昌鸣先　　个人简历：

　　博士，研究员，博士生导师。2001年于华中农业大学获硕士学位;2005年于中国科学院水生生物研究所获博士学位并留所工作;2007年晋升为副研究员。2008年6月至11月在英国阿伯丁大学进行合作研究。2009年3月到2010年3月在英国阿伯丁大学作访问学者。2015年1月起任中国科学院水生生物研究所研究员。

　　先后主持国家自然科学基金重点项目和面上项目等研究任务6项。在PLOS Pathogens、Journal of Virology、Immunology、Developmental and Comparative Immunology等知名期刊发表学术论文50余篇。研究工作主要集中在鱼类免疫学以及感染免疫学。近期研究方向主要是研究脊椎动物免疫系统模式识别受体基因家族及其效应分子的可变剪接、以及可变剪接对免疫反应的调控作用及其分子作用机制。

　　研究方向：

　　抗病原体感染的分子机制，免疫系统基因的可变剪接及其功能，病原体-宿主的相互作用

　　招生专业：水生生物学

　　电话: 　86-**

电子邮件: 　mingxianchang@ihb.ac.cn

　　代表论著：

　　1. Chang MX, Zou J, Nie P, Huang B, Yu Z, Collet B, Secombes CJ. Intracellular interferons in fish: A unique means to combat viral infection. PLOS Pathogens. 2013, 9(11):e**.

　　2. Chang M, Collet B, Nie P, Lester K, Campbell S, Secombes CJ, Zou J. Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in rainbow trout (Oncorhynchus mykiss). J Virol. 2011,85(16):8403-12.

　　3. Chang MX, Wang T, Nie P, Zou J, Secombes CJ. Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains. Fish Shellfish Immunol. 2011,30(1):118-27.

　　4. Chang MX, Chen WQ, Nie P. Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling. Dev Comp Immunol. 2010;34:1-13.

　　5. Chang MX, Wang YP, Nie P. Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Fish Shellfish Immunol. 2009;26:264-74.

　　6. Chang MX, Nie P, Collet B, Secombes CJ, Zou J. Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts. Immunogenetics 2009;61:315-25.

　　7. Chang MX, Nie P. RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Vet Immunol Immunopathol. 2008;124:295-301.

　　8. Chang MX, Nie P, Wei LL. Short and long peptidoglycan recognition proteins (PGRPs) in zebrafish, with findings of multiple PGRP homologs in teleost fish. Mol Immunol. 2007;44(11):3005-23.

　　9. Chang MX, Sun BJ, Nie P. The first non-mammalian CXCR3 in a teleost fish: gene and expression in blood cells and central nervous system in the grass carp (Ctenopharyngodon idella). Mol Immunol. 2007;44(6):1123-34.

　　10. Zou PF, Chang MX*, Li Y, Zhang SH, Fu JP, Chen SN, Nie P*. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish Shellfish Immunol. 2015;43(1):13-24. (*示通讯作者)

　　11. Zou PF, Chang MX*, Xue NN, Liu XQ, Li JH, Fu JP, Chen SN, Nie P*. Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology. 2014;141(2):192-202.

　　12. Li JH, Chang MX*, Xue NN, Nie P*. Functional characterization of a short peptidoglycan recognition protein, PGRP5 in grass carp Ctenopharyngodon idella. Fish Shellfish Immunol. 2013;35(2):221-30.

　　13. Chen WQ, Hu YW, Zou PF, Ren SS, Nie P, Chang MX*. MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Dev Comp Immunol. 2015;49(1):19-30.

　　14. Yu ZL, Li JH, Xue NN, Nie P, Chang MX*. Expression and functional characterization of PGRP6 splice variants in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2014;47(2):264-74.

　　15. Hu YW, Yu ZL, Xue NN, Nie P, Chang MX*. Expression and protective role of two novel NACHT-containing proteins in pathogen infection. Dev Comp Immunol. 2014;46(2):323-32.

　　16. Li JH, Yu ZL, Xue NN, Zou PF, Hu JY, Nie P, Chang MX*. Molecular cloning and functional characterization of peptidoglycan recognition protein 6 in grass carp Ctenopharyngodon idella. Dev Comp Immunol. 2014;42(2):244-55.

　　17. Wang G, Li J, Zou P, Xie H, Huang B, Nie P, Chang M*. Expression pattern, promoter activity and bactericidal property of β-defensin from the mandarin fish Siniperca chuatsi. Fish Shellfish Immunol. 2012;33(3):522-31.

　　18. Guo HZ, Zou PF, Fu JP, Guo Z, Zhu BK, Nie P, Chang MX*. Characterization of two C-type lectin-like domain (CTLD)-containing proteins from the cDNA library of Chinese mitten crab Eriocheir sinensis. Fish Shellfish Immunol. 2011,30(2):515-24.