姓名邓文生性别男职称教授
最终学历博士研究生工作单位生物医学研究院
最终学位博士毕业院校中科院微生物所
毕业专业微生物学联系电话**
电子邮件dengwensheng@wust.edu.cn通信地址
学术兼职英国生化学会会员
研究方向1.人细胞内基因转录调节的基本机制2.基因转录与肿瘤生物学3.基因表达与干细胞生物学
一级学科
二级学科
主要著作
主要科研项目细胞骨架细丝蛋白A在RNA聚合酶III指导的基因转录中的作用机制
主要论文1. Wensheng Deng, Cesar Lopez-Camacho, Jen-Yang Tang, Dean Jackson& Paul Shore (2012) Filamin A is nucleolar protein that suppresses ribosomal RNA gene transcription. Proc Natl Acad Sci（USA) 109:1524-1529. (IF:9.8).2. Mendoza-Villanueva D，Deng W, Lopez-Camacho C & Shore P. (2010) The Runx2 transcriptional co-activator, CBFβ, is essential for invasion of breast cancer cells. Molecular Cancer. 9:171 (IF:4.9)3. Deng W., Malecova B., Oelgerschlager T. and Roberts S.G. E. (2009) TFIIB recognition element controls the NC2-TFIIA axis in transcription regulation. Molecular Cellular Biology 29(6):1389-400) (IF:6.18) 4. McRobert L., Taylor C.J., Deng W*.,Fivelman Q.L.,Cummings R.M., Billker O. & Baker D.A. (2008) Gametogenesis in Malaria Parasites is mediated by the cGMP-Dependent Protein Kinase. PLOS Biology Vol 6(6) 1243-1252.(IF:12.9)（*: Deng W contributed Fig. 4 and Fig 5, which are critical for the conclusion of the paper）.5. Deng W. and Roberts S.G.E. (2007) TFIIB and the regulation of transcription by RNA polymerase II. Chromosoma. 116(5): 417-29 (IF: 4.1)6.Deng W. and Roberts S.G.E (2006) Core promoter elements recognized by transcription factor IIB. Biochemical Society Transaction. 34(Pt 6): 1051-3. (IF:2.5) 7. Deng W. and Roberts S.G.E (2005) A core promoter element downstream of the TATA box that is recognized by TFIIB. Genes & Development 19: 2418-2423. (IF:15.6 (2005))8.Baker D.A. & Deng W (2005) Cyclic GMP-dependent protein kinases in protozoan. Frontier Biosciences 10: 1229-1238.(IF: 2.9) 9. Deng W., Parbhu-Patel A. &. Baker D.A (2003) The role of two novel regulatory sites in the activation ofcGMP-dependent protein kinase from Plasmodium falciparum. Biochemical Journal374: 559-565 (IF: 4.2)10. Deng W. and Baker D.A. (2002) A novel cyclic GMP-dependent kinase is expressed in the ring stage of the Plasmodium falciparum life cycle.Molecular Microbiology.44:
主要获奖情况