一、基本情况
黄仪有 男 博士 研究员 硕士生导师
邮箱：hyyou@hainanu.edu.cn
教育背景及工作经历
2021. 09 – 海南大学药学院，研究员
2020. 09 – 2021. 08 中山大学药学院，特聘副研究员
2018. 09 – 2020. 08 中山大学药学院，博士后
2015. 09 – 2018. 06 中山大学药学院，药物化学博士
2011. 09 – 2014. 06 中山大学药学院，药物化学硕士
2007. 09 – 2011. 06 南方医科大学药学院，药学学士
二、科研情况
利用X射线晶体学等结构生物学技术手段，解析药物靶标的三维结构，并以靶标为中心开展药物设计和药物化学等药学研究，特别是围绕磷酸二酯酶(PDEs)及其选择性抑制剂的开发进行相关研究。主持国家自然科学基金青年基金等4项基金，并在国内外重要学术期刊如Proc Natl Acad Sci USA、J Med Chem、Acta Pharm Sin B、Org Lett等发表论文20余篇，其中（并列）一作/（共同）通讯作者14篇，授权发明专利3项。
三、研究领域
结构生物学及基于靶标结构的药物设计
四、代表性项目
1）海南大学科研启动经费，2021 – 2026，主持
2）国家自然科学基金青年基金，2021 – 2023，主持
3）中国博士后科学基金面上资助二等，2019 – 2020，主持
4）中山大学高校基本科研业务费青年教师培育项目，2018 – 2021，主持
五、代表性成果
1) Yi-You Huang#, Jinhui Deng#, Yi-Jing Tian#, Jinhao Liang, Xi Xie, Yue Huang, Jiaqi Zhu, Ziran Zhu, Qian Zhou, Xixin He*, Hai-Bin Luo*. Mangostanin Derivatives as Novel and Orally Active PDE4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety. J. Med. Chem. 2021. Accept.
2) Yi-You Huang#, Yan-Fa Yu#, Chen Zhang#, Yiping Chen, Qian Zhou, Zhuoming Li, Sihang Zhou, Zhe Li, Lei Guo, Deyan Wu*, Yinuo Wu*, Hai-Bin Luo*. Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly
Selective and Subnanomolar Inhibitors. J. Med. Chem. 2019, 62: 3707-3721
3) Yiyou Huang#, Xin Liu#, Deyan Wu, Guihua Tang, Zengwei Lai, Xuehua Zheng*, Sheng Yin*, Hai-Bin Luo*. The Discovery, Complex Crystal Structure, and Recognition Mechanism of a Novel Natural PDE4 Inhibitor from Selaginella pulvinata. Biochem. Pharmacol. 2017, 130:
51-59.
4) Yi-You Huang, Zhe Li, Yinghong Cai, Lingjun Feng, Yinuo Wu, Xingshu Li, Hai-bin Luo*. The Molecular Basis for the Selectivity of Tadalafil Toward Phosphodiesterase 5 and 6: a Modeling Study. J. Chem. Inf. Model. 2013, 53: 3044-3053.
5) Jinhao Liang#, Yi-You Huang#, Qian Zhou#, Yuqi Gao, Zhe Li, Deyan Wu, Si Yu, Lei Guo, Zhen Chen, Ling Huang, Steven H. Liang, Xixin He*, Ruibo Wu*, Hai-Bin Luo*. Discovery and Optimization of α-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J. Med. Chem. 2020, 63: 3370-3380
6) Zhe Li#, Yiyou Huang #, Yinuo Wu, Jingyi Chen, Deyan Wu, Chang-Guo Zhan*, Hai-Bin Luo*. Absolute Binding Free Energy Calculation and Design of a Subnanomolar Inhibitor of
Phosphodiesterase-10. J. Med. Chem. 2019, 62: 2099-2111
7) Zhe Li#, Xin Li#, Yi-You Huang#, Yaoxing Wu, Runduo Liu, Lingli Zhou, Yuxi Lin, Deyan Wu, Lei Zhang,Hao Liu, Ximing Xu, Kunqian Yu, Yuxia Zhang, Jun Cui*, Chang-Guo Zhan*, Xin Wang*, Hai-Bin Luo*. Identify Potent SARS-CoV-2 Main Protease Inhibitors via Accelerated Free Energy Perturbation-based Virtual Screening of Existing Drugs. Proc. Natl. Acad. Sci. USA .2020, 117: 27381-27387.
8) Yuncong Yang#, Sirui Zhang#, Qian Zhou#, Chen Zhang, Yuqi Gao, Hao Wang, Zhe Li, Deyan Wu, Yinuo Wu, Yi-You Huang*, Lei Guo*, Hai-Bin Luo*. Discovery of Highly Selective and Orally Available Benzimidazole-based Phosphodiesterase 10 Inhibitors with Improved Solubility and Pharmacokinetic Properties for Treatment of Pulmonary Arterial Hypertension. Acta Pharm. Sin. B. 2020, 10(12),2339-2347.
9) Yan-Fa Yu#, Chen Zhang#, Yi-You Huang#, Sirui Zhang, Qian Zhou, Xiangmin Li, Zengwei Lai, Zhe Li, Yuqi Gao, Yinuo Wu, Lei Guo*, Deyan Wu*, Hai-Bin Luo. Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors. ACS Chem. Neurosci. 2020, 11: 1058-1071.
10) Xiaoxia Qiu#, Yiyou Huang#, Deyan Wu, Fei Mao, Jin Zhu, Wenzhong Yan*, Hai-bin Luo*, Jian Li*. Discovery of Novel Purine Nucleoside Derivatives as Phosphodiesterase 2 (PDE2) Inhibitors: Structure-based Virtual Screening, Optimization and Biological Evaluation. Bioorgan. Med. Chem. 2018, 26: 119-133
11) Ting Yao#, Yiyou Huang#, Meng Zhang, Yujuan Chen, Hairun Pei, Jianyou Shi*, Huanchen Wang*, Yousheng Wang*, Hengming Ke*. Crystal Structures of Candida Albicans Phosphodiesterase 2 and Implications for Its Biological Functions. Biochemistry, 2018, 57: 6070-6077.
12) Tingting Lin#, Yiyou Huang#, Guihua Tang, Zhongbin Cheng, Xin Liu, Hai-bin Luo*, Sheng Yin*. Prenylated Coumarins: Natural Phosphodiesterase-4 Inhibitors from Toddalia Asiatica. J. Nat. Prod. 2014, 77: 955-962.
13) Yena Liu#, Yiyou Huang#, Jingmei Bao, Yinghong Cai, Yanqiong Guo, Shaonan Liu, Hai-bin Luo*, Sheng Yin*. Natural Phosphodiesterase-4 (PDE4) Inhibitors from Crotalaria Ferruginea. Fitoterapia, 2014, 94: 177–182.
14) Jiasheng Zhong#, Yiyou Huang#, Wenjing Ding, Xiaofang Wu, Jinzhi Wan*, Hai-bin Luo*. Chemical Constituents of Aloe Barbadensis Miller and Their Inhibitory Effects on Phosphodiesterase-4D. Fitoterapia, 2013, 91: 159-165.