姓名：袁占鹏

职务、职称：教授、博士生导师、MPH教育中心副主任

系别：卫生毒理学系

联系电话：027-6875 9291

邮箱：zpyuan@whu.edu.cn



个人简介：

武汉大学生物系理学学士（细胞生物学；1987）；纽约大学医学院sackler基础生物医学研究生计划理学硕士(基础医学-分子肿瘤发生；1997)和环境医学研究所Ph.D.(哲学博士-环境健康学；2003)。2006年加入武汉大学公共卫生学院。分别牵头申报了公共卫生硕士(Master of Public Health, MPH）专业学位点和起草了全球健康学硕士(Master of Global Health)学术学位点申报书。受邀担任应用毒理湖北省重点实验室（湖北省CDC食品药品安全评价中心）和教育部发酵工程重点实验室（湖北工业大学）独立研究员。

现为中华预防医学会武汉环境卫生学专业委员会委员(2006.6)、美国癌症研究学会(2000)和美国毒理学会 (1999) 会员、Int'l Network of Tropical Aquaculture Scientists of the International Center for Living Aquatic Resources Management成员(1992)。湖北省欧美同学会·留学人员联合会创会理事（2011）。兼任湖北省侨联常务委员、武汉大学侨联常务副主席、中国农工民主党武汉大学委员会副主任委员兼医学支部主任委员。

研究方向：1.环境健康和食药品及相关产品安全评价的毒理学原理与技术；2.蓝藻水华成因

代表性论著 ：（*通讯作者）

1. Zhao W ¹, Chen L¹, Li H, Wang D, Li D, Chen T, Yuan Z*, Tang Y*. 2014 (accepted). A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation. Bioorganic & Medicinal Chemistry. (IF=2.903; 1. equal contributors, * co-corresponding authors)

2. Li D, Liu R, Li H, Yuan Z, Chen T, Tang Y. 2014. Ranking the significance of fermentation conditions on the volatile organic compounds of Tuber melanosporum fermentation system by combination of head-space solid phase microextraction and chromatographic fingerprint similarity analysis. Bioprocess and Biosystems Engineering. DOI 10.1007/s00449-013-1021-4 (2013).

3. Zhu L, Li X, Zhang L, Li H, Liu J, Yuan Z, Chen T, Tang Y. 2013. Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli. Metabolic Engineering. 20: 9-19. (IF: 3.762)

4. 张慧颖，祝雯雯，袁占鹏* 2012. 低剂量PCB 77急性暴露对氧化还原稳态的可能影响。公共卫生与预防医学。 23(1)：8-12。

5. Yuan Z, Courtenay S, Chambers RC, Wirgin I. 2006. Evidence of spatially extensive resistance to PCBs in an anadromous fish of the Hudson River. Environmental Health Perspectives. 144 (1): 77-84. (IF: 5.902)

6. Yuan Z, Courtenay S, Wirgin I. 2006. Comparison of hepatic and extra hepatic induction by graded doses of aryl hydrocarbon receptor agonists in Atlantic tomcod from two populations. Aquat. Toxicol. 76(3): 306-320. (IF: 2.719)

7. Roy NK, Courtenay S, Maxwell G, Yuan Z, Chambers RC, Wirgin I. 2002. Cytochrome P4501A1 is induced by PCB 77 and benzo[a]pyrene treatment but not by exposure to the Hudson River environment in Atlantic tomcod (Microgadus tomcod) post-yolk sac larvae. Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 7(2): 162-173. (IF: 0.929)

8. Yuan Z, Wirgin M, Courtenay S, Ikonomou M, Wirgin I. 2001. Is hepatic cytochrome P4501A1 expression predictive of hepatic burdens of dioxins, furans, and PCBs in Atlantic tomcod from the Hudson River estuary? Aquatic Toxicology (Amsterdam, Netherlands). 54(3-4): 217-230. (IF: 1.708)

9. Roy NK, Courtenay S, Yuan Z, Ikonomou M, Wirgin I. 2001. An evaluation of the etiology of reduced CYP1A1 messenger RNA expression in the Atlantic tomcod from the Hudson River, New York, USA, using reverse transcriptase polymerase chain reaction. Environmental Toxicology and Chemistry/Setac. 20(5), 1022-1030. (IF: 1.964)

10. Yuan Z, Warren N, Courtenay S, Wirgin I. 2001. Genetic evidence of resistance to halogenated aryl hydrocarbons (HAHs) in Atlantic tomcod (Microgadus tomcod) from the Hudson River. AACR 92nd Annual Meeting Proceedings, page 606.

11. Yuan Z, Roy N, Sorrentino C, Wirgin I. 2000. Identification and characterization of aryl hydrocarbon receptor polymorphisms in Atlantic tomcod (Microgadus tomcod) from coastal Atlantic populations. Society of Toxicology 2000 Annual Meeting, Akron, Ohio, Toxicological Sciences. 54(1) Supplement, page 78.