齐昌兴
齐昌兴，博士，男，湖北孝感人。中药与天然药物学系，主要从事植物与真菌来源天然产物的分离、结构鉴定及生物活性研究，研究重点为天然来源抗阿尔茨海默病、抗器官移植后排斥反应、抗自身免疫性肝炎及抗胰腺导管癌先导化合物的发现，以第一作者或通讯作者在Chemical Science、Journal of Natural Products、Phytochemistry、Frontiers in Chemistry、Organic & Biomolecular Chemistry、Bioorganic & Medicinal Chemistry等学术期刊上发表论文十余篇。
1.联系方式
邮箱：qichangxing@hust.edu.cn
地址：武汉市硚口区航空路13号同济医学院药学院1号楼507室邮编430030
2.研究方向
植物与真菌来源天然产物的分离、结构鉴定及生物活性研究。
3.教育与工作经历
2019/7~至今，华中科技大学，讲师
2017/6~2019/6，华中科技大学，博士后，合作导师：张勇慧教授、王小川教授
2018/7~2018/9，德国马尔堡大学，访问****，合作导师：李书明教授
2012/9~2017/6，华中科技大学，药物化学，博士，导师：张勇慧教授
2008/9~2012/6，湖北中医药大学，药学，本科
4.主持或参加科研项目情况
1)中国博士后科学基金面上项目，批准号：2018M632879，杂色曲霉中杂萜类成份及其抗阿尔茨海默病活性的研究，2019/01–2021/12，5万元，在研，主持
2)国外合作项目/中德合作科研项目（PPP），批准号：留金欧[2018]6046，学号9，2018/01–2019/12，在研，参与
3)国家自然科学基金面上项目，批准号：**，黄柄曲霉产细胞松弛素二聚体黄柄霉素A的生物合成研究，2018/01–2021/12，48万元，在研，参与
4)国家自然科学基金面上项目，批准号：**，藤黄科植物中多靶点抗痴呆症天然先导化合物及其作用机制研究，2018/01–2021/12，60万元，在研，参与
5)国家自然科学基金面上项目，批准号：**，石蒜内生真菌抗阿尔茨海默病活性次生代谢产物的研究，2017/01–2020/12，62万元，在研，参与
5.主要学术论文
1)Changxing Qi^(#), Jian Bao^(#), Jianping Wang^(#), Hucheng Zhu, Yongbo Xue, Xiaochuan Wang, Hua Li, Weiguang Sun, Weixi Gao, Yongji Lai, Jian-Guo Chen, andYonghui Zhang.Asperterpenes A and B, Two Unprecedented Meroterpenoids fromAspergillus terreuswith BACE1 Inhibitory Activities.Chemical Science, 2016, 7, 6563–6572.(IF 9.063) (ISSN 2041-6520)
2)Changxing Qi^(#)Yuben Qiao^(#), Weixi Gao, Mengting Liu, Qun Zhou, Chunmei Chen, Yongji Lai, Yongbo Xue, Jinwen Zhang, Dongyan Li, Jianping Wang, Hucheng Zhu, Zhengxi Hu, Yuan Zhou, and Yonghui Zhang. New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities fromAspergillus terreus.Organic & Biomolecular Chemistry, 2018, 16, 9046. (IF 3.423) (ISSN 1477-0520)
3)Mengting Liu^(#),Changxing Qi^(#), Weiguang Sun^(#), Ling Shen, Jianping Wang,Junjun Liu, Yongji Lai, Yongbo Xue, Zhengxi Hu and Yonghui Zhang.α-glucosidase inhibitors from the coral-associated fungusAspergillus terreus.Frontiers in Chemistry,2018, 6, 422. (IF 4.155) (ISSN 2296-2646)
4)Changxing Qi^(#),Weixi Gao^(#),Danyingzi Guan^(#), Jianping Wang, Mengting Liu, Chunmei Chen, Hucheng Zhu, Yuan Zhou, Yongji Lai, Zhengxi Hu, Qun Zhou, and Yonghui Zhang. Butenolides from a Marine-Derived FungusAspergillus terreuswith Antitumor Activities Against Pancreatic Ductal Adenocarcinoma Cells.Bioorganic & Medicinal Chemistry, 2018, 26, 5903–5910.(IF 2.881) (ISSN 0968-0896)
5)Changxing Qi, Weixi Gao, Jianping Wang, Mengting Liu, Jinwen Zhang, Chunmei Chen, Zhengxi Hu, Yongbo Xue, Dongyan Li, Qing Zhang, Yongji Lai, Qun Zhou, Hucheng Zhu, and Yonghui Zhang. Terrusnolides A-D, new butenolides with anti-inflammatory activities from an endophyticAspergillusfromTripterygium wilfordii.Fitoterapia,2018, 130, 134–139. (IF 2.642) (ISSN 0367-326X)
6)Changxing Qi^(#), Qun Zhou^(#),Yuan Zhou, Zengwei Luo, Chong Dai, Hucheng Zhu,Chunmei Chen, Yongbo Xue, Jianping Wang,Yafen Wang,Yaping Liu, Ming Xiang,WeiguangSun, Jinwen Zhang,Yonghui Zhang.Kinsenoside: A Promising Bioactive Compound fromAnoectochilusSpecies.Current Medical science, 2018, 1, 11–18. (IF 0.948) (ISSN 2523-899X)
7)Changxing Qi^(#), Mengting Liu^(#),Qun Zhou^(#), Weixi Gao, Chunmei Chen, Yongji Lai, Zhengxi Hu, Yongbo Xue, Jinwen Zhang, Dongyan Li, Xiao-Nian Li, Qing Zhang, Jianping Wang,Hucheng Zhu, and Yonghui Zhang. BACE1 Inhibitory Meroterpenoids fromAspergillus terreus.Journal of Natural Products,2018, 81, 1937–1945. (IF 3.885) (ISSN 1520-6025)
8)Changxing Qi, Qun Zhou, Weixi Gao, Mengting Liu, Chunmei Chen, Xiao-Nian Li, Yongji Lai, Yuan Zhou, Dongyan Li^(*), Zhengxi Hu^(*), Hucheng Zhu^(*), andYonghui Zhang^(*), Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungusAspergillus terreusThom,Phytochemistry, 2019,165, 112014.(IF 3.186) (ISSN 0031-9422)
9)Fengli Li^(#), Weiguang Sun^(#), Jiankun Guan^(#), Yuanyuan Lu, Shuang Lin, Sitian Zhang, Weixi Gao, Junjun Liu, Guang Du, Jianping Wang, Hucheng Zhu,Changxing Qi^(*), Zhengxi Hu^(*), and Yonghui Zhang^(*). Anti-inflammatory fusicoccane-type diterpenoids from the phytopathogenic fungusAlternaria brassicicola. Organic & Biomolecular Chemistry, 2018, 16, 8751–8760.(IF 3.423) (ISSN 1477-0520)
10)Mengting Liu^(#), Yan He^(#), Ling Shen^(#), Weaam Hasan Al Anbari, Huaqiang Li, JianpingWang,Changxing Qi^(*), Zhengxi Hu^(*),Yonghui Zhang^(*),Asperteramide A, an UnusualN-Phenyl-Carbamic Acid MethylesterTrimer Isolated from the Coral-Derived FungusAspergillus terreus,European Journal of Organic Chemistry, 2019, 2928–2932.(IF 2.882) (ISSN 1099-0690)
11)Weiguang Sun^(#), Shanshan Luan^(#),Changxing Qi^(#), Qingyi Tong,Shan Yan, Hua Li^(*), Yonghui Zhang^(*), Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism,Cell Communication and Signaling, 2019, 17, 111. (IF 5.111) (ISSN 1478-811X)
12) Yulin Duan, Shuangshuang Xie, Yi Guo, Yuben Qiao, Zhengyi Shi, Li Tao, Mengyi Deng, Yunfang Cao, Yongbo Xue^(*),Changxing Qi^(*),Yonghui Zhang^(*),Przewalcyrones A–F,epoxychromene-containingpolycyclicpolyprenylatedacylphloroglucinols withimmunosuppressiveactivity fromHypericum przewalskiiMaxim.,Organic & Biomolecular Chemistry, 2019, Accept. (IF 3.423) (ISSN 1477-0520)
13)Yuben Qiao^(#), Qianqian Xu^(#), Wenya Feng,Li Tao, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Yuanyuan Lu, Jianping Wang,Changxing Qi^(*), Yongbo Xue^(*),Yonghui Zhang^(*),Asperpyridone A,anunusualpyridonealkaloidexertshypoglycemicactivity through theinsulinsignalingpathway,Journal of Natural Products,2019,Accept. (IF 3.885) (ISSN 1520-6025)
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