武宁，华中科技大学同济医学院基础医学院免疫学系教授，博士生导师。
专业方向：免疫信号传导
个人简介：2011年于法国原子能研究所获得细胞与分子生物学博士学位。2011年至2017年在加拿大蒙特利尔临床研究所进行博士后研究。2017年9月入职基础医学院免疫学系，研究方向为免疫信号传导。具体研究内容包括：1）细胞膜非对称性对于免疫细胞信号传导的作用；2）自然杀伤细胞在肿瘤免疫中的作用及分子机理。
主要科研项目：
国自然重点，免疫调节性生物材料诱导心脏瓣膜原位再生的机制研究（**），2020-2024，参与；
国自然面上，跨膜蛋白16F在免疫细胞信号传导中的作用及其机制研究（**），2019-2022，主持；
国自然面上，细胞膜脂搅乱酶TMEM16F在李斯特菌感染早期的作用与免疫调控机制（**），2021-2024，主持；
主要发表论文：
Wu, N.*^,#, Song, H. *, and Veillette, A.^#(2021). Plasma membrane lipid scrambling causing phosphatidylserine exposure negatively regulates NK cell activation.Cell Mol Immunol.DOI:10.1038/s41423-020-00600-9.^#Co-corresponding authors；*Co-first authors
Wu, N.*, V. Cernysiov, D. Davidson, H. Song, J. Tang, S. Luo, Y. Lu, J. Qian, I. E. Gyurova, S. N. Waggoner, V. Q. Trinh, R. Cayrol, A. Sugiura, H. M. McBride, J. F. Daudelin, N. Labrecque and A. Veillette* (2020). Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation.Cell Reports30, 1129-1140 e1125.*Co-corresponding authors
Wu, N.*, Sun, E., Liu, D., and Yu, D. (2019). Tissue-Specific Immunity in Homeostasis and Diseases.J Immunol Res2019, **.*Corresponding author
Wu, N., Zhong, M.C., Roncagalli, R., Perez-Quintero, L.A., Guo, H., Zhang, Z., Lenoir, C., Dong, Z., Latour, S., and Veillette, A. (2016).A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.Nature immunology17, 387-396.
Wu, N.*, and Veillette, A.* (2016). SLAM family receptors in normal immunity and immune pathologies.Current opinion in immunology38, 45-51.*Co-corresponding authors
Wu, N., and Veillette, A. (2011). Immunology: Magnesium in a signalling role.Nature475, 462-463.
Wu, N., Castel, D., Debily, M.A., Vigano, M.A., Alibert, O., Mantovani, R., Iljin, K., Romeo, P.H., and Gidrol, X. (2011). Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation.The Journal of biological chemistry286, 20870-20879.
Wu, N.*, and Gidrol, X.* (2014). The wind rose of human keratinocyte cell fate.Cellular and molecular life sciences: CMLS 71, 4697-4702.*Co-corresponding authors
Wu, N., Rollin, J., Masse, I., Lamartine, J., and Gidrol, X. (2012). p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network.The Journal of biological chemistry287, 5627-5638.
Wu, N., Sulpice, E., Obeid, P., Benzina, S., Kermarrec, F., Combe, S., and Gidrol, X. (2012). The miR-17 family links p63 protein to MAPK signaling to promote the onset of human keratinocyte differentiation.PloS one7, e45761.
Gavino, C., Landekic, M., Zeng, J.,Wu, N., Jung, S., Zhong, M.C., Cohen-Blanchet, A., Langelier, M., Neyret, O., Lejtenyi, D., Rochefort, C., Cotton-Montpetit, J., McCusker, C., Mazer, B., Veillette, A., and Vinh, D.C. (2017). Morpholino-based correction of hypomorphic ZAP70 mutation in an adult with combined immunodeficiency.J Allergy Clin Immunol139, 1688-1692 e1610.
Chen, J., Zhong, M.C., Guo, H., Davidson, D., Mishel, S., Lu, Y., Rhee, I., Perez-Quintero, L.A., Zhang, S., Cruz-Munoz, M.E.,Wu, N., Vinh, D.C., Sinha, M., Calderon, V., Lowell, C.A., Danska, J.S., and Veillette, A. (2017). SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.Nature544, 493-497.
Guo, H., Cranert, S.A., Lu, Y., Zhong, M.C., Zhang, S., Chen, J., Li, R., Mahl, S.E.,Wu, N., Davidson, D., Waggoner, S.N., and Veillette, A. (2016). Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1.The Journal of experimental medicine213, 2187-2207.
Zhang, Z.,Wu, N., Lu, Y., Davidson, D., Colonna, M., and Veillette, A. (2015). DNAM-1 controls NK cell activation via an ITT-like motif.The Journal of experimental medicine212, 2165-2182.
Guo, H., Cruz-Munoz, M.E.,Wu, N., Robbins, M., and Veillette, A. (2015). Immune Cell Inhibition by SLAMF7 Is Mediated by a Mechanism Requiring Src Kinases, CD45, and SHIP-1 That Is Defective in Multiple Myeloma Cells.Molecular and cellular biology35, 41-51.
Li, J., Davidson, D., Martins Souza, C., Zhong, M.C.,Wu, N., Park, M., Muller, W.J., and Veillette, A. (2015). Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition.Molecular and cellular biology35, 4069-4082.
Murn, J., Alibert, O.,Wu, N., Tendil, S., and Gidrol, X. (2008). Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4.The Journal of experimental medicine205, 3091-3103.
Thoby-Brisson, M., Karlen, M.,Wu, N., Charnay, P., Champagnat, J., and Fortin, G. (2009). Genetic identification of an embryonic parafacial oscillator coupling to the preBotzinger complex.Nature neuroscience12, 1028-1035.
Benzina, S., Pitaval, A., Lemercier, C., Lustremant, C., Frouin, V.,Wu, N., Papine, A., Soussaline, F., Romeo, P.H., and Gidrol, X. (2015). A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation.Cellular and molecular life sciences: CMLS.
Gidrol, X.,Wu, N., Frouin, V., and Debily, M.A. (2008). [Inference of transcriptional regulatory networks].Medecine sciences: M/S 24, 629-634.

联系方式：wun@hust.edu.cn