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向明
来源：未知???????? 发布日期：2015-07-17 08:53????????浏览次数：? 【字体：大中 小】

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向明，女，博士，教授，博士研究生导师。中国药学会应用药理专业委员会委员，中国抗炎免疫药理学会委员，湖北省药理学会常务理事，世界中医药免疫专业委员会常务理事，湖北省高等学校女高级知识分子科技创新研究会理事。《医药导报》常务编委，《中国药师》编委，Oncotarget, Journal of Ethnopharmacology等杂志审稿人。
研究方向：抗炎免疫药理学，主要包括：

研究自身免疫性疾病（T1DM，RA，AIH等）及慢性炎症（胰腺炎、糖尿病肾病和胰岛素抵抗）的发病机制；研究Treg和DC在自身免疫病发病中的调控作用及诱导抗原特异性免疫耐受的机制；研究化学及中药新型免疫抑制剂的作用及机制；研究免疫调控抗肿瘤治疗的方式及机制。

科研经历：

2010 年赴美国佐治亚医学院从事抗炎免疫抑制剂治疗作用研究。

2004 年至2005年赴德国海德堡大学从事抗HCV感染基因疫苗及树突状细胞分化及功能研究。

1997 年至 1999 年赴意大利 CATANIA 大学微生物系从事自身免疫病发病和细胞因子抗体的作用及机制研究。

1999年至今负责多项国家及省市科研项目及大中型制药企业联合科技攻关项目研究。

联系方式：xiangming@mails.tjmu.edu.cn

代表作：

1. Liu X,Wang J,Wang H,Yin G,Liu Y,Lei X,Xiang M*.REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop. Cancer Lett.2015 Jun 28;362(1):45-60. (*corresponding author)2. Wang J,Cao H,Wang H,Yin G,Du J,Xia F,Lu J,Xiang M*. Multiple mechanisms involved in diabetes protection by lipopolysaccharide in non-obese diabetic mice. Toxicol Appl Pharmacol.2015 Jun 15;285(3):149-58. doi: .1016/j.taap.2015.04.006.

3. Wang J, Zhou H, Han Y, Liu X, Wang M, Wang X, Yin G, Li X,Xiang M*.SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer. J Mol Med. 2014 Jul 5; 92(12):1257-69.

4. Wang J,Xiang M.Targeting potassium channels Kv1.3 and KC a 3.1: routes to selective immunomodulators in autoimmune disorder treatment? Pharmacotherapy. 2013 May;33(5):515-28. 5. Wang J, Lu J, Lan Y, Zhou H, Li W,Xiang M*.Total coumarins from Urtica dentata Hand prevent murine autoimmune diabetes via suppression of the TLR4-signaling pathways. J Ethnopharmacol.2013 Mar 7;146(1):379-92.6. Xiang M,Lu J, Zhang C, Lan Y, Zhou H, Li X, Peng W. Identification and quantification of total coumarins from Urtica dentata Hand and its roles in promoting immune tolerance via TLR4-mediated dendritic cell immaturation.Biosci Biotechnol Biochem. 2013 Jun 23;77(6):1200-6.7. Xie S, Feng J, Yu C, Li Z, Wu Y, Cao Z, Li W, He X, Xiang M*, Han S. Identification of a new specific Kv1.3 channel blocker, Ctri9577, from the scorpion Chaerilus tricostatus. Peptides. 2012 Jul;36(1):94-9.

8. Lu J, Zeng Y, Hou W, Zhang S, Li L, Luo X, Xi W, Chen Z, Xiang M*. The soybean peptide aglycin regulates glucose homeostasis in type 2 diabetic mice via IR/IRS1 pathway. J Nutr Biochem. 2012；23(11):1449-57.

9. Xiang M*, Zhang S, Lu J, Li L, Hou W, Xie M, Zeng Y. Antilithic effects of extracts from Urtica dentata hand on calcium oxalate urinary stones in rats. J Huazhong Univ Sci Technol. 2011; 31(5): 673-677.

10. Luo X, Li LL, Zhang SS, Lu JL, Zeng Y, Zhang HY, Xiang M*. Therapeutic effects of total coumarins from Urtica dentata Hand on collagen-induced arthritis in Balb/c mice. J Ethnopharmacol. 2011; 138(2): 523-9.

11. Hou WR, Xie SN, Xiang M*, et al. Intramuscular delivery of a naked DNA plasmid encoding proinsulin and pancreatic regenerating III protein ameliorates type 1 diabetes mellitus. Pharmacological Research. 2011; 63（4）: 320-327.

12. Hou WR, Xiang M*, et al. Immunosuppressive constituents from Urtica dentata Hand. J Asian Nat Prod Res. 2010; 12(8): 707-13.

13. Xiang M, Hou WR, Xie SN, et al. Immunosuppressive effects of an ethyl acetate extract from Urtica dentata Hand on skin allograft rejection. J Ethnopharmacol. 2009; 126: 57-63.

14. Zhang CL, Zou XL, Guan LL, Xu J, Xiang M*. Prevention of Type 1 Diabetes by Immature Dendritic Cells Treated with an Ethanol Extract of Paecilomyces hepiali Chen Mycelium. Methods Find Exp Clin Pharmacol. 2008; 30(6): 421-429.

15. Zou XL, Zhao ZY，Wang YY, Su ZQ, Xiang M*. Diabetogenic T cells induce autoimmune diabetes in BALB/c mice. Chin Med Sci J. 2008; 23(2):88-94.

16. Xiang M, Zou X, Zhang C, Zhao Z, Xu J. Insulin administration confers diabetes-preventive properties to NOD mice derived dendritic cells. Immunopharmacol Immunotoxicol. 2007; 29(3-4): 451-64.

17. Zhang CL, Zou XL, Xiang M*. Immune tolerance induced by adoptive transfer of DCs in IDDM murine model. Acta Pharmacologica Sinica. 2007; 28(1): 98-104

18. Xiang M, Eisenbach C, Lupu CM, Ernst E, Stremmel W，Encke J. Induction of antigen-specific immune responses in vivo after vaccination with dendritic cells transduced with adenoviral vectors encoding hepatitis C virus NS3. Viral Immunology. 2006; 19(2): 210-219.

19. Xiang M, Zhang CL, Zou XL, Cai XH, Peng JB.Roles of dendritic cells and regulatory T cells in autoantigen-induced urine immune tolerance model. World Chinese Journal of Digestive. 2006; 14(7): 687-692.

20. Xiang M, Eisenbach C, Ernst E, Weigand K, Stremmel W, Encke J. Humoral and cellular immune responses elicited by immunization with genetically modified dendritic cells expressing HCVNS3. Hepatology.2005; 42 (4) Suppl.1:248A

21. Nicoletti F, Zaccone P, Xiang M, Magro G, Di Mauro M, Di Marco R, Garotta G, Meroni P. Essential pathogenetic role for interferon (IFN-)gamma in concanavalin -induced T cell-dependent hepatitis: exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein. Cytokine. 2000; 12(4): 315-23.

22. Nicoletti F, Di Marco R, Zaccone P, Xiang M, Magro G, Grasso S, Morrone S, Santoni A, Shoenfeld Y, Garotta G, Meroni P. Dichotomic effects of IFN-gamma on the development of systemic lupus erythematosus-like syndrome in MRL-lpr / lpr mice. Eur J Immunol. 2000; 30(2): 438-47.

23. Di Marco R, Xiang M, Zaccone P, Leonardi C, Franco S, Meroni P, Nicoletti F. Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency. Autoimmunity. 1999; 31(2): 75-83.

24. Xiang M, Zaccone P, Di Marco R, Harris R, Magro G, Di Mauro M, Meroni PL, Garotta G, Nicoletti F. Failure of exogenously administered interferon-gamma or blockage of endogenous interleukin-4 with specific inhibitors to augment the incidence of autoimmune diabetes in male NOD mice. Autoimmunity. 1999; 30(2):71-80.

25. Xiang M, Zaccone P, Di Marco R, Magro G, Di Mauro M, Beltrami B, Meroni PL, Nicoletti F. Prevention by rolipram of concanavalin A-induced T-cell-dependent hepatitis in mice. Eur J Pharmacol. 1999; 367(2-3): 399-404.

发明专利：

1. 发明专利 “从红活麻中提取的新型免疫抑制剂及提取方法和应用”（专利号：ZL **2.8）

2. 发明专利 “2H-1-苯并吡喃-2-酮在制备药物中的应用”（专利申请号: **9.0）

学术奖励：

1. “民族药红活麻的物质基础及药效学研究和应用”荣获2014年湖北省科技进步奖贰等奖。（第一完成人）

2. “民族药红活麻的物质基础及药效学研究”荣获2014年武汉市科技进步奖叁等奖。（第一完成人）

教材编写：

1. 向明主编《药物毒理学》第四版 2015 中国医药科技出版社出版

2. 向明副主编《临床药物治疗学》第二版 2011年人民卫生出版社出版

3. 向明主编《临床药物治疗学图表解》2008年人民卫生出版社出版

4. 向明主译《Lippincott’s图解药理学》2006年中国医药科技出版社出版

承担课题：

2015-2018: 国家自然科学基金“当归六黄汤免疫调控胰岛素抵抗的作用机制及配伍研究” No **

2013-2015：国家自然科学基金“RegIII信号通路与SOCS3甲基化协同调控胰腺炎症恶性转化的分子机制研究” No **

2013-2016：国家自然科学基金“新型mcDC负调控T细胞免疫耐受、干预β细胞再生的作用机制及药物靶点研究” No **

2011-2013：国家自然科学基金“红活麻总香豆素调节DC/Treg诱导免疫耐受防治RA的作用机制研究”No **

2008-2010：国家自然科学基金“胰岛素原/Reg联合启动T1DM综合治疗的作用及机制”No**

2014-2015：武汉市科技攻关项目“防治糖尿病中药五类新药-红活麻总香豆素临床前研究” No **10058

2008-2010：武汉市科技攻关项目“胰安肽临床前药学及药理毒理学研究”No