陈隽　研究员博士研究生

职　　称： 研究员
学　　历： 博士研究生
联系方式： 86-
电子邮件： chenjun#ihb.ac.cn(请改#为@)
办公室： 台站岸上办公室一楼
个人网页：


教育经历
1992.9-1995.6 华中农业大学 食品科学专业 本科
1995.9-1998.6 华中师范大学 化学专业 硕士
2003.9-2006.6 中国科学院水生生物研究所 水生生物学专业 博士


主要职历
1998.7-2003.8 武汉市疾病控制中心 中级
2006.7-2007.7 中国科学院水生生物研究所 助理研究员
2007.7-2011.11 中国科学院水生生物研究所 副研究员，2008年任硕士生导师
2009.5-2009.10 英国阿伯丁大学，受“国家自然科学基金国际（地区）合作交流项目—微囊藻毒素及鱼类病原菌对鱼类免疫系统基因的影响”资助，开展合作研究
2010.1-2010.12 英国阿伯丁大学，中国科学院访问****，访学期间作为独立获奖人荣获英国著名信托基金会颁发的“利华休姆信托—海外访问****奖学金”
2011.11-至今 中国科学院水生生物研究所 研究员，2013年任博士生导师


招生专业
水生生物学（硕士生，博士生）


研究方向
蓝藻主要次生代谢产物在生态系统中的迁移转化规律、生态效应及对人类健康的潜在影响
1.微囊藻毒素多器官毒性效应及机制与人类健康的研究
随着水体富营养化与全球气候变化，蓝藻水华大量频繁暴发，已成为全球性的生态灾难。有毒蓝藻的次生代谢产物—蓝藻毒素不仅损害了生态系统的健康，还通过饮水、食物链等途径进入人体，严重威胁着人类健康。利用模式动物、细胞系等建立模型，通过分子生物学技术及多组学关联性分析（转录组学、蛋白质组和代谢组学）对多种靶器官进行生殖毒性、遗传毒性、内分泌系统毒性、神经毒性等方面研究，阐明微囊藻毒素多器官毒性效应及机制。并结合野外调查、人群采样及流行病学数据，系统分析微囊藻毒素对人体健康的影响。为微囊藻毒素控制标准的制定提供理论基础与技术支撑。
2.异味物质的变化特征及其环境影响因子研究
异味物质是蓝藻常见的次生代谢产物，其产生对居民饮水安全、渔业水产品质量等有重大影响，甚至影响全球气候变化。通过长期生态学研究、大范围野外调查以及区域影响评价，建立异味物质定量检测方法，积累大量的研究经验和基础数据，结合室内控制实验，探讨环境因子对异味物质的变化特征的作用机制，评估区域尺度上异味物质对饮水安全和水产品质量的影响，并从全球尺度上分析异味物质与气候变化的关系。


承担项目情况
2008.07-2012.06 蓝藻水华生态灾害形成机理及防治的基础研究，主持，国家级
2011.01-2013.12 谷胱甘肽途径对微囊藻毒素-LR/RR诱导大鼠肝脏DNA损伤的抑制作用及机制探讨，主持，国家级
2012.12-2016.12 湖泛监控指标及环境效应综合评估技术研究，主持，国家级
2012.12-2017.12 洱海藻类水华风险预测技术，主持，国家级
2014.01-2017.12 水生态毒理学，主持，国家级（优秀青年科学基金）
2015.12-2016.12 东湖典型生态系统长期变化趋势分析，主持，部委级
2016.06-2018.12 城市湖泊多组分在线监测平台建设，主持，部委级
2016.01-2018.12 “三河三湖”重点流域水生动物入侵种调查编目，主持，国家级
2017.01-2020.06 滨湖城市湖泊生态系统退化识别与草型湖泊弹性变化阈值，主持，国家级
2018.01-2021.12 微囊藻毒素-LR慢性暴露对哺乳动物大鼠生殖与发育毒性的系统毒理学研究，主持，国家级
2018.07-2023.07 鲤科鱼类东亚特有类群对江湖复合生态系统的繁殖适应策略，主持，中科院级


科研成果
本课题组围绕蓝藻水华的两类衍生污染物—微囊藻毒素（简称MC）和异味化合物，进行了数年的野外调查、室内分析检测技术和方法、及生态毒理学研究，在MC对人类及水生动物的健康与毒性效应、鱼类规模化控制有毒蓝藻的生态学实践、MC的代谢产物（通过GSH途径）与异味物质检测技术等方面取得了若干具有理论和实践意义的创新性研究成果。先后在相关领域核心期刊Water Research, Ecology, Journal of Ecology, Journal of Hazardous Materials, Environmental Science & Technology, Archives of Toxicology, Toxicological Sciences, Environmental Pollution, Science of the Total Environment等上发表 SCI论文87篇。截至2021年4月，SCI他引2200余次，H指数=30，多篇论文被世界卫生组织（WHO）、欧洲食品安全局（EFSA）、美国环境总署（USEPA）和加拿大卫生部（Health Canada）等列为制定MC控制标准的技术支撑文献。

代表性论文：
1. Chen L^#, Shi T^#, Wang YT, He J, Zhao X, Wang YK, Giesy JP, Chen F, Chen Y, Tuo X, Chen J*, Xie P. Effects of acute exposure to microcystins on hypothalamic-pituitary-adrenal (HPA), -gonad (HPG) and -thyroid (HPT) axes of female rats. Sci. Total Environ., 2021: 145196.
2. Chen J, Xie P, Yu DZ, Xie LJ, Chen J*. Dynamic change of sedimental microbial community during black bloom-an in situ enclosure simulation study. Microb. Ecol., 2021, 81: 304-313.
3. Zhang WZ, Shen H*, Zhang J, Yu J, Xie P, Chen J*. Physiological differences between free-floating and periphytic filamentous algae, and specific submerged macrophytes induce proliferation of filamentous algae: A novel implication for lake restoration. Chemosphere, 2020, 239: 124702.
4. Xia WL, Chen L, Deng XW, Liang GD, Giesy JP, Rao QY, Wen ZH, Wu Y, Chen J*, Xie P*. Spatial and interspecies differences in concentrations of eight trace elements in wild freshwater fishes at different trophic levels from middle and eastern China. Sci. Total Environ., 2019, 672: 883-892.
5. Deng XW, Qi M, Ren R, Liu JR, Sun XX, Xie P, Chen J*. The relationships between odors and environmental factors at bloom and non-bloom area in Lake Taihu, China. Chemosphere, 2019, 218: 569-576.
6. Zhang WZ, Wang L, Chen L, Shen H*, Chen J*. Proliferation of filamentous green algae along with submerged macrophytes planting, and the role of microbe. Ecol. Eng., 2019, 139: 105570.
7. Chen L^#, Hu YF^#, He J, Chen J*, Giesy JP, Xie P*. Responses of the proteome and metabolome in livers of zebrafish exposed chronically to environmentally relevant concentrations of microcystin-LR. Environ. Sci. Technol., 2017, 51: 596-607.
8. He J^#, Li G^#, Chen J^#, Lin J, Zeng C, Chen J, Deng J, Xie P*. Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study.Arch. Toxicol., 2017, 91: 465-480.
9. Chen L, Chen J*, Zhang XZ, Xie P*. A review of reproductive toxicity of microcystins. J. Hazard. Mater., 2016, 301: 381-399.
10. Yu DZ, Xie P, Zeng C, Xie LJ, Chen J*. In situ enclosure experiments on the occurrence, development and decline of black bloom and the dynamics of its associated taste and odor compounds. Ecol. Eng., 2016, 87: 246-53.
11. Chen L, Li SC, Guo XC, Xie P, Chen J*. The role of GSH in microcystin-induced apoptosis in rat liver: involvement of oxidative stress and NF-kB. Environ. Toxicol., 2016, 31: 552-560.
12. Chen J, Xie P, Lin J, He J, Zeng C, Chen J*. Effects of microcystin-LR on gut microflora in different gut regions of mice. J. Toxicol. Sci., 2015, 40: 485-494.
13. Zhao SJ, Li GY*, Chen J*. A proteomic analysis of prenatal transfer of microcystin-LR induced neurotoxicity in rat offspring. J. Proteomics., 2015, 114: 197-213.
14. Li SC, Chen J*, Xie P, Guo XC, Fan HH, Yu DZ, Zeng C, Chen L. The role of glutathione detoxification pathway in MCLR-induced hepatotoxicity in SD rats. Environ. Toxicol., 2015, 3: 1470-1480.
15. Li W, Chen J*, Xie P, He J, Guo XC, Tuo X, Zhang W, Wu LY. Rapid conversion and reversible conjugation of glutathione detoxification of microcystins in bighead carp (Aristichthys nobilis). Aquat. Toxicol., 2014, 147: 18-25.
16. Li W, Xie P, Chen J*, He J, Guo XC, Yu DZ, Chen L. Quantitative liquid chromatography-tandem mass spectrometry method for determination of microcystin-RR and its glutathione and cysteine conjugates in fish plasma and bile. J. Chromatogr. B., 2014, 963: 113-118.
17. Ma ZM, Niu Y, Xie P, Chen J*, Tao M, Deng XW. Off-flavor compounds from decaying cyanobacterial blooms of Lake Taihu. J. Environ. Sci.-China., 2013, 25: 495-501.
18. Chen J, Xu QQ, Wang TH, Collet B, Corripio-Miyar Y, Bird S, Xie P, Nie P, Secombes CJ, Zou J. Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage speci?c groups in teleost ?sh. Dev. Comp. Immunol., 2013, 41: 137-152.
19. Qi M^#, Chen J^#, Sun XX, Deng XW, Niu Y, Xie P*. Development of models for predicting the predominant taste and odor compounds in Taihu Lake, China. PLoS ONE, 2012, 7: e51976.
20. He J, Chen J*, Wu LY, Li GY, Xie P*. Metabolic response to oral MC-LR exposure in the rat by NMR-Based metabonomic study. J. Proteom. Res., 2012, 11: 5934-5946.
21. He J, Chen J*, Xie P, Zhang D W, Li G Y, Wu L Y, Zhang W, Guo X C, Li S C. Quantitatively evaluating detoxification of the hepatotoxic microcystins through the glutathione and cysteine pathway in the cyanobacteria-eating bighead carp. Aquat. Toxicol., 2012, 116-117: 61-68.
22. Zhang DW, Yang Q, Xie P, Deng XW, Chen J*, Dai M. The role of cysteine conjugation in the detoxification of microcystin-LR in liver of bighead carp (Aristichthys nobilis): a field and laboratory study. Ecotoxicology, 2012, 21: 244- 252.
23. Cai Y, Li HY, Hao L, Li GY, Xie P, Chen J*. Identification of cda gene in bighead carp and its expression in response to microcystin-LR. Ecotoxicol. Environ. Saf., 2012, 79: 206–213.
24. Deng XW, Xie P*, Qi M, Liang GD, Chen J*, Ma ZM, Jiang Y. Microwave-assisted purge-and-trap extraction device coupled with gas chromatography and mass spectrometry for the determination of five predominant odors in sediment, fish tissues, and algal cells. J. Chromatogr. A, 2012, 1219: 75-82.
25. Wu LY, Xie P*, Chen J*, Zhang DW, Liang GD. Development and validation of a liquid chromatography–tandem mass spectrometry assay for the simultaneous quantitation of microcystin-RR and its metabolites in fish liver. J. Chromatogr. A., 2010, 1217: 1455-1462.
26. Chen J, Xie P*, Ma ZM, Niu Y, Tao M, Deng XW, Wang Q. A systematic study on spatial and seasonal patterns of eight taste and odor compounds with relation to various biotic and abiotic parameters in Gonghu Bay of Lake Taihu, China. Sci. Total Environ., 2010, 409: 314-325.
27. Chen J, Xie P*, Li L, Xu J. First identification of the hepatotoxic microcystins in the serum of a chronically exposed human population together with indication of hepatocellular damage. Toxicol. Sci., 2009, 108: 81-89.
28. Chen J, Zhang DW, Xie P*, Wang Q, Ma ZM. Simultaneous determination of microcystin contaminations in various vertebrates (fish, turtle, duck and water bird) from a large eutrophic Chinese lake, Lake Taihu, with toxic Microcystis blooms. Sci. Total Environ., 2009, 407: 3317-3322.
29. Chen J, Xie P*. Microcystin accumulation in freshwater bivalves from Lake Taihu, China and the potential risk to human consumption. Environ. Toxicol. Chem., 2007, 26: 160-167.
30. Chen J, Xie P*, Zhang DW, Lei HH. In situ studies on the distribution patterns and dynamics of microcystins in a biomanipulation fish - bighead carp (Aristichthys nobilis). Environ. Pollut., 2007, 147: 150-157.
31. Chen J, Xie P*, Zhang DW, Ke ZX, Yang H. In situ studies on the bioaccumulation of microcystins in the phytoplanktivorous silver carp (Hypophthalmichthys molitrix) stocked in Lake Taihu with dense toxic Microcystis blooms. Aquaculture, 2006, 261: 1026-1038.
32. Chen J, Xie P*, Guo LG, Zheng L. Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in a freshwater snail (Bellamya aeruginosa) from a large shallow, eutrophic lake of the subtropical China. Environ. Pollut., 2005, 134: 423-430.
33. Chen J, Xie P*. Seasonal dynamics of the hepatotoxic microcystins in various organs of four freshwater bivalves from the large eutrophic Lake Taihu of subtropical China and the risk to human consumption. Environ. Toxicol., 2005, 20: 572-584.
34. Chen J, Xie P*. Tissue distributions and seasonal dynamics of the hepatotoxic microcystins-LR and -RR in two freshwater shrimps, Palaemon modestus and Macrobrachium nipponensis, from a large shallow, eutrophic lake of the subtropical China. Toxicon, 2005, 45: 615-625.

获奖及荣誉
2005年获中科院院长优秀奖
2010年获利华休姆信托—海外访问****奖学
2012年获第三届武汉青年科技奖
2018年获中国生态系统研究网络(CERN)科技贡献奖


社会任职
2016-2020年任中国海洋湖沼学会湖泊分会常务理事
2017-2020年任武昌区人大代表
2021-至今任Toxins期刊编委


指导研究生情况
在读研究生：
张佳（2018级博士生）、饶骁（2019级博士生）、岳智颖（2020级博士生）、王蓝天（2019级硕士生）、彭扬辉（2020级硕士生）、张佳（2021级硕士生）

毕业研究生：
李尚春（2015年博士毕业）、谢丽娟（2015年硕士毕业）、余得昭（2016年博士毕业）、朱荣（2018年博士毕业）、张蔚珍（2019年博士毕业）、刘佳睿（2019年硕士毕业）、陈峰（2021年博士毕业）、陈阳（2021年硕士毕业）

研究生获奖：
1.2017年张蔚珍获得大北农励志奖学金
2.2019年张蔚珍获得博士研究生国家奖学金


备注
欢迎有生物学、生态学、环境科学、分析化学、医学等背景的考生报考。