职称职务：教授、博士生导师
研究方向：动物资源的认识、保护与利用
实验室位置：生科院5112室

电话：
Email: ylwu@whu.edu.cn


学习简历：
1999.9-2002.7 武汉大学化学系 博士研究生
1996.9-1999.7 南昌大学化学系 硕士研究生
1992.9-1996.7 南昌大学化学系 本科

工作简历：
2009.11-至今 武汉大学生命科学学院，教授、博士生导师
2008.9-2009.10 武汉大学生命科学学院，副教授、博士生导师
2007.10-2008.9 加拿大Ambrilia生物制药公司，多肽药物设计咨询专家
2004.11-2008.8 武汉大学生命科学学院 副教授、硕士生导师
2002.9-2004.10 武汉大学生命科学学院 博士后

学术兼职
2013.11-至今 中国毒理学会生物毒素毒理专业委员会副主任委员
2009.11-2013.10 中国毒理学会生物毒素毒理专业委员会秘书长

研究兴趣:
1. 动物资源的保护与利用
2. 蝎生物学
　　综合运用不同学科（如生态学、化学、生物学、药学）基础知识，在系统水平上认识蝎及其它动物的生物学特征及分子基础、挖掘药用前景多肽分子、开展药用多肽的结构功能关系及与受体作用机制，致力于动物资源的保护与持续利用。

教学情况:
生物信息学，36学时，授课对象为本科生和研究生

主持科研项目:
1. 国家自然科学基金，编号**，起止时间：2017.01-2020.12
2. 国家自然科学基金重点项目，编号**，起止时间：2017.01-2021.12
3. 科技部科技创新重点合作专项，编号 2016YFE**，起止时间：2017.01-2019.12
4. 湖北省自然科学创新群体项目，编号2016CFA018，起止时间：2016.01-2018.12
5. 国家自然科学基金，编号**，起止时间：2015.1-2018.12
6. 教育部新世纪人才项目基金，编号：NCET-10-0651，起止时间：2011.1-2013.12
7. 国家自然科学基金，编号**，起止时间：2012.1-2015.12
8. 国家自然科学基金，编号：**，起止时间：2010.1-2012.12
9. 湖北省****基金，编号：2009CDA076，起止时间：2010.1-2012.12
10. 国家重大新药创制课题，2009ZX09102-207，起止时间：2009.1-2010.12
11. 科技部973课题，编号：2010CB529803，起止时间：2010.1-2014.8
12. 国家自然科学基金，编号：**，起止时间：2008.1-2010.12
13. 国家自然科学基金，编号：**，起止时间：2006.1-2006.12

博士后招聘:
本实验室常年招聘博士后，热烈欢迎不同学科背景的博士到本实验室从事科研合作研究。
　
研究论文（＊为通讯作者）
1. Fan Yang, Shuang Liu, Yaoyun Zhang, Chenhu Qin, Lingna Xu, Wenhua Li, Zhijian Cao, Wenxin Li*, Yingliang Wu*. Expression of recombinant α-toxin BmKM9 from scorpion Buthus martensii Karsch and its functional characterization on sodium channels. Peptides, 2017.10, published online

2. 毛歆，刘辉，李文鑫，吴英亮*。马氏正钳蝎的形态和结构特征。动物学杂志，2017，52(3): 468-477

3. Shen B, Cao Z, Li W, Sabatier JM*, Wu Y*. Treating autoimmune disorders with venom-derived peptides. Expert Opin Biol Ther. 2017, 17(9): 1065-1075

4. Zhang C,Xie Z,Li X,Chen J,Feng J,Lang Y,Yang W,Li W,Chen Z,Yao J,Cao Z*,Wu Y*. Molecular basis for the toxin insensitivity of scorpion voltage-gated potassium channel MmKv1. Biochem J, 2016, 473(9): 1257-66

5. Jing Feng,Zili Xie,Weishan Yang,Yonghui Zhao,Fang Xiang,Zhijian Cao,Wenxin Li, Zongyun Chen*,Yingliang Wu*. Human beta-defensin 1, a new animal toxin-like blocker of potassium channel. Toxicon, 2016, 113: 1-6

6. Lanxia Meng, Zili Xie, Qian Zhang, Yang Li, Fan Yang, Zongyun Chen, Wenxin Li, Zhijian Cao*, Yingliang Wu*. Scorpion potassium channel-blocking defensin highlights a functional link with neurotoxin. J Biol Chem, 2016, 291: 7097-7106

7. Xie Z, Feng J, Yang W, Xiang F, Yang F, Zhao Y, Cao Z, Li W, Chen Z*, Wu Y*. Human α-defensins are immune-related Kv1.3 channel inhibitors: new support for their roles in adaptive immunity. FASEB J, 2015, 29(10): 4324-4333

8. Zongyun Chen, Youtian Hu, Jing Hong, Jun Hu, Weishan Yang, Fang Xiang, Fan Yang, Zili Xie, Zhijian Cao, Wenxin Li, Donghai Lin*, Yingliang Wu*. Toxin acidic residue evolution function-guided design of de novo peptide drugs for immunotherapeutic target Kv1.3 channel. Scientific Reports, 2015, 5: 9881

9. Jing Feng, Weishan Yang, Zili Xie, Fang Xiang, Zhijian Cao, Wenxin Li Hongzhen Hu, Zongyun Chen*, Yingliang Wu*. Kv channel S1-S2 linker working as a binding site of human β-defensin 2 for channel activation modulation. J Biol Chem, 2015, 290(25): 15487-95

10. Weishan Yang, Jing Feng, Fang Xiang, Zili Xie, Guoyi Zhang, Jean-Marc Sabatier, Zhijian Cao, Wenxin Li, Zongyun Chen*, Yingliang Wu*. Endogenous animal toxin-like human β-defensin 2 inhibits own K+ channels through interaction with channel extracellular pore region. Cellular and Molecular Life Science, 2015, 72: 845-853

11. Fang Xiang, Zili Xie, Weishan Yang, Jing Feng, Zhijian Cao, Wenxin Li, Zongyun Chen*, Yingliang Wu*. Plectasin, first animal toxin-like fungal defensing blocking potassium channels through recognizing channel pore region. Toxins, 2015, 7: 34-42

12. Lingna Xu, Tian Li, Honglian Liu, Fan Yang, Songping Liang, Zhijian Cao, Wenxin Li, Yingliang Wu*. Functional characterization of two novel scorpion sodium channel toxins from Lychas mucronatus. Toxicon, 2014, 90: 318-325

13. Zongyun Chen, Youtian Hu, Jun Hu, Weishan Yang, Jean-Marc Sabatier, Michel De Waard, Zhijian Cao, Wenxin Li, Song Han*, Yingliang Wu*. Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues. Biochem Biophys Res Commun, 2014, 447(1): 70-76

14. You-Tian Hu, Jun Hu, Tian Li, Jingjing Wei, Jing Feng, Yimei Du, Zhijian Cao, Wenxin Li*, Yingliang Wu*. Open Conformation of hERG Channel Turrets Revealed by a Specific Scorpion Toxin BmKKx2. Cell & Bioscience, 2014, 4: 18

15. Panpan Hou, Rong Zhang, Yongfeng Liu, Jing Feng, Wei Wang, Yingliang Wu and Jiuping Ding*. Physiological Role of Kv1.3 Channel in T Lymphocyte Cell Investigated Quantitatively by Kinetic Modeling. PLoS ONE, 2014, 9(3): e89975

16. Tian Li, Lingna Xu, Honglian Liu, Yawen He, Wenxin Li*, Yingliang Wu*. Characterization of a novel Bm TX47 toxin modulating sodium channels: crucial role of expression vectors in toxin pharmacological activity. Toxins, 2014, 6: 816-829

17. Cao ZJ, Di ZY, Wu YL*, Li WX*. Overview of scorpion species and their toxins from China. Toxins, 2014, 6: 796?-815

18. Chang Xie, Tian Li,Lingna Xu,Congya Yu,Zhijian Cao,Wenxin Li*, Yingliang Wu*. Kv1.3 potassium channel-blocking toxin Ctri9577, novel gating modifier of Kv4.3 potassium channel from the scorpion toxin family. Biochem Biophys Res Commun, 2014, 444(3): 406-410

19. Jian Ma, Youtian Hu, Mingxiong Guo, Zan Huang, Wenxin Li*, Yingliang Wu*. hERG Potassium Channel Blockage by Scorpion Toxin BmKKx2 Enhances Erythroid Differentiation of Human Leukemia Cells K562. PLoS ONE, 2013, 8(12): e84903

20. Cao Z#, Yu Y#, Wu Y#, Hao P#, Di Z#, He Y, Chen Z, Yang W, Shen Z, He X, Sheng J, Xu X, Pan B, Feng J, Yang X, Hong W, Zhao W, Li Z, Huang K, Li T, Kong Y, Liu H, Jiang D, Zhang B, Hu J, Hu Y, Wang B, Dai J, Yuan B, Feng Y, Huang W, Xing X, Zhao G, Li X*, Li Y*, Li W*. The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun, 2013, 4: 2602 (并列第一作者)

21. Jun Hu, Su Qiu, Fan Yang, Zhijian Cao, Wenxin Li, Yingliang Wu*. Unique mechanism of the interaction between honey bee toxin TPNQ and rKir1.1 potassium channel explored by computational simulations: Insights into the relative insensitivity of channel towards animal toxins. PLoS ONE, 2013, 8(7): e67213

22. Jing Feng, Youtian Hu, Hong Yi, Shijin Yin, Song Han, Jun Hu, Zongyun Chen, Weishan Yang, Zhijian Cao, Michel De Waard, Jean-Marc Sabatier, Wenxin Li, Yingliang Wu*. Two Conserved Arginine Residues from the SK3 Potassium Channel Outer Vestibule Controls Selectivity of Recognition by Scorpion Toxins. J Biol Chem, 2013, 288(18): 12544-12553

23. Zongyun Chen, Fan Luo, Jing Feng, Weishan Yang, Danyun Zeng, Ruiming Zhao, Zhijian Cao, Maili Liu, Wenxin Li*, Ling Jiang*, Yingliang Wu*. Genomic and Structural Characterization of Kunitz-type Peptide LmKTT-1a Highlights Diversity and Evolution of Scorpion Potassium Channel Toxins. PLoS ONE, 2013, 8(4): e60201

24. Chen Zongyun, Wang Bin, Hu Jun, Yang Weishan, Cao Zhijian, Zhuo Ruiming, Li Wenxin*, Wu Yingliang*. SjAPI, the First Functionally Characterized Ascaris-Type Protease Inhibitor from Animal Venoms. PLoS ONE. 2013, 8(3): e57529

25. Zhi Li, Wan-Hong Liu, Song Han, Bi-Wen Peng, Jun Yin, Ying-Liang Wu*, Xiao-Hua He* and Wen-Xin Li. Selective inhibition of CCR7- TEM cells activation by a novel peptide targeting Kv1.3 in a rat EAE model. J Biol Chem, 2012, 287: 29479-29494

26. ZY Chen, DY Zeng, YT Hu, YW He, N Pan, JP Ding, ZJ Cao, ML Liu, WX Li, H Yi*, L Jiang*, YL Wu*. Structural and Functional Diversity of Acidic Scorpion Potassium Channel Toxins, PLoS ONE, 2012, 7(4): e35154

27. Zong-Yun Chen, You-Tian Hu, Wei-Shan Yang, Ya-Wen He, Jing Feng, Bin-Wang, Rui-Ming Zhao, Jiu-Ping Ding, Zhi-Jian Cao, Wen-Xin Li*, Ying-Liang Wu*. Hg1, Novel Peptide Inhibitor Specific for Kv1.3 Channels from First Scorpion Kunitz-type Potassium Channel Toxin Family. J Biol Chem, 2012, 287: 13813-13821

28. Hui Dai, Shijin Yin, Tian Li, Zhijian Cao, Yonghua Ji, Yingliang Wu*, Wenxin Li*. Recombinant expression, purification, and characterization of scorpion toxin BmαTX14. Protein Expression and Purification, 2012, 82: 325-331

29. Su Qiu, Hong Yi, Jun Hu, Zhijian Cao, Yingliang Wu* and Wenxin Li*. The Binding Mode of Fusion Inhibitor T20 onto HIV-1 gp41 and Relevant T20-Resistant Mechanisms Explored by Computational Study. Current HIV Research, 2012, 10(2): 182-194

30. Han, Song; Yin, Shijin; Yi, Hong; Mouhat, Stéphanie; Qiu, Su; Cao, Zhijian; Sabatier, Jean-Marc; Wu, Yingliang*; Li, Wenxin*. Protein-Protein Recognition Control by Modulating Electrostatic Interactions. Journal of Proteome Research, 2010, 9: 3118-3125

31. Ying Wu, Yu Xiong, Sheng Wang, Hong Yi, Hui Li, Na Pan, Frank T Horrigan, Yingliang Wu*, Jiuping Ding*. Inter-subunit coupling in the Pore of BK channels, Journal of Biological Chemistry, 2009, 284(35): 23353-23363

32. Su Qiu, Hong Yi, Hui Liu, Zhijian Cao, Yingliang Wu*, Wenxin Li*. Molecular Information of Charybdotoxin Blockade in the Large Conductance Calcium-activated Potassium Channel. Journal of Chemical Information and Modeling, 2009, 49(7): 1831-1838

33. Shijin Yin, Ling Jiang, Hong Yi, Song Han, Daiwen Yang, Maili Liu, Hui Liu, Zhijian Cao, Yingliang Wu*, Wenxin Li*. Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kv1.3 channels. Journal of Proteome Research, 2008, 7(11): 4890-4897

34. Geliang Gan, Hong Yi, Maorong Chen, Liang Sun, Wenxin Li, Yingliang Wu* and Jiuping Ding*. Structural basis for toxin-resistance of 4 associated calcium-activated potassium (BK) channels. Journal of Biological Chemistry, 2008, 283: 24177-24184

35. Song Han, Hong Yi, Shi-Jin Yin, Zong-Yun Chen, Hui Liu, Zhi-Jian Cao, Ying-Liang Wu*, and Wen-Xin Li*. Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease. Journal of Biological Chemistry, 2008, 283: 19058-19065

36. Yi H, Qiu S, Cao ZJ, Wu YL*, Li WX*. Molecular basis of inhibitory peptide maurotoxin recognizing Kv1.2 channel explored by ZDOCK and molecular dynamic simulations. PROTEINS: Structure, Function, and Bioinformatics, 2008, 70: 744-54

37. Jin L*, Wu Y*. Molecular Mechanism of the Sea Anemone Toxin ShK Recognizing the Kv1.3 Channel Explored by Docking and Molecular Dynamic Simulations. Journal of Chemical Information and Modeling, 2007, 47: 1967-1972

38. Hong Yi, Zhijian Cao, Shijin Yin, Chao Dai, Yingliang Wu*, Wenxin Li*. Interaction Simulation of hERG K+ Channel with its specific Bekm-1 peptide: Insights into the Selectivity of Molecular Recognition. Journal of Proteome Research, 2007, 6: 611-620

39. Yingliang Wu, Hong Yi, Zhijian Cao, Wenxin Li. Conformation of Trimeric Envelope Glycoproteins: The CD4-dependent Membrane Fusion Mechanism of HIV-1. Journal of Biomolecular Structure & Dynamics, 2007, 25: 1-9

40. Yingliang Wu, Zhijian Cao, Hong Yi, Dahe Jiang, Xin Mao, Hui Liu and Wenxin Li. Simulation of the interaction between ScyTx and small conductance calcium-activated potassium channel by docking and MM-PBSA. Biophysical Journal, 2004, 87(1): 105-112

41. 吴英亮，胡斌，江祖成。乙酰丙酮在低温电热蒸发ICP-AES中的化学改进作用机理研究。高等学校化学学报，2004, 25(1): 50-52

42. 吴英亮，江祖成，胡斌。微滴溶液萃取/低温电热蒸发ICP-AES联用新技术用于超痕量元素分析。高等学校化学学报，2003, 24(10): 1793-1794

43. 吴英亮，胡斌，彭天右，陈世忠，江祖成。低温蒸发金属PMBP螯合物的ETV-ICP-AES研究。分析科学学报，2003, 19(1): 24-26

44. Ni YN*, Wu Yingliang, Kokot, S. Improved ICP-OES analysis of trace calcium in rare-earth matrices with the use of iterative target transformation factor analysis and Kalman filter. Journal of Analytical Atomic Spectrometry. 2002, 17 (6): 596-602

45. Wu Yingliang, Hu B, Jiang ZC, Chen SZ. Low temperature vaporization for ICP-AES determination of palladium in geological samples using sample introduction of gaseous palladium oxinate. Journal of Analytical Atomic Spectrometry. 2002, 17 (2): 121-124

46. Wu Yingliang; Hu, B; Peng, TY; Liao, ZH; Jiang, ZC. Electrothermal volatilization of aluminum as 1-phenyl-3-methyl-4-benzoylpyrazolone[5] chelate for gaseous sample introduction in ICP-AES. Talanta, 2001, 55 (4): 841-845

47. Wu Yingliang; Hu, B; Peng, TY; Jiang, ZC. In-situ separation of chromium(III) and chromium(VI) and sequential ETV-ICP-AES determination using acetylacetone and PTFE as chemical modifiers. Fresenius Journal of Analytical Chemistry, 2001, 370 (7): 904-908

48. Wu Yingliang; Hu, B; Peng, TY; Jiang, ZC. Low-temperature volatilization of Be acetylacetonate for sample introduction in ETV-ICP-AES. Analytical Chimica Acta, 2001, 439 (1): 153-158

49. 倪永年*，吴英亮，刘文华。光谱拟合矩阵投影-卡尔曼滤波法校正稀土基体对钙光谱干扰的研究. 光谱学与光谱分析, 2001, 21 (1): 73-76.

50. 倪永年*，吴英亮，刘文华。化学计量学在稀土分析中的应用及进展。分析科学学报，2000, 16(2): 157-163

51. Ni YN*, Wu Yingliang. Spectrophotometric determination of europium, terbium and yttrium in a perchloric acid solution by the Kalman filter approach. Analytical Sciences, 1999, 15 (11): 1123-1127

52. 倪永年*，吴英亮，金玲。主成分回归-络合滴定法测定混合金属离子。高等学校化学学报，1999, 19(3): 359-362

53. Ni YN*, Wu Yingliang. Simultaneous determination of mixtures of metal ions by complexometric titration and multivariate calibration, Analytical Chimica Acta, 1997, 354: 233-240