一、基本情况
郁慧丽，博士，讲师，硕士研究生导师
电子邮件：huiliyu@hubu.edu.cn
研究领域：细菌次级代谢途径中P450酶的发现、挖掘，酶工程和生物催化。
二、教育背景
2013.10–2018.10 德国马尔堡大学药物生物与生物技术研究所，理学博士
2010.09–2013.06 山东大学微生物技术国家重点实验室，理学硕士
2006.09–2010.06 山东大学生命科学学院，理学学士
三、工作经历
2020.12至今 湖北大学生命科学学院，讲师
2018.11–2019.11 德国马尔堡大学，药物生物与生物技术研究所，研究助理
四、发表论文
1. Yu H, Xie X, Li SM*. (2019) Coupling of cyclo-l-Trp-l-Trp with hypoxanthine increases the structure diversity of guanitrypmycins. Organic Letters 21, 9104–9108.
2. Yu H, Li SM*. (2019) Two cytochrome P450 enzymes from Streptomyces sp. NRRL S-1868 catalyze distinct dimerization of tryptophan-containing cyclodipeptides. Organic Letters 21, 7094–7098.
3. Yu H, Xie X, Li SM*. (2018) Coupling of guanine with cyclo-l-Trp-l-Trp mediated by a cytochrome P450 homologue from Streptomyces purpureus. Organic Letters 20, 4921–4925.
4. Liu J^#, Yu H^#, Li SM*. (2018) Expanding tryptophan-containing cyclodipeptide synthase spectrum by identification of nine members from Streptomyces strains. Applied Microbiology and Biotechnology 102, 4435–4444.
5. Yu H, Liebhold M, Xie X, Li SM*. (2015) Tyrosine O-prenyltransferases TyrPT and SirD displaying similar behavior toward unnatural alkyl or benzyl diphosphate as their natural prenyl donor dimethylallyl diphosphate. Applied Microbiology and Biotechnology 99, 7115–7124.
6. Yu H^#, Li H^#, Gao D, Gao C, Qi Q*. (2015) Secretory production of antimicrobial peptides in Escherichia coli using the catalytic domain of a cellulase as fusion partner. Journal of Biotechnology 214, 77–82.
7. Gao D, Wang S, Li H, Yu H, Qi Q*. (2015) Identification of a heterologous cellulase and its N-terminus that can guide recombinant proteins out of Escherichia Coli. Microbial Cell Factories 14, 49.
8. Wang S, Ma C, Yu H, Huang C, Qi Q*. (20) Development of a method for the efficient release of N-glycans from glycoproteins generating native deglycosylated proteins. 2012, Enzyme and Microbial Technology 51, 139–142.
9. 王圣钧, 郁慧丽, 翟琳, 王倚, 梁泉峰, 祁庆生*. 人GLP-1-IgG Fc融合蛋白在毕赤酵母中的高效表达, 2011, [J].生物技术, 21(4), 29–33.
五、获奖
1. 2013年，国家留学基金委（CSC）奖学金博士研究生项目
2. 2012年，研究生国家奖学金
3. 2009年，山东大学优秀学生二等奖学金
4. 2008年，山东大学优秀学生三等奖学金