姓名张文胜性别男职称教授
最终学历博士研究生工作单位英国剑桥Wellcome Trust Sanger Institute
最终学位博士毕业院校新加坡国立大学
毕业专业生物学联系电话**
电子邮件wz1@sanger.ac.uk通信地址湖北省武汉市武汉科技大学黄家湖校区生物医学研究院
学术兼职
研究方向胚胎干细胞全能性及其分化的分子机理
一级学科生物学
二级学科
主要著作
主要科研项目在小鼠胚胎干细胞及小鼠早期胚胎发育中功能及其分子机理的研究，项目号**，国家自然科学基金面上项目- Funding for the WellcomeTrust Sanger Institute 5 year plan,WT098051 M Stratton,WellcomeTrust-Consortium for large-scale production and cryopreservation of knockout mice,U42-RR033192 M Justice,NIH (NHGRI- Mouse Phenotyping Informatics Infrastruture - MP12,U54-HG006370 P Flicek,NIH (NHGRI)-Systems Biology of Stem Cells and Reprogramming (SYBOSS),242129 AF Stewart,EU Funded (FP7Tools for Functional Annotation of the Mouse Genome (EUCOMMTools),261492 W Wurst & A Bradley,EU Funded (FP8)，EUCOMMThe International Data Coordination Centre (IDCC),223592 W Skarnes ,EU Funded (FP7)
主要论文Han J, Zhang J, Chen L, Shen B, Zhou J, Hu B, Du Y, Tate PH, Huang X, Zhang W*. Efficient in vivo deletion of a large imprinted lncRNA by CRISPR/Cas9. RNA Biol. 2014 Aug 19;11(7). [Epub ahead of print]Shen B, Zhang W, Zhang J, Zhou J, Wang J, Chen L, Wang L, Hodgkins A, Iyer V, Huang X, Skarnes WC. Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nat Methods. 2014 Apr;11(4):399-402. Zhou J, Wang J, Shen B, Chen L, Su Y, Yang J, Zhang W, Tian X, Huang X. Dual sgRNAs facilitate CRISPR/Cas9-mediated mouse genome targeting. FEBS J. 2014 Apr;281(7):1717-25. Zhou J, Shen B, Zhang W, Wang J, Yang J, Chen L, Zhang N, Zhu K, Xu J, Hu B, Leng Q, Huang X. One-step generation of different immunodeficient mice with multiple gene modifications by CRISPR/Cas9 mediated genome engineering. Int J Biochem Cell Biol. 2014 Jan;46:49-55.Shen B, Zhang X, Du Y, Wang J, Gong J, Zhang X, Tate PH, Li H, Huang X, Zhang W*. Efficient knockin mouse generation by ssDNA oligonucleotides and zinc-finger nuclease assisted homologous recombination in zygotes. PLoS One. 2013 Oct 22;8(10):e77696.
主要获奖情况