职称职务：副研究员
学科专业：发育生物学
研究方向：基因组学、表观遗传学、分子生物学
实验室位置：5102实验室
联系方式：
Email:　wu.zhiguo@whu.edu.cn

学习经历：

2008/09-2013/06，武汉大学，博士/Wuhan University, PhD
2004/09-2008/06，武汉大学，学士/ Wuhan University, Bachelor's Degree

主要工作经历与任职情况：
2015/03-至今：武汉大学生命科学学院/ College of Life Sciences, Wuhan University；副研究员
2013/09-2015/01：美国辛辛那提儿童医院医学中心/Cincinnati Children’s Hospital Medical Center, USA；Research Fellow.

主要研究领域及兴趣：
基因组测序组装，功能基因和转座元件及其进化关系研究
组蛋白修饰图谱构建，修饰位点与关键发育基因的研究
植物表皮细胞发育研究


代表性论文:
1.Gai Huang#, Zhiguo Wu#, Richard G. Percy, Mingzhou Bai, Yang Li, James E. Frelichowski, Jiang Hu, Kun Wang, John Z. Yu*, Yuxian Zhu*. Genome sequence of Gossypium herbaceum, and genome update of Gossypium arboreum and Gossypium hirsutum provide insights into cotton A-genome evolution, Nature Genetics, 2020,52,516-524. (#共同第一作者)

2. Jing Lin, Ying Cai, Gai Huang, Yan Yang, Yang Li, Kun Wang, Zhiguo Wu*. Analysis of the chromatin binding affinity of retrotransposases reveals novel roles in diploid and tetraploid cotton. J Integr Plant Biol, 2019, 61, 32-44.

3. Zhiguo Wu, Yan Yang, Gai Huang, Jing Lin, Yuying Xia, Yuxian Zhu*. Cotton functional genomics reveals global insight into genome evolution and fiber development. Journal of Genetics and Genomics, 2017, 44, 511-518.

4. Virendra Chaudhri, Krista Dienger, Zhiguo Wu, Mahesh Shrestha, Harinder Singh*. Charting the cis-regulome of activated B cells by coupling structural and functional genomics. Nature Immunology, 2020, 21, 2:210-220.

5. Sofia Sirvent, Andres F Vallejo, James Davies, Kalum Clayton, Zhiguo Wu, Jeong min Woo , Jeremy Riddell, Virendra K Chaudhri, Patrick Stumpf , Liliya Angelova Nazlamova, Gabrielle Wheway, Matthew Rose-Zerilli, Jonathan West, Mario Pujato, Xiaoting Chen, Christopher H Woelk, Ben MacArthur, Michael Ardern-Jones, Peter S Friedmann, Matthew T Weirauch, Harinder Singh, Marta E Polak. Genomic programming of IRF4-expressing human Langerhans cells. Nature Communications, 2020, 11, 1:313.

6. Weiwu Zeng, Fan Wu, Chaoxing Liu, Yan Yang, Bingyao Wang, Yushu Yuan, Jiaqi Wang, Yuqi Chen, Boshi Fu, Zhiguo Wu*, Xiang Zhou*. Small-molecule-based human genome G4 profiling reveals potential gene regulation activity. Chem Commun (Camb), 2019, 55, 2269-2272. (*共同通讯作者)

7. Chen Xu, Jinjun Wu, Wenting Liu, Tingting Hong, Tianlu Wang, Xiaoe Zhang, Boshi Fu, Fan Wu, Zhiguo Wu*, Xiang Zhou*. Detecting 5-methylcytosine using an enzyme-free DNA strand exchange reaction without pretreatment under physiological conditions. Chem Commun (Camb), 2016, 52, 6833-6836. (*共同通讯作者)

8. Heping Xu, Virendra K Chaudhri, Zhiguo Wu, Konstantinos Biliouris, Krista Dienger-Stambaugh, Yrina Rochman and Harinder Singh*. Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8. Nature Immunology, 2015, 16, 1274-1281.

9. Xiaoming Lu, Erin E. Zoller, Matthew T. Weirauch, Zhiguo Wu, Bahram Namjou, Adrienne H. Williams, Julie T. Ziegler, Mary E. Comeau, Miranda C. Marion, Stuart B. Glenn, Adam Adler, Nan Shen, Swapan K. Nath, Anne M. Stevens, Barry I. Freedman, Betty P. Tsao, Chaim O. Jacob, Diane L. Kamen, Elizabeth E. Brown, Gary S. Gilkeson, Graciela S. Alarcón, John D. Reveille, Juan-Manuel Anaya, Judith A. James, Kathy L. Sivils, Lindsey A. Criswell, Luis M. Vilá, Marta E. Alarcón-Riquelme, Michelle Petri, R Hal Scofield, Robert P. Kimberly, Rosalind Ramsey-Goldman, Young Bin Joo, Jeongim Choi, Sang-Cheol Bae, Susan A. Boackle, Deborah Cunninghame Graham, Timothy J. Vyse, Joel M. Guthridge, Patrick M. Gaffney, Carl D. Langefeld, Jennifer A. Kelly, Kenneth D. Greis, Kenneth M. Kaufman, John B. Harley,* Leah C. Kottyan*. Lupus risk-variant increases pSTAT1 binding and decreases ETS1 expression. American Journal of Human Genetics, 2015, 5:731-739.

10. Zhiguo Wu, Xiao Xie, Puzhen Li, Jiayi Zhao, Lili Huang and Xiang Zhou*. Equilibrious Strand Exchange Promoted by DNA Conformational Switching. Scientific Reports, 2013, 3, 1121.

11. Zhiguo Wu, Tian Tian, Junping Yu, Xiaocheng Weng, Yi Liu, and Xiang Zhou*. Formation of Sequence-Independent Z-DNA Induced by a Ruthenium Complex at Low Salt Concentrations. Angew. Chem. Int. Ed., 2011, 50, 11962-11967.

12. Zhiguo Wu, Mingliang Tang, Tian Tian, Jianguo Wu, Yuanlin Deng, Xiaohu Dong, Zheng Tan, Xiaocheng Weng, Zhihong Liu, Chunjiang Wang, Xiang Zhou*. A specific probe for two-photon fluorescence lysosomal imaging. Talanta, 2011, 87, 216-221.

13. Jing Huang#, Guorui Li#, Zhiguo Wu#, Zhibin Song, Yangyang Zhou, Liang Shuai, Xiaocheng Weng, Xiang Zhou* and Guangfu Yang. Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomere G-quadruplex. Chem. Commun., 2009, 28, 902-904. (#共同第一作者)

14. Guorui Li, Jing Huang, Ming Zhang, Yangyang Zhou, Dan Zhang, Zhiguo Wu, Shaoru Wang, Xiaocheng Weng, Xiang Zhou* and Guangfu Yang. Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand. Chem. Commun., 2008, 38, 4564-4566.
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