1.基本情况
丁仁博 男 博士 副教授 硕士生导师
联系方式：海南省海口市人民大道58号热带生物资源教育部重点实验室305室
邮箱：dingrenbo@hainanu.edu.cn
2.教育背景及工作经历
2021.7-至今 海南大学，药学院，副教授
2014.8-2020.7 澳门大学，健康科学学院，生物医药博士
2011.8-2017-7 澳门大学，中药质量研究国家重点实验室，中药学硕士
2007.9-2011.7 南京农业大学，动物科技学院，动物科学本科
3.教学情况
硕士生招生专业：药学学术硕士（100700）、生物与医药专业硕士（086000）
4.科研情况
主要研究方向为肿瘤类器官模型建立、抗肿瘤药理学和肿瘤基因组学。成功建立了多癌种的类器官微肿瘤培养体系，包括乳腺癌、鼻咽癌、结直肠癌、肺癌等。结合肿瘤类器官药敏和基因组学测序，建立了一套基于药物基因组学为核心的肿瘤个体化治疗策略，为数十例晚期癌症患者提供了精准用药指导。在Nature Communications、Advanced Science等期刊发表多篇论文。
5.研究领域
1）肿瘤个体化治疗
2）肿瘤免疫治疗
6.代表性项目
1）海南大学科研启动基金项目，2021.7至2026.7，主持
7.代表性成果
1. RB Ding, P Chen, BK Rajendran, XY Lyu, HT Wang, JL Bao, JM Zeng, WH Hao, H Sun, AH Wong, M Valecha, EJ Yang, SM Su, TK Choi, SM Liu, KI Chan, LL Yang, JB Wu, K Miao, Q Chen, JS Shim, XL Xu, CX Deng*. Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics, Nature Communications, 2021, 12, 3046. (IF=14.919, 中科院大类一区)
2. P Chen, X Zhang, RB Ding, LL Yang, XY Lyu, JM Zeng, HP Lei, LJ Wang, J Bi, N Shao, DT Shu, B Wu, JB Wu, ZH Yang, HY Wang, BQ Wang, K Xiong, Y Lu, SZ Fu, TK Choi, NW Lon, YY Quan, Y Meng, K Miao, H Sun, M Zhao, JB Bao, L Zhang, XL Xu, YX Shi, Y Lin, CX Deng*. Patient-derived organoids can guide personalized-therapies for patients with advanced breast cancer. Advanced Science. 2021, DOI: 10.1002/advs..
3. RB Ding, JL Bao, CX Deng*. Emerging roles of SIRT1 in fatty liver diseases. International Journal of Biological Sciences. 2017, 7, 852-867.
4. RB Ding, K Tian, YW Cao, JL Bao, M Wang, CW He, YJ Hu, HX Su, JB Wan*. Protective effect of panax notoginseng saponins on acute ethanol-induced liver injury is associated with ameliorating hepatic lipid accumulation and reducing ethanol-mediated oxidative stress. Journal of Agricultural and Food Chemistry. 2015, 9, 2413-2422. (中科院大类一区)
5. RB Ding, JL Bao, YW Cao, CW He, YT Wang, JB Wan*. Panax notoginseng saponins protect against chronic ethanol-induced hepatic steatosis. Journal of Chinese Pharmaceutical Sciences. 2014, 6, 361-368.
6. RB Ding, K Tian, CW He, YT Wang, JB Wan*. Herbal medicines for the prevention of alcoholic liver disease: A review. Journal of Ethnopharmacology. 2012, 3, 457-465.
7. RB Ding, H Su, YD Hu, R Shi, F Xie, LJ Wang, SW Gao. Comparison of muscle fiber growth from F1 generations of large yorkshire pig and erhualian pig by reciprocal cross. Animal Husbandry and Feed Science. 2010, 10-12, 1-3,10.
8. 丁仁博，苏浩，胡耀东，石蕊，王丽娟，高树文。猪正反交 F1代背最长肌中 H3.3基因表达的发育性变化. 中国畜牧兽医.2011, 38(10), 113-117.
9. JL Bao, RB Ding, XJ Jia, YE Liang, F Liu, K Wang, C Zhang, MW Chen, P Li, HX Su, JB Wan, YT Wang, CW He*. Fast identification of anticancer constituents in Forsythiae Fructus based on the metabolomics approaches. Journal of Pharmaceutical and Biomedical Analysis. 2018, 5, 312-320.
10. JL Bao, RB Ding, YE Liang, F Liu, K Wang, XJ Jia, C Zhang, MW Chen, P Li, HX Su, JB Wan, YT Wang, CW He*. Differences in chemical component and anticancer activity of green and ripe Forsythiae Fructus. The American Journal of Chinese Medicine. 2017, 7, 1513-1536.
11. JL Bao, RB Ding, LD Zou, C Zhang, K Wang, F Liu, P Li, MW Chen, JB Wan, HX Su, YT Wang, CW He*. Forsythiae Fructus aqueous extract inhibits B16 melanoma growth involving MAPKs/Nrf2/HO-1 mediated anti-oxidation and anti-inflammation. The American Journal of Chinese Medicine. 2016, 5, 1043-1061.
12. F Liu, X Bai, RB Ding, YJ Hu, HX Su, JB Wan*. UPLC/Q-TOF MS-based metabolomics studies on the protective effect of Panax notoginseng saponins on alcoholic liver injury. American Journal of Chinese Medicine. 2015, 4, 695-714.
13. FY Shao, XY Lyu, K Miao, LS Xie, HT Wang, H Xiao, J Li, Q Chen, RB Ding, P Chen, FQ Xing, X Zhang, GH Luo, WL Zhu, G Cheng, NW Lon, SE. Martin, GY Wang, GK Chen, YL Dai, CX Deng*. Enhanced protein damage clearance induces broad drug resistance in multitype of cancers revealed by an evolution drug resistant model and genome‐wide siRNA screening. Advanced Science. 2020, 23, **.