姓 名:
　孙玉华 性 别:
　男
职 称:
　研究员 学 历:
　研究生
电 话:
　86- 邮 箱:
　sunyh@ihb.ac.cn


简历：
博士，研究员，博士生导师。2004年于武汉大学生命科学院获博士学位；2004-2007年华中农业大学水产学院讲师；2007-2015年先后在德国马普发育生物学所和美国佐治亚大学生化与分子生物学系做博士后研究。2015年受聘为中科院水生生物研究所研究员。长期从事脊椎动物早期胚胎发育机制以及多能干细胞自我更新及分化的研究,系统研究了转录因子、信号通路、表观遗传因子以及染色质高级结构在多能干细胞自我更新和分化、谱系命运决定中的作用机制。在《CELL》《Cell Stem Cell》《Developmental Cell》《G&D》《Stem Cell Reports》《Stem Cells》等国际著名刊物上发表SCI文章15篇以上，论文累计被引超过1000次。担任Frontiers in Cell and Developmental Biology的编委。

研究方向：
1.以斑马鱼为模式生物，研究脊椎动物早期胚胎发育的分子机制
2.胚胎干细胞自我更新和分化机制研究
3.基于多能干细胞的类器官构建，干细胞治疗和转化医学研究


职务：


社会任职：


获奖及荣誉：

代表论著：
1.Sun, X., Peng, X., Cao, Y., Zhou, Y., andSun, Y. (2020a). ADNP promotes neural differentiation by modulating Wnt/beta-catenin signaling. Nature Communications11, 2984, doi:10.1038/s41467-020-16799-0 (2020).
2.Sun, X., Yu, W., Li, L., and Sun, Y.(2020b). ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4.Frontiers in cell and developmental biology8, 553, doi:10.3389/fcell.2020.00553 (2020)
3.Sun, X.Y., Chen, J., Zhang, Y.Y., Munisha, M., Dougan, S., and Sun, Y.H.(2018). Mga Modulates Bmpr1a Activity by Antagonizing Bs69 in Zebrafish.Frontiers in cell and developmental biology 6, doi:Unsp 12610.3389/Fcell.2018.00126 (2018).
4.Ryan Berger, Yuhua Sun et al., (2016). ST8SIA4-dependent polysialylation is part of a developmental program required for germ layer formation from human pluripotent stem cells. Stem Cells, DOI:10.1002/stem.2379　　
5.Amar Singh*, Yuhua Sun*, Li Li, Steve Qin, and Steve Dalton (2015). Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency. Stem Cell Reports，3:323 (*equal contribution)　　
6.Yuhua Sun, Weichia Tseng, Rebecca Ball,and Scott Dougan (2014). Extra-embryonic signals under the control of Mga, Max and Smad4 are required for dorsoventral patterning. Developmental Cell, 28: 322　　
7.J Champell*, YH Sun*, A Singh, S Dalton (2013). Myc/Max control Erk signaling and pluripotency by regulation of dual specificity phosphatases 2 and 7. Genes & Development (*equal contribution), 27:725-733　　
8.J Phillips-Cremins, M Sauria, A Sanyal, T Gerasimova, B Lajoie, J Bell, CT Ong, T Hookway, C Guo, YH Sun, M Bland, W Wagstaff, S Dalton, T McDevitt, R Sen, J Dekker, J Taylor, V Corces (2013)．Architectural protein subclasses shape 3- D organization of genomes during lineage commitment．Cell, 153: 1281　　
9.Amar M. Singh, David Reynoids, Timothy Cliff, Satoshi Ohtsuka, Alexa Mattheyses, Yuhua Sun, Laura Menendez, Michael Kulik and Stephen Dalton (2012). Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation. Cell stem cell, 10(3): 312-326
10.Sun YH, Wloga D. and Dougan S. (2011). Embryological manipulations in zebrafish. Methods Mol. Biol., 770: 139-184　　
11.D.M. Webster, C.F. Teo, YH. Sun, D. Wloga, S. Gay, L. Wells and S. T. Dougan (2009). O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. BMC Dev. Biol., 9(1): 28-33Highly Accessed Article　　
12.Chengtai Yang, Ling Cao, Weimin Wang, Yi Yang, Binlun Yan, Li Su, Yuhua Sun, and Huanling Wang (2009). Comparative and evolutionary analysis in natural diploid and tetraploid weather loach Misgurnus anguillicaudatus based on cytochrome b sequence data in central China. Environmental Biology of Fishes, 86(1): 145-153　
13.Treer T., Sprem N, Torcu-Koc, YH Sun, and M. Piria (2008). Length-weight relationship of freshwater fishes of Croatia. J. Appl. Ichthyol, 24: 626-628
14.Yuhua Sun, Rong Tang, Dapeng Li, Xuezhen Zhang, Juan Fu, Ping Xie (2008). Acute effects of microcystins on transcription of antioxidant enzyme genes in crucian carp. Environ. Toxicol., 23: 145-152　
15.Zexia Gao, *Weimin Wang, Khalid Abbas, Xiaoyun Zhou, Yi Yang, James S Diana, Hanping Wang, Huanling Wang, Yang Li, Yuhua Sun (2007). Haematological characterization of loach Misgurnus anguillicaudatus: comparison among diploid, triploid and tetraploid specimens. Comp Biochem Physiol A Mol Integr Physiol. 2007 Aug;147-
16.YH Sun, CX Xie, WM Wang, SY Liu, T. Treer, MM Chang et al (2007). The genetic variation and the biogeography of catostomid fishes based on mitochondrial and nucleic DNA sequences. Journal of Fish Biology, 70: 291-309　　
17.Yuhua Sun, Siyang Liu, Gang Zhao, QX Yu et al (2004). Population structure of Chinese sucker Myxocyprinus asiatus (Cypriniformes: Catostomidae) in the Yangtze River based on Mitochondrial DNA control region sequences. Fisheries Science, 70(3): 412-420　　
18.SUN Yu-Hua; WANG Wei; LIU Si-Yang; HE Shun-Ping; SHAO Xue-Ling; XIE Zhi-Xiong; DENG Feng-Jiao; LIU Yong; TONG Jin-Gou; WU Qing-Jiang (2002). Genetic Diversity Analysis of Mitochondrial D-loop Region of Chinese Sucker (Myxocyprinus asiaticus). Journal of Genetics and Genomics (in Chinese), 29(9): 787-790