郑金华，女，47岁，中共党员，教授,博士生导师,现任人体解剖学教研室副主任,研究室副主任，黑龙江省抗癌协会常委。
1992年毕业于哈尔滨医科大学临床医学专业,同年留校任教,1999年至2005年在日本齿科大学新泻齿学部留学， 2005年获口腔医学博士学位。2005年5月作为引进人才到哈尔滨医科大学基础医学院。主要从事口腔粘膜癌转移机制和口腔癌防治的应用基础性研究。先后获得了国家自然科学基金2项、中国博士后基金、教育部留学回国启动基金和三项省级课题，以上项课题均为主持人，现课题进展顺利，近五年期发表论文30篇，其中SCI检索论文17篇，出版论著5部，；获省高校科技进步奖二等奖1项、省科技厅科技成果1项。目前与哈尔滨工业大学、日本齿科大学进行低强度超声和光学技术进行治疗癌症动物模型试验。指导哈工大的博士生和博士后开展医学相关的科研课题。

主要业绩
1． 教学方面：
留学生局部解剖学、日本留学生局部解剖学、基础与临床七年制局解双语教学 、七年制SPBL教学、成人局部解剖学、 普通高教系统解剖学理论。发表教学论文1篇，获黑龙江省教育厅境外教师资助2项，主编卫生部视听教材 面部局部解剖 一部。

2.科研方面

已发表论文
1.Dong Chen, Jinhua Zheng, Huiping Li, Qi Wang, Xiaohui Jiao Computer-assisted morphometric analysis of lymphatic vessel changes in hamster tongue carcinogenesis 2010 J Oral Pathol Med.;39(7):518-24.

2.Haixia Li, Dayong Huang, Zhongxiuzi Gao, Yanhong Lv, Lina Zhang, Haidong Cui, Jinhua Zheng Scutellarin inhibits cell adhesion and migration through regulates the production of Intergrin αvβ6 and E-cadherin in human tongue cancer cells. 2010 Oncology Reports
24: 1153-1160,

3.Zhong-Xiu-Zi Gao , Da-Yong Huang, Hai-Xia Li, Li-Na Zhang , Yan-Hong Lv, Hai-Dong Cui, Jin-Hua ZhengScutellarin promotes in vitro angiogenesis of human umbilical vein endothelial cells. 2010 Biochemical and Biophysical Research Communications Vol.400, (1)P 151-156

4.WEI SONG, HAIDONG CUI, RUI ZHANG, JINHUA ZHENG and WENWU CAO, Apoptosis of SAS Cells Induced by Sonodynamic Therapy 5-Aminolevulinic Acid Sonosensitizer ANTICANCER RESEARCH 31: 39-46 (2011)

5.Yanhong Lv, Ming Fang, Jinhua Zheng, Bing Yang, Haixia Li, Zhong Xiuzigao, Wei Song, Yan Chen, Wenwu Cao Low-intensity Ultrasound Combined with 5-aminolevulinic Acid Administration in the Treatment of Human Tongue Squamous Carcinoma Cell Physiol Biochem. 2012;30(2):321-33. Epub 2012 Jun 25

6.Hai-Xia Fan, Hai-Xia Li, Dong Chen , Zhong-Xiuzi Gao , Jin-Hua Zheng Changes in the expression of matrix metalloproteinases (MMP-2 and -9) and type IV collagen in stromal cells in oral squamous tongue cell carcinoma: Relationships and prognostic implications.
Journal of Experimental & Clinical Cancer Research. 2012 Oct 29;31:90.

7.Hai-Xia Li , Jin-Hua Zheng, Hai-Xia Fan , Hui-Ping Li , Zhong-Xiuzi Gao , Dong Chen , Wen-Wu Cao Expression of αvβ6 integrin and collagen fibre in oral squamous cell carcinoma: Association with clinical outcomes and prognostic implications. Oral Pathology & Medicine. Article first published online: 18 JAN 2013(IF: 2.017)

8.Haixia Li, Haixia Fan, Zhu Wang, Jinhua Zheng, Wenwu Cao Potentiation of cytotoxicity of scutellarin on human tongue carcinoma xenograft by low-intensity ultrasound PLoS ONE，8(3): e59473. doi:10.1371/journal.pone.** Received: August 2, 2012; Accepted: February 18, 2013; Published: March 25, 2013

9.Zhong Xiuzigao Yanhong Lv, Haixia Li, Jinhua Zheng, Wenwu Cao Sonodynamic therapy Inhibits Angiogenesis and Tumor Growth. Cancer letter, 2013 Feb 9. pii: S0304-3835(13)00117-1. doi: 10.1016/j.canlet.2013.02.006

10.Haixia Li, Dayong Huang, Lina Zhang, YanChen, Jinhua Zheng. Anti-invasion and anti-tumor growth effect of scutellarin treatment for human oral squamous-cell carcinoma - In vitro and in vivo studies. International journal of oncology. 42: 1674-1681, 2013

11.低强度超声联合原卟啉IX诱导人舌鳞癌SAS细胞凋亡作用的研究。口腔医学研究，2011, 27（7）580-582.（通信作者）
12.鼠舌癌发生过程中弹性纤维、胶原纤维的变化 南方医科大学学报(J South Med Univ) 2010;30(11) 2696-2698，通信作者，国家核心期刊
13.野黄芩苷对鼠舌癌移植瘤新生脉管及弹性和胶原纤维的影响 口腔医学研究，2011；27（9）760-762.
14. Light Microscopic and Scanning Electron Microscopic Stereo Structural Changes of the
Lingual Papillae and Their Connective Tissue Cores During DMBA Induced Rat Carcinogenesis.
85(4) 129-137 Okajimas Folia Anat.Jap.,

15.Comparative morphological study on the lingual papillae and their connective tissue cores
CTC) in Reeve’s muntjacs (deer). 2006,188:555-564，Annal Anatomical,

16. Microanatomical study on the nutrient artery of glossopharyngeal nerve root. 2008.Vol: 3
772-776 ，NEURALREGENERATION RESEARCH

17.Nonaka, J.H.Zheng, K.Kobayashi. Comparative morphological study on the lingual papillae and their connective tissue cores in rabbits,2008, 85(2)57-66 Okajimas Folia Anat.Jap.

18.Histology and elemental composition of the thick rodless enamel founding the enamel
projection of human molar 2005.12(2-3) Durham Anthropolgy Journal

20.Comparative morphological studies on the stereo structure of the lingual papillae of selected
primates using scanning electron microscopy 2004.186:525 – 530,Annals of Anatomy

21.半枝莲提取物抗人舌鳞癌SAS细胞增殖作用的研究 2010, Vol.25 No.3 249-253口腔医学
研究

22.鼠舌癌发生过程中PCNA表达、淋巴管密度和面积与淋巴道转移的相关性2009 Vol.40 No.6 902-908解剖学报

23.胶原纤维的重塑与人口腔粘膜癌演进的研究2011-11-30口腔医学研究

24.Comparative study on the tongue carcinoma model induced by local application both of
7,12-dimethylbenz[a]anthracene (DMBA) and injury. 2007，解剖学研究Vol.29 No.6 405-409

25.Morphological Features of the Initial Portion of Intralingual Lymphatic Vessels in the
Sprague-Dawley Rat Tongue: An Enzyme-Histochemical and Electron Microscopic
Observation. 美国中华淋巴与肿瘤学杂志2007.Vol.6

26.舌癌鼠舌乳头及结缔组织芯扫描电镜观察 2007解剖科学展 Vol.13 No.1 1-7
27.舌咽神经根及其滋养动脉的显微解剖学研究 2007，解剖学研究Vol.29 No.2 122-124
28.日本齿科大学人体解剖学教学的特色与启迪2007中华医学教育杂志27 3期 107-108
29扫描电镜观察大鼠舌乳头结缔组织芯的形态2007.解剖学杂6 808-810



主要学会发表
1.Wenwu Cao, Jinhua Zheng, Yanhong Lv, Wei Song, Haidong Cui， Zhongxiuzi Gao, Haixia Li. Apoptotic effects of sonodynamic therapy with protoporphyrin IX on SAS human tongue carcinoma cell and Xenografts. The16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine. October 6-8, 2011 in Greece
2.Jinhua Zheng, Yanhong Lv, Haidong Cui, Haixia Li， Zhongxiuzi Gao, Wenwu Cao. Sonodynamic therapy with 5-Aminolevulinic Acid induce apoptosis in SAS cells via the mitochondrial mediated caspase pathway. The 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine. October 6-8, 2011 in Greece
主要科研成果及获奖情况

1.口腔粘膜癌的组织化学与电镜研究 黑2008-0319 基础理论成果 第1位 2008.4.18
2.口腔粘膜癌的组织化学与电镜研究 省教育厅科技成果 2等奖 第1位 2009.2

在研科研项目
1.黑龙江省博士后启动基金 半枝莲提取物有效部位体内、外抗肿瘤作用及机制研究 5万 2009.5 2011.12
2.癌声动力治疗生物学机制 哈工大横向合作 100万 2011.7～ 2014.6
3.361055 国家自然基金 低强度超声联合5ALA治疗鼠舌癌 65万 2012.1-2016.12