职称职务：副教授
学科专业：微生物学
研究方向：病毒感染细胞生物学
实验室位置：中国典型培养物保藏中心
联系方式：
Email:　shenchao@whu.edu.cn

学习经历：
2002.09～2008.12　　武汉大学生命科学学院，微生物系，博士

1997.09～2001.06　　武汉大学生命科学学院，生物学基地班，学士

主要工作经历与任职情况：
2020.07 - 今　　　　 武汉大学生命科学学院 副教授
2011.11 - 2013.11　　美国中佛罗里达大学医学院 博士后
2009.07 - 2020.07　　武汉大学生命科学学院 讲师
2001.09 - 2002.07　　共青团中央青年志愿者研究生支教团 支教

主要社会兼职：
中国典型培养物保藏中心 副主任
国际细胞系鉴定委员会（ICLAC）委员

承担课程：
本科生：《微生物学实验》
研究生：《低温生物学》

主持课题项目：
1. 国家实验细胞资源共享平台建设，科技部，子课题主持人，个人经费270万。
2. EPSTI1在肺癌细胞上皮间质转化及转移中的功能研究，教育部国际合作与交流司，主持，3万。
3. EPSTI1在肝癌细胞上皮间质转化中的作用研究，湖北省自然科学基金 主持，3万。
4. STING在肿瘤组织中的表达与调控机制，中央高校基本科研业务费，主持，20万。
5. 病毒分离纯化虚拟仿真实验项目的建设，武汉大学，主持，16万。
6. 细胞系质量控制服务，横向，主持，164万。
7. 细胞系质量控制新技术开发，横向，主持，150万。

发表的论文（*通讯作者）:
1. Meijia Gu, Jingxuan Liu, Meimei Yang, Mingmin Zhang, Jian Yang, Suling Duan, Xuxu Ding, Jie Liu, Chuguang Chen, Yundian Zeng, Chao Shen*. Advantages of a 21-loci short tandem repeat method for detection of cross- contamination in human cell lines. Gene. 2020, 763: 145048.

2. Yao Hao, Yao Huang, Jingyi Chen, Li Jiadai, Yuan Yuncong, Mingzhen Wang, Lingling Han, Xiu Xin, Hailong Wang, Danqing Lin, Fang Peng, Fang Yu, Congyi Zheng, Chao Shen*. Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling. Cell Prolif. 2020, e12869.

3. Hailong Wang, Xiu Xin*, Congyi Zheng, Chao Shen*. Single-Cell Analysis of Foot-and-Mouth Disease Virus. Frontiers in Microbiology. 2020, 11:361. Doi: 10.3389/fmicb.2020.00361.

4. Jiadai Li, Lingling Han, Yao Hao, Yuncong Yuan, Mingzhen Wang, Xiu Xin, Hailong Wang, Fang Yu, Congyi Zheng, Chao Shen*. Comparative Transcriptome Analysis Reveals Different Host Cell Responses to Acute and Persistent Foot-and-Mouth Disease Virus Infection. Virologica Sinica. 2019, 35:52-63.

5. Mingzhen Wang, Yu Wang, Yuehong Liu, Hailong Wang, Xiu Xin, Jiadai Li, Yao Hao, Lingling Han, Fang Yu, Congyi Zheng, Chao Shen*. SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation. PLOS ONE, 2019, 14(7):e**.

6. Meijia Gu, Chao Shen*. Novel cancer cell lines derived from primary breast tumors in Chinese patients. American Journal of Translational Research. 2018, 10(12):3956-3968.

7. Xiu Xin, Hailong Wang, Lingling Han, Mingzhen Wang, Hui Fang, Yao Hao, Jiadai Li, Hu Zhang, Congyi Zheng, Chao Shen*. Single-cell analysis of the impact of host-cell heterogeneity on infection with foot and mouth disease virus. Journal of Virology. 2018, 92(9), e00179-18.

8. Hailong Wang, Xiu Xin, Mingzhen Wang, Lingling Han, Jiadai Li, Yao Hao, Congyi Zheng, Chao Shen*. Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation. Archives of Virology, 2018, 163:1429–1438.

9. Lingling Han, Xiu Xin, Hailong Wang, Jiadai Li, Yao Hao, Mingzhen Wang, Congyi Zheng, Chao Shen*. Cellular response to persistent foot-and-mouth disease virus infection is linked to specific types of alterations in the host cell transcriptome. Scientific Reports, 2018, 8:5074.

10. Ming-Shun Sun, Jie Zhang, Li-Qun Jiang, Yi-Xi Pan, Jiao-Yi Tan, Fang Yu, Lin Guo, Lei Yin, Chao Shen, Hong-Bing Shu, Yu Liu. TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking. Cell Reports, 2018, 25(11):3086-3098.

11. Hu Zhang, Qingyi Wang, Lingling Han, Congyi Zheng, Chao Shen*. Cross-species hybridization of foot-and-mouth disease virus-infected BHK-21 cells using human and mouse oligonucleotide microarrays. Acta virologica, 2017, 61(3): 299-307.

12. Hui Fang, Bing Yuan, Lingling Han, Xiu Xin, Hailong Wang, Fangyan Yu, Congyi Zheng*, Chao Shen*. Single?cell analysis reveals the relevance of foot?and?mouth disease virus persistence to emopamil?binding protein gene expression in host cells. Archives of Virology, 2017, 162(12):3791-3802.

13. Yaqing Huang, Yuehong Liu, Congyi Zheng*, Chao Shen*. Investigation of Cross-Contamination and Misidentification of 278 Widely Used Tumor Cell Lines. PLOS ONE, 2017, 12(1): e**.

14. Wei Xiong, Jie Yang，Mingzhen Wang, Hailong Wang, Zhipeng Rao, Cheng Zhong, Xiu Xin，Lin Mo，Shujuan Yu, Chao Shen*, Congyi Zheng*. Vinexin β interacts with Hepatitis C Virus NS5A modulating its hyperphosphorylation to regulate viral propagation. Journal of Virology, 2015, 89(14):7385-7400.

15. Bing Yuan, Hui Fang, Chao Shen*, Zheng C*. Expression of porcine Mx1 with FMDV IRES enhances the antiviral activity against foot-and-mouth disease virus in PK-15 cells. Archives of Virology. 2015, 160(8):1989-1999