刘玉兰
作者: 办公室日期: 2015/3/19查看数: 527

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姓名：刘玉兰

性别：女

职称：教授

最高学历、学位：博士

毕业院校：中国农业大学

从事专业：动物营养与饲料科学

联系电话：**

E-Mail：yulanflower@126.com

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主要研究方向：

1.??????? 猪的营养与免疫

2.??????? 猪胃肠道结构与功能的调控

3.??????? 饲料添加剂的研究与开发

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目前主持的主要项目：

1.??????? 2014年国家自然科学基金优秀青年科学基金“仔猪营养”（**），100万；

2.??????? 2013年国家自然科学基金面上项目“TLRs 信号负调控因子SIGIRR 在仔猪免疫应激中的作用及其营养调控”（**），83万；

3.??????? 2013年湖北省自然科学基金杰出青年人才项目“仔猪肠黏膜免疫功能的营养调控机理研究”（2013CFA029），10万；

4.??????? 2011年国家自然科学基金面上项目“NODs信号通路在仔猪免疫应激中的作用及其营养调控”（**），60万；

5.??????? 2011年教育部“新世纪优秀人才支持计划”（编号NCET-10-0158），50万；

6.??????? 2011年湖北省国际科技合作项目“营养调控断奶仔猪肠黏膜免疫功能的研究与技术开发（编号2011BFA008），10万

7.??????? 2011年武汉市科技计划项目（国际合作项目）“仔猪肠黏膜免疫功能的营养调控研究与技术开发”（**0），7万元；

8.??????? 2011年湖北省教育厅科学技术研究计划优秀中青年人才项目“NOD样受体与仔猪免疫应激关系的研究”（Q**），2万元；

9.??????? 2009年国家自然科学基金面上项目“TLR4／NF-κB信号通路与仔猪免疫应激的关系及其营养调控”（**），30万；

10.??? 2009年教育部科学技术研究重点项目“精氨酸通过PPARγ-NFκB信号通路对仔猪肠道损伤的调控作用”（209082），10万；

11.??? 2010年湖北省自然科学基金重点项目“仔猪免疫应激的营养调控及其细胞信号机制”（2010CDA050），10万元；

12.??? 2009年湖北省自然科学基金面上项目“TLR4／NF-κB信号通路与仔猪免疫应激的关系”（2009CDB006），2万元；

13.??? 2007年湖北省教育厅重点科研项目“精氨酸对断奶仔猪肠道黏膜结构和功能的调节作用及其信号机制”（D**），3万元；

14.??? 2007年嘉吉公司（中国）动物营养部课题“Biotite V对断奶仔猪生长和免疫功能的调节作用研究”，15.6万元；

15.??? 2007年动物营养学国家重点实验室开放课题“精氨酸对断奶仔猪肠道黏膜结构和功能的调节作用及其信号机制”（编号2007KLAN002），10万；

16.??? 2005年国家自然科学基金面上项目“PPARγ在仔猪免疫应激中的调控作用”（**），25万元；

17.??? 2004年973项目“畜禽肉品质性状形成的代谢与调控机理”专题“胃肠道结构与功能的发育规律及其调节”（2004CB117504），22万元（子课题主持人）。

18.??? 2005年湖北省自然科学基金项目“几种植物多糖对断奶仔猪抗免疫应激作用及其机理研究”（2005ABA091），3万元；

19.??? 2005年湖北省科技攻关计划项目“绿色饲料添加剂—甘露聚糖霉菌毒素吸附剂的研制与开发”（2005AA201C30）；3万元；

20.??? 2005年武汉市青年科技晨光计划项目“三种植物多糖对断奶仔猪免疫应激调节作用及其协同效应”（**-46）；3万元；

21.??? 2005年湖北省教育厅重点科研项目“新型霉菌毒素吸附剂的研制与开发”（B**）。

22.??? 2003年美国NOVUS课题“Bio-efficacy of Alimet and Methionine requirement of Broilers fed with Cottenseed Meal Diet”； 6万元。

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获得的主要奖励及荣誉：

1.??????? 2014年国家自然科学基金优秀青年科学基金

2.??????? 2013年湖北省自然科学基金杰出青年基金；

3.??????? 2011年丰益青年教师奖

4.??????? 2012年丰益青年教师奖

5.??????? 2011年教育部“新世纪优秀人才支持计划”；

6.??????? 2011年湖北省新世纪高层次人才工程第二层次人选；

7.??????? 2011年湖北省科技进步一等奖“仔猪生理机能营养调控与饲料产业化关键技术”（排2）；

8.??????? 2011年湖北省青年科技奖；

9.??????? 2011年武汉市自然科学优秀学术论文一等奖（排1）；

10.??? 2010年武汉市自然科学优秀学术论文三等奖（排1）；

11.??? 2008年湖北省科技进步二等奖“畜禽肉质改进技术的研究与产品开发”（排4）；

12.??? 2007年湖北省教育工会先进女教职工；

13.??? 2008、2010年湖北省优秀硕士学位论文指导教师；

14.??? 2004、2007年湖北省优秀学士学位论文一、二等奖指导教师。

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以第一或通讯作者发表的主要论文论著（SCI收录，*表示通讯作者）：

1.??????? Leng WB, Liu YL*, Shi HF, Li S, Zhu HL, Pi DA, Hou YQ, Gong J. 2014. Aspartate alleviates liver injury and regulates mRNA expressions of TLR4 and NOD signaling related genes in weaned pigs after lipopolysaccharide challenge. Journal of Nutritional Biochemistry. 25:592-599.

2.??????? Pi DA, Liu YL*, Shi HF, Li S, Odle J, Lin Xi, Zhu HL, Chen F, Hou YQ, Leng WB. 2014. Dietary supplementation of aspartate enhances intestinal integrity and energy status in weanling piglets after lipopolysaccharide challenge. Journal of Nutritional Biochemistry. 25:456-462.

3.??????? Kang P, Liu YL*, Zhu HL, Li S, Shi HF, Chen F. Leng WB, Pi DA, Hou YQ, Yi D. The effect of aspartate on the energy metabolism in the liver of weanling pigs challenged with lipopolysaccharide. European Journal of Nutrition. Doi: 10.1007/s00394-014-0739-3.

4.??????? Liu YL*, Chen F, Li Q, Odle J, Lin X, Zhu HL, Hong Y, Hou YQ, Yi D, Shi HF. 2013. Fish oil alleviates activation of hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaning pigs after an LPS challenge. Journal of Nutrition. 143: 1799–1807.

5.??????? Liu YL*, Chen F, Odle J, Lin X, Zhu HL, Shi HF, Hou YQ, Yin JD. 2013. Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4 and NOD signaling in weaning piglets after LPS challenge. The Journal of Nutrition. 143: 1331–1339.

6.??????? Zhu HL, Liu YL*, Xie XL, Huang JJ, Hou YQ. 2013. Effect of L-arginine on intestinal mucosal immune barrier function in weaned pigs after Escherichia coli LPS challenge. Innate Immunity. 19: 242–252.

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7.??????? Chen F, Liu YL*, Zhu HL, Hong Y, Wu ZF, Hou YQ, Li Q, Ding BY, Yi D, Chen HB. 2013. Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and NOD signaling pathways. Innate Immunity. 19: 504–515.

8.??????? Liu YL*, Chen F, Odle J, Lin X, Jacobi SK, Zhu HL, Wu ZF, Hou YQ. 2012. Fish Oil Enhances Intestinal Integrity and Inhibits TLR4 and NOD2 Signaling Pathways in Weaned Pigs after LPS Challenge. The Journal of Nutrition. 142: 2017–2024.

9.??????? Li Q, Liu YL*, Che ZQ, Zhu HL, Meng GQ, Hou YQ, Ding BY, Yin YL, Chen F. 2012. Dietary L-arginine supplementation alleviates liver injury caused by Escherichia coli LPS in weaned pigs. Innate Immunity. 18: 804–814.

10.??? Che ZQ, Liu YL*, Wang HR, Zhu HL, Hou YQ, Ding BY. 2011. The Protective Effects of Different Mycotoxin Adsorbents against Blood and Liver Pathological Changes Induced by Mold-contaminated Feed in Broilers. Asian-Australasian Journal of Animal Sciences. 24: 250-257.

11.??? Liu YL*, Meng GQ, Wang HR, Zhu HL, Hou YQ, Wang WJ, Ding BY. 2011. Effect of three mycotoxin adsorbents on growth performance, nutrient digestibility and meat quality in broilers fed mold-contaminated feed. British Poultry Science. 52: 255-263.

12.??? Fan W, Liu YL*, Wu ZF, Hong Y, Zhu HL, Hou YQ, Yin YL, Han J. 2010. Effects of rosiglitazone, an agonist of the peroxisome proliferator-activated receptor gamma, on intestinal damage induced by Escherichia coil lipopolysaccharide in weaned pigs. American Journal of Veterinary Research. 71: 1331-1338.

13.??? Liu YL*, Shi JX, Lu J, Che ZQ, Zhu HL, Hou YQ, Yin YL, Zhao SJ, Ding BY, Liu HM. 2010. Up-regulated expression of the peroxisome proliferator-activated receptor γ in hypothalamic–pituitary-adrenal axis of weaned pigs after Escherichia coli lipopolysaccharide challenge. The Veterinary Journal. 184: 230-235.

14.??? Chao J, Liu YL*, Yin YL, Hou YQ, Zhu HL, Kong XF. 2010. Effects of dietary energy density on plasma glucose and lipid profile, morphofunctional aspects and chemical characteristics in adipose tissue of finishing pigs. Journal of Animal Science and Biotechnology. 1: 25-34.

15.??? Liu YL*, Shi JX, Lu J, Meng GQ, Zhu HL, Hou YQ, Yin YL, Zhao SJ, Ding BY. 2009. Activation of peroxisome proliferator-activated receptor γ potentiates pro-inflammatory cytokine production, and adrenal and somatotropic changes of weaned pigs after Escherichia coli lipopolysaccharide challenge. Innate Immunity. 15: 169-178.

16.??? Liu YL*, Han J, Huang JJ, Wang XQ, Wang FL, Wang JJ*. 2009. Dietary L-Arginine Supplementation Improves Intestinal Function in Weaned Pigs after an Escherichia coli Lipopolysaccharide. Asian-Australasian Journal of Animal Sciences. 22: 1667-1675.

17.??? Han J, Liu YL*, Fan W, Chao J, Hou YQ, Yin YL, Zhu HL, Meng GQ, Che ZQ. 2009. Dietary L-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs. Amino Acids. 37: 643–651.

18.??? Guo GL, Liu YL*, Fan W, Han J, Hou YQ, Yin YL, Zhu HL, Ding BY, Shi JX, Lu J, Wang HR, Chao J, Qu YH. 2008. Effects of achyranthes bidentata polysaccharide on growth performance, immunological, adrenal, and somatotropic responses of weaned pigs challenged with Escherichia coli lipopolysaccharide. Asian-Australasian Journal of Animal Sciences. 21: 1189-1195.

19.??? Liu YL*, Huang JJ, Hou YQ, Zhu HL, Zhao SJ, Ding BY, Yin YL, Yi GF, Shi JY, Fan W. 2008. Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs. British Journal of Nutrition. 100: 552-560.

20.??? Liu YL*, Lu J, Shi JX, Hou YQ, Zhu HL, Zhao SJ, Liu HM, Ding BY, Yin YL, Yi GF. 2008. Increased expression of the peroxisome proliferator-activated receptor γ in the immune system of weaned pigs after Escherichia coli lipopolysaccharide challenge. Veterinary Immunology and Immunopathology. 124: 82-92.

21.??? Liu YL*, Yi GF, Song GL, Hou YQ, Huang JW, Vazquez-Anon M, Knight CD. 2007. Impact of feeding 2-hydroxy-4-(methylthio) butanoic acid and DL-methionine supplemented maize-soya bean-rapeseed meal diets on growth performance and carcass quality of broilers. British Poultry Science. 48: 190-197.

22.??? Liu YL*, Song GL, Yi GF, Hou YQ, Huang JW, Vazquez-Anon M, Knight CD. 2006. Effect of supplementing 2-hydroxy-4-(methylthio) butanoic acid and DL-methionine in corn-soybean-cottonseed meal diets on growth performance and carcass quality of broilers. Asian-Australasian Journal of Animal Sciences. 19: 1197-1205.

23.??? Hou YQ, Liu YL*, Hu J, Shen WH. 2006. Effects of lactitol and tributyrin on growth performance, small intestinal morphology and enzyme activity in weaned pigs. Asian-Australasian Journal of Animal Sciences. 19: 1470-1477.

24.??? Liu YL, Li DF*, Gong LM, Yi GF, Gaines AM, Carroll JA. 2003. Effects of fish oil supplementation on the performance and the immunological, adrenal, and somatotropic responses of weaned pigs after an Escherichia coli lipopolysaccharide challenge. Journal of Animal Science. 81: 2758-2765.

25.??? Liu YL, Gong LM*, Li DF, Feng ZY, Zhao LD, Dong T. 2003. Effects of fish oil on lymphocyte proliferation, cytokine production and intracellular signaling in weanling pigs. Archives of Animal Nutrition. 57: 151-165.