＞教授 姓　　名： 姜　伟 部　　门： 生物数学教研室 职　　称： 教授、硕士生导师 学　　历： 博士研究生 职　　务： 党总支委员、科研负责人、教研室主任 办公电话： 0451-86669617 办公地址： 外语学馆411室 Email： bioccjw(at)126.com 主要研究方向： 计算系统生物学、药物基因组信息学　　　实验室网址：　　http://bioinfo.hrbmu.edu.cn/jianglab 个人简介 　　姜伟，博士、副教授、硕士研究生导师，2008年毕业于哈尔滨医科大学获博士学位，主要从事复杂生物分子网络、非编码RNA与小分子药物关联的研究，承担本科生和留学生的《数理逻辑》、《生物芯片》、《生物信息学进展》、《生物信息数据挖掘》、《微积分》等课程的教学工作。近年来在《Bioinformatics》、《Briefings in Bioinformatics》、《Cell Death & Disease》、《Scientific Reports》、《Genomics》、《PLoS ONE》等期刊发表SCI论文40余篇，主持国家自然科学基金（青年项目）、黑龙江省自然科学基金、哈医大杰出青年培养基金等课题项目9项。并先后获得哈尔滨医科大学杰出青年、优秀科研工作者、优秀教师、青年科技创新之星等荣誉称号。 　　主持的科研项目： 　　1.国家自然科学基金（青年项目） 　　2.哈尔滨医科大学于维汉院士杰出青年培养基金 　　3.黑龙江省自然科学基金 　　4.黑龙江省博士后基金 　　5.黑龙江省博士后科研启动金 　　6.黑龙江省教育厅青年学术骨干计划支持项目 　　7.黑龙江省教育厅项目 　　8.黑龙江省卫生厅项目 　　9.哈尔滨市科技局青年科技创新人才 　　发表的科研论文 （?Co-first author, *Corresponding author） 1. Yu, X., B.L., Wang, L., Zhang, Y., Dai, E., Meng, F., Liu, D., Wang, S., Liu, X., Wang, J., Li, X and Jiang, W.* (2014) The pan-cancer analysis of gene expression patterns in the context of inflammation. Molecular bioSystems. 2. Yang, L., Wang, J., Wang, H., Lv, Y., Zuo, Y. and Jiang, W.* (2014) Analysis and identification of toxin targets by topological properties in protein-protein interaction network. Journal of theoretical biology, 349, 82-91. 3. Yang, L., Wang, J., Wang, H., Lv, Y., Zuo, Y. * and Jiang, W.* (2014) Characterization of essential genes by topological properties in the perturbation sensitivity network. Biochemical and biophysical research communications, 448, 473-479. 4. Yang, L., Lv, Y., Li, T., Zuo, Y. and Jiang, W.* (2014) Human proteins characterization with subcellular localizations. Journal of theoretical biology, 358C, 61-73. 5. Wang, Y., Li, Y., Wang, Q., Lv, Y., Wang, S., Chen, X., Yu, X., Jiang, W.* and Li, X. (2014) Computational identification of human long intergenic non-coding RNAs using a GA-SVM algorithm. Gene, 533, 94-99. 6. Meng, F., Dai, E., Yu, X., Zhang, Y., Chen, X., Liu, X., Wang, S., Wang, L. and Jiang, W.* (2014) Constructing and characterizing a bioactive small molecule and microRNA association network for Alzheimer's disease. Journal of the Royal Society, Interface / the Royal Society, 11, 20131057. 7. Dai, E., Yu, X., Zhang, Y., Meng, F., Wang, S., Liu, X., Liu, D., Wang, J., Li, X. and Jiang, W.* (2014) EpimiR: a database of curated mutual regulation between miRNAs and epigenetic modifications. Database : the journal of biological databases and curation, 2014, bau023. 8. Dai, E., Lv, Y., Meng, F., Yu, X., Zhang, Y., Wang, S., Liu, X., Liu, D., Wang, J., Li, X. and Jiang, W.* (2014) CREAM: a database for chemotherapy resistance-associated miRSNP. Cell death & disease, 5, e1272. 9. Shi, H., Xu, J., Zhang, G., Xu, L., Li, C., Wang, L., Zhao, Z., Jiang, W., Guo, Z. and Li, X. (2013) Walking the interactome to identify human miRNA-disease associations through the functional link between miRNA targets and disease genes. BMC systems biology, 7, 101. 10. Liu, X., Wang, S., Meng, F., Wang, J., Zhang, Y., Dai, E., Yu, X., Li, X. and Jiang, W.* (2013) SM2miR: a database of the experimentally validated small molecules' effects on microRNA expression. Bioinformatics, 29, 409-411. 11. Jiang, W., Zhang, Y., Meng, F., Lian, B., Chen, X., Yu, X., Dai, E., Wang, S., Liu, X., Li, X. et al. (2013) Identification of active transcription factor and miRNA regulatory pathways in Alzheimer's disease. Bioinformatics, 29, 2596-2602. 12. Han, H., Wang, Y.H., Qu, G.J., Sun, T.T., Li, F.Q., Jiang, W. * and Luo, S.S. (2013) Differentiated miRNA expression and validation of signaling pathways in apoE gene knockout mice by cross-verification microarray platform. Experimental & molecular medicine, 45, e13. 13. Wang, L., Liu, W., Jiang, W., Lin, J., Jiang, Y., Li, B. and Pang, D. (2012) A miRNA binding site single-nucleotide polymorphism in the 3'-UTR region of the IL23R gene is associated with breast cancer. PloS one, 7, e49823. 14. Wang, L., Jiang, Y., Zhang, Y., Wang, Y., Huang, S., Wang, Z., Tian, B., Yang, Y., Jiang, W. * and Pang, D. (2012) Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer. PloS one, 7, e34400. 15. Li, X., Jiang, W. ?, Li, W., Lian, B., Wang, S., Liao, M., Chen, X., Wang, Y., Lv, Y., Wang, S. et al. (2012) Dissection of human MiRNA regulatory influence to subpathway. Briefings in bioinformatics, 13, 175-186. 16. Li, C., Shang, D., Wang, Y., Li, J., Han, J., Wang, S., Yao, Q., Wang, Y., Zhang, Y., Zhang, C. et al. (2012) Characterizing the network of drugs and their affected metabolic subpathways. PloS one, 7, e47326. 17. Jiang, W., Chen, X., Liao, M., Li, W., Lian, B., Wang, L., Meng, F., Liu, X., Chen, X., Jin, Y. et al. (2012) Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses. Scientific reports, 2, 282. 18. Chen, X., Jiang, W. ?, Wang, Q., Huang, T., Wang, P., Li, Y., Chen, X., Lv, Y. and Li, X. (2012) Systematically characterizing and prioritizing chemosensitivity related gene based on Gene Ontology and protein interaction network. BMC medical genomics, 5, 43. 19. Xu, J., Li, C.X., Li, Y.S., Lv, J.Y., Ma, Y., Shao, T.T., Xu, L.D., Wang, Y.Y., Du, L., Zhang, Y.P. et al. (2011) MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features. Nucleic acids research, 39, 825-836. 20. Wang, Y., Chen, X., Jiang, W., Li, L., Li, W., Yang, L., Liao, M., Lian, B., Lv, Y., Wang, S. et al. (2011) Predicting human microRNA precursors based on an optimized feature subset generated by GA-SVM. Genomics, 98, 73-78. 21. Wang, C., Jiang, W. ?, Li, W., Lian, B., Chen, X., Hua, L., Lin, H., Li, D., Li, X. and Liu, Z. (2011) Topological properties of the drug targets regulated by microRNA in human protein-protein interaction network. Journal of drug targeting, 19, 354-364. 22. Zhang, S., Wu, C., Li, X., Chen, X., Jiang, W., Gong, B.S., Li, J. and Yan, Y.Q. (2010) From phenotype to gene: detecting disease-specific gene functional modules via a text-based human disease phenotype network construction. FEBS letters, 584, 3635-3643. 23. Xiang, G., Zhenkun, F., Shuang, C., Jie, Z., Hua, Z., Wei, J., Da, P. and Dianjun, L. (2010) Association of DNMT1 gene polymorphisms in exons with sporadic infiltrating ductal breast carcinoma among Chinese Han women in the Heilongjiang Province. Clinical breast cancer, 10, 373-377. 24. Liao, M., Jiang, W., Chen, X., Lian, B., Li, W., Lv, Y., Wang, Y., Wang, S. and Li, X. (2010) Systematic analysis of regulation and functions of co-expressed microRNAs in humans. Molecular bioSystems, 6, 1863-1872. 25. Fu, Z., Li, D., Jiang, W., Wang, L., Zhang, J., Xu, F., Pang, D. and Li, D. (2010) Association of BTLA gene polymorphisms with the risk of malignant breast cancer in Chinese women of Heilongjiang Province. Breast cancer research and treatment, 120, 195-202. 26. Zhu, M., Gao, L., Li, X., Liu, Z., Xu, C., Yan, Y., Walker, E., Jiang, W., Su, B., Chen, X. et al. (2009) The analysis of the drug-targets based on the topological properties in the human protein-protein interaction network. Journal of drug targeting, 17, 524-532. 27. Zhang, J., Zhang, M., Jiang, W., Wang, L., Fu, Z., Li, D., Pang, D. and Li, D. (2009) B7-H4 gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population. BMC cancer, 9, 394. 28. Li, C., Li, X., Miao, Y., Wang, Q., Jiang, W., Xu, C., Li, J., Han, J., Zhang, F., Gong, B. et al. (2009) SubpathwayMiner: a software package for flexible identification of pathways. Nucleic acids research, 37, e131. 29. Li, C., Zhang, G., Li, X., Rao, S., Gong, B., Jiang, W., Hao, D., Wu, P., Wu, C., Du, L. et al. (2008) A systematic method for mapping multiple loci: an application to construct a genetic network for rheumatoid arthritis. Gene, 408, 104-111. 30. Jiang, W., Li, X., Rao, S., Wang, L., Du, L., Li, C., Wu, C., Wang, H., Wang, Y. and Yang, B. (2008) Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements. BMC systems biology, 2, 72. 31. Zhang, W., Li, L., Li, X., Jiang, W., Huo, J., Wang, Y., Lin, M. and Rao, S. (2007) Unravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering. BMC genomics, 8, 332. 32. Wang, L., Li, D., Fu, Z., Li, H., Jiang, W. and Li, D. (2007) Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population. BMC cancer, 7, 173. 33. Li, X., Rao, S., Jiang, W. ?, Li, C., Xiao, Y., Guo, Z., Zhang, Q., Wang, L., Du, L., Li, J. et al. (2006) Discovery of Time-Delayed Gene Regulatory Networks based on temporal gene expression profiling. BMC bioinformatics, 7, 26. 34. Jiang, W., Li, X., Guo, Z., Li, C., Wang, L. and Rao, S. (2006) A novel model-free approach for reconstruction of time-delayed gene regulatory networks. Science in China. Series C, Life sciences / Chinese Academy of Sciences, 49, 190-200. 35. Li, L., Jiang, W., Li, X., Moser, K.L., Guo, Z., Du, L., Wang, Q., Topol, E.J., Wang, Q. and Rao, S. (2005) A robust hybrid between genetic algorithm and support vector machine for extracting an optimal feature gene subset. Genomics, 85, 16-23.