黄建耿，男，博士，副教授，硕士研究生导师。


联系方式：jiangenghuang@hust.edu.cn


研究方向：药代动力学研究（药物体内转运与代谢）


教育背景:
博士 2008.07 华中科技大学同济医学院药学院
本科 2003.07 华中科技大学同济医学院(原同济医科大学)药学院


工作经历:
副教授 2012.04-至今 华中科技大学同济医学院药学院
博士后 2010.08-2012.03 美国University of Iowa药学院
兼职讲师 2011.08-2011.11 美国Drake University药学院
博士后 2008.10-2010.07 美国University of Nebraska Medical Center药学院


主持科研课题：
1. 国家自然科学基金项目：α-突触核蛋白调控uptake 2转运体：多巴胺受体激动剂抗帕金森降效机制研究2018.01-2021.12 课题编号：**
2. 企业委托项目：苦荞麦提取物体内代谢谱研究 2018.03-2018.12
3. 国家自然科学基金项目：基于NTCP/Ntcp和BSEP/Bsep介导的胆汁酸转运受阻导致托伐普坦药物性肝损伤机理研究 2014.01-2016.12 课题编号：**
4. 湖北省自然科学基金项目：基于胆汁酸代谢的药物性肝损伤诊断研究2014.01-2015.12 课题编号：2014CFB956
5. 湖北省卫生厅青年科技人才项目：普拉克索鼻黏膜给药脑靶向治疗帕金森及其跨鼻黏膜转运机制研究 2013.01-2014.12 课题编号：QJX2012-02


代表作：
1. Yang Hu^#, Wenwen Zhu^#, Yeli Guan, Sanlan Wu, Xiaoyin Zhang, Gao Li, Luqin Si*, Jiangeng Huang*. Accurate determination of a novel vasodilatory β‐blocker TJ0711 using LC‐MS/MS: Resolution of an isobaric metabolite interference in dog plasma. Biomed Chromatogr. 2018 Jun;32(6):e4196. doi: 10.1002/bmc.4196. (^#Both authors contributed equally)
2. Sijie He^#, Sanlan Wu^#, Wenwen Zhu, Yeli Guan, Gao Li, Luqin Si*, Jiangeng Huang*. Enantioselective determination of 1-[4-(2-methoxyethyl)phenoxy]-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanol hydrochloride, a novel antihypertensive agent, in rat plasma and tissues by LC–MS/MS. J Sep Sci. 2017, DOI: 10.1002/jssc.(^#Both authors contributed equally)
3. Li Kang^#, Luqin Si^#, Jing Rao, Dan Li, Ya Wu, Sanlan Wu, Minghui Wu, Sijie He, Wenwen Zhu, Yang Wu, Jiaqiang Xu, Gao Li, Jiangeng Huang*. Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes. Toxicol In Vitro. 2017, 40:313-323. (#Both authors contributed equally)
4. Mengzhu Zheng^#, Weiguang Sun^#, Suyu Gao^#, Shanshan Luan, Dan Li, Renqi Chen, Qian Zhang, Lixia Chen*, Jiangeng Huang* and Hua Li*. Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1. Oncotarget. 2017, 8:44255-44265.
5. Jiaqiang Xu, Gao Li, Zhuoyi Wang, Luqin Si, Sijie He, Jialing Cai, Jiangeng Huang*, Maureen D. Donovan*. The role of L-type amino acid transporters in the uptake of glyphosate across mammalian epithelial tissues. Chemosphere. 2016, 145:487-494.
6. Peng Cao, Gao Li, Ling Huang, Shouwei Zhao, Yang Hu, Lixia Qin, Lihui Qiu, Wenwen Zhu, Luqin Si*, Jiangeng Huang*. Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood. Bioanalysis. 2015, 8(17):1823-1835.
7. Kewen Xue, Gao Li, Xiao Sun, Yang Hu, Lei Hu, Jiangeng Huang*, Luqin Si*. Simultaneous quantification of fosinopril and its active metabolite fosinoprilat in rat plasma by UFLC-MS/MS: Application of formic acid in the stabilization of an ester-containing drug. J Chromatogr B Analyt Technol Biomed Life Sci. 2015, 990:141-149.
8. Lei Hu, Zhenhua Lv, Gao Li, Xiaolong Xu, Chenghao Zhang, Peng Cao, Jiangeng Huang*, Luqin Si*. Study of the in vitro metabolism of TJ0711 using ultra high performance liquid chromatography with quadrupole time-of-flight and ultra fast liquid chromatography with quadrupole linear ion trap mass spectrometry. J Sep Sci. 2015, 38(11):1837-1849.
9. Weilin Guo, Gao Li, Yanxia Yang, Conglian Yang, Luqin Si*, Jiangeng Huang*. LC-MS/MS analysis of pramipexole in mouse plasma and tissues: Elimination of lipid matrix effects using weak cation exchange mode based solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2015, 988:157-165.
10. Jiangeng Huang, Lei Hu, Li Xu, Minghui Sun, Zhaoze Fan, Jun Qiu, Gao Li, Luqin Si*. In vitro enantioselective metabolism of TJ0711 hydrochloride by human liver microsomes using a novel chiral liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2012, 891-892:98-101.
11. Jiangeng Huang, Juanjuan Liu, Cong Zhang, Jiaojiao Wei, Li Mei, Shan Yu, Gao Li*, Li Xu*. Determination of sulfonamides in food samples by membrane-protected micro-solid phase extraction coupled with high performance liquid chromatography. J Chromatogr A. 2012, 1219:66-74.
12. Jiangeng Huang, Luqin Si, Zhaoze Fan, Lei Hu, Jun Qiu, Gao Li*. In vitro metabolic stability and metabolite profiling of TJ0711 hydrochloride, a newly developed vasodilatory β-blocker, using a liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2011, 879(30):3386-3392.
13. Jiangeng Huang, Nagsen Gautam, Sai Praneeth R. Bathena, Upal Roy, JoEllyn McMillan, Howard E. Gendelman, Yazen Alnouti*. UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. J Chromatogr B Analyt Technol Biomed Life Sci. 2011, 879(23):2332-2338.
14. Jiangeng Huang, Sai Praneeth R. Bathena, Ivan L. Csanaky, Yazen Alnouti*. Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS. J Pharm Biomed Anal. 2011, 55(5):1111-1119.
15. Jiangeng Huang, Sai Praneeth R. Bathena, Yazen Alnouti*. Metabolite profiling of Praziquantel and its analogs during the analysis of in vitro metabolic stability using information-dependent acquisition on a hybrid triple-quadrupole linear ion trap mass spectrometer. Drug Metab Pharmacokinet. 2010, 25(5):487-499.
16. Jiangeng Huang, Sai P. Bathena, Jing Tong, Megan Roth, Bruno Hagenbuch, Yazen Alnouti*. Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010, 40(3):184-194.
17. Jiangeng Huang, Luqin Si, Lingli Jiang, Zhaoze Fan, Jun Qiu, Gao Li. Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism. Int J Pharm. 2008, 356(1-2):351-353.


学术任职
2018.04--至今 国家食品药品监督管理局药物临床试验数据核查检查员
2017.11--至今 中国药理学会药物代谢专业委员会青年委员会委员
2017.11--至今 国际药物及化学异物代谢学会（ISSX）会员
2015.05--至今 国家自然科学基金委评审专家
2015.01--至今 教育部学位论文评审专家
2014.05--至今 《医药导报》编委
2013.04--至今 武汉市药学会药学教育专业委员会委员
2012.12--2017.11 中国抗癌协会纳米肿瘤学专业委员会委员
2010.10--至今 美国药学科学家协会（AAPS）会员