精氨酸抗氧化作用机制

梁明才,杨林

(哈尔滨工业大学 化工与化学学院,哈尔滨 150001)



摘要:

精氨酸是一种功能性氨基酸,在机体生理功能、新陈代谢和营养等方面发挥着重要作用。精氨酸具有抗氧化能力。目前的体外研究表明精氨酸具有较强的清除DPPH自由基、ABTS自由基、超氧自由基能力以及一定的还原力。作为一种带电子的碱性氨基酸,精氨酸可能通过胍基基团向自由基提供电子并与其作用,终止自由基链式反应,从而显示出还原能力与体外抗氧化能力。体内实验则表明精氨酸能有效地提高机体总抗氧化能力,降低体内自由基含量,抑制ROS生成与积累,促进谷胱甘肽(GSH)合成与积累,增强内源性抗氧化酶(CAT、SOD、GPx等)活性,抑制氧化应激的产生。精氨酸能够通过精氨酸——一氧化氮途径、GSH途径、Nrf2信号通路途径及其他途径发挥体内抗氧化作用。本文主要综述了目前精氨酸体外与体内抗氧化功能及其相关作用机制的研究进展,为精氨酸的实际应用提供理论指导意义。

关键词:  精氨酸  抗氧化  分子机制

DOI：10.12113/202007001

分类号:Q517

文献标识码:A

基金项目:国家自然科学基金项目(No.31371755).



Antioxidant mechanism of arginine

LIANG Mingcai, YANG Lin

(School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin 150001,China)

Abstract:

Arginine, a functional amino acid, plays an important role in physiological function, metabolism, and nutrition. Current studies show that arginine has a strong ability to scavenge DPPH radicals, ABTS radicals, and superoxide radicals, and possesses reducing power to some extend. As an electron-carrying basic amino acid, arginine may provide electrons to free radicals through the guanidine group and react with the free radicals, resulting in the termination of free radical chain reaction. Therefore, arginine shows reducing power and in vitroantioxidant capacity. In vivoexperiments show that arginine can effectively improve total antioxidant capacity, reduce free radicals, decrease generation and accumulation of reactive oxygen species, promote GSH synthesis and accumulation, and enhance the activities of endogenous antioxidant enzymes (e.g.,CAT, SOD, GPx), thereby inhibiting oxidative stress. Arginine can exert antioxidant activity through arginine-NO pathway, GSH synthesis pathway, Nrf2 signal pathway, and other pathways. This paper reviews the current research progress of arginine in vitroand in vivoantioxidant functions and their mechanisms, so as to provide a scientific theoretical basis for the rational application of arginine in future studies.

Key words:  Arginine  Antioxidant  Molecular mechanism