出生年月：1983年9月
民族：汉族
职称：教授/博士生导师
学科专业：天然药物化学
研究方向：中药资源化学/微生物药物化学/天然药物生物合成
电子邮箱：yxl**@163.com

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n 教育及工作经历
2019.3-至今
中南民族大学药学院，教授/博士生导师

2016.2-2019.2
重庆大学药学院，入选重庆大学“****”****，研究员/博士生导师

2014.5-2015.5
德国莱布尼茨汉诺威大学，博士后，合作导师: Prof. Russell J. Cox

2012.4-2014.4
日本东京大学药学院，日本JSPS特别研究员，合作导师: Prof. Ikuro Abe

2009.9-2012.4
河北大学药学院，副教授/硕士生导师

2004.9-2009.7
中科院昆明植物研究所，博士（硕博连读），导师：刘吉开教授

2000.9-2004.7
西北农林科技大学，理学学士

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n 社会和学术任职情况
兼任广西科学院客座研究员（2020.1-至今）
兼任中国科学院藏药研究重点实验室客座研究员（2018.5-至今）
兼任中国科学院西北高原生物所客座研究员（2018.9 -至今）
担任中国菌物学会菌物化学专业委员会委员（2018.7-至今）
担任中国抗癌协会肿瘤代谢专业委员会委员（2019.1-至今）
担任广西海洋天然产物与组合生物合成化学重点实验室学术委员会委员（2018.10-至今）
担任河北省自然科学奖励评审专家（2018.4-至今）
担任国际期刊Drug Discoveries & Therapeutics编委（2018.1-至今）
兼任重庆市紫杉烷类药物工程技术研究中心专家委员会副主任 （2016.10-至今）
曾担任重庆大学药学院党委委员和教工党支部书记（2016.12-2019.3）
曾担任重庆大学药学院药物分析、药物设计与天然药物学系副主任（2018.10-2019.3）
担任J. Am. Chem. Soc., Org. Biomol. Chem., J. Nat. Prod., RSC Adv.等多个SCI期刊审稿人

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n 研究领域
1、微生物天然药物发现及其生物合成研究
2、中药资源化学及中药新资源的评价与开发研究
3、道地药材溯源及其品质形成机制研究

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n 教学工作
参与编写“十三五”规划教材《天然产物结构解析》1部。共承担多门课程教学工作，本科生课程包括：《有机波谱解析》、《天然药物化学》、《天然药物化学实验》、《药理学实验》、《生理解剖学实验》和《药剂学实验》；研究生课程包括：《高等天然药物化学》和《高等有机化学》。作为校级第一个跨学科科普教学实践团队骨干参与制作了思政课程《科普·神奇世界的解密者》，并在中宣部学习强国平台等展播。已指导多名本科生完成国家级等大学生创新训练项目和荣获校级优秀毕业论文。已指导多名研究生荣获多种奖励和荣誉。

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n 科研项目
[1] 国家重点研发计划“中医药现代化研究”重点专项子课题：白术、菊花和百合产地溯源检测数据集构建（2020YFC**），经费266.73万，2020.10-2022.9，主持，在研。
[2] 国家自然科学基金面上项目：基因组挖掘驱动的翘孢霉属真菌中“隐形”聚酮-非核糖体肽类化合物的发现及其生物合成研究(**)，直接经费55万元，2021.01-2024.12，主持，在研。
[3] 国家自然科学基金面上项目：表观遗传修饰策略驱动的11株植物内生真菌中新型抗耐药菌活性分子合成潜能的挖掘(**)，直接经费57万元，2019.01-2022.12，主持，在研。
[4] 国家自然科学青年基金：拟盘多毛孢内生真菌中抗肿瘤活性先导化合物的发现及活性评价 (**)， 25万元，2013.01-2015.12，主持，已结题。
[5] 国家民委中青年英才培养计划项目：两株药用植物内生真菌中新型抗肿瘤药物先导结构的发现及其作用机制研究，10万元，2021.01-2022.12，主持，在研。
[6] 中央高校基本科研业务费专项资金重点培育项目：六种药用植物内生真菌中新型抗耐药性细菌药物先导化合物的发现（CZP20007）， 40万，2020.1-2022.12，主持，在研。
[7] 中南民族大学海外高层次人才（学术带头人）引进项目：民族药内生真菌新颖结构药用活性功能分子的发现及其生物合成研究（YZZ18008）， 160万，2019.3-2024.2，主持，在研。
[8] 河北省自然科学基金：特殊生境真菌中结构新奇化学成分的发现及抗真菌活性研究 (C)， 3万元，2012.01-2015.01，主持，已结题。
[9] 中国科学院藏药研究重点实验室开放课题：青藏高原特境真菌资源库构建及药用活性分子发现 (2017-ZJ-Y11)，5万元，2018.11-2019.12，主持，结题。
[10] 重庆大学“****”****引进启动基金：特殊生境真菌资源库的构建及新颖结构药用活性物质的挖掘 (1)， 100万元，2016-2019，主持，已结题。
[11] 横向课题：抗菌消炎类物质的发现及其在新型烟草中的应用研究， 79万元，2019.9-2021.2，主持，结题。
[12] 横向课题：病害丹参应激化学成分及其抗病活性研究，25万元，2018.12-2019.12，主持，结题。
[13] 横向课题：一株假单胞细菌代谢产物的活性检测及分离鉴定, 15万元，2020.3-2021.1，主持，结题。
[14] 横向课题：产紫衫醇微生物的发现及产业化研究 (01)， 100万元，2016.05-2017.12，主持，已结题。
[15] 科技部引智司委托项目：“科技创新”背景下加快民族地区科普与教育相融合的发展策略研究 (BZY20021)，45万， 2020.11-2021.8, 第四参加人，在研。

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n 获奖及荣誉
2020：入选国家民委中青年英才培养计划
2015: 入选重庆大学“****”****
2012: 获得日本振兴学会(JSPS)外国特别研究员
2008: 获得中国科学院朱李月华优秀博士奖学金
2006: 获得中国科学院西部学子一等奖学金

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n 论文发表
截至目前，已在Nat. Prod. Rep. (IF= 11.406)、Chem. Sci. (IF= 9.556)、Org. Lett. (IF=6.555)、 Cancer Lett. (IF=6.508)、Cell Death Dis. (IF=6.304)等本领域权威期刊上发表论文70余篇，其中SCI收录论文近60篇。
主要代表性SCI论文：
[1] Wen-Ting Zhao^#, Xiong Shi^#, Peng-Jie Xian, Zhang Feng*, Jian Yang*, Xiao-Long Yang*. A new fusicoccane diterpene and a new polyene from the plant endophytic fungus Talaromyces pinophilus and their antimicrobial activities. Natural Product Research, 2021, 35:124-130.
[2] Yong Xia*, Shu-Zhi Liu, Chang-Lin Li, Zhi-Ying Ai, Wen-Zhi Shen, Wen-Qi Ren, Xiao-Long Yang*. Discovery of a novel ferroptosis inducer - talaroconvolutin A - killing colorectal cancer cells in vitro and in vivo. Cell Death & Disease, 2020, 11:988.
[3] Wen-Ting Zhao^#, Qing-Pei Liu^#, Heng-Ye Chen, Wei Zhao*, Yuan Gao*, Xiao-Long Yang*. Two novel eremophylane acetophenone conjugates from Colletotrichum gloeosporioides, an endophytic fungus in Salvia miltiorrhiza. Fitoterapia, 2020, 141: e104474.
[4] Hai-Li Chen^#, Wen-Ting Zhao^#, Qing-Pei Liu, Heng-Ye Chen, Wei Zhao*, Deng-Feng Yang*,
Xiao-Long Yang*. (±)-Preisomide: A new alkaloid featuring a rare naturally occurring tetrahydro-2H-1,2-oxazin skeleton from an endophytic fungus Preussia isomera by using OSMAC strategy. Fitoterapia, 2020, 141: e104475.
[5] Sheng-Xiang Yang^#, Jing-Fang Xiao^#, Ting-Kai Liu, Ze-Diao Huang, Xiang Li, Ye-Miao Chen^#, Xiao-Long Yang*. A 3D screening approach identifies the compound epitajixanthone hydrate as a new inhibitor of cancer cell growth and invasion. Anti-cancer Drugs, 2020, 31(9):890-899.
[6] Peng-Jie Xian, Heng-Ye Chen, Zhang Feng*, Wei Zhao*, Xiao-Long Yang*. Capsulactone: a new 4-hydroxy-α-pyrone derivative from an endophytic fungus Penicillium capsulatum and its antimicrobial activity. Journal of Asian Natural Products Research, 2020, doi: 10.1080/**.2020.**.
[7] Xiao-Long Yang, Steffen Friedrich, Sen Yin, Oliver Piech, Katherine Williams, Thomas J. Simpson, Russell J. Cox*. Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase. Chemical Science, 2019, 10, 8478–8489.
[8] Lu-Lin Xu^#, Hai-Li Chen^#, Ping Hai, Yuan Gao, Chuan-Dong Xie, Xiao-Long Yang*, Ikuro Abe*. (+)- and (?)-Preuisolactone A: A pair of caged norsesquiterpenoidal enantiomers with a tricyclo[4.4.01,6.02,8]decane carbon skeleton from the endophytic fungus Preussia isomera. Organic Letters, 2019, 21: 1078?1081.
[9] Lu-Lin Xu, Ping Hai, Shuai-Bing Zhang, Jing-Fang Xiao, Yuan Gao, Bing-Ji Ma, Hai-Yan Fu*, Ye-Miao Chen*, Xiao-Long Yang*. Prenylated Indole Diterpene Alkaloids from a Mine Soil-derived Tolypocladium sp. Journal of Natural Products, 2019, 82: 221-231.
[10] Heng-Ye Chen^#, Ting-Kai Liu^#, Jian Yang*, Xiao-Long Yang*. Emerones A-C: Three novel merosesquiterpenoids with unprecedented skeletons from Emericella sp. XL029. Organic & Biomolecular Chemistry, 2019, 17: 8450 -8455.
[11] Heng-Ye Chen, Ting-Kai Liu, Qiong Shi, Xiao-Long Yang*. Sesquiterpenoids and diterpenes with antimicrobial activity from Leptosphaeria sp. XL026, an endophytic fungus in Panax notoginseng. Fitoterapia, 2019, 137: 104243.
[12] Wei Zhao, Hai-Li Chen, Liu Hong, Xia Zhang, Xian-Jun Jiang, Dong-Lai Zhu*, Fei Wang*, Xiao-Long Yang*. Five new polyphenolic derivatives with antimicrobial activities from the root barks of Periploca sepium. Fitoterapia, 2019, 137: 104254.
[13] Xia Zhang, Hai-Li Chen, Liu Hong, Lu-Lin Xu, Xiao-Wei Gong, Dong-Lai Zhu, Xiao-Hua Xu, Wei Zhao*, Fei Wang*, Xiao-Long Yang*. Three new hopane-type triterpenoids from the aerial part of Adiantum capillus-veneris and their antimicrobial activities. Fitoterapia, 2019, 133: 146-149.
[14] Dan Xu, Xia Zhang, Xiong Shi, Peng-Jie Xian, Liu Hong, Yan-Duo Tao*, Xiao-Long Yang*. Two new cytochalasans from the marine sediment-derived fungus Westerdykella dispersa and their antibacterial activities. Phytochemistry Letters, 2019, 32: 52-55.
[15] Lu-Lin Xu^#, Xue-Jiao Pang^#, Xiong Shi, Peng-Jie Xian, Hai-Li Chen, Deng-Feng Yang*, Xiao-Long Yang*. Two new prenylated indole diterpenoids from Tolypocladium sp. XL115 and their antimicrobial activities. Chemistry & Biodiversity, 2019, 16: e**.
[16] Sheng-Xiang Yang^#, Wen-Ting Zhao^#, Heng-Ye Chen, Lei Zhang, Ting-Kai Liu, He-Ping Chen*, Jian Yang*, Xiao-Long Yang*. Two new C₁₃-polyketides from Chaetomium globosum, an endophytic fungus in Salvia miltiorrhiza. Chemistry & Biodiversity, 2019, 16: e**.
[17] Ting Zhao, Lu-Lin Xu, Yan Zhang, Zheng-Hong Lin, Tao Xia, Deng-Feng Yang*, Ye-Miao Chen*, Xiao-Long Yang *. Three new α-pyrone derivatives from the plant endophytic fungus Penicillium ochrochloronthe and their antibacterial, antifungal and cytotoxic activities. Journal of Asian Natural Products Research, 2019, 21: 851-858.
[18] Wei Zhao, Xiao-Wei Gong, Yuan-Xing Duan, Ji Yang, Xia Wu, Xian-Jun Jiang, Xiao-Hua Xu, Yong-Kuan Chen, Liu Yang*, Fei Wang*, Xiao-Long Yang*. Two new triterpenoids with antimicrobial activity from the leaves and twigs of Orophea yunnanensis. Natural Product Research, 2019, 33: 3472-3477.
[19] Xue-Jiao Pang, Shuai-Bing Zhang, Peng-Jie Xian, Xia Wu, Deng-Feng Yang*, Hai-Yan Fu*, Xiao-Long Yang*. Emericellins A and B: Two sesquiterpenoids with an unprecedented tricyclo[4,4,2,1]hendecane scaffold from the liquid cultures of endophytic fungus Emericella sp. XL 029. Fitoterapia, 2018, 131: 55-58.
[20] Wei Zhao, Lu-Lin Xu, Xia Zhang, Xiao-Wei Gong, Dong-Lai Zhu, Xiao-Hua Xu, Fei Wang*, Xiao-Long Yang*. Three new phenanthrenes with antimicrobial activities from the aerial parts of Juncus effuses. Fitoterapia, 2018, 130: 247-250.
[21] Xia Wu, Xue-Jiao Pang, Lu-Lin Xu, Qiong-Yin Zhang, Xin-Yu Long, Hai-Li Qin, Deng-Feng Yang*, Xiao-Long Yang*. Two new alkylated furan derivatives with antifungal and antibacterial activities from the plant endophytic fungus Emericella sp. XL029. Natural Product Research, 2018, 32: 2625-2631.
[22] Xue-Jiao Pang^#, Shuai-Bing Zhang^#, Hai-Li Chen, Wen-Ting Zhao, Deng-Feng Yang, Peng-Jie Xian, Lu-Lin Xu, Yan-Duo Tao*, Hai-Yan Fu*, Xiao-Long Yang*. Emericelactones A-D: Four novel polyketides produced by Emericella sp. XL 029, a fungus associated the leaves of Panax notoginseng. Tetrahedron Letters, 2018, 59: 4566-4570.
[23] Dan Xu, Ming-He Luo, Feng-Lou Liu, Dong Wang, Xue-Jiao Pang, Ting Zhao, Lu-Lin Xu, Xia Wu, Ming-Yu Xia*, Xiao-Long Yang*. Cytochalasan and tyrosine-derived alkaloids from the marine sediment-derived fungus Westerdykella dispersa and their bioactivities. Scientific Reports, 2017, 7:11956-11964.
[24] Xia Wu, Li-Zhen Fang, Feng-Lou Liu, Xue-Jiao Pang, Hai-Li Qin, Ting Zhao, Lu-Lin Xu, Deng-Feng Yang, Xiao-Long Yang*. New prenylxanthones, polyketide hemiterpenoid pigments from the endophytic fungus Emericella sp. XL029 and their anti-agricultural pathogenic fungal and antibacterial activities. RSC Advances, 2017, 7, 31115-31122.
[25] Dan Xu, Xue-Jiao Pang, Ting Zhao, Lu-Lin, Xiao-Long Yang*. New alkenylated tetrahydropyran derivatives from the marine sediment-derived fungus Westerdykella dispersa and their bioactivities. Fitoterapia, 2017, 122:45-51.
[26] Feng-Lou Liu, and Xiao-Long Yang*. Indole derivatives produced by the metagenome genes of the Escherichia coli-harboring marine sponge Discodermia calyx. Molecules, 2017, 22: 681.
[27] Dan Xu, Bing-Yang Zhang, Xiao-Long Yang*. Antifungal monoterpene derivatives from the plant endophytic fungus Pestalotiopsis foedan. Chemistry & Biodiversity, 2016, 13: 1422-1425.
[28] Xiao-Long Yang*, Le Huang, Hai-Ying Li, Deng-Feng Yang, Zhuangzhuang Li. Two new compounds from the plant endophytic fungus Pestalotiopsis versicolor. Journal of Asian Natural Products Research, 2015, 17(4):333-337.
[29] Xiao-Long Yang*, Le Huang, Xiao-Li Ruan. Epigenetic modifiers alters the secondary metabolite composition of a plant endophytic fungus, Pestalotiopsis crassiuscula obtained from the leaves of Fragaria chiloensis. Journal of Asian Natural Products Research, 2014. 16(4):412-417.
[30] Xiao-Long Yang, Takayoshi Awakawa, Toshiyuki Wakimoto, and Ikuro Abe*. Three acyltetronic acid derivatives: Noncanonical cryptic polyketides from Aspergillus niger identified by genome mining. ChemBioChem, 2014, 15:1578-1583.
[31] Xiao-Long Yang, Takayoshi Awakawa, Toshiyuki Wakimoto, and Ikuro Abe*. Induced production of novel prenyldepside and coumarins in endophytic fungi Pestalotiopsis acaciae. Tetrahedron Letters, 2013, 54: 5814-5817.
[32] Xiao-Long Yang, Toshiyuki Wakimoto, Yuya Takeshige, Rui He, Yoko Egami, Ikuro Abe*. Indole-porphyrin hybrids produced by metagenomics. Bioorganic & Medicinal Chemistry Letters, 2013, 23:3810-3813.
[33] Xiao-Long Yang, Takayoshi Awakawa, Toshiyuki Wakimoto, and Ikuro Abe*. Induced production of the novel glycolipid ustilagic acid C in the plant pathogen Ustilago maydis. Tetrahedron Letters, 2013, 54:3655-3657.
[34] Xiao-Long Yang*, Zhuang-Zhuang Li. New spiral γ-lactone enantiomers from the plant endophytic fungus Pestalotiopsis foedan. Molecules, 2013, 18: 2236-2242.
[35] Xiao-Long Yang, Jing-Ze Zhang and Du-Qiang Luo*. The taxonomy, biology and chemistry of the fungal Pestalotiopsis genus. Natural Product Reports, 2012, 29(6):622-641. (Cover article)
[36] Xiao-Long Yang*, Zhuang-Zhuang Li, Su Zhang, He Yu, Hua-Jie Zhu, Du-Qiang Luo. A new spirocyclic compound from the liquid culture of entomogenous fungus Isaria cateniannulata. Journal of Asian Natural Products Research, 2012, 14(11):1093-1096.
[37] Xiao-Long Yang, Su Zhang, Hua-Jie Zhu, Du-Qiang Luo*, Xue-Yan Gao. Eremophilane-type sesquiterpenoids from the fermentation broth of plant endophytic fungus Pestalotiopsis photiniae isolated from the Chinese podocarpaceae plant Podocarpus macrophyllus. Helvetica Chimica Acta, 2011, 94, 1463-1469.
[38] Xiao-Long Yang*, Su Zhang, Hua-Jie Zhu, Du-Qiang Luo*. Dihydroberkleasmin A: A new eremophilane sesquiterpenoid from the fermentation broth of plant endophytic fungus Pestalotiopsis photiniae. Molecules, 2011, 16, 1910-1916.
[39] Xiao-Long Yang, Su Zhang, Qiong-Bo Hu*, Du-Qiang Luo*, Yan Zhang. Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae. Journal of Antibiotics, 2011, 64, 723-727.
[40] Xiao-Long Yang, Zheng-Hong Xie, Xian-Jun Jiang, Yan-Bing Huang and Ji-Kai Liu*. A new acridone alkaloid from Micromelum integerrimum. Chemical & Pharmaceutical Bulletin, 2009, 57(7), 734-735.
[41] Xiao-Long Yang, Cheng Qin, Fei Wang, Ze-Jun Dong, and Ji-Kai Liu*. A new meroterpenoid pigment from the basidiomycete Albatrellus confluens. Chemistry & Biodiversity, 2008, 5 (3): 484-489.
[42] Xiao-Long Yang, Kun-Lung Hsieh, and Ji-Kai Liu*. Guajadial: An unusual meroterpenoid from guava leaves Psidium guajava. Organic Letters, 2007, 9: 5135-5138.
[43] Xiao-Long Yang, Du-Qiang Luo, Ze-Jun Dong, Ji-Kai Liu*. Two new pigments from the fruiting bodies of the basidiomycete Lactarius deliciosus. Helvetica Chimica Acta, 2006, 89: 988-990.
[44] Xiao-Long Yang, Du-Qiang Luo, and Ji-Kai Liu*. A new pigment from fruiting bodies of the basidiomecete Lactarius deliciosus. Zeitschrift für Naturforschung B-A Journal of Chemical Sciences, 2006, 61:1180-1182.