出生年月：1970.11
民族：汉族
学历学位：药学博士
职称：教授
学科专业：药理学
电话：
电子邮箱：hbtang2006@mail.scuec.edu.cn
研究方向包括：肝损伤机制及民族药物干预；皮肤创伤修复的民族药物药理学机制研究；慢性疼痛机制研究及民族药物干预等。
受教育经历
2002/04-2005/03，日本广岛大学，医齿药学综合研究科药学系药理学专业，博士；
2000/04-2002/03，日本广岛大学，医齿药学综合研究科药学系药理学专业，硕士；
1998/10-2000/03，日本广岛大学，医学研究科生命科学系药理学专业，研究生；
1991/09-1996/06，湖南中医学院，中医医疗一系五官科学专业，学士
研究工作经历
2009/04-至今，中南民族大学，药学院药理学研究室，教授
2005/04-2009/03，日本广岛大学，药学院药理学研究室，助理教授；
1996/07-1998/09，湖南省株洲市中医伤科医院，五官科，医师
1996年毕业于湖南中医学院（现更名湖南中医药大学），获医学学士学位；同年任湖南株洲市中医伤科医院五官科医师；1998年9月赴日本国立广岛大学医学部留学，于2005年3月，获博士（药学）学位；2005年4月至2009年3月任广岛大学药学部助理教授；在日本广岛大学任教期间，主持日本国家自然科学基金项目2项，并与Nippon Chemiphar、大鹏药品工业和协和发酵工业等几家主要药业公司合作开展扎托洛芬、紫杉醇等4项新药的研发工作。2009年4月回国，任中南民族大学教授，兼职中国中医药信息研究会临床研究分会常务理事、湖北省药理学会理事、中国中药实验药理学学会委员、日本药理学会会员等。回国后主持完成包括国家自然科学基金项目在内的各级研究项目17项。多年来主要从事中西医结合科学领域的研究工作，自主开发了生肤油和降糖剂等多个产品，相关成果已获中国发明专利授权，并先后与上海新生源、广州无限极等公司合作开展了“OAGel注射液”及功能性油脂等产品的开发；在Nanomedicine NBM、Journal of Agricultural and Food Chemistry、InternationalJournal of Nanomedicine、Neuropharmacology、ToxicologyResearch等期刊上发表论文60余篇，申报发明专利11项，其中7项已授权。
近年代表性研究论文
1.Huang XL, Li XJ, Qin QF, Li YS, Zhang WK, Tang HB*. Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material. Journal of Ethnopharmacology. 2019, 239:111916.DOI: 10.1016/j.jep.2019.111916
2.Chen MT, Zhang WK, Liang WL, Li YS, Li XJ, Zhu LH, Tang HB*. Controllable and extra-fast synthesis of bio-applicable silver nanoparticles with Lycium Barbarum L. Materials Technology. 2019, DOI: 10.1080/**.2019.**
3.Liang WL, Xiao L, Gu HW, Li XJ, Li YS, Zhang WK, Tang HB*. Solid lipid nanoparticle induced apoptosis of macrophages via a mitochondrial-dependent pathway in vitro and in vivo. International Journal of Nanomedicine. 2019, 14: 3283-3295.
4.Li XJ, Huang FZ, Wan Y, Li YS, Zhang WK, Xi Y, Tian GH, Tang HB*. Lipopolysaccharide Stimulated the Migration of NIH3T3 Cells Through a Positive Feedback Between β-Catenin and COX-2. Frontiers in Pharmacology. 2018, 9: 1487.
5.Chen XZ, Zhang WK, Tang HB, Li XJ, Tian GH, Shang HC, Li YS*. The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice.Canadian Journal of Gastroenterology and Hepatology. 2018, 2018: **.
6.Zhang MT, Ye XX, Lan W, Yang YL, Wu T, Li YS*, Tang HB. Strategic Combination of Isocratic and Gradient Elution for Simultaneous Separation of Polar Compounds in Traditional Chinese Medicines by HPLC.Journal of Analytical Methods in Chemistry. 2018, 2018: **.
7.Li XJ, Mu YM, Qin QF, Zeng ZX, Li YS, Zhang WK, Tang HB*, Tian GH, Shang HC. Chronic high-dosage fish oil exacerbates gut–liver axis injury in alcoholic steatohepatitis in mice: the roles of endotoxin and IL-4 in Kupffer cell polarization imbalance.Toxicology Research. 2017, 6: 611–620.
8.Razzaque S, Cai C, Lu QW, Huang FZ, Li YS, Tang HB*, Hussaind I, Tan BE. Development of functionalized hollow microporous organic capsules encapsulating morphine – an in vitro and in vivo study. Journal of Materials Chemistry B. 2017, 5, 742-749
9.Chen MT, Yang YJ, Li YS, Li XJ, Zhang WK, Wang JP, Wang X, Tian GH, Tang HB*, Shang HC. Shengfu Oil Enhances the Healing of Full-Thickness Scalded Skin Accompanying the Differential Regulation of β-Catenin, Dlk1, and COX-2. Frontiers in Pharmacology. 2017, 8(801):1-10.
10.Ning D, Zhang WK, Tian H, Li XJ, Liu M, Li YS, Tang HB. The Involvement of β-Catenin/COX-2/VEGF Axis in NMDA-Caused Retinopathy. Journal of Ophthalmology. 2017, 2017(**): 1-12.
11.Zhang WK, Gu HW, Li XJ, Li YS, Tang HB*, Tian GH, Shang HC. The dark side of the force - lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice. Nanomedicine: Nanotechnology, Biology, and Medicine. 2017, 13(2): 701-711.
12.Razzaque S, Cai C, Lu QW, Huang FZ, Li YS, Tang HB*, Hussaind I, Tan B. Development of functionalized hollow microporous organic capsules encapsulating morphine – an in vitro and in vivo study. Journal of Materials Chemistry B. 2017, 5: 742-749
13.Tian GH, Tao SS, Chen MT, Li YS, Li YP, Shang HC, Tang XY, Chen JX, Tang HB*. Electroacupuncture treatment alleviates central poststroke pain by inhibiting brain neuronal apoptosis and aberrant astrocyte activation. Neural Plasticity.2016, 2016: **
14.Zhang WK, Tao SS, Li TT, Li YS, Li XJ, Tang HB*, Cong RH, Ma FL, Wan CJ. Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo. Food & Nutrition Research. 2016, 60: 30849.
15.Li YS, Leng CL, Chen MT, Zhang WK, Li XJ, Tang HB*, Shang HC, Zhu LH. Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway. Toxicology Research. 2016, 5:210-223.
16.Wan Y, Yang YJ, Li YS, Li XJ, Zhang W, Liu M, Tang HB*. Effects of San-huang-sheng-fu oil on peripheral circulatory disorders and foot ulcers in diabetic rats and the mechanisms. Zhonghua Shao Shang Za Zhi. 2016, 32(3):168-75.
17.Li XJ, Yang YJ, Li TT, Li YS, Zhang WK, Tang HB*, α-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2. Journal of Ethnopharmacology. 2016, 179:22-26.
18.Li XJ, Mu YM, Li TT, Yang YL, Zhang MT, Li YS, Zhang WK, Tang HB*, Shang HC. Gynura procumbensreverses acute and chronic ethanol-induced liver steatosis through MAPK/SREBP-1c-dependent and -independent pathways. Journal of Agricultural and Food Chemistry. 2015, 63(38):8460-8471.
19.Li YS, Xi Y, Li XJ, Leng CL, Jia MM, Zhang WK, Tang HB*. Up-regulation of the biosynthesis and release of substance P through Wnt/β-catenin signaling pathway in rat dorsal root ganglion cells. PLoS One. 2015, 10(6):e**.
20.Zhao XJ, Chen Q, Li YS,Tang HB, Liu W, Yang XL. Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice. European Journal of Pharmaceutics and Biopharmaceutics. 2015, 93: 27-36.
21.Zhao XJ, Chen Q, Liu W, Li YS, Tang HB, Liu XH and Yang XL. Co-delivery of doxorubicin and curcumin withlipid nanoparticles results in improved efficacy of chemotherapy in liver cancer. International Journal of Nanomedicine. 2015, 10: 257–270.
22.Li YS, Chen BF, Li XJ, Zhang WK, Tang HB*. Cytotoxicity of polyaniline nanomaterial on rat celiac macrophages in vitro. PLoS One. 2014, 9(9):e107361.
23.Li XJ, Jia MM, Li YS, Yang YL, Mao XQ, Tang HB. Involvement of substance p/neurokinin-1 receptor in the analgesic and anticancer activities of minimally toxic fraction from the traditional Chinese medicine Liu-Shen-Wan in vitro.Biol Pharm Bull. 2014, 37(3):431-438.
24.Li L, Guo QL, Li J, Yan W, Leng CL, Tang HB*, Lu QW, Tang BE. Design of a polymer ligand for the one-step preparation of highly stable fluorescent Ag5 clusters for tissue labeling. Journal of Materials Chemistry B. 2013, 1, 3999-4004.
25.Jia MM, Li YS, Pei LJ, Liu M, Li XJ, Tang HB*. Effect of San-huang-sheng-fu oil on wounds of full-thickness scald in rabbits. Zhonghua Shao Shang Za Zhi. 2013, 29(1): 50-54.
26.Li YS, Wang JX, Jia MM, Liu M, Li XJ, Tang HB*. Dragon's Blood Inhibits Chronic Inflammatory and Neuropathic Pain Responses by Blocking the Synthesis and Release of Substance P in Rats. Journal of Pharmacological Sciences. 2012,118: 43-54.
27.Li YS, Liu M, Nakata Y,Tang HB*. β-Catenin accumulation in nuclei of hepatocellular carcinoma cells up-regulates glutathione-s-transferase M3 mRNA.World Journal of Gastroenterology. 2011, 17: 1772-1778.
近年主持或参与的国家自然科学基金项目
1. 平卧菊三七干预“β-catenin/COX-2”炎性环路的防治肝癌机制研究.2016年国家自然科学基金面上项目；
2. 傣药帕崩板激活肠肝轴AMPK治疗酒精性肝病的机制研究.2014年国家自然科学基金青年项目；
3. 生肤油促进Ⅲ度烫伤皮肤无瘢痕修复的机制研究。2013年国家自然科学基金面上项目；
4. Wnt/β-catenin信号通路调控原发性肝癌发生的机制研究.2011年国家自然科学基金青年项目；
5. 非神经细胞对背根神经节神经细胞内P物质释放的调控机制。2010年国家自然科学基金面上项目；