基本信息

姓名: 范楚川 出生年月:


性别: 男 硕/博导： 博导

民族: 汉 开设课程： 《普通遗传学》、《细胞生物学》、《植物生物技术概论》和《植物功能基因组学研究进展》

职称: 教授 研究方向： 油菜产量相关性状的重要基因的克隆与功能鉴定

学位: 理学博士

联系方式

办公电话：
电子邮件：fanchuchuan@mail.hzau.edu.cn

个人简介

2006年6月博士毕业于华中农业大学生化与分子生物学专业，后留校于植物科学技术学院遗传教研室。2008年3月-9月在美国Donald Danforth Plant Science Center进行访问学习。现为作物遗传改良国家重点实验室研究人员、油菜研究团队成员。主要研究领域包括：1）油菜重要产量性状的遗传基础解析：通过基因定位与克隆、关联分析等手段分离鉴定控制油菜重要产量性状的基因位点，并开展遗传调控机理研究；2）基因编辑技术在油菜中的应用：在油菜中建立和发展各种高效的基因编辑技术，并应用于油菜重要性状的遗传改良；利用该技术已成功创建了具有多室、黄籽、抗裂角、多粒、高油酸、矮杆、早花、多分枝和抗除草剂等多种优良性状的油菜资源；3）油菜的生物技术育种：利用转基因技术和基因组定点编辑技术等创建的优异油菜材料，结合分子标记辅助选择技术和小孢子培养技术开展油菜品种的遗传改良。在教学上，面向本科生主讲《普通遗传学》、《细胞生物学》和《生物技术综合实验》等课程；面向研究生讲授《植物生物技术概论》和《植物功能基因组学研究进展》。

科研项目

1.拟南芥AtPAT-PLA-IIIδ基因在非生物胁迫中的功能研究。国家自然基金，2010-2012，主持
2.油菜千粒重性状的基因定位与克隆。教育部新教师基金，2007-2009，主持
3.主要农作物产量和品质相关性状的基因克隆。国家自然基金，2007-2010，项目主持
4.高含油量的优质脂肪酸组成转基因油菜子课题。国家863计划，2009-2012，项目主持
5.利用拟南芥PLDα1基因改良作物抗旱和种子耐储藏性的研究。湖北省自然基金，2010-2012，主持
6.甘蓝型油菜千粒重主效位点TSWA7b的基因精细定位与候选基因鉴定。国家自然基金，2012-2015，主持
7.白菜型油菜角果多室基因mc的克隆与功能分析。国家自然基金，2014-2017，主持
8.油菜种质资源创新。湖北省科技支撑计划，2014-2015，主持
9.油菜粒重优异等位基因的克隆及调控机理研究。国家重点基础研究发展计划（973计划）子项目，2015-2019，主持
10.多室油菜的分子调控机理及其应用研究。校自主创新基金（高水平论文培育项目），2015.9-2020.9，主持
11.甘蓝型油菜多室种质资源创新及其形成的分子机理研究。国家自然科学基金面上项目，2017.1-2020.12，主持
12.转基因油菜新品种培育及产业化研究。转基因生物新品种培育重大专项，2018.01-2020.12，子项目主持

发明专利及获奖情况

发明专利：
1.张启发，范楚川，邢永忠. 一种控制水稻谷粒粒长和粒重的主效基因GS3. 中国专利授权号：ZL 7.4
2.Zhang QF, Fan Chuchuan, Xing YZ.　Rice Gene, GS3, Exerting Primary Control Over Grain Length and Grain Weight.　美国专利，Application No. US 12/159964
3.周永明，傅廷栋，范楚川，蔡光勤，一种甘蓝型油菜粒重性状分子标记及制备方法与应用，2013.03，中国，ZL0.X
4.周永明，傅廷栋，范楚川，蔡光勤，甘蓝型油菜粒重相关基因的特异分子标记及应用，2013.03，中国，ZL2.X
5.周永明，傅廷栋，范楚川，蔡光勤，甘蓝型油菜粒重主效QTLs的分子标记及其应用，2013.03，中国，ZL5.6X
6.何予卿；李一博； 邢永忠；范楚川；张启发，一种控制水稻谷粒粒宽和粒重的主效基因GS5的克隆与应用，中国专利

获奖情况：
1.2009年华中农业大学第九届青年教师讲课竞赛三等奖
2.邢永忠、张启发、何予卿、范楚川、徐才国. 水稻产量和品质的遗传基础剖析及两个数量性状位点克隆. 2011年湖北省的自然科学一等奖
3.李一博、何予卿、范楚川、邢永忠等. Natural variation in GS5 plays an important role in regulating grain size and yield in rice. 2012年湖北省自然科学优秀论文奖特等奖
4.2013年华中农业大学教学质量三等奖
5. 张启发、邢永忠、何予卿、余四斌、范楚川.水稻产量性状的遗传与分子生物学基础. 2016年国家自然科学奖二等奖
6. 李一博、何予卿、范楚川、邢永忠等. Chalk5 encodes a vacuolar H+-translocating pyrophosphatase influencing grain chalkiness in rice. 2016年湖北省自然科学优秀论文奖特等奖

发表的论文及著作

发表论文：
1. Fan CC, Yu XQ, Xing YZ et al. The main effects, epistatic effects and environmental interactions of QTLs on cooking and eating quality of rice in a doubled haploid line population. Theor Appl Genet, 2005, 110:1445-1452

2. Fan CC, Xing YZ, Mao HL et al. GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in rice, encodes a putative transmembrane protein. Theor Appl Genet, 2006, 112: 1164-1171

3. Fan CC, Pecchioni N, Chen LQ. Genetic structure and proposed conservation strategy for natural populations of Calycanthus chinensis Cheng et S.Y. Chang (Calycanthaceae). Canadian Journal of Plant Science, 2008, 88:179-186

4. Fan CC, Yu SB, Wang CR et al. A causal C–A mutation in the second exon of GS3 highly associated with rice grain length and validated as a functional marker. Theor Appl Genet, 2009, 118:465-472

5.Fan CC, Cai GQ, Qing J et al. Mapping of quantitative trait loci and development of allele-specific markers for seed weight in Brassica napus. Theor Appl Genet, 2010, 121:1289-1301

6.Li Yibo, Fan CC, Xing YZ et al. Natural variation in GS5 plays an important role in regulating grain size and yield in rice. Natural Genetics, 2011, 43(12):1266-1269

7.Li X, Yu E, Fan C, Zhang C, Fu T, Zhou Y. Developmental, cytological and transcriptional analysis of autotetraploid Arabidopsis. Planta, 2012，236(2): 1266-1269

8.Yang,Q,Fan C, Guo Z, Qin J, Wu J, Li Q, Fu T, Zhou Y. Identification of FAD2 and FAD3 genes in Brassica napus genome and development of allele-specific markers for high oleic and low lonolenic acid contents. Theor Appl Genet，2012，125:715-729

9.Guangqin Cai, Qingyong Yang, Qian Yang, Zhenxing Zhao, Hao Chen, Jian Wu, Chuchuan Fan and Yongming Zhou*. Identification of candidate genes of QTLs for seed weight in Brassica napus through comparative mapping among Arabidopsis and Brassica species. BMC Genetics, 13, pp105, 2012

10.Maoyin Li, Sung Chul Bahn, Chuchuan Fan, Jia Li, Tien Phan, Michael Ortiz, Mary R. Roth, Ruth Welti, Jan Jaworski, and Xuemin Wang. Patatin-Related Phospholipase pPLAIIIδ Increases Seed Oil Content with Long Chain Fatty Acids in Arabidopsis. Plant Physiology, 2013, 162: 39-51

11.Jian Wu, Guangqin Cai, Jiangying Tu, Lixia Li, Sheng Liu, Xinping Luo, Lipeng Zhou, Chuchuan Fan, Yongming Zhou. Identification of QTLs for Resistance to Sclerotinia Stem Rot and BnaC.IGMT5.a as a Candidate Gene of the Major Resistant QTL SRC6 in Brassica napus. Plos one, 2013, 8(7): e67740

12.Yibo Li, Chuchuan Fan, Yongzhong Xing, Peng Yun, Lijun Luo, Bao Yan, Bo Peng, Weibo Xie, Gongwei Wang, Xianghua Li, Jinghua Xiao, Caiguo Xu & Yuqing He. Chalk5 encodes a vacuolar H+-translocating pyrophosphatase influencing grain chalkiness in rice. Nature Genetics, 2014, 46:398-404

13.Guangqin Cai, Jiejing Ban, Keqiao Zhang, Chuchuan Fan*, and Yongming Zhou. Characteristics of a novel multilocular mutant of Brassica napus L. for increasing plant yield. Jokull Journal, 2014, 64(5): 350-361

14.Yu Erru*, Fan Chuchuan*, Yang Qingyong, Li Xiaodong, Wan Bingxi, Dong Yanni, Wang Xuemin, Zhou Yongming. Identification of heat responsive genes in Brassica napus siliques at the seed-filling stage through transcriptional profiling. Plos one, 2014, 9(7): e101914

15.Chuchuan Fan, Yudi Wu, Qingyong Yang, Yang Yang, Qingwei Meng, Keqiao Zhang, Jinguo Li, Jinfang Wang, Yongming Zhou. A Novel Single-Nucleotide Mutation in a CLAVATA3Gene Homologue Controls a Multilocular Silique Trait in Brassica rapa L. Molecular plant, 2014, doi:10.1093/mp/ssu090

16.Nailin Xing, Chuchuan Fan, Yongming Zhou. Parental selection of hybrid breeding based on maternal and paternal inheritance of traits in rapeseed (Brassica napus L.). PLOS One, 2014, 9 (7): e103165

17.Boulos Chalhoub, France Denoeud, Shengyi Liu et al. Early allopolyploid evolution in the post-neolithic Brassica napus oilseed genome. Science, 2014, 345, 950: DOI: 10.1126/science.**

18. 李永鹏, 程焱, 蔡光勤, 范楚川, 周永明. 油菜每角果粒数差异的细胞学基础和分子机理. 中国科学(生命科学), 2014, 44(8): 822-831

19. Bo Peng, Lingqiang Wang, Chuchuan Fan, Gonghao Jiang, Lijun Luo, Yibo Li, Yuqing He. Comparative mapping of chalkiness components in rice using five populations across two environments. BMC Genetics, 2014, 15:49

20.Dong Yanni, Li Maoyin, Zhang Peng, Wang Xuemin, Fan Chuchuan*, Zhou Yongming*. Patatin-related phospholipase pPLAIIIδ influences auxin-responsive cell morphology and organ size in Arabidopsis and Brassica napus. BMC Plant Biology, 2014, 14:332

21. Cai G, Yang Q, Yi B, Fan C, Edwards D, Batleyet J, Zhou Y. A Complex Recombination Pattern in the Genome of Allotetraploid Brassica napus as Revealed by a High-Density Genetic Map. PLoS ONE, 2014 9(10): e109910

22. Liu H, Yang QY, Fan CC*, Zhao XQ, Wang XM, Zhou YM*. Transcriptomic basis of functional difference and coordination between seeds and the silique wall of Brassica napus during the seed-?lling stage. Plant Science, 2015, 233:186-199

23. Qingyuan Li, Mei Yin, Yongpeng Li, Chuchuan Fan, Qingyong Yang, Jian Wu, Chunyu Zhang, Hong Wang and Yongming Zhou*. Expression of Brassica napus TTG2, a regulator of trichome development, increases plant sensitivity to salt stress by suppressing the expression of auxin biosynthesis genes. Journal of Experimental Botany, 2015, doi:10.1093/jxb/erv287

24. Cai G, Yang Q, Chen H, Yang Q, Zhang C, Fan C, Zhou Y*, Genetic dissection of plant architecture and yield-related traits in Brassica napus, Sci Rep, 2016, 6: 21625

25. Wu J, Zhao Q, Yang Q, Liu H, Li Q, Yi X, Cheng Y, Guo L, Fan C, Zhou Y*, Comparative transcriptomic analysis uncovers the complex genetic network for resistance to Sclerotinia sclerotiorum in Brassica napus, Sci Rep, 2016, 6: 19007

26. Liu S, Fan C, Li J, Cai G, Yang Q, Wu J, Yi X, Zhang C, Zhou Y*, A genome-wide association study reveals novel elite allelic variations in seed oil content of Brassica napus, Theor Appl Genet, 2016, DOI 10.1007/s00122-016-2697-z


27. Yang Yang, Kaiyu Zhu, Huailin Li, Shaoqing Han, Qingwei Meng, Shahid Ullah Khan, Chuchuan Fan**, Kabin Xie, Yongming Zhou. Precise editing of CLAVATA genes in Brassica napus L. regulates multilocular silique development. Plant Biotechnology Journal, 2018, 16 (7) : 1322-1335


28. Muhammad Hafeez Ullah Khan, Shahid U. Khan, Ali Muhammad, Limin Hu, Yang Yang, Chuchuan Fan**. Induced Mutation and Epigenetics Modification in Plants for crop improvement by targeting CRISPR/Cas9 technology. Journal of Cellular Physiology, 2018, 233(6): 4578-4594


29. Limin Hu, Hao Zhang, Qingyong Yang, Qingwei Meng, Shaoqing Han, Chinedu Charles Nwafor, Muhammad Hafeez Ullah Khan, Chuchuan Fan**, Yongming Zhou. Promoter variations in a homeobox gene, BnA10.LMI1, determine lobed leaves in rapeseed (Brassica napus L.). TAG, 2018: 131:2699-2708


30. Yungu Zhai, Shengli Cai, Limin Hu, Yang Yang, Olalekan Amoo, Chuchuan Fan**, Yongming Zhou. CRISPR/Cas9-mediated genome editing reveals differences in the contribution of INDEHISCENT homologues to pod shatter resistance in Brassica napus L. Theor Appl Genet, 2019, 132: 2111-2123


31. Shahid Ullah Khan, Jiao Yangmiao, Sheng Liu, Kunpeng Zhang, Muhammad Hafeez Ullah Khan, Yungu Zhai, Amoo Olalekan, Chuchuan Fan**, and Yongming Zhou. Genome-wide association studies in the genetic dissection of ovule number, seed number, and seed weight in Brassica napus L. INDUSTRIAL CROPS AND PRODUCTS, 2019, 142: 111877


32. Qing Zhao, Jian Wu, Guangqin Cai, Qingyong Yang, Muhammad Shahid, Chuchuan Fan, Chunyu Zhang and Yongming Zhou**. A novel quantitative trait locus on chromosome A9 controlling oleic acid content in Brassica napus. Plant Biotechnology Journal, 2019, 17: 2313-2324


33. Muhammad Shahid, Guangqin Cai, Feng Zu, Qing Zhao, Muhammad Uzair Qasim, Yueyun Hong, Chuchuan Fan and Yongming Zhou**. Comparative Transcriptome Analysis of Developing Seeds and Silique Wall Reveals Dynamic Transcription Networks for Effective Oil Production in Brassica napus L. Int. J. Mol. Sci. 2019, 20: 1982.


34. Muhammad Uzair Qasim, Qing Zhao, Muhammad Shahid, Rana Abdul Samad, Sunny Ahmar, Jian Wu, Chuchuan Fan and Yongming Zhou**. Identi?cation of QTLs Containing Resistance Genes for Sclerotinia Stem Rot in Brassica napus Using Comparative Transcriptomic Studies. Frontiers in Plant Science, 2020, doi: 10.3389/fpls.2020.00776


35. Yungu Zhai, Kaidi Yu, Shengli Cai, Limin Hu, Olalekan Amoo, Lei Xu, Yang Yang, Boyuan Ma, Yangmiao Jiao, Chaofeng Zhang, Muhammad Hafeez Ullah Khan, Shahid Ullah Khan, Chuchuan Fan**, Yongming Zhou. Targeted mutagenesis of BnTT8 homologs controls yellow seed coat development for effective oil production in Brassica napus L.Plant Biotechnology Journal, 2020, 18: 1153-1168


36. Sheng Liu, Huibin Huang, Xinqi Yi, Yuanyuan Zhang, Qingyong Yang, Chunyu Zhang, Chuchuan Fan and Yongming Zhou**. Dissection of genetic architecture for glucosinolate accumulations in leaves and seeds of Brassica napus by genome-wide association study. Plant Biotechnology Journal, 2020, 18:1472-1484


37. Shaoqin Han, Muhammad Hafeez Ullah Khan, Yang Yang, Kaiyu Zhu, Huailin Li, Miaoshan Zhu, Olalekan Amoo, Shahid Ullah Khan, Chuchuan Fan**, Yongming Zhou. Identi?cation and comprehensive analysis of the CLV3/ESR-related (CLE) gene family in Brassica napus L. Plant Biology, 2020, 22: 709-721


38. Huibin Huang, Tingting Cui, Lili Zhang, Qingyong Yang, Yang Yang, Kabin Xie, Chuchuan Fan**, Yongming Zhou**. Modifications of fatty acid profile through targeted mutation at BnaFAD2 gene with CRISPR/Cas9?mediated gene editing in Brassica napus. Theor Appl Genet, 2020, 133: 2401-2411


39. Limin Hu, Hao Zhang, Yunxia Sun, Xiaoxiao Shen, Olalekan Amoo, Yuguang Wang, Chuchuan Fan**, Yongming Zhou. BnA10.RCO, a homeobox gene, positively regulates leaf lobe formation in Brassica napus L. Theor Appl Genet, 2020, doi.org/10.1007/s00122-020-03672-3


40. Muhammad Hafeez Ullah Khan, Limin Hu, Miaoshan Zhu, Yungu Zhai, Shahid Ullah Khan, Sunny Ahmar, Olalekan Amoo, Kunpeng Zhang, Chuchuan Fan**, Yongming Zhou. Targeted mutagenesis of EOD3 gene in B. napus L. regulates seed production. Journal of Cellular Physiology, 2020, DOI:10.1002/jcp.29986


41. Shahid Ullah Khan, Muhammad Hafeez Ullah Khan, Chuchuan Fan**. Comprehensive study and multipurpose role of the CLV3/ESR-related (CLE) genes family in plant growth and development. Journal of Cellular Physiology, 2020, DOI:10.1002/jcp.30021




编写教材：
细胞生物学实验教程. 北京: 中国农业出版社, 2014.1 (普通高等教育农业部”十二五”规划教材, 全国高等农林院校”十二五”规划教材, ISBN 978-7-109-18621-7