姓名 阳小飞 （Xiaofei Yang)
民族 汉
职称 教授
学科专业 生物医学工程
研究方向 神经生物学
电子邮箱 sunlittlefly@hotmail.com


简历
博士，教授，硕士生导师。曾在美国西南医学中心、斯坦福大学诺贝尔奖得主Thomas C. Südhof教授实验室从事博士后研究，长期从事囊泡转运与释放，钙离子调节神经递质释放机制的科学研究工作。在包括Science，Neuron，PNAS，EMBO Rep，J Neurosci等国际著名期刊在内的各类SCI收录期刊中发表文章20余篇。主持多项国家自然科学基金、湖北省自然科学基金。先后入选国家民委中青年英才计划及湖北省优秀青年骨干人才计划。目前主要运用分子/生化，遗传学，电生理和光学等手段，在生理和病理情况下研究神经系统细胞信号跨膜传导的时空调节机制，研究重点包括神经递质释放分子机制，神经突触形成与调节机理，神经网络发育调控，药物镇痛机制等。研究成果为诊断、治疗重大神经性疾病提供生物学基础。




近年代表性研究成果（论文、专著、获奖、专利等）

1.Xiaofei Yang*, Yea Jin Kaeser-Woo*, Zhiping P. Pang, Wei Xu, Thomas C. Südhof. Complexin Clamps Asynchronous Releaseby Blocking a Secondary Ca2+-Sensor via its Accessory a-Helix. Neuron. 2010 Dec 9:68,907-920.
2.Xiaofei Yang, Peng Cao, Thomas C. Südhof. Deconstructing Complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. Proc Natl Acad Sci U S A.2013 Dec 17;110(51):20777-82.
3.XiaofeiYang#, DongmeiHou,Wei Jiang, Chen Zhang#. Intercellular protein-protein interactions at synapses. Protein Cell.2014 Jun;5(6):420-44.(#共同通讯作者)
4.Wei Jiang, Rui Hua, Mengping Wei, Chenhong Li, Zilong Qiu,Xiaofei Yang#, Chen Zhang. An optimized method for high-titer lentivirus preparations without ultracentrifugation. Sci Rep. 2015 Sep 8;5:13875. doi: 10.1038/srep13875.(#共同通讯作者)
5.Xiaofei Yang#，Jimin Pei，Yea Jin Kaeser-Woo，Taulant Bacaj，Nick V. Grishin，Thomas C. Südhof#，Evolutionary Conservation of Complexins: From Choanoflagellates to Mice，EMBO Reports，2015，16（10）：1308-1317. (#共同通讯作者)
6.Jihong Gong; Ying Lai; Xiaohong Li; Mengxian Wang; Jeremy Leitz; Yachong Hu; Yunxiang Zhang; Ucheor B. Choi; Daniel Cipriano; Richard A. Pfuetzner; Thomas C. Südhof;XiaofeiYang#; Axel T. Brunger#; Jiajie Diao#, C-terminal domain of mammalian complexin-1 localizes to highly curved membranes, Proc Natl Acad Sci U S A., 2016.11.22, 113(47): E7590~E7599(#共同通讯作者)
7.Shen Wang ; Ucheor B. Choi ; Jihong Gong ; Xiaoyu Yang; Yun Li; Austin L. Wang;Xiaofei Yang#; Axel T. Brunger#; Cong Ma#, Conformational Changes of Syntaxin Linker Region induced by Munc13s Ignite SNARE-Complex Assembly in Synaptic Exocytosis, The EMBO Journal, 2017.3.15, 36(6): 816~829(#共同通讯作者)
8.Wei Jiang; Mengping Wei; Mengna Liu; Yunlong Pan; Dong Cao;Xiaofei Yang#; Chen Zhang#, Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation, Journal of Neuroscience, 2017.10.11, 37(41): 9828~9843(#共同通讯作者)
9.YiYu, Su Chen, Xiaoqiang Mo, Jihong Gong, Chenhong Li, Xiaofei Yang#. Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis. Front Mol Neurosci.2018 Feb 26;11:61.(#通讯作者)
10.Su Chen, Yi Rong, Mengxue Liu, Song Cheng, Xiangming Liu, Xiaohong Li, Yi Yu, Guangzhong Yang, Xiaofei Yang#. Analgesic Effects of Triterpenoid Saponins From Stauntonia chinensis via Selective Increase in Inhibitory Synaptic Response in Mouse Cortical Neurons. Front Pharmacol. 2018 Nov 12;9:1302.(#共同通讯作者)