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万谦
来源：未知???????? 发布日期：2015-07-22 08:54????????浏览次数：? 【字体：大中 小】

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万谦, 教授



电子信箱: wanqian@hust.edu.cn

地址: 武汉市航空路13号华中科技大学同济医学院药学院 430030
工作经历:

2014 今 副院长，华中科技大学同济药学院

2012 今 教授，博士生导师，华中科技大学同济药学院

2007 2011 研究科学家, 美国安进制药, 药物化学部

2004 2007 博士后，美国哥伦比亚大学，斯隆-凯特林癌症研究中心

2000 2004 研究助理, 法国巴黎第十一大学分子与材料化学学院
教育经历:

2007“药品生产质量管理规范” 课程, 美国斯隆-凯特林癌症研究中心

2000 2004 理学博士, 法国巴黎第十一大学分子与材料化学学院

1999 2000 理学硕士, 法国巴黎第十一大学分子与材料化学学院

1997 1999 硕士研究生, 华中师范大学化学系

1993 1997 理学学士, 华中师范大学化学系



研究领域：

? 具有自主知识产权的新药开发

? 新的糖化学的合成方法和策略发展

? 具有生物活性有机小分子的设计与合成

? 自由基化学及水相有机反应

? 以糖化合物为基础的抗癌疫苗的研制(设计, 合成及评价)

? 生物活性寡糖(包括肿瘤相关寡糖抗原)的合成及活性评价



主要荣誉及主持项目:



2015 2017 湖北省杰出青年基金 No. 2015CFA035 (20 万)

2015 2018 国家自然科学基金面上项目No. ** (85 万)

2014 华中科技大学科技创新活动优秀指导教师

2014 2015 华中科技大学自主创新研究基金: 国际科技合作专项No. 2014ZZGH015 (10万)

2014 2015 上海有机化学研究所生命有机化学国家重点实验室开放基金 (5 万)

2013 湖北省特聘专家

2013 2016 国家自然科学基金面上项目No. ** (80 万)

2012 高等学校博士学科点专项科研基金（新教师类）No. **092 (4 万)

2012 中共中央组织部“****-青年项目”入选者 (200 万)

2012 2015华中科技大学人才引进基金 (200 万)

2011美国安进制药“第一届绿色药物化学奖”

2006 美国威廉和爱丽丝·古德温公益癌症研究基金会基金 (13 万美元)

2000 2004 法国外交与欧洲事务部“艾菲尔-优秀人才”国际学生奖学金
专业学会: 美国化学学会、美中生物医药协会、美中医药开发协会、中国化学会
学术兼职： 《Frontiers in Chemical Biology》Review Editor；荆楚理工学院客座教授

专利申请:
3. 万谦，苏朋华，曾静，赵岳琦 “一种糖基硫醇及金诺芬的合成方法”CN**5.0
2. Danishefsky, S. J.; Zhu, J.; Wan, Q.; Jeon, I.; Kim, W.; Nagorny, P.; Lee, D.; Livingston, P.; Ragupathi, G. “Glycopeptide constructs and uses thereof”. US2011/** A1.
1. Danishefsky, S. J.; Warren, J. D.; Chen, J.; Wu, B.; Chen, G.; Wan, Q.; Tan, Z.; Kan, C.; Yuan. Y.; Hua, Z.; Ranganathan, K.; Trzupek, J. D. “Preparation of homogeneous erythropoietin and other peptides and proteins”. US2010/** A1.



学术专著：



1. Luo, J.; Wan, Q.* “Recent Advances in Gold-Catalyzed Glycosylation” Carbohydrate Chemistry: Chemical and Biological Approaches 2014, 40, 140-159.



发表论文:
38. Zhang, M.; Xie, Y.; Zhan, G.; Lei, L.; Shu, P.; Chen, Y.; Xue, Y.; Luo, Z.; Wan, Q.; Yao, G.;* Zhang, Y.* “Grayanane and Leucothane Diterpenoids from Rhododendron Micranthum and Their Immunomodulatory Activities” Phytochemistry 2015, 117, 107. (IF: 2.547)
37. Ma, J.; Zeng, J.; Wan, Q.* “Postligation-Desulfurization: A General Approach for Chemical Protein Synthesis” Topics in Current Chemistry 2015, 363, 57. (IF: 4.464)
36. Shu, P.; Zeng, J.; Tao, J.; Zhao, Y.; Yao, G.; Wan, Q.* “Selective S-deacetylation Inspired by Native Chemical Ligation: Practical Syntheses of Glycosyl Thiols and Drug Mercapto-analogues” Green Chem. 2015, 17, 2545. (IF: 8.020)

? 舒朋华 第二届阿达玛斯学术论文奖 “探索优秀奖”
35. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Zhao, Y.; Xu, Y.; Yao, W.; Zeng, J.; Wan, Q.* “Stereoselective Synthesis of α-linked 2-Deoxy Glycosides Enabled by Visible Light Mediated Reductive Deiodination” Chem. Eur. J. 2014, 20, 17319. (IF: 5.731)

? Highlighted by Photocatalysis:Wiley-VCH Hot Topics

? 王浩第二届阿达玛斯学术论文奖 “探索鼓励奖”
34. Copeland, K. W.; Boezio, A. A.; Cheung, E.; Lee, J.; Olivieri, P.; Schenkel, L. B.; Wan, Q.; Wang, W.; Wells, M. C.; Youngblood, B.; Gavva, N. R.; Lehto, S. G.; Geuns-Meyer, S. Bioorg. Med. Chem. Lett. 2014, 3464. (IF: 2.420)
33. 张孟科, 朱焰, 詹冠群, 薛永波, 罗增伟, 万谦, 姚广民^*, 张勇慧, “照山白花水溶性成分研究”, 中国科技论文在线, 2014, http://www.paper.edu.cn/releasepaper/content/201401-1247.
32. 张孟科, 詹冠群, 雷亮, 薛永波, 罗增伟, 万谦, 姚广民^*, 张勇慧, “照山白枝叶化学成分研究”, 中国科技论文在线, 2014, http://www.paper.edu.cn/releasepaper/content/201401-1244.
31. Yang, K.; Li, S.; Wang, Y.; Zhang, W.; Xu, Z.; Zhou, X.; Zhu, R.*; Luo, J.*; Wan, Q.* “Enantio-selective recognition of inherently chiral calyx[4]arene crown-6 carboxylic acid cone conformer towards chiral aminoalcohols” RSC Advances, 2014, 4, 6517. (IF: 3.840)
30. Li, S.; Yang, K.; Liu, H., Xia, Y.; Zhu, R.*; Luo, J.*; Wan, Q.* “Inherently chiral biscalixarene conecone conformers consisting of calix[4]arene and calix[5]arene subunits” Tetrahedron Lett. 2013, 54, 5901. (IF: 2.379)
29. Zhang, M.; Zhu, Y.; Zhan, G.; Shu, P.; Sa, R.; Lei, L.; Xiang, M.; Xue, Y.; Luo, Z.; Wan, Q.; Yao, G.;* Zhang, Y.* “Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum” Org. Lett. 2013, 3094. (IF: 6.364)
28. Shi, J.; Li, S.; Xia, X.; Wang, X.;* Luo, J.;* Wan, Q. “An inherently chiral calix[4]crown carboxylic acid in the 1,2-alternate conformation” J. Incl . Phenom. Macrocycl. Chem. 2013, 327. (IF: 1.426)
27. Schenkel, L.; Huang, X.; Cheng, A.; Deak, H.; Doherty, E.; Emkey, R.; Gu, Y.; Gunaydin, H.; Kim, J.; Lee, J.; Loberg, R.; Olivieri, P. Pistillo, J.; Tang, J.; Wan, Q.; Wang, H.; Wang, S.; Wells, M.; Wu, B.; Yu, V.; Liu, L.; Geuns-Meyer, S.* “Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors” J. Med. Chem. 2011, 54, 8440. (IF: 5.447)
26. Yuan, Y.; Chen, J.; Wan, Q.; Wilson, R. M.; Danishefsky, S. J.* “Toward Fully Synthetic, Homogeneous Glycoproteins: Advances in Chemical Ligation ” Biopolymers 2010, 94, 373. (IF: 2.385)
25. Chen, J.; Wang, P.; Zhu, J.; Wan, Q.; Danishefsky, S. J.* “A Program for Ligation at Threonine Sites: Application to the Controlled Total Synthesis of Glycopeptides” Tetrahedron 2010, 66, 2277. (IF: 2.641)

? Highlighted as Cover
24. Nagorny, P.; Kim, W. H.; Wan, Q.; Lee, D.; Danishefsky, S. J.* “On the Emerging Role of Chemistry in the Fashioning of Biologics: Synthesis of a Bidomainal Fucosyl GM1-Based Vaccine, for the Treatment of Small Cell Lung Cancer” J. Org. Chem. 2009, 74, 5157. (IF: 4.721)

? Highlighted as Featured Article
23. Zhu, J.; Wan, Q.; Lee, D.; Yang, G.; Spassova, M. K.; Ouerfelli, O.; Ragupathi, G.; Damani, P.; Livingston, P. O.; Danishefsky, S. J.* “From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine” J. Am. Chem. Soc. 2009, 131, 9298. (IF: 12.113)



22. Kan, C.; Trupek, J.; Wu, B.; Wan, Q.; Chen, G.; Tan, Z.; Yuan, Y.; Danishefsky, S. J.* “Toward Homogeneous Erythropoietin: Chemical Synthesis of the Ala1-Gly28 Glycopeptide Domain by “Alanine” Ligation” J. Am. Chem. Soc. 2009, 131, 5438. (IF: 12.113)
21. Yuan, Y.; Chen, J.; Wan, Q.; Tang, Z.; Chen, G.; Kan, C.; Danishefsky, S. J.* “Toward Homogeneous Erythropoietin: Fine Tuning of the C-Terminal Acyl Donor in the Chemical Synthesis of the Cys29–Gly77 Glycopeptide Domain” J. Am. Chem. Soc. 2009, 131, 5432. (IF: 12.113)
20. Zhu, J.; Wan, Q.; Ragupathi, G.; George, C. M.; Livingston, P. O.; Danishefsky, S. J.* “ Biologic Through Chemical: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer Orchestration of Oligosaccharide and Polypeptide Domains” J. Am. Chem. Soc. 2009, 131, 4151. (IF: 12.113)

? Highlighted in ACS Chemical Biology 2009, 4, 238 (spotlight).
19. Zhu, J.; Wan, Q.; Yang, G.; Ouerfelli, O.; Danishefsky, S. J.* “Synthesis of Human Cancer Associated Globo-H (MBR1) Glycosylamino Acid: Some Mechanistic and Conformational Reinvestigations” Heterocycles, 2009, 79, 441. (IF: 0.908)
18. Zhu, J.; Wan, Q.; Danishefsky, S. J.* “Synthesis of Biotinylated Tumor-Associated Carbohydrate Antigens for Immunological Studies” Tetrahedron Lett. 2009, 50, 712. (IF: 2.391)
17. Chen, J.; Wan, Q.; Yuan, Y.; Zhu, J.; Danishefsky, S. J.* “Native Chemical Ligation at Valine: A Contribution to Peptide and Glycopeptide Synthesis” Angew. Chem. 2008, 120, 8649; Angew. Chem. Int. Ed. 2008, 47, 8521. (IF: 11.261)
16. Wan, Q.; Chen, J.; Yuan, Y.; Danishefsky, S. J.* “Oxo-ester Mediated Native Chemical Ligation: Concept and Applications” J. Am. Chem. Soc. 2008, 130, 15814. (IF: 12.113)

? Highlighted in Faculty of 1000 Biology 2009 (article ID **)
15. Wan, Q.; Lubineau, A.; Guillot, R.; Scherrmann, M. -C.* “Synthesis of C-disaccharides via a Hetero-Diels-Alder Reaction and Further Stereocontrolled Transformations” Carbohydrate Res. 2008, 343, 1754-1765. (IF: 1.966)
14. Wan, Q.; Danishefsky, S. J.* “Free Radical Based, Specific Desulfurization of Cysteine: A Powerful Advance in the Synthesis of Polypeptides and Glycopolypeptides” Angew. Chem. 2007, 119, 9408; Angew. Chem. Int. Ed. 2007, 46, 9248. (IF: 11.261 )

? Highlighted as a Very Important Paper (VIP)

? Highlighted in Angew. Chem. Int. Ed. 2008, 47, 1553.

? Abstracted by Cheminform 2008, 13-185.
13. Chen, G.; Wan, Q.; Tan, Z.; Kan, C.; Hua, Z.; Ranganathan, K.; Danishefsky, S. J.* “ Development of Efficient Methods for Accomplishing Cysteine-Free Peptide and Glycopeptide Coupling” Angew. Chem. 2007, 119, 7527; Angew. Chem. Int. Ed. 2007, 46, 7383. (IF: 11.336)

? Highlighted as a Hot Paper

? Abstracted by Cheminform 2007, 51-199
12. Wu, B.; Tan, T.; Chen, G.; Chen, J.; Hua, Z.; Wan, Q.; Ranganathan, K.; Danishefsky, S. J.* “Mature Homogeneous Erythropoietin Building Blocks by Chemical Synthesis: The EPO 22-37 Glycopeptide Domain Presenting the Fully N-Linked Dodecasaccharide” Tetrahedron Lett. 2006, 47, 8009. (IF: 2.391)

? Abstracted by Cheminform 2007, 02-181
11. Chen, J.; Chen, G.; Wu, B.; Wan, Q.; Tan, Z.; Hua, Z.; Danishefsky, S. J.* “Mature Homogeneous Erythropoietin Building Blocks by Chemical Synthesis: The EPO 114-166 Glycopeptide Domain Presenting Its O-Linked Glycophorin” Tetrahedron Lett. 2006, 47, 8013. (IF: 2.391)

? Abstracted by Cheminform 2007, 02-182
10. Wan, Q.; Chen, J.; Chen, G.; Danishefsky, S. J.* “A Valuable Advance in the Synthesis of Carbohydrate Based Anticancer Vaccines Through Extended Cycloaddition Chemistry:” J. Org. Chem. 2006, 71, 8244. (IF: 4.721)

? Abstracted by Cheminform 2007, 01-187



9. Wu, B.; Hua, Z.; Warren, D. J.; Ranganathan, K.; Wan, Q.; Chen, G.; Tang, Z.; Chen, J.; Endo, A.; Danishefsky, S. J.* “Synthesis of the Biantennary N-Glycan of Erythropoietin” Tetrahedron Lett. 2006, 47, 5577. (IF: 2.683)
8. Chen, J.; Warren, D. J.; Wu, B.; Chen, G.; Wan, Q.; Danishefsky, S. J.* “ Synthesis of Cyclic Peptides and Glycopeptides by Native Chemical Ligation Using in situ Derived Thioester” Tetrahedron Lett. 2006, 47, 1969. (IF: 2.683)
7. Chen, G.; Warren, D. J.; Chen, J.; Wu, B.; Wan, Q.; Danishefsky, S. J.* “New Chemical Ligation Method for Peptide Synthesis: Concept, Model Study, and Mechanistic Investigation” J. Am. Chem. Soc. 2006, 7460. (IF: 12.113)

? Highlighted in Chem. Eng. News, 2006, 84 (June, 5).
6. Ragupathi, G.; Koide, F.; Livingston, P. O.; Cho, Y. S.; Atsushi, E.; Wan, Q.; Spassova, M. K.; Keding, S. J.; Allen, J.; Ouerfelli, O.; Wilson, R. M.; Danishefsky, S. J.* “Preparation and Evaluation of Unimolecular Pentavalent and Hexavalent Antigenic Constructs Targeting Prostate and Breast Cancer: A Synthetic Route to Anticancer Vaccines Candidates” J. Am. Chem. Soc. 2006, 2715. (IF: 12.113)

? 科学通报 2008, 53, 17, 2126. 动态报道
5. Wan, Q.; Cho, Y. S.; Lambert, T. H.; Danishefsky, S. J.* “Olefin Cross-Metathesis: A Powerful Tool for Constructing Vaccines Composed of Multimeric Antigens.” J. Carbohydr. Chem. 2005, 24, 425. (IF: 1.417)
4. Cho, Y. S.; Wan, Q.; Danishefsky, S. J.* “Organic Synthesis in Pursuit of Immunology: Large Scale Synthesis of Peracetylated GM₂ Glycosylamino Acid for Preparation of a Multiantigenic Prostate Cancer Vaccine” Bioorg. Med. Chem. 2005, 13, 5259. (IF: 2.793)
3. Wan, Q.* “Di-n-butyltin oxide (DBTO)” Synlett. 2004, 1847. (IF: 2.419)
2. Wan, Q.; Lubineau, A.;* Scherrmann, M. -C.* “Synthesis of C-3 branched allyl and pentadienyl glucosamines via radical coupling of sugar-thionocarbonates.”J. Carbohydr. Chem. 2004, 23, 83. (IF: 1.417)

? Abstracted by Cheminform 2004, 41-190
1. Yu, X.Y.; Lu, B. X.; Wan, Q.; Wang, Y. G.* “Synthesis and biological activity of Schiff base on carboxylate of triazole.” J. Central China Normal. University. (Natural Sciences). 1999, 225.



邀请报告：
12. 山东大学，济南， 2015年6月1日
11. 中国海洋大学，青岛，2015年5月29日
10. 扬州大学， 2015年4月24日
9. 糖合成化学青年高峰论坛，南昌，江西师范大学， 2015年4月11日
7. 中国化学会第29届学术年会, 北京大学, 6 August, 2014.
6. 2014全国糖生物学学术会议, 西安,18 July, 2014.
5. Frontier Research in Advanced Organic Synthesis and Catalysis, Wuhan University, May 28, 2014 .
4. 武汉工程大学，2014年4月25日.
3. 华中科技大学基础医学院第二期青年学术论坛，2014年4月10日.
2. “****”常州化工新材料产业发展高峰论坛， 2013年7月21日.
1. 2013 International Symposium of Frontier Sciences on New Drug Discovery and Symposium of Medicinal Chemistry and Antibiotics of Pharmaceutical Association of Hubei Province, Wuhan University, Wuhan, Hubei, China, December 24, 2013.
会议论文：



15. Wang, H.; Shu, P.; Tao, J.; Chen, W.; Yao, W.; Xu, Y.; Zhao, X.; Zhao, Y.; Xiao, X.; Zhu, Y.; Imberg, L.; Zeng, J.; Wan, Q.* “Stereoselective Synthesis of alpha-Linked 2-Deoxy Glycosides Enabled

by Visible-Light-Mediated Reductive Deiodination” 7^thPacific Symposium on Radical Chemistry, Singapore, 15-18 July, 2015.
14. Shu, P.; Zeng, J.; Tao, J.; Zhao, Y.; Yao, G.; Wan, Q.* “Selective S-deacetylation Inspired by Native Chemical Ligation: Practical Syntheses of Glycosyl Thiols and Drug Mercapto-analogues” Gordon Research Conferences Frontiers of Science, Vermont, USA, June 14-19, 2015.
13. 舒朋华，曾静，陶锦毅，赵岳琦，姚广明，万谦* “基于自然化学连接法的选择性脱硫乙酰基合成糖基硫醇” 糖合成化学青年高峰论坛，南昌， April 11-12, 2015.
12. 王浩，舒朋华，陶锦毅，陈薇，姚旺，徐阳，赵祥，赵岳琦，肖雄， Imberg Lukas，蔡鑫培，曾静，万谦* “可见光催化的碘脱除反应在脱氧糖合成中的应用” 糖合成化学青年高峰论坛，南昌， April 11-12, 2015.
11. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Xu, Y.; Zhao, Y.; Zeng, J.; Wan, Q.* “Synthesis of 2-Deoxy Oligosaccharides via Visible Light Mediated Tin Free Deiodination” 第十三届国际华人有机化学研讨会暨第十届国际华人无机化学研讨会，厦门, 19-22, December, 2014.
10. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Xu, Y.; Zhao, Y.; Luo, J.; Zeng, J.; Wan, Q.* 2014 French-Chinese Conference on Green Chemistry, Wuhan, 3-7 November, 2014.



9. 王浩,陶锦毅,蔡鑫培,陈薇,赵岳琦,徐阳,罗钧,曾静,万谦^*“可见光催化的碘脱除反应在2-脱氧糖苷的合成中的应用”2014全国糖生物学学术会议, 西安，16-19 July, 2014.



8. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Xu, Y.; Zhao, Y.; Luo, J.; Zeng, J.; Wan, Q.* “Visible Light Mediated Tin Free Deiodination: An Application in the Stereoselective Synthesis of 2-Deoxy Oligosaccharides ” The 10^th Sino-US Chemistry Professors Conference, 济南, 15-17 June, 2014.
7. Wang, H.; Tao, J.; Cai, X.; Chen, W.; Xu, Y.; Zhao, Y.; Luo, J.; Wan, Q.* “Visible Light Mediated Deiodination: An Application in the Stereoselective Synthesis of 2-Deoxy Oligosaccharides” 15^th Tetrahedron Symposium, London, UK, 24-27^th June 2014.
6. 王浩; 陶锦毅; 蔡鑫培; 陈薇; 赵岳琦; 徐阳; 罗钧; 万谦* “可见光催化反应在脱氧糖苷的合成中的应用” 2013年国际药学前沿科学研讨会暨药物化学与抗生素专业委员会学术年会, 武汉大学, 24 Dec 2013.
5. Schenkel, R.; Deak, H.; Doherty, E.; Olivieri, P.; Wan, Q.; Wang, H.; Wu, B.; Chen, A.; Emkey,R.; Gunaydin, H.; Huang, X.; Kim, J,; Loberg, R.; Pistillo, J.; Sinclair, A.; Wang, S.; Yu, V.; Liu, L.; Geuns-Meyer, S. “Discovery of Potent Jak2 Inhibitors That Demonstrate High Jak Family Selectivity in Enzyme, Engineered Cell, and Cytokine-Stimulated Primary Whole Blood Assays” Gordon Research Conference Medicinal Chemistry, Colby-Sawyer College, New London, NH, USA 08-13 Aug 2010.
4. Kan, C.; Trupek, J.; Wu, B.; Wan, Q.; Chen, G.; Tan, Z.; Yuan, Y.; Danishefsky, S. J. “Towards the chemical synthesis of homogeneous erythropoietin: The EPO(Ala1-Gly28) glycopeptide domain via native chemical ligation and desulfurization” 239^th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010.
3. Scherrmann, M. -C.; Wan, Q.; Lubineau, A. “Synthèse de C-disaccharides par reaction d’Hétéro Diels-Alder et fonctionalisations stérérocontrollées des adduits” XX^th Journées de Chimie et Biochimie des Glucides, Douran, France, 2004
2. Wan, Q.; Lubineau, A.; Scherrmann, M. -C. “Synthesis of C-disaccharides via hetero-Diels-Alder reaction and further stereo-controlled transformations” 12^th European Carbohydrate Symposium, Grenoble, France, July 6-11, 2003, Abstract PB061, P. 273.
1. Wan, Q.; Lubineau, A.; Scherrmann, M. -C. “Synthesis of C-3 diene branched glucosamine” XIX^th Journées de Chimie et Biochimie des Glucides, Albé, France, 2002.