姓 名 曾宪春 性 别 男
出生年月 1966年7月 籍贯 湖北武汉市
民 族 汉族 政治面貌 民建会员
最后学历 最后学位
技术职称 教授 导师类别 博导
行政职务 Email xianchun_zeng@hotmail.com
工作单位 邮政编码
通讯地址
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个人简介
曾宪春 男 博士、教授、博士生导师、湖北省楚天********、生物地质与环境地质国家重点实验室研究员、国际杂志 (Frontiers in Bioscience) (IF:3.5) 编委 (Managing Editor)、湖北省生物物理学会常务理事、国家科技奖励评审专家。
在武汉大学先后获得生物化学专业学士、分子生物学专业硕士、微生物学专业博士学位。2001-2008年先后赴德国马普免疫学研究所、美国国家卫生研究院和美国马里兰大学医学院从事研究工作；2009年在美国科贝尔国际公司任部门负责人；2010年起任中国地质大学 (武汉)“湖北省楚天********”。主要从事分子生物学、地质微生物学和环境基因组学领域的研究工作。近年来发表SCI期刊论文45篇，其中以第一作者或通讯作者发表32篇 (第一作者19篇，通讯作者13篇，总影响因子93，论文被引用780余次。2005年获湖北省自然科学一等奖，2008年获国际基因组先驱者奖 (Genomic Pioneer Awards) 提名奖。

工作经历

2010.02 -- 现在 中国地质大学（武汉）生物地质与环境地质国家重点实验室，湖北省
楚天********，博士生导师
2008.04 – 2009.12 美国Colbell International Inc. 生物技术首席科学家
2005.10 – 2008.04 University of Maryland School of Medicine, Baltimore, USA
美国马里兰大学医学院/研究员
2002.01 – 2005.09 National Institutes of Health, NHLBI, USA ,Research Sciensist
美国国立卫生研究院，心肺血液研究所研究科学家
2001.03 – 2001.12 Max-Planck Institute of Immunobiology, Freiburg, Germany
德国马普免疫生物学研究所/高级访问****
1995.09 – 2001.03 武汉大学生命科学学院生物技术系，团队负责人/副教授
1990.09 – 1995.08 武汉大学生物毒素研究中心，助教，讲师

教育经历
博士，2001，武汉大学生命科学学院生物技术系
研究领域：分子细胞生物学
硕士，1990，武汉大学生命科学学院分子生物学专业
学士，1987，武汉大学生物系生物化学专业

获奖、荣誉称号
1、国际基因组先驱者奖（Genomic Pioneer Awards）提名奖，2008；
2、湖北省自然科学一等奖，2005（排名第二，排名第一为武汉大学副校长李文鑫教授）；
3、武汉大学杰出研究成就奖，1999 – 2000；
4、武汉大学突出业绩津贴奖，1999；
5、国家医药技术创新人才基金，1997；
6、湖北省优秀科技论文二等奖 ，1994；
7、武汉大学三好学生奖，1985/1986。

社会、学会及学术兼职
1、Frontiers in Bioscience (影响因子4.0) 编委会成员；
2、The Scientific World Journal (影响因子1.7) 编委会成员；
3、Current Genomics(影响因子2.87) Guest Editor；
4、Current Proteins and Peptites Science(影响因子2.33) Guest Editor；
5、Journal of Biochemistry and Biotechnology(影响因子1.7) Guest Editor；
6、湖北省生物物理学会 常任理事；
7、美国多肽协会（American Peptide Society）会员；
8、美国实验生物学联合会（FASEB）会员。

研究领域
1、 地质与极端环境微生物介导的生物地球化学循环
2、地质与环境微生物分子生态学研究；
3、 毒素多肽药物开发与地质微生物酶的工业应用研究

科研项目
1、 国家自然科学基金：大同盆地高砷沉积物中微生物砷氧化酶与还原酶基因的多样性及其活性调节的研究(No. )(2015-2018)
2、 国家自然科学基金：微生物参与江汉平原高砷地下水形成的分子机制(No. )(2013-2016)
3、 国家自然科学基金：微生物参与江汉平原高砷地下水形成的分子机制 (No.**) (2011-2013)
4、 国家自然科学基金：基于环境基因组和转录组学的高砷地下水沉积物微生物群落的生物地球化学作用的研究 (No.**) (2013-2016)
5、 国家重点基础研究发展计划 (973) 项目子课题：我国特有产毒动物多肽毒素的基础与应用基础研究 (No.2010CB529800)(2010-2014)
6、中央高校基本科研业务费课题：
A 楚天********科研启动基金 (No.CUGL100613)
B 蝎毒素活性多肽的基础和应用研究 (No.CUGL110604)
C 蝎毒素转录组学和蛋白组学的研究 (No.CUGL120608)
7、 生物地质与环境地质国家重点实验室自主开放基金：塔克拉玛干沙漠典型大气-植被-土壤-地下水系统中的氮的生物地球化学循环过程
8、 国家科技部重点科技项目(攻关)计划, 抗癫痫肽的克隆和大量表达(Grant No. 96-901-033) (1996–1999)
9、 武汉晨光计划，东亚钳蝎神经毒素多肽的克隆分析和表达
(No. -24) (1997-2000)
10、 武汉大学自强基金，基因工程法生产重组抗癫痫肽的研究 (2000)

发表论文
1.H Li,X-C Zeng*, Z He, X Chen, G E, Y Han, Y Wang, Long-term performance of rapid oxidation of arsenite in simulated groundwater using a population of arsenite-oxidizing microorganisms in a bioreactor, Water Research,101 (2016) 393e401.（*代表通讯作者，下同）
2.Y Mu, Y Pan, W Shi, L Liu, Z Jiang X Luo,X-C Zeng*,W-J Li, Luteimonas arsenica sp. nov., a new arsenic-tolerant bacterium isolated from arsenic contaminated soil, International Journal of Systematic and Evolutionary Microbiology, 2016, 66.
3.L Zhang, W Shi, XC Zeng*, F Ge, M Yang, Y Nie, Unique diversity of the venom peptides from the scorpion Androctonus bicolor revealed by transcriptomic and proteomic analysis, Journal of Proteomics, 2015,Volume 128, 231–250.
4.A Bao, J Zhong, XC Zeng*, Y Nie,A novel cysteine‐free venom peptide with strong antimicrobial activity against antibiotics‐resistant pathogens from the scorpion Opistophthalmus glabrifrons, Journal of Peptide Science, 2015, Volume 21, Issue 10, 758–764
5.Ao L, XC Zeng*, Nie Y, Mu Y, Zhou L, Luo X. Flavobacterium arsenatis sp. nov., a novel arsenic-resistant bacterium from high-arsenic sediment. Int J Syst Evol Microbiol. 2014 ;64(Pt 10):33,69-74.
6.Xu L, XC Zeng*, Nie Y, Luo X, Zhou E, Zhou L, Pan Y, Li W. Pontibacter diazotrophicus sp. nov., a novel nitrogen-fixing bacterium of the family Cytophagaceae. PLoS One. 2014 ;9(3):e,922-940.
7.Yang Y, XC Zeng*, Zhang L, Nie Y, Shi W, Liu Y. Androcin, a novel type of cysteine-rich venom peptide from Androctonus bicolor, induces akinesia and anxiety-like symptoms in mice. IUBMB Life. 2014 ;66(4):277-285.
8.Cao H, Nie Y, XC Zeng*, Xu L, He Z, Luo X, Wu R. Pontibacter yuliensis sp. nov., isolated from soil. Int J Syst Evol Microbiol. 2014 ;64(Pt 3):968-972.
9.Wu S, Nie Y, XC Zeng*, Cao H, Zhang L, Zhou L, Yang Y, Luo X, Liu Y. Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. Peptides. 2014 ;53:30-41.
10.XC Zeng*, Liu Y, Shi W, Zhang L, Luo X, Nie Y, Yang Y. Genome-wide search and comparative genomic analysis of the trypsin inhibitor-like cysteine-rich domain-containing peptides. Peptides. 2014 ;53:106-114.
11.XC Zeng*, Zhou L, Shi W, Luo X, Zhang L, Nie Y, Wang J, Wu S, Cao B, Cao H Three new antimicrobial peptides from the scorpion Pandinus imperator. Peptides. 2013 ;45:28-34.
12.XC Zeng*, Nie Y, Luo X, Wu S, Shi W, Zhang L, Liu Y, Cao H, Yang Y, Zhou J.Molecular and bioinformatical characterization of a novel superfamily of cysteine-rich peptides from arthropods. Peptides. 2013 ;41:45-58.
13.XC Zeng*, Luo X, Wang SX, Zhan X. Fibronectin-mediated cell spreading requires ABBA-Rac1 signaling. J Cell Biochem. 2013 ;114(4):773-781.
14.Nie Y, XC Zeng*, Yang Y, Luo F, Luo X, Wu S, Zhang L, Zhou J. A novel class of antimicrobial peptides from the scorpion Heterometrus spinifer. Peptides. 2012 ;38(2):389-394.
15.Nie Y, XC Zeng*, Luo X, Wu S, Zhang L, Cao H, Zhou J, Zhou L. Tremendous intron length differences of the BmKBT and a novel BmKBT-like peptide genes provide a mechanical basis for the rapid or constitutive expression of the peptides. Peptides. 2012 ;37(1):150-160.
16.Luo X, Wang J, XC Zeng*, Wang Y, Zhou L, Nie Y, Dai J, Fang C. Mycetocola manganoxydans sp. nov., an actinobacterium isolated from the Taklamakan desert.Int J Syst Evol Microbiol. 2012 ;62(Pt 12):29,67-70.
17.XC Zeng*, Zhang L, Nie Y, Luo X. Identification and molecular characterization of three new K+-channel specific toxins from the Chinese scorpion Mesobuthus martensii Karsch revealing intronic number polymorphism and alternative splicing in duplicated genes. Peptides. 2012 ;34(2):311-323.
18.XC Zeng*, Wang S, Nie Y, Zhang L, Luo X. Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch:gaining insight into a new mechanism for the functional diversification of scorpion venom peptides. Peptides. 2012 ;33(1):44-51.
19.Zheng D, Niu S, Yu D, Zhan XH, XC Zeng, Cui B, Chen Y, Yoon J, Martin SS, Lu X, Zhan X, Abba promotes PDGF-mediated membrane ruffling through activation of the small GTPase Rac1. Biochem. Biophys. Res. Commun.2010; 401(4):527-532.
20.Zhu J, Yu D, XC Zeng, Zhou K, Zhan X, Receptor-mediated endocytosis involves tyrosine phosphorylation of cortactin. J. Biol. Chem. 2007; 282(22): 16086-16094.
21.Wang Y, Zhou K, XC Zeng, Lin J, Zhan X, Tyrosine phosphorylation of missing in metastasis protein is implicated in platelet-derived growth factor-mediated cell shape changes. J. Biol. Chem.2007; 282(10): 7624-7631.
22.XC Zeng, Feng L, Li WX, Molecular dissection of venom from Chinese scorpion Mesobuthus martensii Karsch: identification and characterization of four novel disulfide-bridged venom peptides. Peptides.2006; 27(7): 1745-1754.
23.XC Zeng, Feng L, Li WX, Characterization of a novel cDNA encoding a short venom peptide derived from venom gland of scorpion Buthus martensii Karsch: trans-splicing may play an important role in the diversification of scorpion venom peptides. Peptides.2006; 27(4): 675-681.
24.Luo F, XC Zeng, Hahin R, Cao ZJ, Liu H, Li WX, Genomic organization of four novel non-disulfide-bridged peptides from scorpion Mesobuthus martensii Karsch: gaining insight into evolutionary mechanism. Peptides.2005; 26(12): 2427-2433.
25.XC Zeng, Hahin R,Corzo G Scorpion venom peptides with no disulfide bridge. IUBMB Life.2005; 57 (1):13-21.
26.XC Zeng, Bhasin S, Wu X, Lee JG, Kaushal S, Nichols CJ, Taylor JP, Greene LE, Eisenberg E Hsp70 dynamics in vivo: effect of heat shock and protein aggregation. J. Cell Sci.2004; 117 (21):4991-5000.
27.XC Zeng, Wang SX, Zhu Y, Zhu SY,Li WX, Identification and functional characterization of novel scorpion venom peptides with no disulfide bridge from Buthus martensii Karsch. Peptides.2004; 25(2):143-150.
28.Herzog W, XC Zeng, Lele Z, Sonntag C, Ting JW, Chang CY, Hammerschmidt M Adenohy○physis formation in zebrafish and its dependence on Sonic Hedgehog. Developmental Biology.2003; 254(1):36-49.
29.XC Zeng, Wang SX, Li WX ,Identification of BmKAPi, a novel type of scorpion venom peptide with peculiar disulfide bridge pattern from Buthus martensii Karsch. Toxicon.2002; 40(12): 1719-1722.
30.Peng F, XC Zeng, He XH, Pu J, Li WX, Zhu ZH, Liu H, Molecular cloning and functional expression of a gene encoding an antiarrhythmia peptide derived from the scorpion toxin. Eur. J. Biochem. 2002;269(18): 4468-4475.
31.XC Zeng, Wang SX, Evidence for that BmKTXKbeta-BmKCT cDNA from Chinese scorpion Buthus martensii Karsch is an artifact generated in the reverse transcription process. FEBS Letters.2002; 520(1-3):183-184.
32.XC Zeng, Li WX, Peng F, Luo F, Zhu SY, Liu H, Li WX, Molecular cloning and characterization of four scorpion K+-toxin-like peptides: a new subfamily of scorpion venom peptides (alpha-KTx14) and genomic analysis of a member. Biochimie.2001; 83(9):883-889.
33.XC Zeng, Li WX, Wang SX, Zhu SY, Luo F, Precursor of a novel scorpion venom peptide (BmKn1) with no disulfide bridge from Buthus martensii Karsch. IUBMB Life.2001; 51(2):117-120.
34.Zhu SY, Li WX, XC Zeng, Precursor nucleotide sequence and genomic organization of BmTXKS1, a new scorpion toxin-like peptide from Buthus martensii Karsch. Toxicon.2001; 39:1291-1296.
35.Zhu SY, Li WX, Jiang DH, XC Zeng, Evidence for existence of insect defensin-like peptide in scorpion venom. IUBMB Life.2000; 50(1):57-61.
36.XC Zeng, Zhu SY, Li WX, Peng F, Zhu ZH, Liu H, Mao X, Molecular cloning and characterization of cDNAs encoding the precursors of a beta-toxin-like peptide and two MkTx1 homologues from the scorpion Buthus martensii Karsch. Toxicon.2001; 39(2/3):225-232.
37.XC Zeng, Zhu ZH, Li WX, Zhu SY, Peng F, Mao X, Liu H, Molecular cloning and genomic organization of a K+ channel toxin from Chinese scorpion Buthus martensii Karsch, Toxicon.2001; 39(2/3):407-410.
38.XC Zeng, Li WX, Zhu SY, Peng F, Zhu ZH, Wu KL, Yang FH, Cloning and characterization of a novel cDNA sequence encoding the precursor of a chlorotoxin-like peptide from the Chinese scorpion Buthus martensii Karsch. Toxicon.2000; 38(8):1009-1014.
39.XC Zeng, Li WX, Zhu SY, Peng F, Jiang DH, Yang FH, Wu KL, Cloning and characterization of cDNA sequences encoding precursors of two venom peptides from Chinese scorpion Buthus martensii Karsch. Toxicon.2000; 38(7):893-899.
40.XC Zeng, Li WX, Peng F, Zhu ZH, Molecular cloning and characterization of a cDNA sequence encoding the precursor of a novel venom peptide related to a bradykining-potentiating peptide (peptide K-12) from the Chinese scorpion Buthus martensii Karsch. IUBMB Life.2000; 49(3):207-210.
41.Zhu, SY; XC Zeng; Li, WX; Jiang, DH, Molecular characterization of a K+ channel blocker in the scorpion Buthus martensii Karsch . Chin. Sci. Bull.2000; 45 (8):739-743.
42.Zhu SY, Li WX, XC Zeng, Liu H, Jiang DH, Mao X , Nine novel precurcurs of Buthus martensii Karsch scorpion alpha-toxin homologues. Toxicon.2000; 38:1653-1661.
43.Zhu SY, Li WX, Jiang DH, XC Zeng , Evidence for the existence of insect defensin-like peptide in scorpion venom. IUBMB Life.2000; 50(1):57-61.
44.Zhu SY, Li WX, XC Zeng, Jiang DH, Liu H, Mao Molecular cloning and sequencing of two short-chain and two long-chain K+-channel blocker from Chinese scorpion Buthus martensii Karsch. FEBS Letters.1999; 457(3):509-514.
45.XC Zeng, Jaing DH, Li WX, Perbal B Studies on nov gene. Prog. Biochem. Biophys.1997; 24(5):414-418.

科研创新
1、一种亚洲雨林蝎抗菌肽及其用途(2.1)
2、 蝎抗心律失常肽及其制备方法和应用 (CN**)

教学活动
本科生细胞生物学