陈川 姓 名：陈川
职 称：副教授
邮 箱：hyperchuan@163.com
联系电话：
联系地址：河北省保定市五四东路180号，河北大学中试基地 210实验室，邮编：071002


个人简介
科研领域
代表性论文
教育经历：
2018-2019 访学 佛罗里达州立大学
2002-2006 理学博士 厦门大学
1999-2002理学硕士 河北大学
1995-1999理学学士 河北大学
工作经历：
2008年-至今，副教授，河北大学
2006年- 2008年 康弘药业生物技术有限公司

执教课程：病毒学，抗体工程，生物制药等

国际合作研究：
佛罗里达州立大学合作研究酵母特异性自噬和以此为基础进行的药物筛选

1.重组蛋白类和病毒类基因工程药物的制备及机理研究。
2.基于肿瘤和糖尿病分子靶点构建抑制剂筛选平台，对生物来源的天然产物进行药物筛选；使用分子生物学、细胞生物学、生物化学和药理学的方法研究药物的作用的机理，并探索肿瘤和糖尿病新的药物作用靶点。


1. Chen C, Xue TD, Fan P, Meng L, Wei JJ, Luo DQ. Cytotoxic activity ofShp2 inhibitor fumosorinone in human cancer cells. Oncology Letters, 2018, 15: 10055-10062.
2.Chen C, Liang F, Chen Bo, Sun Z, Xue TD, Yang RL, Luo DQ. Identification of demethylincisterol A(3) as a selective inhibitor of protein tyrosine phosphatase Shp2. European Journal of Pharmacology, 2017, 795:124-133.
3.Chen C, Cao M, Zhu S, Wang C, Liang F, Yan L, Luo D. Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2. Sci Rep, 2015, 5:17626.
4.Chen C, Wang CC, Wang Z, Geng WY, H Xu, Song SM, Luo DQ. Cytotoxic activity of a synthetic deoxypodophyllotoxin derivative with an opened D-ring. Journal of Asian Natural Products Research , 2016, 486-494.
5.Chen C, Hu SY, Luo DQ, Zhu SY, Zhou CQ. Potential antitumor agent from the endophytic fungus Pestalotiopsis photiniae induces apoptosis via the mitochondrial pathway in HeLa cells. Oncology Rep, 2013, 30: 1773-1781.
6.Chen C, Yang RL. A phthalide derivative isolated from endophytic fungi Pestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells. Brazilian Journal of Medical and Biological Research, 2013,46: 643-649.
7.Liu L, Zhang J, Chen C, Teng J, Wang C, Luo D. Structure and biosynthesis of fumosorinone, a new protein tyrosine phosphatase 1B inhibitor firstly isolated from the entomogenous fungus Isaria fumosorosea. Fungal Genet Biol, 2015,81:191-200.
8.Liu ZQ, Liu T, Chen C, Li MY, Wang ZY, Chen RS, Wei GX, Wang XY, Luo DQ. Fumosorinone, a novel PTP1B inhibitor, activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice. Toxicol Appl Pharmacol, 2015, 285:61-70.
9.Wei PY, Liu LX, Liu T, Chen C, Luo DQ, Shi BZ. Three new pigment protein tyrosine phosphatases inhibitors from the insect parasite fungus Cordyceps gracilioides: terreusinone A, pinophilin C and cryptosporioptide A, Molecules, 2015 20:5825-34.
10.Chen C, Hu SY, Luo DQ, Zhu SY, Zhou CQ. Potential antitumor agent from the endophytic fungus Pestalotiopsis photiniae induces apoptosis via the mitochondrial pathway in HeLa cells. Oncology Rep. 30: 1773-1781, 2013.
11.Luo DQ, Chen YP, Zhang J, Chen C. A New Glycine Derivative and a New Indole Alkaloid from the Fermentation Broth of the Plant Endophytic Fungus Pestalotiopsis podocarpi Isolated from the Chinese Podocarpaceae Plant Podocarpus macrophyllus. Helvetica Chimica Acta . 96: 309-312, 2013.
12.Chuan Chen, Caoxin Huang, Shouhui Chen, Jie Liang, Wenbo Lin, Guifen Ke, Hongxin Zhang, Bing Wang, Jian Huang, Zeguang Han, Lixin Ma, Keke Huo, Xiaoming Yang, Pengyuan Yang, Fuchu He, Tao Tao. Subunit–subunit interactions in the human 26S proteasome. Proteomics 8: 508-520, 2008.
13.Chen C, Tao tao. An interaction map of Chinese liver 26S proteasome subunits. Mol. Cell. Proteomics 2006, 5:S607.
14. 陈川, 朱思宇, 李丽, 胡淑媛, 罗都强.常规PCR法快速鉴别粗品肝素钠不同种属来源. 药学学报, 2014
15.陈川, 俞德超, 滕理送. 以VEGF/VEGFR为靶点的抗肿瘤药物的研究进展.中国肿瘤生物治疗杂志, 3:35-38, 2007.
16.陈川,王三英，彭宣宪.嗜水气单胞菌耐四环素的蛋白质组学初步研究.微生物学报,44:396-398, 2004.


专利：
1.俞德超 陈川. VEGF受体融合蛋白在制备治疗与血管生成有关的疾病中的应用. 发明人授权公告日 2010-10-27 授权号 CN B
2.陈川，杨润蕾，罗都强. 一种抗肿瘤融合蛋白及其制备方法用途 2014-4-30 CN B
3.陈川，杨润蕾，粗品肝素钠不同种属来源的快速鉴别 . 7X