 郭政 (2011) 基于Gene Ontology功能体系分析肺腺癌相关功能的共扰动机制. 生物物理学报 27, 12 (核心) 13. Wang Dong, Cheng Lixin, Wang Mingyue, Wu Ruihong, Li Pengfei, Li Bin, Zhang Yuannv, Gu Yunyan, Zhao Wenyuan, Wang Chenguang, and Guo Zheng (2011) Extensive increase of microarray signals in cancers calls for novel normalization assumptions. Comput Biol Chem 35, 126-130 (SCI IF=1.551) 14. Gong Xue, Wu Ruihong, Wang Hongwei, Guo Xinwu, Wang Dong, Gu Yunyan, Zhang Yuannv, Zhao Wenyuan, Cheng Lixin, Wang Chenguang, and Zheng Guo (2011) Evaluating the consistency of differential expression of microRNA detected in human cancers. Mol Cancer Ther 10, 752-760 (SCI IF=5.226) 15. Ma Wencai, Guo Xinwu, Wang Chenguang, Gu Yunyan, Zhang Yuannv, Xia Jiguang, and Zheng Guo (2010 ) Extracting multi-function features for cancer genes. In Fuzzy Systems and Knowledge Discovery (FSKD), 2010 Seventh International Conference Vol. 5 p. 4 (EI) 16. Gong Xue, Wu Ruihong, Zhang Yuannv, Zhao Wenyuan, Cheng Lixin, Gu Yunyan, Zhang Lin, Wang Jing, Zhu Jing, and Zheng Guo (2010) Extracting consistent knowledge from highly inconsistent cancer gene data sources. BMC Bioinformatics 11, 76 (SCI IF=2.751) 17. Ma Wencai, Yang Da, Gu Yunyan, Guo Xinwu, Zhao Wenyuan, and Zheng Guo (2009) Finding disease-specific coordinated functions by multi-function genes: insight into the coordination mechanisms in diseases. Genomics 94, 94-100 (SCI IF=3.019) 18. Zhu Jing, Shen Xiaopei, Zhang Yang, Guo Zheng, Xiao Hui, and Gu Yunyan (2009) Identifying Candidate Cancer Genes Based on Their Somatic Mutations Co-Occurring with Cancer Genes in Cancer Genome Profiling. In The 2nd International Conference on Biomedical Engineering and Informatics Vol. 3 p. 1448:1451 (EI)