周炳升　研究员博士研究生

职　　称： 研究员
学　　历： 博士研究生
联系方式： 86-
电子邮件： bszhou@ihb.ac.cn
办公室： 3号楼729
个人网页：


教育经历
1982.9-1986.6 武汉大学 生物系 细胞生物学专业 本科
1986.9-1989.6 武汉大学 生物系 动物学专业 硕士
1997.5-2000.12 香港城市大学 生物与化学系 环境毒理学专业博士


主要职历
1989.7-1995.8中国科学院水生生物研究所，研究实习员、助理研究员
1995.9-1996.10香港城市大学生物与化学系，研究助理
2001.7-2003.6加拿大McMaster大学生物系，博士后
2003.7-2004.12 香港城市大学，海岸污染与生态毒理学研究中心，博士后
2005.1-至今 中国科学院水生生物研究所，水环境工程研究中心，研究员


招生专业
水生生物学（硕士生，博士生）


研究方向
环境毒理学，特别是基于水环境中典型有机污染物对水生生物的毒性效应、风险评价、健康危害以及毒理机制的研究，并发展有机污染物水生态风险评价的技术和方法，以及典型有机污染物在水环境中的行为、转移规律。


承担项目情况
1. 国家自然科学基金委员会，面上项目，典型溴代阻燃剂与纳米二氧化钛、有机碳相互作用诱导的斑马鱼甲状腺内分泌干扰效应，2020-01至2023-12, 主持。
2. 国家重点研发计划蓝色粮仓科技创新重点专项“典型养殖系统对自然水域生态系统的影响机理”项目，课题“池塘养殖物质循环及对湖泊生态系统的影响机理”。2018-12至2022-12，主持课题。
3. 国家自然科学基金委员会，重点项目，新兴溴代阻燃剂的水环境暴露、毒性效应及分子机制，2018-01至2022-12,主持。
4. 国家科技重大专项, 南水北调中线输水水质预警与业务化管理平台，南水北调课题：中线总干渠重金属与持久性有机污染物的时空格局及其生态风险，2017-01至2021-06，参加。
5. 中科院先导专项B，典型内分泌干扰物对斑马鱼发育毒性效应与分子机制研究，2014-06至2018-12，主持子课题。
6. 环保部公益项目，电子废弃物溴代阻燃剂和重金属复合污染的人体评价技术研究，2013-01-2016-12，参加。
7. 科技部863计划，溴代阻燃剂的暴露和效应评估新技术，2007-01至2009-12，主持。
8. 国家自然科学基金委员会，面上项目，纳米TiO2与典型有机污染物的复合暴露对斑马鱼的毒性效应，2016-01至2019-12，主持。
9. 国家自然科学基金委员会，面上项目，水环境中的孕激素类污染物对斑马鱼的内分泌干扰效应和分子机制，2013-01至2016-12，主持。
10. 国家自然科学基金委员会，重点项目，有机农药与含铜锌无机农药的协同毒性作用机理研究，2013-01至2017-12，参加。
11. 中科院知识创新重要方向项目，离体细胞系的构建和有毒污染物离体筛选技术的研究，2008-01至2010-12，主持子课题。
12. 国家自然科学基金委员会，重大项目，典型持久性有机污染物的环境过程与毒理效应，2009-01至2012-12，主持项目中的课题，典型持久性有机污染物的毒理学效应。
13. 国家自然科学基金委员会，面上项目，典型全氟代有机污染物对斑马鱼的发育毒性及雌激素效应的机理研究，2009-01至2011-12，主持。
14. 国家自然科学基金委员会，面上项目，有机污染物全氟辛烷磺酰基化合物的分子生态毒理学效应及危险评价，2006-01至2008-12，主持。
15. 中科院知识创新重要方向项目，持久性有机污染物的分子生态毒理学效应与生物可降解性研究，2005-01至2007-12，主持。
16. 中国科学院，****人才项目，2005-01至2007-12，主持。


科研成果
发展了以斑马鱼早期发育敏感期为对象的生物毒性测试方法，推进了小型模式鱼类胚胎期在评价污染物毒理学效应研究中的应用。建立了水体中钛纳米颗粒的检测技术，明确纳米二氧化钛可作为有机污染物和重金属的载体，增强对鱼类的毒性。发现多溴联苯醚和有机磷阻燃剂三(1,3-二氯-2-丙基)磷酸盐（TDCIPP）可经由母代积累传递给子代，引起对子代的健康危害。揭示了鱼类早期发育阶段有机磷阻燃剂TDCIPP暴露引起成年期神经毒性的表观遗传学机制。发现新溴代阻燃剂四溴邻苯二甲酸双酯（TBPH）干扰斑马鱼脂质代谢、引起非酒精性脂肪肝以及表观修饰的作用。

代表性论文：
1. Wei Guo, Lei Lei, Xiongjie Shi, Ruiwen Li, Qiangwei Wang, Jian Han, Lihua Yang, Lianguo Chen, Bingsheng Zhou*, 2021. Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant. Environ. Sci. & Technol., 55, 6926-6935.
2. Qipeng Shi, Wei Guo, Qiancheng Shen, Jian Han, Lei Lei, Lianguo Chen, Lihua Yang, Chenglian Feng, Bingsheng Zhou*, 2021. In vitro biolayer interferometry analysis of acetylcholinesterase as a potential target of aryl-organophosphorus flame-retardants. Journal of Hazardous Materials, 409, 124999.
3. Xiangping Chen, Wei Guo, Lei Lei, Yongyong Guo, Lihua Yang, Jian Han, Bingsheng Zhou*. 2021. Bioconcentration and developmental neurotoxicity of novel brominated flame retardants, hexabromobenzene and pentabromobenzene in zebrafish. Environmental Pollution, 268, 115895.
4. Wei Guo, Jian Han, Shengmin Wu, Xiongjie Shi, Bingsheng Zhou*, 2020. Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate affects lipid metabolism in zebrafish larvae via DNA methylation modification. Environ. Sci. & Technol., 54,355-363.
5. Ruiwen Li, Wei Guo, Lei Lei, Ling Zhang, Yunhao Liu, Jian Han, Lianguo Chen, Bingsheng Zhou*, 2020. Early-life exposure to the organophosphorus flame retardant tris (1, 3-dichloro-2-propyl) phosphate induces delayed neurotoxicity associated with DNA methylation in adult zebrafish. Environment International 134, 105293.
6. Shengmin Wu, Shenghu Zhang, Yang Gong, Lili Shi, Bingsheng Zhou^*, 2020. Identification and quantification of titanium nanoparticles in surface water: A case study in Lake Taihu, China. Journal of Hazardous materials, 382, 121045.
7. Lianguo Chen*, James C. W. Lam, Lizhu Tang, Chenyan Hu, Mengyuan Liu, Paul K. S. Lam, Bingsheng Zhou*, 2020. Probiotic Modulation of Lipid Metabolism Disorders Caused by Perfluorobutanesulfonate Pollution in Zebrafish. Environ. Sci. & Technol., 54,7494-7503.
8. Xiaochen Wang, Siyuan Ling, Kelan Guan, Xiaojun Luo, Lianguo Chen, Jian Han,Wei Zhang, Bixian Mai, Bingsheng Zhou*, 2019. Bioconcentration, Biotransformation, and Thyroid Endocrine Disruption of Decabromodiphenyl Ethane (DBDPE), A Novel Brominated Flame Retardant, in Zebrafish Larvae. Environ. Sci. & Technol., 53, 8437-8446.
9. Yongyong Guo, Lianguo Chen, Juan Wu, Jianghuan Hua, Lihua Yang, Wei Zhang, Bingsheng Zhou*, 2019. Transgenerational Effects of Parental Bisphenol A and Nano-TiO2 Co-exposure on the Thyroid Endocrine System and Neurodevelopment of Zebrafish Offspring. Sci Total Environ, 650, 557-565.
10. Lianguo Chen, Chenyan Hu, Mirabelle M. P. Tsui, Teng Wan, Drew R. Peterson, Qipeng Shi, Paul K. S. Lam, Doris W. T. Au, James C. W. Lam*, Bingsheng Zhou*, 2018. Multigenerational Disruption of Thyroid Endocrine System in Marine Medaka after A Life-Cycle Exposure to Perfluorobutane Sulfonate (PFBS). Environ Sci & Technol, 52, 4432-4439.
11. Lianguo Chen, Weipeng Zhang, Chenyan Hu, Nelson Lok-Shun Lai, Jianghuan Hua, Paul K.S. Lam, James Lam*, Bingsheng Zhou*, 2018. Acute exposure to PBDEs at an environmentally realistic concentration causes abrupt changes in the gut microbiota and host health of zebrafish. Environmental Pollution 240, 17-26.
12. Lianguo Chen,Yongyong Guo,Chenyan Hu,Paul K.S. Lam,James CW Lam*, BingshengZhou*, 2018. Dysbiosis of gut microbiota by chronic coexposure to titanium dioxide nanoparticles and bisphenol A: Implications for host health in zebrafish. Environmental Pollution, 234, 307-317.
13. Chen L, Zhang W, Hua J, Hu C, Lok-Shun Lai N, Qian PY, Lam PKS, Lam JCW, Zhou B*. 2018. Dysregulation of Intestinal Health by Environmental Pollutants: Involvement of the Estrogen Receptor and Aryl Hydrocarbon Receptor. Environ Sci & Technol., 52, 2323-2330.
14. Li R, Zhou P*, Guo Y, Lee JS, Zhou B*, 2017. Tris (1, 3-dichloro-2-propyl) phosphate induces apoptosis and autophagy in SH-SY5Y cells: Involvement of ROS-mediated AMPK/mTOR/ULK1 pathways. Food & Chemical Toxicology 100, 183-196.
15. Chen L, Au DWT, Hu C, Peterson DR, Zhou B* and Qian PY*, 2017. Identification of Molecular Targets for 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in Teleosts: New Insight into Mechanism of Toxicity. Environ Sci &Technol 51, 1840-1847.
16. Lianguo Chen, Xianfeng Wang, Xiaohua Zhang, Paul K.S. Lam, Yongyong Guo, James C.W. Lam*, Bingsheng Zhou*, 2017. Transgenerational endocrine disruption and neurotoxicity in zebrafish larvae after parental exposure to binary mixtures of decabromodiphenyl ether (BDE-209) and lead. Environmental Pollution 230, 96-106.
17. Hua J, Han J, Wang X, Guo Y, Zhou B*, 2016. The binary mixtures of megestrol acetate and 17a-ethynylestradiol adversely affect zebrafish reproduction. Environmental Pollution 213, 776-784.
18. Lianguo Chen, Biran Zhu, Yongyong Guo, Tao Xu, Jae-Seong Lee, Pei-Yuan Qian, Bingsheng Zhou*, 2016. High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE- 209) and lead, in zebrafish larvae. Environmental Pollution 214, 324-333.
19. Qi Fang, Qipeng Shi, Yongyong Guo, Jianghuan Hua, Xianfeng Wang, Bingsheng Zhou*, 2016. Enhanced Bioconcentration of Bisphenol A in the Presence of Nano-TiO₂ Can Lead to Adverse Reproductive Outcomes in Zebrafish. Environ Sci &Technol 50, 1005-1013.
20. Biran Zhu,Qiangwei Wang,Xiongjie Shi,Yongyong Guo,Tao Xu,BingshengZhou*, 2016. Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae. Chemosphere 144, 1646-1654.
21. Zhou B*, 2015. Adverse outcome pathway: Framework, application, and challenges in chemical risk assessment. Journal of Environmental Sciences 35, 191-193.
22. Jianghuan Hua, Jian Han, Yongyong Guo, Bingsheng Zhou*, 2015.The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations. Aquatic Toxicology 166, 1-9.
23. Qiangwei Wang, Nelson Lok-Shun Lai, Xianfeng Wang, Yongyong Guo, Paul Kwan-Sing Lam^, James Chung-Wah Lam*, Bingsheng Zhou*, 2015. Bioconcentration and Transfer of the Organophorous Flame Retardant 1,3-dichloro 2-propyl phosphate (TDCPP) Causes Thyroid Endocrine Disruption and Developmental Neurotoxicity in Zebrafish Larvae. Environ Sci &Technol 49, 5123–5132.
24. Yongyong Guo, Yuanjin Yang, Yong Gao, Xianfeng Wang, Bingsheng Zhou*, 2015. The impact of long term exposure to phthalic acid esters on reproduction in Chinese rare minnow (Gobiocypris rarus). Environmental Pollution 203, 130-136.
25. Qiangwei Wang, James CW Lam, Jian Han, Xianfeng Wang, Yongyong Guo, Paul KS Lam, Bingsheng Zhou*, 2015. Developmental exposure to the organophosphorus flame retardant Tris(1,3-dichloro-2-propyl) phosphate: estrogenic activity, endocrine disruption and reproductive effects on zebrafish. Aquatic Toxicology 160, 163–171.
26. Xianfeng Wang, Lihua Yang, Yuanyuan Wu, Changjiang Huang, Qiangwei Wang, Jian Han, Yongyong Guo, Xiongjie Shi, Bingsheng Zhou*, 2015. The developmental neurotoxicity of PBDEs: Effect of DE-71 on dopamine in zebrafish larvae. Environ Toxicol & Chem 34, 1119–1126.
27. Qi Fang, Xiongiie Shi, Liping Zhang, Qiangwei Wang, Xianfeng Wang, Yongyong Guo, Bingsheng Zhou*, 2015. Effect of titanium dioxide nanoparticles on the bioavailability, metabolism, and toxicity of pentachlorophenol in zebrafish larvae. Journal of Hazardous Materials 283, 897-904.
28. Qiangwei Wang, James Chung-Wah Lam, Yin-Chung Man, Nelson Lok-Shun Lai, Karen Ying Kwok, Yong yong Guo, Paul Kwan-Sing Lam, Bingsheng Zhou*, 2015. Bioconcentration, Metabolism and Neurotoxicity of the Organophorous Flame Retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to Zebrafish. Aquatic Toxicology 158, 108-115.
29. Biran Zhu, Qiangwei Wang, Xianfeng Wang, Bingsheng Zhou*, 2014. Impact of co-exposure of lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae. Aquatic Toxicology 157, 186-195.
30. Jian Han, Qiangwei Wang, Xianfeng Wang, Yonggang Li, Sheng Wen, Shan Liu, Guangguo Ying, Yongyong Guo, Bingsheng Zhou*, 2014. Impact of the synthetic progestin megestrol acetate on zebrafish reproduction. Aquatic Toxicology 150, 66-72.
31. Liqin Yu, Chunsheng Liu, Qi Chen, Bingsheng Zhou*, 2014. Endocrine disruption and reproduction impairment in zebrafish after long-term exposure to DE-71. Environ Toxicol & Chem 33, 1354–1362.
32. Wang Q, Chen Q, Zhou P, Li W, Wang J, Huang C, Wang X, Lin K, Zhou B*, 2014. Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae. Nanotoxicology 8 (S1), 196–207.
33. Guo Y, Zhou B*, 2013. Thyroid endocrine system disruption by pentachlorophenol: an in vitro and in vivo assay. Aquatic Toxicology 142–143, 138-145.
34. Wang X, Yang Y, Zhang L, Ma Y, Han J, Yang L, Zhou B*, 2013. Endocrine disruption by di-(2-ethylhexyl)-phthalate in Chinese rare minnow (Gobiocypris rarus). Environ Toxicol & Chem 32, 1846-1854.
35. Chen L, Huang Y, Huang C, Hu B, Hu C, Zhou B*, 2013. Acute exposure to DE-71 causes alterations in visual behavior in zebrafish larvae. Environ Toxicol & Chem 32, 1370-1375.
36. Wang Q, Liang K, Liu J, Yang L, Guo Y, Liu C*, Zhou B*, 2013. Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis. Aquatic Toxicology 126, 207-213.
37. Chen L, Huang C, Hu C, Ke Y, Yang L, Zhou B*, 2012. Acute exposure to DE-71: Effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae. Environ Toxicol & Chem 31, 2338-2344.
38. Chen L^, Yu K, Huang C, Yu L, Zhu B, PKS Lam, JCW Lam*, Zhou B*, 2012. Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. Environ Sci & Technol 46, 9727-9734.
39. Ma Y, Han J, Guo Y, Lam PKS, Wu RSS, Giesy JP, Zhang X, Zhou B*, 2012. Disruption of endocrine function in in vitro H295R cell-based and in in vivo assay in zebrafish by 2,4-dichlorophenol. Aquatic Toxicology 106-107, 173-181.
40. Chen Q, Yu L, Yang L, Zhou B*, 2012. Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae.Aquatic Toxicology 110-111, 141-148.
41. Chen L, Hu C, Huang C, Wang Q, Wang X, Yang L, Zhou B*, 2012. Alterations in retinoid status after long-term exposure to PBDEs in zebrafish (Danio rerio). Aquatic Toxicology 120–121, 11–18.
42. Ma Y, Han J, Guo Y, Lam PKS, Wu RSS, Giesy JP, Zhang X, Zhou B*, 2011. Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP. Toxicology 282, 146–153.
43. Yu L, Lam JCW, Guo Y, Wu RSS, Lam* PKS, Zhou B*, 2011. Parental transfer of PBDEs and thyroid endocrine disruption in zebrafish. Environ Sci & Technol 45, 10652–10659.
44. Liu C, Zhang X, Deng J, Hecker M, AL-Khedhairy A, Giesy JP, Zhou B*, 2011. Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA and HPT Axes in zebrafish. Environ Sci & Technol 45, 769–775.
45. Liu C, Zhang X*, Chang H, Jones P, Wiseman S, Naile J, Hecker M, Giesy JP, Zhou B*, 2010. Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: Targeting the cAMP signaling cascade. Toxicology & Applied Pharmacology 247, 222-228.
46. Shi X, Zhou B*, 2010. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicological Sciences 115, 391 – 400.
47. Yu L, Deng J, Shi X, Liu C, Yu K, Zhou B*, 2010. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis of zebrafish larvae. Aquatic Toxicology 97, 226-233.
48. Liu C, Deng J, Yu L, Ramesh M, Zhou B*, 2010. Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol. Aquatic Toxicology 96, 70-76.
49. Deng J, Liu C, Yu L, Zhou B*, 2010. Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction. Toxicology & Applied Pharmacology 243, 87-95.
50. Shi X, Yeung LWY, Lam PKS, Wu RSS, Zhou B*, 2009. Protein Profiles in Zebrafish (Danio rerio) Embryos Exposed to PFOS. Toxicological Sciences 110, 334-340.
51. Deng J, Yu L, Liu C, Yu K, Shi X, Yeung L, Lam PKS, Wu RSS, Zhou B*, 2009. Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos. Aquatic Toxicology 93, 29-36.
52. Liu C, Yu L, Deng J, Lam PKS, Wu RSS, Zhou B*, 2009. Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic–pituitary–gonadal (HPG) axis of zebrafish. Aquatic Toxicology 93, 131-137.
53. Du Y, Shi X, Liu C, Yu K, Zhou B*, 2009. Chronic effects of waterborne PFOS exposure on growth, survival and hepatotoxicity in zebrafish: a partial life-cycle test. Chemosphere 74, 723-729.
54. Yu K, He Y, Yeung LWY, Lam PKS, Wu RSS, Zhou B*, 2008. DE-71-induced apoptosis involving intracellular calcium and the Bax-mitochondria-caspase protease pathway in human neuroblastoma cells in vitro. Toxicological Sciences 104, 341-351.
55. Shi X, Du Y, Lam PKS, Wu RSS, Zhou B*, 2008. Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS. Toxicology & Applied Pharmacology 230, 23-32.
56. Liu C, Du Y, Zhou B*, 2007. Evaluation of estrogenic activities and mechanism of action of perfluorinated chemicals determined by vitellogenin induction in primary cultured tilapia hepatocytes. Aquatic Toxicology 85, 267-277.
57. Liu C, Yu K, Shi X, Wang J, Lam PKS, Wu RSS, Zhou B*, 2007. Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus). Aquatic Toxicology 82, 135-143.
58. Zhou B*, Liu C, Wang J, Lam PKS, Wu RSS, 2006. Primary cultured cells as sensitive in vitro model for assessment of toxicants-comparison to hepatocytes and gill epithelia. Aquatic Toxicology 80, 109-118.

专利：

论著：周炳升，杨丽华，刘春生：“持久性有机污染物的内分泌干扰效应”。科学出版社，2018。

获奖及荣誉
2011年获中国科学院优秀研究生导师奖
2012年获中国科学院朱李月华优秀教师奖
2013年获中国科学院优秀研究生指导教师奖
2015年获政府特殊津贴
2019年获教育部高校科学研究优秀成果奖（二等）（林群声、林忠华、周炳升、吕绮霞、陈联国）。“新兴有机污染物在环境介质中的赋存、富集与生物毒性。


社会任职
中国化学会环境化学专业委员会委员
中国毒理学会分析毒理专业委员会委员
Aquatic Toxicology, Chemosphere, Journal of Environmental Sciences, 生态毒理学报、水生生物学报，环境化学，编委。


指导研究生情况
研究生获奖：
1. 2013年度和2016年度，刘春生、王蔷薇获中国科学院优秀博士论文奖；
2. 2012年度和2015年度，马彦博、王蔷薇获2012和2015年度博士研究生国家奖学金；孙玉苗获2020年度硕士研究生国家奖学金。