基本信息研究与项目 / Research and Fundings教育教学 / Teaching论文著作 / Publications团队成员 / Research Group国内外合作 / International-domestic Cooperation
基本信息
约翰尼斯 福如亨 副教授

Johannes Frueh Associate Professor

(1983年 德国/ Germany Hinter dem Wald)




微系统与微结构制造教育部重点实验室，微纳米技术研究中心，哈尔滨工业大学

Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), Micro/Nano Technology Research Center, Harbin Institute of Technology

教育经历

标题学士学位 / Bachelor Degree

起讫时间2003.09-2006.07

所学专业化学与市场经济 / Chemistry with Marketing

学习机构罗伊特林根大学 （德国）/ Reutlingen University (Germany）



标题硕士学位 / Master Degree

起讫时间2006.09-2008.07

所学专业生物和过程分析 / Bio- and Process-analytics

学习机构罗伊特林根大学（德国） / Reutlingen University（Germany）



标题博士学位 / PhD Degree

起讫时间2008.09-2011.09

所学专业物理化学 / Physical Chemistry

学习机构德国马克斯普朗克胶体与界面研究所 / Max Plank Institute for Colloids and Interfaces （Germany）

简单介绍博士期间，曾到日本九州大学合作交流学习5个星期。 / During PhD study time, I worked 5 weeks at Kyushu University in Japan.


工作经历

标题默克公司 / Merck Selbstmedication Darmstadt

职位,职务,职称学士论文/ Company Intership and Bachelor thesis

工作地点,工作单位默克Selfmedication分析发展中心/Analytical Development Center of Merck Selfmedication

起讫时间2005.07-2006.02

简单介绍德国默克制药公司默克Selfmedication达姆施塔特是一个子公司,总部在达姆施塔特,德国液晶的世界领先供应商。默克Selfmedication食品补充,分析专业发展中心在达姆施塔特。Merck Selfmedication Darmstadt is a daughter company of Merck KGaA, which has its headquarters in Darmstadt, Germany and is the world leading supplier of liquid crystals. Merck Selfmedication is specialized on food supplementary and has a analytical development center in Darmstadt where I aided the development of novel food supplements and analytical techniques to detect these vitamins quantitatively.


标题索尼公司 / Sony Corporation

职位,职务,职称硕士论文 / Company Intern Master Thesis

工作地点,工作单位斯图加特 索尼斯图加特材料科学实验室 / Sony Material Science lab in Stuttgart

起讫时间2007.07-2008.02

简单介绍索尼公司是日本的一家全球知名的大型综合性跨国企业集团，在德国斯图加特设有材料科学实验室。本人在其实验室完成了关于“仿生/程序分析材料”等硕士研究课题。 / Sony Corporation is a Japanese high technology electronics and medical company; it has a material science lab in Stuttgart Germany. I worked on electronic noses for intelligent medical robots.


标题哈尔滨工业大学 博士后 / Harbin Institute of Technology postdoctor

职位,职务,职称博士后 / postdoctor

工作地点,工作单位哈尔滨工业大学化学工程流动站 / Harbin Institute of Technology Chemical Engineering Stration

起讫时间2012.04-2014.04

简单介绍在德国马克思普朗克研究所博士毕业之后，进入了哈工大贺强教授课题组开展了关于海洋防污涂层材料以及基于聚电解质多层膜的微纳米马达运动的研究。 / After got the PhD degree in Max Plank Institute, I joined in Professor He Qiang research Group and carried out the research about Marine Antibiofouling Coatings materials and also on Nano-Micrometer sized motor movements.


标题哈尔滨工业大学海内外人才引进 / HIT Overseas Talents Introduction Project

职位,职务,职称副教授 / Associate Professor

工作地点,工作单位哈尔滨工业大学微纳米技术研究中心 / HIT Micro/Nanotechnology Research Center

起讫时间2014.05-至今 / till now

简单介绍主要从事仿生马达(2维盘状马达以及3维微胶囊马达)的制备，运动机理研究以及微纳米胶囊抗癌药物包裹与靶向释放（近红外激光，超声以及酶催化等）应用于活细胞和小鼠实验等。 / I mainly work with Micro-nanometer motors (2D PEM microplates and 3D microcapsules) fabricaion. In addition i analyze the movement mechanism of micromotors accompanied by anticancer drug encapsulation and targeted release by NIR laser, ultrasound and enzymatic reactions for living cells and in vivo.

研究领域 / Research Interests
（1）Anti-biofouling: Utilization of a variety of structures, which repel life forms purely due to surface minimization, unfavorable settlement sites as well as light-life form interaction due to photocatalytic properties of the surface. This will be achieved by means of Oswald ripened metal-oxide surfaces on structured templates and subsequent analyzation of the interaction of the structures and life forms with a recently home-build 3D microscope. This research is intended with the collaboration of HIT Weihai campus.

（2）Drug delivery in collaboration with Prof. Qiang He: I intend to Utilize the same 3D microscope, and optical tweezers, which I currently build to detect and analyze the 3D movement and control of drug delivery systems.











科研项目 / Research Projects

项目名称 脂质体在聚合物多层表面的吸附及支撑流动磷脂双层形成的机理研究 / Mechanism of Absorption of Lipsomes on Polymer Multilayers and Formation of Cushioned Fluid Lipid Bilayers

项目来源国家自然科学基金青年科学基金/ National Natural Science Foundation Young Scientist Funding

开始时间2016.01

结束时间2018.12

项目经费￥246，000

担任角色负责
项目类别纵向项目
项目状态进行中


项目名称哈工大海内外人才引进项目启动资金 / HIT overseas Talents Projects Reasearch Starting Money

项目来源哈尔滨工业大学 / Harbin Institute of Technology

开始时间2014.05

结束时间2017.05

项目经费￥200，000

担任角色负责
项目类别纵向项目
项目状态进行中


项目名称中国博士后科学基金第53批面上资助/ China Postdoctoral Science Foundation No. 53funding

项目来源中国博士后科学基金委 / China Postdoctoral Science Foundation

开始时间2012.05

结束时间2015.05

项目经费￥50,000

担任角色负责
项目类别纵向项目
项目状态完成


项目名称热泳自驱动2维微纳米杂化马达运动机理研究/Self-propelled Thermophoretic 2D Micro-Nano Hybrid Motors Photothermal-Driving Mechanisms

项目来源哈尔滨工业大学微系统与微结构制造教育部重点实验室开放基金/State Key Laboratory Foundation (project Nr. 2016KM008)

开始时间2017.01

结束时间2018.12

项目经费￥50，000

担任角色负责
项目类别横向项目
项目状态进行中


论文著作 / Publications
29) Wenhao Li, Meiyu Gai,*, Johannes Frueh*, Valeriya L. Kudryavtseva|, Gleb B. Sukhorukov*, “Ultrasound Triggered Release of Cargo Loaded into Polyelectrolyte Multilayer Microchambers: Low Frequencies vs. High Frequencies”, Colloids and Surfaces A.16.03.2018.







28) M. Gai, M. A. Kurochkin, D.Li, N. Tarakina, D. J. Gould, J. Frueh*, G. B. Sukhorukov*, “Biodegradable Microcontainer-Arrays Controlled Spatiotemporal Drug Release for Triggering EGFP Expression on Single Cell level”, Journal of Controlled Release. 03.2018. DOI: 10.1016/j.jconrel.2018.02.044



27）M. Gai, J.Frueh*, T. Tao, A. V. Petrov, V. V. Petrov, S. I. Tverdokhlebov, E. V.Shesterikov and G. B. Sukhorukov, Polylactic acid nano- and microchamber arrays for encapsulation of small hydrophilic molecules featuring drug release via high intensity focused ultrasound, Nanoscale, (2017.04)



26）M. Gai, J.Frueh*, V. L. Kudryavtseva, A. M. Yashchenok and G. B. Sukhorukov, Polylactic Acid Sealed Polyelectrolyte Multilayer Microchambers for Entrapment of Salts and Small Hydrophilic Molecules Precipitates, ACS Applied Materials and Interfaces, (2017.04)



25) M. Chen, J. Frueh, D. Wang, X. Lin, H. Xie, Q. He, Polybenzoxazole Nanofiber-Reinforced Moisture-Responsive Soft Actuators, Sci. Rep, asap (2017) DOI: SREP-16-51323A.




24) N. Hu, B. Zhang, M. Gai, C. Zheng, J. Frueh* and Q. He*, Forecastable and Guidable Bubble-Propelled Microplate Motors for Cell Transport Macromol. Rapid Comm., asap

(2017). DOI: 10.1002/marc.**


23) M. Gai, V. L. Kudryavtseva, G. B. Sukhorukov *and J. Frueh*. Micro-Patterned Polystyrene Sheets as Templates for Interlinked 3D Polyelectrolyte Multilayer Microstructures. Bionanoscience,1–15(2017).http://link.springer.com/article/10.1007/s12668-017-0403-5






22) J. Shao,C. Wen, M. Xuan, H. Hang, J. Frueh, M. Wan, L. Gao* and Q. He *, Polyelectrolyte Multilayer-Cushioned Fluid Lipid Bilayers: A Parachute Model.

Phys.Chem. Chem. Phys. 19, 2008–2016 (2017). http://pubs.rsc.org/en/content/articlelanding/2017/cp/c6cp06787e#!divAbstract



21) M. Gai, J. Frueh*, V. L. Kudryavtseva, R. Mao, M. V. Kiryukhin, and G. B. Sukhorukov*, Patterned Microstructure Fabrication: Polyelectrolyte Complexes vs Polyelectrolyte Multilayers. Scientic. Report. 6,37000 (2016)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC**/




20) W. He, J.Frueh*, N. Hu, L. Liu, M. Gai, and Q. He*, Guidable Thermophoretic Janus Micromotors Containing Gold Nanocolorifiers for Infrared Laser Assisted Tissue Welding. Adv. Sci. ** (2016) http://onlinelibrary.wiley.com/doi/10.1002/advs.**/full









19) W. He, J. Frueh*, J. Shao, M. Gai, N. Hu, and Q. He*, Guidable GNR-Fe3O4-PEM@SiO2 composite Particles containing Near Infrared Active Nanocalorifiers for Laser assisted Tissue Welding,Colloid. Surf., A, vol. 511, 73-81, (2016). http://www.sciencedirect.com/science/article/pii/S**8020










18) M. Gai, J. Frueh*, T. Si, N. Hu, G. B. Sukhorukov, Q. He*, The collision phenomena of Janus polymer micro-plate motors propelled by oscillating micro-bubbles Colloid.Surf.A. DOI: 10.1016/j.colsurfa.2016.04.042 http://linkinghub.elsevier.com/retrieve/pii/S**2746



17) W. He, J. Frueh*, Z. Wu, Q. He*, Langmuir, 32, 16, 3637–3644 (2016)http://pubsdc3.acs.org/doi/full/10.1021/acs.langmuir.5b04762






16) W. He, J. Frueh*, Z. Wu, Q. He*, ACS Appl.Mater. Interfaces 8, 7 4407–4415 (2016)http://pubs.acs.org/doi/abs/10.1021/acsami.5b10885



15) M. Gai, J. Frueh*, N. Hu, T. Si, G. B.Sukhorukov, Q. He*, Phys. Chem. Chem. Phys., 18, 3397-3401 (2016)http://pubs.rsc.org/en/content/articlelanding/2014/cp/c5cp07697h#!divAbstract






14) N. Hu, J. Frueh, C. Zheng, B. Zhang,Q. He, Colloid. Surf., A 482, 315-323 (2015).http://www.sciencedirect.com/science/article/pii/S**0339






13) M. Gai, J. Frueh*, A. Girard-Egrot, S.Rebaud, B. Doumeche, Q. He*, RSC Adv. 5 (64), 51891-51899 (2015).http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C5RA08456C#!divAbstract






12) M. Gai, J. Frueh*, G. B. Sukhorukov,A. Girard-Egrot, S. Rebaud, B. Doumeche, Q. He* Colloid Surf. A 483,271-278 (2015).http://www.sciencedirect.com/science/article/pii/S**4197






11) Z. Wu, C. Gao, J. Frueh*, J. Sun, Q. He, Macromol.Rapid Commun. 36 (15) 1444-1449 (2015).http://onlinelibrary.wiley.com/doi/10.1002/marc.**/abstract









10) Y. Wu, J. Frueh, T. Si, M. Helmuth, Q. He, Phys.Chem. Chem. Phys. 17,3281–3286 (2015).http://pubs.rsc.org/en/Content/ArticleLanding/2015/CP/C4CP05231E#!divAbstract






9) J.Früh*, A.Rühm, H.M？hwald, R.Krastev,R.K？hler*, Annual Report 2014: Technische Universit？t München FRM-Page 104-105 II,Munich 2015.https://www.frm2.tum.de/fileadmin/w00bnv/www/Aktuelles___Medien/Broschueren/Jahresberichte/annual_report_2014.pdf






8) J. Frueh*, A.Ruehm, H. Moehwald, R. Krastev, R. Koehler, Physika B, 457, 202-211 (2015)http://pubs.acs.org/doi/abs/10.1021/jp310727f






7) J. Frueh*, Meiyu Gai, Zhibo Yang, Qiang He,J. Nanosci. Nanotechnol. 14 (6),4341-4345 (2014)http://chinesesites.library.ingentaconnect.com/content/asp/jnn/2014/**/**/art00051







6) J. Frueh*, G. Reiter, H. M？hwald, Q. He, and R. Krastev, J Phys Chem B 117 (10), 2918-2925 (2013).http://pubs.acs.org/doi/abs/10.1021/jp310727f






5) J. Frueh*, G. Reiter, J. Keller, H. Moehwald, Q. He, and R. Krastev, Phys. Chem.Chem. Phys. 15, 483–488 (2013).http://pubs.rsc.org/en/content/articlelanding/2012/cp/c2cp43302h






4) J. Frueh*, G. Reiter, H. M？hwald, Q. He, and R. Krastev, Colloid Surface A 415,366–373 (2012).http://www.sciencedirect.com/science/article/pii/S**6139






3) J. Frueh*, N. Nakashima, Q. He, and H. Moehwald, J Phys Chem B 116, 12257–12262 (2012).http://pubs.acs.org/doi/abs/10.1021/jp**?prevSearch=Johannes+Frueh&searchHistoryKey=






2) X. Yan, Y. Su, J. Li, J. Frueh, and H.Moehwald, Angew. Chem. Int. Ed. 50,11186–11191 (2011).http://onlinelibrary.wiley.com/doi/10.1002/anie.**/pdf






1) J. Frueh*, R. Koehler, H. Moehwald, and and R. Krastev, Langmuir 26, 15516–15522 (2010).http://pubs.acs.org/doi/abs/10.1021/la**






讲授课程 / Teaching course
授课语言 / Teaching Language: English
生物化学 / Biochemistry: 本科生及研究生 / undergraduate students and graduate students



招生 / Recruit
硕士招生, 博士（海外）/ Recruit of Graduates （Overseas students） :




欢迎有化学、物理、材料、生物等学科背景的同学加入我们的研究团队！

Welcome the students who have Chemistry, Physics, Materials or Biological background to join our research team !

书籍著作 / Published book chapter

论文标题Structure and Thermodynamics of Polyelectrolyte Complexes, chapter 2

作者Johannes Frueh, Meiyu Gai, Simon Halstead and Qiang He

期刊名称Springer, Berlin, Heidelberg

简单介绍http://www.springer.com/gb/book/**95This book offers a valuable reference source to graduate and post graduate students, engineering students, research scholars polymer engineers from industry. The book provides the reader with current developments of theoretical models describing the thermodynamics polyelectrolytes as well as experimental findings. A particular emphasis is put on the rheological description of polyelectrolyte solutions and hydrogels.Editors: Visakh P. M. Oguz Bayraktar, Guillermo Picó. eBook ISBN: 978-3-319-01680-1


专利 / Patents
团队成员 / Research Group






在读博士 / PhD Students：




2012级 和文平，研究方向，新型药物载体的合成及其活体研究（副导师 ） ，已毕业。

Year 2012. Wenping He, Research direction: Fabrication of new type drug carriers and applied in vivo. (Co-supervisor)



2014 级 盖美玉 (英国攻博-伦敦大学玛丽女王学院-生物医学材料专业), 资助于国家留学基金委. 研究方向，新型生物芯片的制备以及载药，释药及应用（副导师）

Year 2014 Meiyu Gai（PhD in UK, Queen Mary University of London, Major in Biomedical Materials, Funded by Chinese Scholarship Council of the Ministry of Education (CSC). Research Direction: Fabrication of novel 3D biochips with drug loading, release and its applications. (Co-supervisor together with Professor Gleb Sukhorukov)




2016级 Sven Rutkowski（德籍）研究方向：在环境压力的电子喷雾电离的多功能检测系统研究。中国国家留学基金委资助博士生 (导师)

Year 2016 Sven Rutkowski, (German) Research Direction: Electron spray ionization at ambient pressures as a multifunctional detection system. Funded by Chinese Scholarship Council of the Ministry of Education (CSC) (Supervisor)







在读硕士/ Master Student：




2015级 孙猛, 研究方向: 基于水凝胶粒子的水下超疏油材料（副导师）

Year 2015 Meng Sun, Research Direction: Underwater super- hydrophobic oil material based on water gel particles (Co-supervisor)

2016级 李文豪 研究方向：设计及制备不同类型微纳米空腔用于亲水性小分子药物包裹及可控释放

Year 2016 Wenhao Li, Research Direction: Design and fabricate different types of microchambers for drug encapsulation and control release

友情链接 / Useful links

链接名称哈工大贺强教授

链接地址http://homepage.hit.edu.cn/heqiang

简单介绍龙江特聘教授,德国洪堡基金会洪堡学者称号


链接名称哈尔滨工业大学

链接地址http://www.hit.edu.cn/

简单介绍中华人民共和国工业和信息化部直属重点大学，首批“211工程”、“985工程”重点建设院校，“九校联盟(C9)”、


链接名称伦敦大学玛丽女王学院

链接地址http://www.qmul.ac.uk/

简单介绍QM在世界各大排名中稳居前100名，在2016泰晤士世界大学排名位列全球98位。

国际国内合作交流 / International - domestic cooperation
伦敦大学玛丽女王学院 （英国）Queen Mary University of London (QMUL), School of Engineering and Materials Science, Professor Gleb Sukhorukov, Dr. Andrei Sapelkin 萨拉托夫州立大学（俄罗斯）Saratov State University, Faculty of Nano and Biomedical Technology, Profeseor Dmitry A. Gorin,Dr. Alexey Mikhailovich Yashchenok托木斯克州立大学（俄罗斯）Tomsk Polytechnic University,Department of Experimental Physics，Valeriya L. Kudryavtsevac 材料科学与工程研究所（新加坡）Institute of Materials Research and Engineering (IMRE), A*STAR, Singapore，Dr. Maxim V. Kiryukhind 自然与药物科学研究所(德国) Natural and Medical Sciences Institute，Prof. Dr. Rumen Krastev

斯科尔科沃科学与技术研究院 (俄罗斯) Skolkovo Institute of Science and Technology,Center for Photonics and Quantum Materials, Professor Nikolay Gippius.


中国科学院微纳米技术中心（中国）Micro/nano Technology Center, Chinese Academy of Sciences. Professor Luru Dai