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张勇慧
来源：未知???????? 发布日期：2015-03-17 10:25????????浏览次数：? 【字体：大中 小】

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张勇慧，天然药物化学教授，博士生导师，药学院院长，教育部新世纪优秀人才支持计划获得者。中国中药和天然药物专业委员会委员，湖北省药学会副秘书长，湖北省中药和天然药物专业委员会主任委员，武汉市药学会副理事长。国家/教育部科技奖励评审专家，国家CFDA新药/化妆品审评专家，国家重大新药创制专项“十二五”《糖尿病新药临床前研究》课题组长。课题组主持国家“重大新药创制”专项课题3项， 863计划1项，国家自然科学基金项目12项，总经费4000余万元。参加编写国家级教材/配套教材8部。2012年获华中科技大学“青年五四奖章”，2011年获湖北省科技进步二等奖。申请专利10项，发表SCI收录论文65篇。

申请者带领研究团队近十年来一直致力于药用植物和不同来源共生真菌的天然产物化学研究，包括：（1）天然药物活性成分的分离和结构解析；（2）活性天然先导物的结构修饰与生物活性研究；（3）绿色合成在活性天然产物合成中的应用；（4）基于药食同源植物的具有自主知识产权创新药物和保健品的研究与开发。对二十余种药用植物化学成分和节肢动物共生菌等不同来源真菌次生代谢产物进行了系统而深入的研究。迄今共分离和鉴定天然产物近 1000 个，新化合物 320 余个，包括全新碳架类型的二萜类、生物碱类和间苯三酚类衍生物等三十余种。
(一)近年主持的科研项目

2014.1-2016.12国家高技术研究发展计划（863计划）《促肝细胞再生金线莲胶囊保健品的研究与开发》625万元

2014.1-2017.12国家自然科学基金《肉桂和川桂中抗肿瘤二萜化学成分及作用机制研究》80万元

2013.1-2015.12 科技部中韩国际合作项目《化药一类降血糖新药KD10临床前研究》90万元

2012.1-2014.12 武汉市3551人才项目《化药一类降血糖新药KD10临床前研究》100万元

2011.1-2013.12国家重大新药创制专项课题《糖尿病新药临床前研究》2291万元

2011.1-2013.12国家重大新药创制专项课题《中药6.1类治疗类风湿关节炎新药复方鹿角霜片临床前研究》150万元

2011.1-2013.12国家自然科学基金《黄芫花中抗肿瘤二萜活性成分及抑制肿瘤侵袭转移作用机制研究》35万元

2009.1-2011.12 教育部新世纪优秀人才支持计划《楮头红保护肝损伤的活性成分及作用机制研究》50万元

2006.1-2008.12国家自然科学基金《浙贝乙素抑制HDAC的构效关系及机制》26万元

2005.1-2007.12国家自然科学基金《金线莲中抑制IKK-β增敏胰岛素的活性成分及作用机制研究》22万元

(二)近年发表的主要论文

50. Fuqian Wang, Qingyi Tong, Haoran Ma, Hongfeng Xu, Song Hu, Wei Ma, Yongbo Xue, Junjun Liu, Jianping Wang, Hongping Song, Jinwen Zhang, Geng Zhang, Yonghui Zhang^(*), Indole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death, Scientific Reports, 2015, (Accepted).

49. Tao Zheng^(#), Xiaoyan Yang^(#), Dan Wu, Shasha Xing, Fang Bian, Wenjing Li, Jiangyang Chi, Xiangli Bai, Guangjie Wu, Xiaoqian Chen, Yonghui Zhang^(*), Si Jin*, Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway, British Journal of Pharmacology, 2015, ID: 2014-BJP-1544-RP.

47. Chunmei Chen, Hucheng Zhu, Jianping Wang, Jing Yang, Xiao-Nian Li, Jing Wang, Keliang Chen, Yanyan Wang, Zengwei Luo, Guangmin Yao, Yongbo Xue^(*), and Yonghui Zhang^(*), Armochaetoglobins K–R, Anti-HIV Pyrrole-based Cytochalasans from Chaetomium Globosum TW1-1, European Journal of Organic Chemistry, Doi: 10.1002/ejoc.**R1.

46. Dongyan Li, Hucheng Zhu, Changxing Qi, Yongbo Xue^(*), Guangmin Yao, Zengwei Luo, Jianping Wang, Jinwen Zhang, Guang Du^(*), and Yonghui Zhang^(*), Two New adamantyl-Like polyprenylated Acylphloroglucinols from Hypericum attenuatum Choisy, Tetrahedron Letters, Doi: 10.1016/j.tetlet.2015.02.056.

45. Hucheng Zhu^(#), Chunmei Chen^(#), Junjun Liu, Bin Sun, Guangzheng Wei, Yan Li, Jinwen Zhang, Guangmin Yao, Zengwei Luo, Yongbo Xue^(*), and Yonghui Zhang^(*), Hyperascyrones A–H, Polyprenylated Spirocyclic Acylphloroglucinol Derivatives from Hypericum ascyron Linn., Phytochemistry, Doi: 10.1016/j.phytochem.2015.02.009.

44. Hucheng Zhu^(#), Chunmei Chen^(#), Jianping Wang, Xiao-Nian Li, Guangzheng Wei, Yi Guo, Guangmin Yao, Zengwei Luo, Jinwen Zhang, Yongbo Xue^(*), and Yonghui Zhang^(*), Penicamedine A, a highly oxygenated hexacyclic indole alkaloid from Penicillium camemberti, Chemistry Biodiversity, (Accepted).

43. Qi Ye^(#), Guangmin Yao^(#), Mengke Zhang, Guoli Guo, Yufeng Hu, Jue Jiang, Ling Cheng, Hua Li, Guoliang Qing, and Yonghui Zhang^(*), Hudan Liu^(*), A novel ent-kaurane diterpenoid executes anti-tumor function in colorectal cancer cells by inhibiting Wnt/β-catenin signaling, Carcinogenesis, 2015, 36(3):318-26.

42. Chunmei Chen^(#), Hucheng Zhu^(#), Xiao-Nian Li, Jing Yang, JianpingWang, Gentao Li, Yan Li, Qingyi Tong, Guangmin Yao, Zengwei Luo, Yongbo Xue^(*), and Yonghui Zhang^(*), Armochaeglobines A and B, Two New Indole-Based Alkaloids from the Arthropod-Derived Fungus Chaetomium globosum, Organic Letters, 2015, 17(3): 644–647.

41. MingYuan, Li Chen, Junwei Wang, Shenjie Chen, Kongchao Wang, Yongbo Xue, Guangmin Yao, Zengwei Luo^(*), and Yonghui Zhang^(*), Transition-Metal-Free Synthesis of Phenanthridinones from Biaryl-2-oxamic Acid under Radical Conditions, Organic Letters, 2015, 17(2): 346–349.

40. Dongyan Li^(#), Yongbo Xue^(#), Hucheng Zhu, Yan Li, Bin Sun, Junjun Liu, GuangminYao, Jinwen Zhang, Guang Du^(*), and Yonghui Zhang^(*), Hyperattenins A–I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy, RSC Advances, 2015, 5: 5277–5287.

39. Hucheng Zhu, Chunmei Chen., Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao, Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue^(*), and Yonghui Zhang^(*), Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum sampsonii, Organic letters, 2014, 16(24): 6322–6325.

38. Fang Bian^(#), XiaoyanYang^(#), Fan Zhou, Pin-Hui Wu, Shasha Xing, Gao Xu, Wenjing Li, Jiangyang Chi, Changhan Ouyang, Yonghui Zhang, Bin Xiong, Yongsheng Li, Tao Zheng, Dang Wu, Xiaoqian Chen, and Si Jin^(*), C-reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells, British Journal of Pharmacology, 2014, 171(10): 2671–2684.

37. Ying Tang, Yongbo Xue, Lei Zhou, Jin-Wen Zhang, Guang-Min Yao, Zeng-Wei Luo, Guang Du^(*),Yong-Hui Zhang^(*). New Norclerodane Diterpenoids from the Tubers of Dioscorea bulbifera. Chemical & Pharmaceutical Bulletin, 2014; 62(7):719–724.

36. Yang Zhang^(#), Yihong Xia^(#), Yongji Lai, Fang Tang, Zengwei Luo, Yongbo Xue, Guangmin Yao, Yonghui Zhang, and Jinwen Zhang^(*), Efficient Synthesis of Kinsenoside and Goodyeroside A by a Chemo-Enzymatic Approach, Molecules, 2014, 19(10): 16950–16958.

35. Yongbo Xue^(*), Ye Wu, Hucheng Zhu, Xiao-Nian Li, Jin-Fu Qian, Yongji Lai, Chunmei Chen, Guangmin Yao, Zengwei Luo, Yan Li, and Yonghui Zhang^(*), Salviprzols A and B, C₂₁- and C₂₂-terpenoids from the roots of Salvia przewalskii Maxim, Fitoterapia, 2014, 99: 204–210.

34. Junfen Zeng^(#), Yongbo Xue^(#), Yongji Lai, Guangmin Yao, Zengwei Luo, Yonghui Zhang, and Jinwen Zhang^(*), A New Phenolic Glycoside from the Barks of Cinnamomum cassia. Molecules 2014, 19(11): 17727–17734.

33. Guoli Guo^(#), Guangmin Yao^(#), Guanqun Zhan, Yufeng Hu, Ming Yue, Ling Cheng, Yaping Liu, Qi Ye, Guoliang Qing, Yonghui Zhang^(*), Hudan Liu^(*), N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation, Toxicology and Applied Pharmacology, 2014, 280(3): 475–483.

32. Zheng-Xi Hu^(#), Yong-Bo Xue^(#), Xiao-Bin Bi, Jin-Wen Zhang, Zeng-Wei Luo, Xiao-Nian Li, Guang-Min Yao, Jian-Ping Wang^(*), and Yong-Hui Zhang^(*), Five new secondary metabolites produced by a marine-associated fungus, Daldinia eschscholzii. Marine drugs, 2014, 12(11): 5563–5575.

31. Zhengxi Hu, Jianping Wang, Xiaobin Bi, Jinwen Zhang, Yongbo Xue^(*), Yingda Yang, Zengwei Luo, Guangmin Yao, and Yonghui Zhang^(*), Colletotrichumine A, a novel indole-pyrazine alkaloid with an unprecedented C16N3-type skeleton from cultures of Colletotrichum capsici, Tetrahedron Letters, 2014, 55(44): 6093–6095.

30. Junfen Zeng, Yongbo Xue, Penghua Shu, Huiqin Qian, Rongjian Sa, Ming Xiang, Xiao-Nian Li, Zengwei Luo, Guangmin Yao^(*), and Yonghui Zhang^(*), Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia, Journal of Natural Products, 2014, 77(8): 1948–1954.

29. Zhengxi Hu, Yongji Lai, Jinwen Zhang, Ye Wu, Zengwei Luo,Guangmin Yao, Yongbo Xue^(*), and Yonghui Zhang^(*), Phytochemical and chemotaxonomic studies on Phyllanthus urinaria, Biochemical Systematics and Ecology, 2014, 56: 60–64.

28. Hucheng Zhu^(#), Lijun Huan^(#), Chunmei Chen, Jing Yang, Jiangbo He, Yong Chen, Guangmin Yao, Zengwei Luo, Yongbo Xue^(*), and Yonghui Zhang^(*), A Pair of Unprecedented Cyclohexylethanoid Enantiomers Containing Unusual Trioxabicyclo[4.2.1]nonane Ring from Clerodendrum bungei, Tetrahedron Letters, 2014, 55: 2277–2279.

27. Fuqian Wang^(#), Shishi Han^(#), Song Hu, Yongbo Xue, Jianping Wang, Hongfeng Xu,Lu Chen, Geng Zhang^(*), and Yonghui Zhang^(*), Two New Secondary Metabolites from Xylaria sp. cfcc 87468, Molecules, 2014, 19: 1250–1257.

26. Yingda Yang, Zhengxi Hu, Zengwei Luo, Yongbo Xue, Guangmin Yao, Yanyan Wang^(*), Yonghui Zhang^(*), A New Sesquilignan Glucoside from Uraria sinensis, Molecules, 2014, 19: 1178–1188.

25. Heng Zheng, Qiong Chen, Mengke Zhang, Yongji Lai, Liang Lei, Penghua Shu, Jinwen Zhang, Yongbo Xue, Zengwei Luo, Yan Li, Guangmin Yao^(*), and Yonghui Zhang^(*), Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei, Journal of Natural Products, 2013, 76: 2253–2262.

24. Chunmei Chen, Hucheng Zhu, De Zhao, Jun Deng^(*), and Yonghui Zhang^(*), Two new lignans from Phryma leptostachya L, Helvetica Chimica Acta, 2013, 96: 1392–1396.

23. Yongji Lai^(#), Yongbo Xue^(#), Mengke Zhang, Jinwen Zhang, Wei Tang, Junjun Liu, Liang Lei, Juming Yan, Zengwei Luo, Jianping Zuo, Yan Li, Guangmin Yao^(*), and Yonghui Zhang^(*), Scapiformolactones A–I: germacrane sesquiterpenoids with an unusual Δ³-15,6-lactone moiety from the whole plants of Salvia scapiformis, Phytochemistry, 2013, 96: 378–388.

22. Zhengxi Hu , Yongbo Xue , Guangmin Yao , Zengwei Luo , Yanyan Wang^(*), and Yonghui Zhang^(*), Chemical constituents from the leaves of Premna microphylla Turcz, Journal of Chinese Pharmaceutical Sciences, 2013, 22 (5): 431–434.

21. Xincai Hao^(#), Jinwen Zhang^(#), Guanqun Zhan,Yongbo Xue, Zengwei Luo, Guangmin Yao^(*), and Yonghui Zhang^(*), Chemical constituents from Teucrium viscidum, Biochemical Systematics and Ecology, 2013, 51: 78–82.

20. Yongji Lai, Shuiping Ding, Huiqin Qian, Jinwen Zhang, Yongbo Xue, Zengwei Luo, Guangmin Yao^(*), and Yonghui Zhang^(*), A new lignan glucoside from the whole plants of salvia scapiformis, Molecules, 2013, 18: 11377–11383.

19. Penghua Shu, Xialan Wei, Yongbo Xue, Weijie Li, Jinwen Zhang, Ming Xiang, Mengke Zhang, Zengwei Luo, Yan Li, Guangmin Yao^(*), and Yonghui Zhang^(*), Wilsonols A?L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii, Journal of Natural Products, 2013, 76: 1303–1312.

18. Mengke Zhang, Yan Zhu, Guanqun Zhan, Penghua Shu, Rongjian Sa, Liang Lei, Ming Xiang, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao^(*), and Yonghui Zhang^(*), Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum, Organic Letters, 2013, 15(12): 3094–3097.

17. Wei Xialan, Shu Penghua, Liu Tingting, Xiang Ming, Zhang Jinwen, Xue Yongbo, Luo Zengwei, Yao Guangmin^(*), and Zhang Yonghui^(*), Steroids and Phenylpropanoids with Immunomodulatory Activities from the Stem Barks of Cinnamomum wilsonii, Chinese Journal of Organic Chemestry, 2013, 33(6): 1273–1278.

16. Xincai Hao^(#), Jinwen Zhang^(#), Guangxin Xia, Yongbo Xue, Zengwei Luo, Yanyan Si 1,Guangmin Yao^(*), and Yonghui Zhang^(*), A New Triterpenoid from Teucrium viscidum, Molecules, 2013, 18: 1262–1269.

15. Zengwei Luo, Bo Yang, Cheng Zhong, Fang Tang, Min Yuan, Yongbo Xue, Guanmin Yao, Jingwen Zhang^(*), Yonghui Zhang^(*), A dual-channel probe for selective fluoride determination and application in live cell imaging, Dyes and Pigments, 2013, 97: 52–57.

14. Jieru Guo, Jinwen Zhang, Guangmin Yao, Mei LIAO, Huadong Chen, Xixiong Yang^(*), Yonghui Zhang^(*), Hepatoprotective Activity of the Ethanol Extract of Sarcopyramis Nepalensis, Journal of Huazhong University of Science and Technology [Medical Sciences], 2012, 32(6): 663–666.

13. Zengwei Luo^(#), Fuqian Wang^(#), Jinwen Zhang, Xingyao Li, Mengke Zhang, Xincai Hao,Yongbo Xue, Yan Li, F. David Horgen, Guangmin Yao^(*), Yonghui Zhang^(*), Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida, Journal of Natural Products, 2012, 75: 2113–2120.

12. Jieru Guo, Jinwen Zhang, Penghua Shu, Lingmei Kong, Xincai Hao, Yongbo Xue, Yan Li, Gao Li, Guangmin Yao^(*), Yonghui Zhang^(*), Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne, Molecules,2012, 17: 6424–6433.

11. Jian-Ping Wang，Ya-Ming Zhou, Yong-Hui Zhang^(*), Kirenol production in hairy root culture of Siegesbeckea orientalis and its antimicrobial activity, Pharmacognosy Magazine, 2012, 8(30): 149–155.

10． Jinglou Chen, Yongfang Lei, Guanghua Wu, Yonghui Zhang^(*), Wei Fu, Chaomei Xiong, Jinlan Ruan^(*), Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines, Journal of Ethnopharmacology, 2012, 139(1): 207–213.

9． Yong-Fang Lei, Jing-Lou Chen, Han Wei, Chao-Mei Xiong, Yong-Hui Zhang^(*), Jin-Lan Ruan^(*), Hypolipidemic and anti-in?ammatory properties of Abacopterin A from Abacopteris penangiana in high-fat diet-induced hyperlipidemia mice, Food and Chemical Toxicology, 2011, 49 (12): 3206–3210.

8. Jin-Wen Zhang, Mei Liao, Hua-Dong Chen, Yong-Hui Zhang^(*), Structural elucidation of a new flavone from Sarcopyramis nepalensis, Journal of Asian Natural Products Research, 2011, 13(3): 256–259.
7. Yong-Hui Zhang, Xi-Liang Yang, Peng Zhang, Xue-Feng Zhou, Han-Li Ruan^(*), Hui-Fang Pi, Ji-Zhou Wu^(*), and Han-Dong Sun, Cytotoxic Alkaloids from the Bulbs of Fritillaria hupehensis, Chemistry & Biodiversity, 2008, 5(2): 259–266.

6. Yong-Hui Zhang, Han-Li Ruan, Ji-Zhou Wu, Han-Dong Sun, and Tetsuro Fujita, Preparation and antitussive, expectorant and antiasthmatic activities of verticinone’s derivatives, Journal of Asian Natural Products Research, 2008, 10(7): 627–633.

5. Yonghui Zhang, Jinyan Cai, Hanli Ruan, Huifang Pi, and Jizhou Wu^(*), Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats, Journal of Ethnopharmacology, 2007, 114(2): 141–145.

4. Zhang, Yong-Hui, Yang, Xi-Liang, Zhou, Xue-Feng, Ruan, Han-Li, Pi, Hui-Fang, Wu, Ji-Zhou^(*), and Sun, Han-Dong, Alkaloids from Fritillaria hupehensis, Chinese Journal of Chemistry, 2007, 25(11):1728–1731.

3. Yong Hui Zhang, Xi Liang Yang, Xue Feng Zhou, Han Li Ruan, Hui Fang Pi, Ji Zhou Wu^(*), Han Dong Sun, and Tetsuro Fujita, A New Veratramine Alkaloids from the Bulbs of Fritillaria Hupehensis, Chinese Chemical Letters, 2007, 18(2) 175–177.

2. Yong-Hui Zhang^(*), Han-Li Ruan, Hui-fang Pi, Ji-Zhou Wu, Han-Dong Sun, and Tetsuro Fujita, Structural elucidation of fritillahupehin from bulbs of Fritillaria hupehensis Hsiao et KC Hsia, Journal of Asian Natural Products Research, 2004, 6(1): 29–34.

1. Zhang Yong-hui, Ruan Han-li, Fang Pi-hui, Cai Jin-yan, and Wu Ji-zhou^(*), A new steroidal alkaloid from bulbs of Fritillaria hupehensis Hsiao et K.C. Hsia., Chemical Research in Chinese Universities, 2004, 20 (6): 804–806.

(三)教材编写及组织会议情况

8)国家规划本科生统编教材《天然药物化学》(人民卫生出版社)，编委，2011年；

7)国家规划本科生统编教材《天然药物化学》配套教材《天然药物化学习题集》(人民卫生出版社) 编委，2011年

6)高等院校药学与制药工程专业规划教材《天然药物化学》(浙江大学出版社)，副主编，2011年

5)21世纪高等教育规划教材《有机化合物及药物波谱分析》(华中师范大学出版社)，副主编，2008年；

4)国家规划本科生统编教材配套教材《天然药物化学习题集》(人民卫生出版社) 编委，2007年；

3)《药物计量学》 (中国医药科技出版社)，主译之一，2007年；

2)国家规划本科生统编教材配套教材《天然药物化学学习指导》(人民卫生出版社) 编委，2005年；

1)本科生统编教材《有机化合物波谱解析》(中国医药科技出版社)，参编，2004年第一版及2006年第二版。

联系方式

中国 湖北省 武汉市 汉口 航空路13号(邮编430030)

华中科技大学同济医学院药学院

电话 (Tel): 0086－** (办公室)

E-mail：zhangyonghui5@sina.com