何春江 博士、教授、博导
che@whu.edu.cn；che@mail.hzau.edu.cn


实验室网站：
http://geneyun.net


教育经历：
1999.9-2003.6 武汉大学生命科学学院 生物技术 学士
2003.9-2008.6 武汉大学生命科学学院 细胞生物学 博士



工作经历与任职：
2009.2-2012.4 芝加哥大学医学院血液与肿瘤部 博士后 导师：陈建军
2012.5-2013.12 斯坦福大学医学院心血管与干细胞研究所 博士后 导师： Joseph Wu
2014.1-2020.9 武汉大学基础医学院 副教授
2020.10至今 华中农业大学生物医学与健康学院 教授



研究方向：
RNA代谢与疾病
结合组学大数据和实验方法研究疾病和免疫相关的RNA表达和调控
研究RNA代谢、非编码RNA在白血病及肿瘤中的作用和机制



代表论文：
1. Xu X*, Zhang J*, Tian Y*, Gao Y*, Dong X, Chen W, Yuan X, Yin W, Xu J, Chen K#, He C#, Wei L#. CircRNA inhibits DNA damage repair by interacting with host gene. Molecular Cancer. 2020 Aug 24;19(1):128. doi: 10.1186/s12943-020-01246-x.

2. Xiao S*, Cao S*, Huang Q*, Xia L*, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W, Li Y, Liu S, Zhu H, Tan K, Luo Q, Zhong M#, He C#, Xia L#. The RNA N(6)-methyladenosine modification landscape of human fetal tissues. Nature Cell Biology. 2019 Apr 29. doi: 10.1038/s41556-019-0315-4

3. Feng J*#, Chen K*, Dong X*, Xu X, Jin Y, Zhang X, Chen W, Han Y, Shao L, Gao Y, He C#. Genome-wide identification of cancer-specific alternative splicing in circRNA. Molecular Cancer. 2019 Mar 8; 18(1):35. doi: 10.1186/s12943-019-0996-0.

4. Han Y*, Feng J*, Xia L*, Dong X, Zhang X, Zhang S, Miao Y, Xu Q, Xiao S, Zuo Z, Xia L, He C#. CVm6A: A Visualization and Exploration Database for m6As in Cell Lines. Cells. 2019 Feb 17; 8(2). pii: E168. doi: 10.3390/cells**.

5. Feng J*, Xiang Y*, Xia S*, Liu H, Wang J, Ozguc F, Lei L, Kong R, Diao L, He C#, Han L#. CircView: a visualization and exploration tool for circular RNAs. Briefings in Bioinformatics. 2018 Nov 27. doi: 10.1093/bib/bbx070.

6. Lei L*, Xia S*, Liu D*, Li X*, Feng J, Zhu Y, Hu J, Xia L, Guo L, Chen F, Cheng H, Chen K, Hu H, Chen X, Li F, Zhong S, Mittal N, Yang G, Qian Z, Han L#, He C#. Genome-wide characterization of lncRNAs in acute myeloid leukemia. Briefings in Bioinformatics. 2018 Jun 20. doi: 10.1093/bib/bbx007.

7. Xia S*, Feng J*, Chen K*, Ma Y, Gong J, Cai F, Jin Y, Gao Y, Xia L, Chang H, Wei L, Han L#, He C#. CSCD: A database for cancer-specific circular RNAs. Nucleic Acids Research. 2018 Jan 4. doi: 10.1093/nar/gkx863. ESI高被引

8. Xia S*, Feng J*, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L#, He C#. Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Briefings in Bioinformatics. 2017 Nov 1. doi: 10.1093/bib/bbw081. ESI高被引

9. He C*#, Hu H*, Wilson KD*, Wu H, Feng J, Xia S, Churko J, Qu K, Chang HY, Wu JC#. Systematic Characterization of Long Non-Coding RNAs Reveals the Contrasting Coordination of Cis- and Trans- Molecular Regulation in Human Fetal and Adult Heart. Circulation Cardiovascular Genetics. 2016 Apr. pii: CIRCGENETICS.115.001264.

10. Li Z*, Herold T*, He C*, Valk PJ, Chen P, Jurinovic V, Mansmann U, Radmacher MD, Maharry KS, Sun M, Yang X, Huang H, Jiang X, Sauerland MC, Büchner T, Hiddemann W, Elkahloun A, Neilly MB, Zhang Y, Larson RA, Le Beau MM, Caligiuri MA, D?hner K, Bullinger L, Liu PP, Delwel R, Marcucci G, Lowenberg B, Bloomfield CD, Rowley JD, Bohlander SK, Chen J. Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study. Journal of Clinical Oncology. 2013 Mar 20;31(9):1172-81. doi: 10.1200/JCO.2012.44.3184.

11. He C*, Li Z*, Chen P*, Huang H, Hurst LD, Chen J. Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution. Nucleic Acids Research. 2012 May;40(9):4002-12. doi: 10.1093/nar/gkr1312.

12. Mi S*, Li Z*, Chen P*, He C*, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, Thirman MJ, Mulloy JC, Liu PP, Rowley JD, Chen J. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3710-5. doi: 10.1073/pnas..

13. He C*, Zhou F, Zuo Z, Cheng H, Zhou R. A global view of cancer-specific transcript variants by subtractive transcriptome-wide analysis. PLoS One. 2009;4(3):e4732. doi: 10.1371/journal.pone.**.

14. He C*, Cheng H, Zhou R. GATA family of transcription factors of vertebrates: phylogenetics and chromosomal synteny. Journal of Biosciences. 2007 Dec;32(7):1273-80.

15. He C*, Zuo Z, Chen H, Zhang L, Zhou F, Cheng H, Zhou R. Genome-wide detection of testis- and testicular cancer-specific alternative splicing. Carcinogenesis. 2007 Dec;28(12):2484-90.

其它共同作者论文：
Chen G, Yuan C, Duan F, Liu Y, Zhang J, He Z, Huang H, He C, Wang H. IGF1/MAPK/ERK signaling pathway-mediated programming alterations of adrenal cortex cell proliferation by prenatal caffeine exposure in male offspring rats. Toxicol Appl Pharmacol. 2018 Jan 14. pii: S0041-008X(18)30008-5. doi: 10.1016/j.taap.2018.01.008.

Chen X, Loo JX, Shi X, Xiong W, Guo Y, Ke H, Yang M, Jiang Y, Xia S, Zhao M, Zhong S, He C, Fu L, Li F. E6 protein expressed by high-risk HPV activates super-enhancers of the EGFR and c-MET oncogenes by destabilizing the histone demethylase KDM5C. Cancer Res. 2018 Jan 16. pii: canres.2118.2017. doi: 10.1158/0008-5472.CAN-17-2118.

Jiang X, Hu C, Ferchen K, Nie J, Cui X, Chen CH, Cheng L, Zuo Z, Seibel W, He C, Tang Y, Skibbe JR, Wunderlich M, Reinhold WC, Dong L, Shen C, Arnovitz S, Ulrich B, Lu J, Weng H, Su R, Huang H, Wang Y, Li C, Qin X, Mulloy J, Zheng Y, Diao J, Jin J, Li C, Liu PP, He C, Chen Y, Chen J. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099. doi: 10.1038/s41467-017-02290-w.

Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC. Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome. J Am Coll Cardiol. 2016 Nov 8;68(19):2086-2096. doi: 10.1016/j.jacc.2016.07.779.

Chen J, Zhuang Y, Zhang ZF, Wang S, Jin P, He C, Hu PC, Wang ZF, Li ZQ, Xia GM, Li G, Wang Y, Wan Q. Glycine confers neuroprotection through microRNA-301a/PTEN signaling. Mol Brain. 2016 May 26;9(1):59. doi:10.1186/s13041-016-0241-3.

Mukherjee D, Lu H, Yu L, He C, Lahiri SK, Li T, Zhao J. Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis. Oncotarget. 2016 Mar 14. doi: 10.18632/oncotarget.8083.

Gu M, Mordwinkin NM, Kooreman NG, Lee J, Wu H, Hu S, Churko JM, Diecke S, Burridge PW, He C, Barron FE, Ong SG, Gold JD, Wu JC. Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism. Eur Heart J. 2015 Apr 1;36(13):806-16. doi: 10.1093/eurheartj/ehu411.

Huang H, Jiang X, Li Z, Li Y, Song CX, He C, Sun M, Chen P, Gurbuxani S, Wang J, Hong GM, Elkahloun AG, Arnovitz S, Wang J, Szulwach K, Lin L, Street C, Wunderlich M, Dawlaty M, Neilly MB, Jaenisch R, Yang FC, Mulloy JC, Jin P, Liu PP, Rowley JD, Xu M, He C, Chen J. TET1 plays an essential oncogenic role in MLL-rearranged leukemia. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11994-9. doi: 10.1073/pnas..

Chen P, Price C, Li Z, Li Y, Cao D, Wiley A, He C, Gurbuxani S, Kunjamma RB, Huang H, Jiang X, Arnovitz S, Xu M, Hong GM, Elkahloun AG, Neilly MB, Wunderlich M, Larson RA, Le Beau MM, Mulloy JC, Liu PP, Rowley JD, Chen J. miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11511-6. doi: 10.1073/pnas..

Sharma A, Diecke S, Zhang WY, Lan F, He C, Mordwinkin NM, Chua KF, Wu JC. The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J Biol Chem. 2013 Jun 21;288(25):18439-47. doi: 10.1074/jbc.M112.405928.

Li Z, Zhang Z, Li Y, Arnovitz S, Chen P, Huang H, Jiang X, Hong GM, Kunjamma RB, Ren H, He C, Wang CZ, Elkahloun AG, Valk PJ, D?hner K, Neilly MB, Bullinger L, Delwel R, L?wenberg B, Liu PP, Morgan R, Rowley JD, Yuan CS, Chen J. PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood. 2013 Feb 21;121(8):1422-31. doi: 10.1182/blood-2012-07-442004.

Jiang X, Huang H, Li Z, He C, Li Y, Chen P, Gurbuxani S, Arnovitz S, Hong GM, Price C, Ren H, Kunjamma RB, Neilly MB, Salat J, Wunderlich M, Slany RK, Zhang Y, Larson RA, Le Beau MM, Mulloy JC, Rowley JD, Chen J. MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19397-402. doi: 10.1073/pnas..

Jiang X, Huang H, Li Z, Li Y, Wang X, Gurbuxani S, Chen P, He C, You D, Zhang S, Wang J, Arnovitz S, Elkahloun A, Price C, Hong GM, Ren H, Kunjamma RB, Neilly MB, Matthews JM, Xu M, Larson RA, Le Beau MM, Slany RK, Liu PP, Lu J, Zhang J, He C, Chen J. Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell. 2012 Oct 16;22(4):524-35. doi: 10.1016/j.ccr.2012.08.028.

Li Z, Huang H, Chen P, He M, Li Y, Arnovitz S, Jiang X, He C, Hyjek E, Zhang J, Zhang Z, Elkahloun A, Cao D, Shen C, Wunderlich M, Wang Y, Neilly MB, Jin J, Wei M, Lu J, Valk PJ, Delwel R, Lowenberg B, Le Beau MM, Vardiman J, Mulloy JC, Zeleznik-Le NJ, Liu PP, Zhang J, Chen J. miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nat Commun. 2012 Feb 21;3:688. doi: 10.1038/ncomms1681.

Li Z, Huang H, Li Y, Jiang X, Chen P, Arnovitz S, Radmacher MD, Maharry K, Elkahloun A, Yang X, He C, He M, Zhang Z, Dohner K, Neilly MB, Price C, Lussier YA, Zhang Y, Larson RA, Le Beau MM, Caligiuri MA, Bullinger L, Valk PJ, Delwel R, Lowenberg B, Liu PP, Marcucci G, Bloomfield CD, Rowley JD, Chen J. Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. Blood. 2012 Mar 8;119(10):2314-24. doi: 10.1182/blood-2011-10-386235.

Wang Y, Li Z, He C, Wang D, Yuan X, Chen J, Jin J. MicroRNAs expression signatures are associated with lineage and survival in acute leukemias. Blood Cells Mol Dis. 2010 Mar 15;44(3):191-7. doi: 10.1016/j.bcmd.2009.12.010.





研究资助：
1.国家自然科学面上项目circ-AFF2调控PRC2复合物介导的AML发生发展机制研究 2019.1- 2022. 12 主持
2.国家自然科学青年基金LncRNA-LINC01268通过激活HDAC2促进急性髓性白血病增殖的分子机制研究 2016.1-2018.12 主持
3.国家科技重大专项 艾滋病和病毒性肝炎等重大传染病防治(子课题) 基于大数据分析的风险评估和预警预测 2018.1-2020.12 参与
4.湖北省自然科学青年基金 基于生物信息学的急性髓性白血病lncRNA与mRNA作用网络的建立与验证 2015.1-2016.12 主持
5.中央高校自主科研青年项目 基于生物信息学的急性髓性白血病lncRNA与mRNA作用网络的建立与验证 2015.1-2016.12 主持
6.中央高校自主科研交叉项目 癌症特异环状RNA剪切数据库的构建 2018.1.-2019.12 主持




学术兼职：
Nucleic Acids Research，Briefings in Bioinformatics，Genomics, Proteomics & Bioinformatics，Genomics，Gene Reports，遗传学报，Journal of Cellular Biochemistry，European Journal of Pharmacology，Gene，Frontiers in Immunology, Scientific reports, Plos One, Inflammatory Bowel Diseases, Biomed Research International, Database等杂志审稿人