彭东海 【副教授】 姓名彭东海性别男
职称副教授学位博士
电话 **邮箱donghaipeng@mail.hzau.edu.cn
工作单位华中农业大学生科院
研究方向噬菌体农药，噬菌体-宿主相互作用
教育经历2000.09-2004.06，华中农业大学生，生物技术，本科
2003.09-2009.06，华中农业大学生，微生物学，硕博连读

主要职历2009.07-至今，华中农业大学生生科院，讲师，副教授
2009.12-2010.02，英国UniversityofSussex，访问学者
科研成果


近年来日益严重的抗生素耐药性使得细菌性病害的治疗越来越困难，而新型抗生素药物的研发速度远远赶不上耐药性细菌出现的速度。噬菌体是细菌的病毒，已成为替代抗生素药物和解决细菌耐药性的首选方案。国际上利用噬菌体疗法在医药卫生领域已获成功，一批噬菌体药物已进入临床试验。本人一方面拟利用噬菌体防控农业生产中难以防治的重要细菌性土传病害，开发相关噬菌体农药。另一方面开展噬菌体-宿主相互作用研究，解析宿主应对噬菌体感染的策略和宿主对噬菌体产生抗性的分子机制，为开发新型高效环保噬菌体农药提供理论基础。




代表性论文 (#为共同第一作者) ：

Peng DH, Lin J, Hang Q, Zheng W, Liu GQ, Zheng JS, Zhu L, Sun M*. (2015) A novel metalloproteinase virulence factor is involved in B. thuringiensis pathogenesis in nematodes and insects. Environ Microbiol, Accepted. (5-Year IF: 6.24)
Peng DH, Wang FS, Li NS, Zhang ZY, Song R. Zhu ZM, Ruan LF, Sun M*. (2011) Single cysteine substitution in Bacillus thuringiensis Cry7Ba1 improves the crystal solubility and produces toxicity to Plutella xylostella larvae. Environ Microbiol, 13:2820-2831. (5-Year IF: 6.24)
Peng DH, Pang CY, Wu H, Huang Q, Zheng JS, Sun M*. (2015) TheexpressionandcrystallizationofCry65AarequiretwoC-termini,revealinganovelevolutionarystrategyof Bacillusthuringiensis Cryproteins. Sci Rep. 5: 8291 (IF: 5.578)
Peng DH, Qiu DW, Ruan LF, Zhou CF, Sun M*. (2011) Protein elicitor PemG1 from Magnaporthe grisea induces SAR in plants through the salicylic acid and Ca²⁺-related signaling pathways. Mol Plant Microbe Interact, 24:1239-1246. (5-Year IF: 4.871)
Peng DH#, Xu XH#, Ye WX, Yu ZN, Sun M*. (2010) Helicoverpa armigera cadherin fragment enhances Cry1Acinsecticidal activity by facilitating toxin-oligomer formation. Appl Microbiol Biotechnol, 85:1033-1040. (5-Year IF: 4.138，他引21次)
Peng DH, Luo Y, Guo SX, Zeng H, Ju SY, Yu ZN, Sun M*. (2009) Elaboration of an electroporation protocol for larger plasmids and wild-type strains in Bacillus thuringiensis. J Appl Microbiol, 106:1849-1858. (5-Year IF: 2.657，他引33次)
Peng DH, Chen SW, Ruan LF, Li L, Yu ZN, Sun M*. (2007) Safety assessment of transgenic Bacillus thuringiensis with VIP insecticidal protein gene by feeding studies. Food Chem Toxicol 45, 1179-1185. (5-Year IF: 3.21, 他引12次)
Peng DH, Chai LJ, Wang FS, Zhang FJ, Ruan LF, Sun M*. (2011) Synergistic activity between Bacillus thuringiensis Cry6Aa and Cry55Aa toxins against Meloidogyne incognita. Microb Biotechnol, 4(6):794-798. (5-Year IF: 3.365)
Peng DH, Zhou CF, Chen SW, Ruan LF, Yu ZN, Sun M*. (2008) Toxicological safety assessment of genetically modified Bacillus thuringiensis with additional N-Acyl homoserine lactonase gene. Environ Toxicol Chem, 27: 173-180. (5-Year IF: 3.282)
Peng DH, Xu XH, Ruan LF, Yu ZN, Sun M*. (2010) Enhancing Cry1Actoxicity by expression of the Helicoverpa armigera cadherin fragment in Bacillus thuringiensis. Res Microbiol, 161:383-389. (5-Year IF: 2.978)
Zhang FJ#, Peng DH#, Ye XB, Yu ZQ, Hu ZF, Ruan LF, Sun M*. (2012) In vitro uptake of 140 kDa Bacillus thuringiensis nematicidal crystal proteins by the second stage juvenile of Meloidogyne hapla. PLoS One, 7:e38534. (5-Year IF: 4.015)
Zhong CY#, Peng DH#, Ye WX, Chai LJ, Qi JL, Yu ZN, Ruan LF, Sun M*. (2011) Determination of plasmid copy number reveals the total plasmid DNA amount is greater than the chromosome DNA amount in Bacillus thuringiensis YBT-1520. PLoS One, 6:e16025. (5-Year IF: 4.015)




备注主持国家自然科学基金2项、国家973子课题一项、横向课题2项；
获授权专利7项；
国家精品资源共享课程《基因操作原理》，2013，课程主要参与者
获湖北省优秀学士学位论文指导奖，2012；
获湖北省自然科学优秀学术论文二等奖，2012。
华中农业大学教学质量三等奖，2013，,2014
华中农业大学优秀学士学位论文指导奖，2011,2012,2015

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