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姜宏梁
来源：未知???????? 发布日期：2015-03-05 10:24????????浏览次数：? 【字体：大中 小】

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姜宏梁，1976年11月，男，博士，教授、博士生导师，湖北省“楚天学者”，武汉市首批“黄鹤英才计划”入选者，中国生物分析协会指导委员会委员，世界中联中药鉴定委员会理事，武汉市药学会药物分析专业委员会副主任委员。主持国家自然科学基金、湖北省卫生厅、武汉市人才计划及多项企业合作项目等。为国家科学技术奖励评审、国家自然科学基金、教育部博士点基金评审专家，Journal of Chromatography A, Journal of Chromatography B及 Talanta等学术期刊特邀审稿人。
主要研究兴趣与方向：药物分析和代谢、中药化学与分析、中药药代动力学及代谢组学。
一、教育背景

2001/08-2005/07 美国亚利桑那大学 (University of Arizona) 药学博士

1998/09-2001/07 中国协和医科大学生药学硕士

1994/09-1998/07 沈阳药科大学中药制药专业学士
二、工作经历

2011/04-现在华中科技大学 中药化学与分析，药物分析与代谢 教授、博导

2010/11-2011/04 美国Covance Inc.公司药物分析与药代动力学 资深研究员

2006/12-2010/11 美国Covance Inc. 公司 药物分析与药代动力学 研究员

2005/08-2006/11 美国西北太平洋国家实验室 （Pacific Northwest National Lab） 博士后
三、科研经历：

1、基于LC-MS/MS特征轮廓谱分析方法的姜黄中强抗肿瘤活性微量姜黄素类化合物的快速发现，项目批准号：**，国家自然科学基金，2013.01-2016.12，项目主持人。

2、姜黄中姜黄素类化合物的系统分离与抗肿瘤活性研究，湖北省中医药中西医结合科研项目-湖北省卫生厅项目，2012.01-2014.12，项目主持人。

3、药物分析和药代动力学研究技术服务平台建设，武汉市首批“黄鹤英才计划”资助， 2012.03-2014.12，项目主持人。
四、发表论文：

1) Zhongzhe Cheng^#, Lian Ding^#, Yang Zhang, Guiying Chen, Chang Chen, Yi-Qiang Cheng, Hongliang Jiang*, Determination of Thailandepsin B in RatPlasma with a LC-MS/MS Method, Bioanalysis, 2015, 7(1): 39-52.

2) Hui Ouyang, Yicheng Guo, Mingzhen He, Jinlian Zhang, Xiaofang Huang, Xin Zhou, HongliangJiang, Yulin Feng*, Shilin Yang, A Rapid and Sensitive LC-MS/MS Method for the Determination of Pulsatilla Saponin D in Rat Plasma and its Application in a Rat Pharmacokinetic and Bioavailability Study, Biomedical Chromatography, 2015, 29(3): 373-378.

3) Cai Huang^#, Qiongming Xu^#, Chang Chen, Chengwu Song, Yong Xu, Yi Xiang, Yulin Feng, Hui Ouyang, Yang Zhang, HongliangJiang*, The Rapid Discovery and Identification of Physalins in the Calyx of Physalis Alkekengi L.Var.franchetii (Mast.) Makino Using Ultra-high Performance Liquid Chromatography-quadrupole Time of Flight Tandem Mass Spectrometry together with a Novel Three-step Data Mining Strategy. Journal of Chromatography A, 2014, 1361: 139-152.

4) Shuna Jin, Chengwu Song, Sen Li, Yang Zhang, Chang Chen, Xin Zhou, Yong Xu, Yulin Feng, Zhiping Zhang*, HongliangJiang*, Preventative Effects of Turmeric on the High-fat Diet-induced Hyperlipidaemia in Mice Associated with a Targeted Metabolomic Approach for the Analysis of Serum Lysophosphatidylcholine Using LC-MS/MS. Journal of Functional Foods, 2014, 11: 130-141.

5) Zhongzhe Cheng, Lin Zhang, Yang Zhang, Guiying Chen, HongliangJiang*, Simultaneous Determination of Capilliposide B and Capilliposide C in Rat Plasma by LC-MS/MS and its Application to a PK Study, Bioanalysis, 2014, 6(7): 935-945.

6) Ning Li, Xuefeng Zhou, Jiyan Yuan, Guiying Chen, HongliangJiang, WenZhang*, Ceftriaxone and Acute Renal Failure in Children, Pediatrics, 2014, 133(4): 917-922.

7) Yang Zhang, Huachuan Cao, HongliangJiang*. Supported Liquid Extraction versus Liquid-liquid Extraction for Sample Preparation in LC-MS/MS-based Bioanalysis, Bioanalysis, 2013, 5(3): 285-288.

8) Daniel Tang*, Dafang Zhong, Kelly Dong, Pei Hu, Huichen Liu, HongliangJiang，Alicia Du. China Bioanalysis Forum, Bioanalysis, 2013, 5(6): 641-643.

9) Pei-pei Zhang, Sha-sha Gao, Tian-tian Zhang, Xiao-gang Wang, Guo-liang Qing, Hong-liangJiang, Jia-chun Chen, Hong-quan Duan, Jin-bo Fang*, Two New Compounds from Schisandra Glaucescens, Journal of Asian Natural Products Research, 2013, 15(5): 466-472.

10) Hongliang Jiang^#*, Huachuan Cao^#*, Yang Zhang, Douglas M. Fast, Systematic Evaluation of Supported Liquid Extraction in Reducing Matrix Effect and Improving Extraction Efficiency in LC-MS/MS based Bioanalysis for 10 Model Pharmaceutical Compounds, Journal of Chromatography B, 2012, 891-892: 71-80.

11) Yang Zhang, HongliangJiang, Paul Hutson*, Stability of Acetyl-I-carnitine in 5% Dextrose Using a High-performance Liquid Chromatography-mass Spectrometry Times 2 Method, International Journal of Pharmaceutical Compounding, 2012, 16(2): 170-173.

12) Yi Xiang, Liping Zhou, Zhenyu Qian, Kelong Peng, Dongyan Li, Xiaomei Chen, HongliangJiang, Heng Zheng*, Determination of Cyclobenzaprine in Human Plasma by Liquid Chromatography-electrospray Ionization Tandem Mass Spectrometry and its Application in a Pharmacokinetic Study, Biomedical Chromatography, 2012, 26(9): 1083-1088.

13) Yifan Shi*,Hongliang Jiang, Assay Dynamic Range for DBS: battles on two Fronts, Bioanalysis, 2011, 3(20): 2259-2262.

14) Hongliang Jiang H*, Yurong Wang, Manjunath S. Shet, Yang Zhang, Duane Zenke, Douglas M. Fast, Development and Validation of a Sensitive LC-MS/MS Method for the Simultaneous Determination of Naloxone and its Metabolites in Mouse Plasma, Journal of Chromatography B, 2011, 879(25): 2663-2668.

15) Hongliang Jiang H*, Yang Zhang, Matt Ida, Amber LaFayette, Douglas M. Fast, Determination of Carboplatin in Human Plasma Using HybridSPE-precipitation along with Liquid Chromatography-tandem Mass Spectrometry, Journal of Chromatography B, 2011，879 (22): 2162-2170.

16) Xiaorong Liang^#*, Hongliang Jiang^#, Xi Chen,Human DBS Sampling with LC-MS/MS for Enantioselective determination of Metoprolol and its Metabolite O-Desmethyl Metoprolol, Bioanalysis, 2010, 2(8): 1437-1448.

17) Hongliang Jiang*, Michelle J. Cannon, Maria Banach, Anatoly N. Pinchuk, Giangthy N. Ton, Christie Scheuerell, Marc A. Longino, Jamey P. Weichert, Richard Tollefson, William R. Clarke, Qin C. Ji, Xiangyu Jiang, Quantification of CLR1401, a Novel Alkylphosphocholine Anticancer Agent, in Rat Plasma by Hydrophilic Interaction Liquid Chromatography-tandem Mass Spectrometric Detection, Journal of Chromatography B, 2010, 878(19): 1513-1518.

18) Hongliang Jiang*, Christopher Randlett, Heiko Junga, Xiangyu Jiang, Qin C. Ji*, Using Supported Liquid Extraction together with Cellobiohydrolase Chiral Stationary Phases-based Liquid Chromatography with Tandem Mass Spectrometry for Enantioselective Determination of Acebutolol and its Active Metabolite Diacetolol in Spiked Human Plasma, Journal of Chromatography B, 2009, 877(3): 173-180.

19) Hongliang Jiang*, Xiangyu Jiang, Qin C. Ji*, Enantioselective Determination of Alprenolol in Human Plasma by Liquid Chromatography with Tandem Mass Spectrometry Using Cellobiohydrolase Chiral Stationary Phases, Journal of Chromatography B, 2008, 872(1-2): 121-127.

20) Jie Ding, Christina M. Sorensen, Navdeep Jaitly, HongliangJiang, Daniel J. Orton, Matthew E. Monroe, Ronald J. Moore, Richard D. Smith, Thomas O. Metz*, Application of the Accurate Mass and Time Tag Approach in Studies of the Human Blood Lipidome, Journal of Chromatography B, 2008, 871(2): 243-252.

21) Wei-jun Qian, David T. Kaleta, Brianne O. Petritis, HongliangJiang, Tao Liu, Xu Zhang, Heather M. Mottaz, Susan M. Varnum, David G. Camp, Lei Huang, Xiangming Fang, Wei-wei Zhang, Richard D. Smith*, Enhanced Detection of Low Abundance Human Plasma Proteins Using a Tandem IgY12-SuperMix Immunoaffinity Separation Strategy, Molecular & Cellular Proteomics, 2008, 7(10): 1963-1973.

22) Hongliang Jiang*, Yinghe Li, Mary Pelzer, Michelle J. Cannon, Christopher Randlett, Heiko Junga, Xiangyu Jiang, Qin C. Ji*, Determination of Molindone Enantiomers in Human Plasma by High-performance Liquid Chromatography-tandem Mass Spectrometry Using Macrocyclic Antibiotic Chiral Stationary Phases, Journal of Chromatography A, 2008, 1192(2): 230-238.

23) Jie Ding, Christina M. Sorensen, Qibin Zhang, HongliangJiang, Navdeep Jaitly, Eric A. Livesay, Yufeng Shen, Richard D. Smith, Thomas O. Metz*. Capillary LC Coupled with High-Mass Measurement Accuracy Mass Spectrometry for Metabolic Profiling, Analytical Chemistry, 2007, 79(16): 6081-6093.

24) Hongliang Jiang, Barbara N. Timmermann, David R. Gang*, Characterization and Identification of Diarylheptanoids in Ginger (Zingiber officinale Rosc.) Using High-performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2007, 21(4): 509-518.

25) Hongliang Jiang, Arpad Somogyi, Barbara N. Timmermann, David R. Gang*, Instrument Dependence of Electrospray ionization and tandem mass spectrometric fragmentation of the gingerols, Rapid Communications in Mass Spectrometry, 2006, 20(20): 3089-3100.

26) Hongliang Jiang, Barbara N. Timmermann, David R. Gang*, Use of Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry to Identify Diarylheptanoids in Turmeric (Curcuma longa L.) Rhizome, Journal of Chromatography A, 2006, 1111(1): 21-31.

27) Hongliang Jiang, Arpad Somogyi, Neil E. Jacobsen, Barbara N. Timmermann, David R. Gang*, Analysis of Curcuminoids by Positive and Negative Electrospray Ionization and Tandem Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2006, 20(6): 1001-1012.

28) Hongliang Jiang, Zhengzhi Xie, Hyun Jo Koo, Steven P. McLaughlin, Barbara N. Timmermann, David R. Gang*, Metabolic Profiling and Phylogenetic Analysis of Medicinal Zingiber Species: Tools for Authentication of Ginger (Zingiber officinale Rosc), Phytochemistry, 2006, 67(15): 1673-1685.

29) Hongliang Jiang, Aniko M. Solyom, Barbara N. Timmermann, David R. Gang*, Charaterization of Gingerol-related Compounds in Ginger Rhizome (Zingiber officinale Rosc.) by High-performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry, Rapid Communications in Mass Spectrometry, 2005, 19(20): 2957-2964.

30)姜宏梁，杨学东，张达，徐丽珍，杨世林，邹忠梅. 中药北刘寄奴的化学成分研究.中国药学杂志，2003，38(2),97-99.

31)姜宏梁，徐丽珍，杨学东，张达，杨世林，邹忠梅. 北刘寄奴中奎尼酸酯类化学成分研究.中国中药杂志，2002,27(12),923-926.

32)张达，姜宏梁，杨学东，徐丽珍，杨世林，邹忠梅. 北刘寄奴中黄酮类化学成分的研究. 中草药,2002,33(11),974-975.
五、联系方式：

Email:jianghongliang@hust.edu.cn；jianghongliang668@163.com

电话:**.

地址：湖北省武汉市航空路13号华中科技大学同济医学院药学院2号楼，430030