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薛永波
来源：未知???????? 发布日期：2015-06-19 17:11????????浏览次数：? 【字体：大中 小】

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理学博士，硕士研究生导师，中国化学会会员，湖北省药学会秘书。2011年7月毕业于中国科学院昆明植物研究所药物化学专业（天然药物化学研究方向），师从著名植物化学家 孙汉董 院士。2011年9月至今，在华中科技大学同济医学院药学院中药与天然药物化学系任教。

他主要从事药用植物和真菌来源天然产物化学研究工作。研究团队在唇形科鼠尾草属、五味子科北五味子属、藤黄科金丝桃属、大戟科叶下珠属、天南星科菖蒲属、薯蓣科薯蓣属、菊科兔儿风属等药用植物，以及药用节肢动物共生菌和不同来源真菌等次生代谢产物研究中，鉴定天然产物近600个，其中包括新化合物240多个、具全新的新颖骨架类型化合物40余种。主持国家自然科学基金1项、湖北省自然科学基金1项、华中科技大学人才引进启动基金1项、华中科技大学创新基金2项、指导华中科技大学大学生创新训练计划项目3项；作为主要负责人参与“863”计划、国家国际合作计划和国家重大新药创制专项等多项国家级科研项目。发表科研论文50篇，会议论文10篇，其中SCI收录46篇，总Impact Points 142.93，分布在学术刊物Org. Lett.，J. Nat. Prod.，Phytochemistry，Euro. J. Org. Chem.，RSC adv.，Mar. Drugs，Sci. Rep. UK，Tetrahedron Lett.，Fitoterapia和Chem. Pharm. Bull.等。



研究方向——天然药物化学和化学生物学：

1．中药及天然药物药效物质基础研究

2．新颖结构天然产物的发现及其生物学研究

3．抗肿瘤及治疗老年退行性疾病创新药物研究




近年代表性科研工作：

[1] Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis, Yongbo Xue, Xifeng Li, Xue Du, Xiaonian Li, Weiguang Wang, Jianhong Yang, Jijun Chen, Jianxin Pu,* Handong Sun*: Phytochemistry 2015; 116:253–61. DOI: 10.1016/j.phytochem.2015.03.009.

[2] Armochaetoglobins A–J: cytochalasan alkaloids from Chaetomium globosum TW1-1, a fungus derived from the terrestrial arthropod Armadillidium vulgare, Chunmei Chen, Jianping Wang, Junjun Liu, Hucheng Zhu, Bin Sun, Jing Wang, Jinwen Zhang, Zengwei Luo, Guangmin Yao, Yongbo Xue*, Yonghui Zhang*: J. Nat. Prod. 2015; Accepted.

[3] Armochaetoglobins K–R, Anti-HIV Pyrrole-based Cytochalasans from Chaetomium Globosum TW1-1, Chunmei Chen, Hucheng Zhu, Jianping Wang, Jing Yang, Xiao-Nian Li, Jing Wang, Keliang Chen, Yanyan Wang, Zengwei Luo, Guangmin Yao, Yongbo Xue,* Yonghui Zhang*: Euro. J. Org. Chem. 2015; 14:3086–94. DOI: 10.1002/ejoc.**.

[4] Hyperascyrones A–H, Polyprenylated Spirocyclic Acylphloroglucinol Derivatives from Hypericum ascyron Linn, Hucheng Zhu, Chunmei Chen, Junjun Liu, Bin Sun, Guangzheng Wei, Yan Li, Jinwen Zhang, Guangmin Yao, Zengwei Luo, Yongbo Xue,* Yonghui Zhang*: Phytochemistry 2015; 115:222–30 DOI: 10.1016/j.phytochem.2015.02.009.

[5] Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum, Chunmei Chen, Hucheng Zhu, Xiao-Nian Li, Jing Yang, Jianping Wang, Gentao Li, Yan Li, Qingyi Tong, Guangmin Yao, Zengwei Luo, Yongbo Xue,* and Yonghui Zhang*: Org. Lett. 2015; 17(3):644–7. DOI: 10.1021/ol503666b.

u Highlighted as Hot off the press in Nat. Prod. Rep., 2015; 32, 512–516
[6] Neolignans with a Rare 2-Oxaspiro[4.5]deca-6,9-dien-8-one Motif from the Stem Bark of Cinnamomum subavenium, Yongji Lai, Tingting Liu, Rongjian Sa, Xialan Wei, Yongbo Xue, Zhaodi Wu, Zengwei Luo, Ming Xiang, Yonghui Zhang*, Guangmin Yao*: J. Nat. Prod. 2015; Accepted.

[7] Grayanane and leucothane diterpenoids from the leaves of Rhododendron micranthum, Mengke Zhang, Yangyang Xie, Guanqun Zhan, Liang Lei, Penghua Shu, Yongli Chen, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao*, Yonghui Zhang*: Phytochemistry 2015; 117: 107–15. DOI: 10.1016/j.phytochem.2015.06.007.

[8] Transition-Metal-Free Synthesis of Phenanthridinones from Biaryl-2-Oxamic Acid under Radical conditions, Ming Yuan, Li Chen, Junwei Wang, Shenjie Chen, Kongchao Wang, Yongbo Xue, Guangmin Yao, Zengwei Luo*, Yonghui Zhang*: Org. Lett. 2015; 17(2):346–9. DOI: 10.1021/ol503459s.

[9] Hyperattenins A–I, Bioactive Polyprenylated Acylphloroglucinols from Hypericum attenuatum Choisy, Dongyan Li, Yongbo Xue ^#, Hucheng Zhu, Yan Li, Bin Sun, Junjun Liu, Guangmin Yao, Jinwen Zhang, Guang Du*, Yonghui Zhang*: RSC Adv. 2015; 5:5277–87. DOI: 10.1039/C4RA11675E. (#: co-first)

[10] Indole diketopiperazines from endophytic Chaetomium sp 88194 induce breast cancer cell apoptotic death, Fuqian Wang, Qingyi Tong, Haoran Ma, Hongfeng Xu, Song Hu, Wei Ma, Yongbo Xue, Junjun Liu, Jianping Wang, Hongping Song, Jinwen Zhang*, Geng Zhang*, Yonghui Zhang*: Sci. Rep. -UK 2015; 5:9294. DOI: 10.1038/srep09294.

[11] A new 3,4-seco-oleanane-type triterpenoid with an unusual enedione moiety from Hypericum ascyron, Chunmei Chen, Guangzheng Wei, Hucheng Zhu, Yi Guo, Xiao-Nian Li, Jinwen Zhang, Yanfei Liu, Guangmin Yao, Zengwei Luo, Yongbo Xue,* and Yonghui Zhang*: Fitoterapia 2015; 103:227-30. DOI: 10.1016/j.fitote.2015.04.009.

[12] Two New Adamantyl-Like Polyprenylated Acylphloroglucinols from Hypericum attenuatum choisy, Dongyan Li, Hucheng Zhu, Changxing Qi, Yongbo Xue,* Guangmin Yao, Zengwei Luo, Jianping Wang, Jinwen Zhang, Guang Du,* Yonghui Zhang*: Tetrahedron Lett. 2015; 56(15):1953–5. DOI: 10.1016/j.tetlet.2015.02.056.

[13] Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum sampsonii, Hucheng Zhu, Chunmei Chen, Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao, Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue*, Yonghui Zhang*: Org. Lett. 2014; 16(23):6322–5. DOI: 10.1021/ol**.

u Highlighted as Hot off the press in Nat. Prod. Rep., 2015; 32, 512–516
[14] Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii, Zheng-Xi Hu, Yongbo Xue^#, Xiao-Bin Bi, Jin-Wen Zhang, Zeng-Wei Luo, Xiao-Nian Li, Guang-Min Yao, Jian-Ping Wang*, Yong-Hui Zhang*: Mar. Drugs 2014; 12(11):5563–75.DOI: 10.3390/md**. (#: co-first)

[15] Salviprzols A and B, C₂₁- and C₂₂-terpenoids from the roots of Salvia przewalskii Maxim, Yongbo Xue*, Ye Wu, Hucheng Zhu, Xiao-Nian Li, Jin-Fu Qian, Yongji Lai, Chunmei Chen, Guangmin Yao, Zengwei Luo, Yan Li, Yonghui Zhang*: Fitoterapia 2014; 99:204–10. DOI: 10.1016/j.fitote.2014.09.022.

[16] Colletotrichumine A, a novel indole–pyrazine alkaloid with an unprecedented C₁₆N₃-type skeleton from cultures of Colletotrichum capsici, Zhengxi Hu, Jianping Wang, Xiaobin Bi, Jinwen Zhang, Yongbo Xue*, Yingda Yang, Zengwei Luo, Guangmin Yao, Yonghui Zhang*: Tetrahedron Lett. 2014; 55(44):6093–5. DOI: 10.1016/j.tetlet.2014.09.041.

[17] Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia, Junfen Zeng, Yongbo Xue, Penghua Shu, Huiqin Qian, Rongjian Sa, Ming Xiang, Xiao-Nian Li, Zengwei Luo, Guangmin Yao*, Yonghui Zhang*: J. Nat. Prod. 2014; 77(8):1448–54. DOI: 10.1021/np500465g.

[18] A pair of unprecedented cyclohexylethanoid enantiomers containing unusual trioxabicyclo[4.2.1]nonane ring from Clerodendrum bungei, Hucheng Zhu, Lijun Huan, Chunmei Chen, Jing Yang, Jiangbo He, Yong Chen, Guangmin Yao, Zengwei Luo, Yongbo Xue*, Yonghui Zhang*: Tetrahedron Lett. 2014; 55(14):2277–9. DOI: 10.1002/chin.**.

u Highlighted as Hot off the press in Nat. Prod. Rep., 2014; 31, 706–10

u Abstracted by Cheminform 2014; 45(37): DOI: 10.1002/chin.**
[19] New Norclerodane Diterpenoids from the Tubers of Dioscorea bulbifera, Ying Tang, Yongbo Xue, Lei Zhou, Jin-Wen Zhang, Guang-Min Yao, Zeng-Wei Luo, Guang Du*, Yong-Hui Zhang*: Chem. Pharm. Bull. 2014; 62(7):719–24. DOI: 10.1002/chin.**.

u Abstracted by Cheminform 2014; 45(52): DOI: 10.1002/chin.**
[20] Phytochemical and chemotaxonomic studies on Phyllanthus urinaria, Zhengxi Hu, Yongji Lai, Jinwen Zhang, Ye Wu, Zengwei Luo, Guangmin Yao, Yongbo Xue*, Yonghui Zhang*: Biochem. System. Ecol. 2014; 56:60–4. DOI: 10.1016/j.bse.2014.04.016.

[21] Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei, Heng Zheng, Qiong Chen, Mengke Zhang, Yongji Lai, Liang Lei, Penghua Shu, Jinwen Zhang, Yongbo Xue, Zengwei Luo, Yan Li, Guangmin Yao*, Yonghui Zhang*: J. Nat. Prod. 2013; 76: 2253?62. DOI: 10.1021/np401015a.

[22] Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum, Mengke Zhang, Yan Zhu, Guanqun Zhan, Penghua Shu, Rongjian Sa, Liang Lei, Ming Xiang, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao*, Yonghui Zhang*: Org. Lett. 2013; 15 (12):3094–7. DOI: 10.1021/ol401292y.

[23] Wilsonols A–L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii, Penghua Shu, Xialan Wei, Yongbo Xue, Weijie Li, Jinwen Zhang, Ming Xiang, Mengke Zhang, Zengwei Luo, Yan Li, Guangmin Yao*, Yonghui Zhang*: J. Nat. Prod. 2013; 76(7):1303–12. DOI: 10.1021/np**.

[24] Scapiformolactones A–I: Germacrane sesquiterpenoids with an unusual Δ⁽³⁾-15,6-lactone moiety from Salvia scapiformis, Yongji Lai, Yongbo Xue^#, Mengke Zhang, Jinwen Zhang, Wei Tang, Junjun Liu, Liang Lei, Juming Yan, Zengwei Luo, Jianping Zuo, Yan Li, Guangmin Yao*, Yonghui Zhang*: Phytochemistry 2013; 96:378–88. DOI: 10.1016/j.phytochem.2013.10.003. (#: co-first)

[25] Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida, Zengwei Luo, Fuqian Wang, Jinwen Zhang, Xingyao Li, Mengke Zhang, Xincai Hao, Yongbo Xue, Yan Li, F David Horgen, Guangmin Yao*, Yonghui Zhang*: J. Nat. Prod. 2012; 75(12): 2113–20. DOI: 10.1021/np**.

[26] Structure and cytotoxicity of diterpenoids from Isodon adenolomus, Wei Zhao, Jian-Xin Pu*, Xue Du, Jia Su, Xiao-Nian Li, Jian-Hong Yang, Yongbo Xue, Yan Li, Wei-Lie Xiao, Han-Dong Sun*: J. Nat. Prod. 2011; 74(5):1213–20. DOI: 10.1016/S1875-5364(11)60060-5.

[27] Schicagenins A–C: three cagelike nortriterpenoids from leaves and stems of Schisandra chinensis, Yi-Ming Shi, Xing-Yao Li, Xiao-Nian Li, Xiao Luo, Yongbo Xue, Cheng-Qin Liang, Juan Zou, Ling-Mei Kong, Yan Li, Jian-Xin Pu, Wei-Lie Xiao*, Han-Dong Sun*: Org. Lett. 2011; 13(15):3848–51. DOI: 10.1021/ol201366d.

[28] Henrischinins A–C: three new triterpenoids from Schisandra henryi, Yongbo Xue, Jian-Hong Yang, Xiao-Nian Li, Xue Du, Jian-Xin Pu*, Wei-Lie Xiao, Jia Su, Wei Zhao, Yan Li, Han-Dong Sun*: Org. Lett. 2011; 13(6):1564–7. DOI: 10.1021/ol200283y.

[29] Cytotoxic triterpene dilactones from the stems of Kadsura ananosma, Jian-Hong Yang, Jian-Xin Pu*, Jin Wen, Xiao-Nian Li, Fei He, Yongbo Xue, Yuan-Yuan Wang, Yan Li, Wei-Lie Xiao, Han-Dong Sun*: J. Nat. Prod. 12/2009; 73(1):12–6. DOI: 10.1021/np900506g.

[30] Nortriterpenoids and lignans from the fruit of Schisandra chinensis, Yongbo Xue, Yan-Long Zhang, Jian-Hong Yang, Xue Du, Jian-Xin Pu*, Wei Zhao, Xiao-Nian Li, Wei-Lie Xiao, Han-Dong Sun*: Chem. Pharm. Bull. 2010; 58(12):1606–11. DOI: 10.1002/chin.**.

会议论文

[1] 元宝草和球毛壳霉次生代谢产物及其生物活性研究，朱虎成，陈春梅，汪建平，罗增伟，姚广民，薛永波，张勇慧，中国化学会第十届天然有机化学学术会议，2011.11.21

[2] 照山白酮A;照山白中一个新碳骨架类型的二萜，张孟科，雷亮，薛永波，罗增伟，姚广民，张勇慧，2013全国中药与天然药物高峰论坛暨第十三届全国中药和天然药物学术研讨会，2013.6.16

[3] 葱莲中生物碱类成分的分离、鉴定和细胞毒性研究，詹冠群，周俊飞，王富乾，薛永波，罗增伟，姚广民，张勇慧，2013全国中药与天然药物高峰论坛暨第十三届全国中药和天然药物学术研讨会，2013.6.16

[4] 川桂皮中具有免疫调节活性的甾体和苯丙素类化学成分，魏夏兰，舒朋华，刘婷婷，薛永波，罗增伟，姚广民，张勇慧，2013全国中药与天然药物高峰论坛暨第十三届全国中药和天然药物学术研讨会，2013.6.16

[5] 川桂叶中降倍半萜类化合物的分离鉴定以及药理活性研究，舒朋华，魏夏兰，薛永波，罗增伟，姚广民，张勇慧，2013全国中药与天然药物高峰论坛暨第十三届全国中药和天然药物学术研讨会，2013.6.16

[6] 兴安杜鹃中二萜化学成分研究，谢阳阳，卢韶华，王晓敏，赵蜻，陈雨深，陈玉媛，薛永波，罗增伟，姚广民，张勇慧，2013全国中药与天然药物高峰论坛暨第十三届全国中药和天然药物学术研讨会，2013.6.16

[7] 地埂鼠尾草中倍半萜的分离鉴定以及药理活性研究，赖永继，薛永波，罗增伟，姚广民，张勇慧，2013全国中药与天然药物高峰论坛暨第十三届全国中药和天然药物学术研讨会，2013.6.16

[8] 金丝桃属植物元宝草的化学成分研究，朱虎成，陈春梅，薛永波，罗增伟，姚广明，张勇慧，第十五届中国科协年会第21分会场：中药与天然药物现代研究学术研讨会，2013.5.25

[9] 四种药用植物中萜类成分研究，张勇慧，姚广民，薛永波，罗增伟，中药与天然药高峰论坛暨第十二届全国中药和天然药物学术研讨会，2012.11.02

[10] 东北产五味子化学成分及生物活性的研究，肖伟烈，黄胜雄，薛永波，石一鸣，孙汉董*，中国化学会第28届学术年会，2012.04.13



获奖情况

1. 2011年度中国科学院研究生院三好学生标兵

2. 2011年度中国科学院研究生院地奥奖学金一等奖
联系方式：

电子邮件：yongboxue@mail.hust.edu.cn, xueyongbo@yahoo.com

通讯地址：湖北省武汉市航空路13号华中科技大学同济药学院 430030

欢迎对药物化学专业天然产物研究方向感兴趣的同学咨询、报考！