郭蕊 姓名：郭蕊
职称：教授
邮箱：rguo2020@163.com
办公地址：河北大学生命科学学院，综合科研楼“干细胞与生物医学研究”科研团队
通讯地址：河北省保定市五四东路180号，邮政编码071002


个人简介
科研领域
代表性论文
郭蕊，美国怀俄明大学生物医学科学博士，2018年12月全职引进河北大学。现任河北大学生命科学学院教授，研究生导师。美国心脏学会会员，美国糖尿病学会会员，中国细胞生物学学会会员，河北省高层次引进人才，国家自然科学基金评审专家，河北省科技奖励评审专家，《前沿生理学》Frontiers inPhysiology，《氧化医学与细胞长寿》Oxidative Medicine andCellular Longevity国际期刊客座编辑，《临床与实验药理及生理杂志》Clinical& Experimental Pharmacology &Physiology、《酗酒：临床与实验研究》Alcoholism:Clinical and Experimental Research、《人类精神药理学：临床与实验》Human Psychopharmacology: Clinical and Experimental 等国际期刊评委。迄今发表近40篇国际性高水平论著及摘要，其中包括肝病领域国际权威期刊《Journal of Hepatology》，细胞生物学领域国际权威期刊《Autophagy》，心血管领域国际权威期刊《Circulation》，《European Heart Journal》和糖尿病领域国际权威期刊《Diabetes》等。曾参加多次国际与国内顶级学术会议，并做口头演讲和展板交流，在心血管代谢性疾病领域有自己的独到见解，其成果得到同行的认可，截止到目前为止（2020年9月），论文引用率已经超过1351（Google Scholar）。

主要研究兴趣与方向：
1.代谢性心血管疾病和心力衰竭的分子机制及治疗靶标的研究
2.糖尿病并发症的分子机制及其靶向药物的研究
3.环境污染对心肌毒性的分子机制研究
4.干细胞在心血管疾病和肿瘤中的研究与应用
5.蛋白酶在肿瘤和心血管疾病发生与发展中的作用机制
6.脂肪肝和肝癌的发生机制和靶向治疗
7.细胞代谢、细胞自噬、线粒体功能、表观遗传、蛋白质翻译后修饰等在心血管疾病、糖尿病和肿瘤发生发展中的作用机制和病理生理学意义
主要荣誉奖项：
2019: 河北省高层次创新人才
2017：国家优秀自费留学生奖
2015-2018: 美国国立卫生研究院 (NIH) 生物医学科学研究资助与奖励
主要科研项目：
1.国家自然科学基金青年项目，2020.1-2022.12，主持
2.河北省自然科学基金和重点基础研究专项，2019.1-2021.12，主持
主要课程教学：
3.生物工程专业外语，河北大学
4.研究生专业英语与科技论文写作，河北大学
5.细胞生物学实验，河北大学
6.生命科学研究进展，河北大学



代表性论文(^#并列第一作者，相同贡献; *共同通讯作者)
1.Yang H,Heyer J, Zhao H, Liang S, Guo R*, Zhong L*: The Potential Role ofCathepsin K in Non-Small Cell Lung Cancer. Molecules. 2020, 25(18):4136.
2.Wang Q, GuoR, Nair S, Smith D, Bisha B, Nair A, Nair R, Downs B, Kushner S, Bagchi M:Safety and Efficacy of N-SORB®, a Proprietary KD120 MEC Metabolically ActivatedEnzyme Formulation: A Randomized, Double-Blind, Placebo-Controlled Study. Journal of the American College of Nutrition.2019, DOI: 10.1080/**.2019.**.
3. Guo R, Hua Y, Ren J, Bornfeldt K, Nair S:Cardiomyocyte-Specific Disruption of Cathepsin K Protects AgainstDoxorubicin-Induced Cardiotoxicity. Cell death & disease. 2018, 9:692.
4. GuoR, Wang Q, Nair R, BarnesS, Smith D, Dai B, Robinson T, Nair S: Furosap, a novel Fenugreek seed extractimproves lean body mass and serum testosterone in a randomized,placebo-controlled, double blind clinical investigation. Functional Foods inHealth and Disease. 2018 8(11): 508-519.
5. Guo R, Nair S, Zhang Y, Ren J. Adiponectin DeficiencyRescues High Fat Diet-Induced Hepatic Injury, Apoptosis and Autophagy LossDespite Persistent Steatosis. International Journal of Obesity. 2017,41(9):1403-1412.
6. Guo R, Nair S. Role of MicroRNA in DiabeticCardiomyopathy: from Mechanism to Intervention. Biochimica et BiophysicaActa (BBA) - Molecular Basis of Disease. 2017, 1863(8):2070-2077.
7. Guo R, Hua Y, Rogers, O, Ren J, Nair S. CathepsinK knockout preserves cardiac function in diabetic mice. Scientific Report.Aug. 2017, 7(1):8703.
8.Guo R,Rogers O, Nair S. Targeting Apelinergic System in Cardiometabolic Disease. Currentdrug targets. 2017;18(15):1785-1791.
9. Guo R, Nair S, Ren J. Role of theCathepsin K/Calcineurin/NFATs Axis in the Pathogenesis and Management ofDiabetic Cardiomyopathy. Cardiology Plus. 2016, 1(3).
10. Guo R, Xu X, Babcock SA, Zhang Y,Ren J: Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronicalcohol-induced hepatic steatosis and inflammation through regulation ofautophagy. J Hepatol. 2015, 62(3):647-656.
11. Guo R, Zhang Y, Turdi S, Ren J：Adiponectin Knockout Accentuates High FatDiet-Induced Obesity and Cardiac Dysfunction: Role of Autophagy. BiochimBiophys Acta. 2013, 1832(8):1136-1148.
12.Jiang S^#, Guo R^#,Zhang Y, Zuo Y, Ren J: Heavy Metal Scavenger Metallothionein Mitigates DeepHypothermia-Induced Myocardial Contractile Anomalies: Role of Autophagy. AmJ Physiol Endocrinol Metab. 2013, 304(1):e74-86.
13. Guo R, Hu N, Kandadi M, Ren J: Facilitatedethanol metabolism promotes cardiomyocyte contractile dysfunction throughautophagy in murine Hearts. Autophagy. 2012, 8(4):593-608.
14. Guo R, Ren J: Deficiency in AMPK attenuatesethanol-induced cardiac contractile dysfunction through inhibition ofautophagosome formation. Cardiovasc Res. 2012, 94(3):480-491.
15. Guo R, Scott GI, Ren J: Involvement of AMPK inalcohol dehydrogenase accentuated myocardial dysfunction following acuteethanol challenge in mice. PLoS One. 2010, 5(6):e11268.
16. Guo R, Ren J: Alcohol dehydrogenase accentuatesethanol-induced myocardial dysfunction and mitochondrial damage in mice: roleof mitochondrial death pathway. PLoS One. 2010, 5(1):e8757.
17.Guo R, RenJ: Alcohol and acetaldehyde in public health: from marvel to menace. Int JEnviron Res Public Health. 2010, 7(4):1285-1301.
18. Guo R, Ma H, Gao F, Zhong L, RenJ: Metallothionein alleviates oxidative stress-induced endoplasmic reticulumstress and myocardial dysfunction. J Mol Cell Cardiol. 2009, 47(2):228-237.
19. Guo R, Zhong L, Ren J: Overexpression of aldehydedehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, changein Akt and Pim signalling in liver. Clin Exp Pharmacol Physiol. 2009,36(5-6):463-468.
20.Ma H, Guo R, Yu L, Zhang Y, Ren J: Aldehydedehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: roleof autophagy paradox and toxic aldehyde. Eur Heart J. 2011,32(8):1025-1038.
21.Ge W, Guo R, Ren J: AMP-dependent kinase andautophagy are involved in aldehyde dehydrogenase 2-offered protection againstcardiac toxicity of ethanol. Free Radic Biol Med. 2011, 51(9):1736-1748.
22.Turdi S, Guo R, Huff AF, Wolf EM, Culver B,Ren J: Cardiomyocyte contractile dysfunction in the APPswe/PS1dE9 mouse modelof Alzheimer's disease. PLoS One. 2009, 4(6):e6033.
23.Hu N, Guo R, Han X, Zhu B, Ren J:Cardiac-specific overexpression of metallothionein rescues nicotine-inducedcardiac contractile dysfunction and interstitial fibrosis. Toxicol. Lett.2011, 202(1): 8-14.
24.Ma H, Jones KR, Guo R, Xu P, Shen Y, Ren J:Cisplatin compromises myocardial contractile function and mitochondrialultrastructure: role of endoplasmic reticulum stress. Clin Exp PharmacolPhysiol. 2010, 37(4):460-465.
25.Han X, Turdi S, Hu N, Guo R, Zhang Y, Ren J:Influence of long-term caloric restriction on myocardial and cardiomyocytecontractile function and autophagy in mice. J Nutr Biochem.2012,23(12):1592-1599.
26.Dong M, Hu N, Hua Y, Xu X, Kandadi MR, Guo R,et al. Chronic Akt activation attenuated lipopolysaccharide-induced cardiacdysfunction via Akt/GSK3beta-dependent inhibition of apoptosis and ER stress. BiochimBiophys Acta. 2013;1832(6):848-863.
27.Pang J, Fuller N.D., Hu N, Barton L. A., Henion J.M., Guo R, Chen Y, Ren J. AlcoholDehydrogenase Protects against Endoplasmic Reticulum Stress-Induced MyocardialContractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Roleof PTEN-Akt-mTOR Signaling. PLOS ONE. 2016, 11(1);e**.
代表性著作
1. Guo R,Nair S. Protease Cathepsins in Cardiomyopathy: from Mechanism to Intervention. Proteasesin human Diseases. p.447. Chapter 21. Springer. 2017. DOI10.1007/978-981-10-3162-5_21.
国际顶级学术会议及摘要发表
1. Zhao H, Yang H,Sun J, Liang G, Zhao Q, Zhang X, Liang S, Guo R and Zhong L. Mesenchymalstem cells promote PD-L1 expression in lung cancer cells. AACR Annual Meeting2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. Cancer Research, Aug 2020, 80(16) Supplement: a6011.
2. Guo R, Yang H, Zhang Y, Li B, Liu X, Zhong L. The PotentialClinical Role of Cathepsin K and Autophagy in the Prevention of AlcoholicCardiomyopathy. American Heart Association (AHA) ScientificSessions, Philadelphia, Pennsylvania, November 15-18, 2019. POSTERpresentation. Circulation, Nov 2019, 140 (Supplement 1): a15085.
3. Guo R, ZhangL, Thakar A, Brown T.E., Ren J, Zgheib C, Xu J, Liechty W.L., Nair S. Geneticand Pharmacological Suppression of Cathepsin K Promotes Wound Healing inDiabetic Mice. American Diabetes Association (ADA) Scientific Sessions, SanFrancisco, California, June 7-11, 2019; POSTER presentation. June 2019, Diabetes68 (Supplement 1):1154-P.
4. Guo R, Ren J, Nair S. Cathepsin K Knockout InhibitsCalcification, Migration and Proliferation of Aortic Vascular Smooth MuscleCells. American Heart Association (AHA) Scientific Sessions, 2017. POSTERpresentation. Abstract: Circulation, Jun 2018, 136:A19464. (IF 19.3)
5. Guo R, Hua Y, Ren J, Bornfeldt K, Nair S.Cardiomyocyte-Specific Deletion of Cathepsin K Protects AgainstDoxorubicin-Induced Cardiac Dysfunction. American Heart Association (AHA)Scientific Sessions, New Orleans, LA, Nov 12-16, 2016; POSTER presentation.Abstract: Circulation Mar 2018, 134:A16698. (IF 19.3)
6. Guo R, Hua Y, Rogers O, Ren J, Nair S. Cathepsin Kknockout Preserves Cardiac Function in Diabetic Mice: Role of Calcineurin/NFATSignaling. American Diabetes Association (ADA) Scientific Sessions, NewOrleans, LA, June 10-14, 2016; POSTER presentation. Abstract: Diabetes 2016,65 (Supplement 1): A101-A169. (IF 8.7)
7. Guo R,Ren J. Aldehyde Dehydrogenase-2 (ALDH2) Ameliorates Chronic AlcoholIngestion-Induced Hepatic Steatosis and Inflammation. Experimental BiologyAnnual Scientific Meeting, San Diego Convention Center, San Diego, CA, Apr.21-25, 2012; ORAL presentation. Abstract: The FASEB Journal 2012, 26(1), Supplement 405.8. (IF 5.7)
8. Guo R,Ren J. Adiponectin Deficiency Accentuates High Fat Diet-Induced CardiacHypertrophy and Contractile Dysfunction through Regulation of Autophagy.Experimental Biology Annual Scientific Meeting, San Diego Convention Center,San Diego, CA, Apr. 21-25, 2012; ORAL presentation. Abstract: The FASEB Journal 2012, 26 (1), Supplement 137.10. (IF 5.7)
9. Nair S, Guo R, Nair R, Zgheib C, Xu J, Liechty K. TargetingCathepsin K to Promoted Diabetic Wound Healing. Experimental Biology (EB)Scientific Sessions, Chicago, Illinois, Apr. 22-26. 2017; POSTER presentation.Abstract: The FASEB Journal 2017, 31 (1), Supplement 673.11. (IF 5.5)
10. Guo R, Hua Y, Ren J, Bornfeldt K, Nair S.Cardiomyocyte-Specific Deletion of Cathepsin K Protects AgainstDoxorubicin-Induced Cardiac Dysfunction. College of Health Sciences COMPETITIVEPOSTER Presentation, April 13, 2016.
11. Guo R, Ren J, Nair S. Cathepsin K Knockout Protect AgainstEthanol Toxicity-Induced Cardiac Dysfunction. INBRE Conference, UW ConferenceCenter. April 28, 2016. POSTER presentation.
12. Guo R, Ren J, Nair S. Cathepsin K Knockout Protect AgainstEthanol Toxicity-Induced Cardiac Dysfunction. College of Health SciencesCOMPETITIVE POSTER Presentation, April 13, 2016;
13. Guo R, Ren J, Nair S. Cathepsin K Knockout Protect AgainstEthanol Toxicity-Induced Cardiac Dysfunction. American Heart AssociationScientific Session, Orlando, Florida, November 7-11, 2015; Abstract: Circulation, November 2015. POSTER presentation.
14. Guo R, Ren J. Deficiency in AMP-activated protein kinaseattenuates acute ethanol-induced cardiac contractile dysfunction: Role ofautophagy. Second Biennial Western Region IDeA Scientific Conference, (featuredspeaker series), Reno, NV, June 6-8, 2011. POSTER presentation.
15. Guo R, Scott G, Ren J. Involvement of AMPK in alcoholdehydrogenase accentuated myocardial dysfunction following acute ethanolchallenge in mice. National IDeA Symposium of Biomedical Research Excellence(NISBRE) Conference, Bethesda, Maryland, June 2010. POSTER presentation.
16. Guo R, Ma H, Ren J. Aldehyde Dehydrogenase 2 Rescues MyocardialContratile Function against Ischemia (Hypoxia)-Reperfusion (Reoxygenation)Injury: Role of Autophagy. American Heart Association Scientific Session,Chicago, Illinois, Nov. 13-17, 2010.
17. Guo R, Hu N, Kandadi MR, Ren J. Alcohol Dehydrogenase Accentuates EthanolToxicty Induced Cardiomyocyte Dysfunction through Autophagy in Murine Hearts.American Heart Association Scientific Session, Chicago, Illinois, Nov. 13-17,2010.