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黄建耿
来源：未知???????? 发布日期：2015-06-29 09:51????????浏览次数：? 【字体：大中 小】

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黄建耿，男，浙江温州人，博士，华中科技大学同济医学院药学院副教授，硕士生导师。主要从事药物体内转运与代谢方面研究工作。目前承担华中科技大学人才引进基金、湖北省卫生厅青年人才基金、湖北省自然科学基金、国家自然科学基金等项目，发表论文40余篇，其中在国际重要学术期刊Int J Pharm、Drug Metab Pharmacokinet、Xenobiotica、J Chromatogr A、J Chromatogr B、J Pharm Biomed Anal、J Sep Sci等杂志发表论文20余篇，获授权发明专利2项。
联系方式

办公室：** 手 机：**

E-mail: jiangenghuang@hust.edu.cn QQ：**

通讯地址：湖北省武汉市航空路13号药学院二号楼211室 邮编：430030



研究方向

1. 基于药物转运体与代谢酶功能改变引发药物性肝损伤机理研究

2. 药物跨血脑屏障转运机制研究

3. 药物鼻黏膜给药脑靶向转运机制研究



教育背景

博士 2008.07

华中科技大学同济医学院药学院

本科 2003.07

华中科技大学同济医学院(原同济医科大学)药学院



工作经历

副教授 2012.04-至今

华中科技大学同济医学院药学院

博士后 2010.08-2012.03

美国爱荷华大学（University of Iowa）药学院

兼职讲师 2011.8-2011.11

美国德雷克大学（Drake University）药学院

博士后2008.10-2010.07

美国内布拉斯加州大学医学中心（University of Nebraska Medical Center）药学院
学术任职

2010.10--至今 美国药学会会员

2012.12--至今 中国抗癌协会纳米肿瘤学专业委员会委员

2013.04-2017.04 武汉市药学会药学教育专业委员会委员

2014.05--至今 《医药导报》编委



主持的科研课题

1. 国家自然科学基金青年科学基金项目：基于NTCP/Ntcp和BSEP/Bsep介导的胆汁酸转运受阻导致托伐普坦药物性肝损伤机理研究 2014.01-2016.12 课题编号：** 资助经费：23万元

2. 湖北省卫生厅青年科技人才项目：普拉克索鼻黏膜给药脑靶向治疗帕金森及其跨鼻黏膜转运机制研究 2013.01-2014.12 课题编号：QJX2012-02 资助经费：4万元

3. 湖北省自然科学基金项目：基于胆汁酸代谢的药物性肝损伤诊断研究2014.01-2015.12 课题编号：2014CFB956 资助经费：3万元

4. 中央高校基本科研业务费资助（华中科技大学自主创新重点专项基金）项目：细胞转染模型研究托伐普坦肝毒性发生机制 2014.01-2015.12 课题编号：2014QN135 资助经费：4万元

5. 中央高校基本科研业务费资助（华中科技大学自主创新青年基金）项目：抗帕金森药物鼻黏膜给药脑靶向转运机制研究 2012.07-2013.12 课题编号：2012QN014 资助经费：4万元

6. 华中科技大学人才引进基金（2012年）：鼻黏膜给药实现脑靶向及其转运机制研究 2012.04-2015.03 资助经费：20万元
发表论文：

1. Peng Cao, Gao Li, Ling Huang, Shouwei Zhao, Yang Hu, Lixia Qin, Lihui Qiu, Wenwen Zhu, Luqin Si*, Jiangeng Huang*. Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood. Bioanalysis. 2015 (DOI: 10.4155/BIO.15.74)

2. Kewen Xue, Gao Li, Xiao Sun, Yang Hu, Lei Hu, Jiangeng Huang*, Luqin Si*. Simultaneous quantification of fosinopril and its active metabolite fosinoprilat in rat plasma by UFLC-MS/MS: Application of formic acid in the stabilization of an ester-containing drug. J Chromatogr B Analyt Technol Biomed Life Sci. Apr 3 2015, 990:141-149.

3. Lei Hu, Zhenhua Lv, Gao Li, Xiaolong Xu, Chenghao Zhang, Peng Cao, Jiangeng Huang*, Luqin Si*. Study of the in vitro metabolism of TJ0711 using ultra high performance liquid chromatography with quadrupole time-of-flight and ultra fast liquid chromatography with quadrupole linear ion trap mass spectrometry. J Sep Sci. Mar 20 2015, DOI: 10.1002/jssc.**

4. Weilin Guo, Gao Li, Yanxia Yang, Conglian Yang, Luqin Si*, Jiangeng Huang*. LC-MS/MS analysis of pramipexole in mouse plasma and tissues: Elimination of lipid matrix effects using weak cation exchange mode based solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci. Mar 2 2015, 988:157-165.

5. Chenru Yin, Liyun Ma, Jiangeng Huang, Li Xu, Zhiguo Shi*. Fast profiling ecotoxicity and skin permeability of benzophenone ultraviolet filters using biopartitioning micellar chromatography based on penetrable silica spheres. Analytica Chimica Acta. Dec 4 2013, 804:321-327.

6. Gang Zhao, Jiangeng Huang, Kewen Xue, Luqin Si*, Gao Li. Enhanced intestinal absorption of etoposide by self-microemulsifying drug delivery systems: roles of P-glycoprotein and cytochrome P450 3A inhibition. European Journal of Pharmaceutical Sciences. Aug 25 2013, 50:429-439.

7. Yani Liu, Jiangeng Huang, Jinmei Liu, Lin Ma, Yongning Lv, Shaojun Shi*. A simple and sensitive liquid chromatographic technique for the determination of cefotetan disodium in human plasma and its application in a pharmacokinetic study. J Huazhong Univ Sci Technolog Med Sci. Oct 18 2012, 32(5):779-784.

8. Hardeep S Oberoi, Natalia V Nukolova, Frederic C Laquer, Larisa Y Poluektova, Jiangeng Huang, Yazen Alnouti, Masanao Yokohira, Lora L Arnold, Alexander V Kabanov, Samuel M Cohen, Tatiana K Bronich*. Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice. Int J Nanomedicine. Jun 8 2012, 7:1-15.

9. Sai P. Bathena, Jiangeng Huang, Adrian A. Epstein, Howard E. Gendelman, Michael D. Boska, Yazen Alnouti*. Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. Apr 15 2012, 893-894:15-20.

10. Jiangeng Huang, Lei Hu, Li Xu, Minghui Sun, Zhaoze Fan, Jun Qiu, Gao Li, Luqin Si*. In vitro enantioselective metabolism of TJ0711 hydrochloride by human liver microsomes using a novel chiral liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. April 1 2012, 891-892:98-101.

11. Jiangeng Huang, Juanjuan Liu, Cong Zhang, Jiaojiao Wei, Li Mei, Shan Yu, Gao Li*, Li Xu*. Determination of sulfonamides in food samples by membrane-protected micro-solid phase extraction coupled with high performance liquid chromatography. J Chromatogr A. Jan 6 2012, 1219:66-74.

12. Jiangeng Huang, Luqin Si, Zhaoze Fan, Lei Hu, Jun Qiu, Gao Li*. In vitro metabolic stability and metabolite profiling of TJ0711 hydrochloride, a newly developed vasodilatory β-blocker, using a liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. Nov 15 2011, 879(30):3386-3392.

13. Jiangeng Huang, Nagsen Gautam, Sai Praneeth R. Bathena, Upal Roy, JoEllyn McMillan, Howard E. Gendelman, Yazen Alnouti*. UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. J Chromatogr B Analyt Technol Biomed Life Sci. Aug 1 2011, 879(23):2332-2338.

14. Jiangeng Huang, Sai Praneeth R. Bathena, Ivan L. Csanaky, Yazen Alnouti*. Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS. J Pharm Biomed Anal. Jul 15 2011, 55(5):1111-1119.

15. Jiangeng Huang, Sai Praneeth R. Bathena, Yazen Alnouti*. Metabolite profiling of Praziquantel and its analogs during the analysis of in vitro metabolic stability using information-dependent acquisition on a hybrid triple-quadrupole linear ion trap mass spectrometer. Drug Metab Pharmacokinet. Sep 22 2010, 25(5):487-499.

16. Jiangeng Huang, Sai P. Bathena, Jing Tong, Megan Roth, Bruno Hagenbuch, Yazen Alnouti*. Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. Mar 1 2010, 40(3):184-194.

17. Jiangeng Huang, Luqin Si, Lingli Jiang, Zhaoze Fan, Jun Qiu, Gao Li. Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism. Int J Pharm. May 22 2008, 356(1-2):351-353.



专利：

1. 斯陆勤，李高，赵瑛，黄建耿. 喷滴法微球制备装置，2008.12，中国，专利号：CN**2.0.

李高，胡磊，陈邦银，裘军，斯陆勤，黄建耿，苏玉永. 一种α/β受体双重抑制剂及其盐的制备方法，2012.02，中国，专利申请号：CN**0.8专利公开号：CN**A.